Many organizations critically depend on very large information systems. In the authors' experience these organizations often struggle to find the right strategy to sustainably develop their systems. Based on their own experience at a major bank, over more than a decade, the authors have developed a successful strategy to deal with these challenges, including: - A thorough analysis of the challenges associated with very large information systems - An assessment of possible strategies for the development of these systems, resulting in managed evolution as the preferred strategy - Describing key system aspects for the success of managed evolution, such as architecture management, integration architecture and infrastructure - Developing the necessary organizational, cultural, governance and controlling mechanisms for successful execution
Many organizations critically depend on very large information systems. In the authors' experience these organizations often struggle to find the right strategy to sustainably develop their systems. Based on their own experience at a major bank, over more than a decade, the authors have developed a successful strategy to deal with these challenges, including: - A thorough analysis of the challenges associated with very large information systems - An assessment of possible strategies for the development of these systems, resulting in managed evolution as the preferred strategy - Describing key system aspects for the success of managed evolution, such as architecture management, integration architecture and infrastructure - Developing the necessary organizational, cultural, governance and controlling mechanisms for successful execution
The Second World War is omnipresent in contemporary memory debates. As the war fades from living memory, this study is the first to systematically analyze how Second World War museums allow prototypical visitors to comprehend and experience the past. It analyzes twelve permanent exhibitions in Europe and North America – including the Bundeswehr Military History Museum in Dresden, the Museum of the Second World War in Gdańsk, the House of European History in Brussels, the Imperial War Museums in London and Manchester, and the National WWII Museum in New Orleans – in order to show how museums reflect and shape cultural memory, as well as their cognitive, ethical, emotional, and aesthetic potential and effects. This includes a discussion of representations of events such as the Holocaust and air warfare. In relation to narrative, memory, and experience, the study develops the concept of experientiality (on a sliding scale between mimetic and structural forms), which provides a new textual-spatial method for reading exhibitions and understanding the experiences of historical individuals and collectives. It is supplemented by concepts like transnational memory, empathy, and encouraging critical thinking through difficult knowledge.
An Innovative Approach to Studying and Treating Cancer: Targeting pH describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognized as one of the most selective and differential hallmarks of all cancer cells and tissues, being the opposite of the condition found in normal tissues and a potential target in order to achieve either a stable disease or even regression with no toxicity. The book discusses topics such as lactic acid and its transport system in the pH paradigm, mechanisms to decrease extra cellular pH and increase intracellular pH, NHE-1 activity in cancer, carbonic anhydrases, vacuolar ATPase proton pump, and the sodium-bicarbonate cotransporter system. Additionally, it discusses complementary pharmacological interventions, cellular acidification and extracellular alkalinization as a new and integral approach to cancer treatment. Analyzes the mechanisms that lead to the inversion of pH gradient in cancer tissues Summarizes almost 100 years of research on pH inversion in cancer in one single source, discussing the most relevant and updated researches in the field Proposes new efficient treatments against cancer using pH inversion mechanisms, either with new drugs like proton transport inhibitors and proton pump inhibitors (PTIs and PPIs) or with repurposed drugs
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