Wnt signaling in Development and Disease: Molecular Mechanisms and Biological Functions reviews the core topics in Wnt signaling, from molecular pathway mechanisms to its role in embryogenesis, adult tissue homeostasis, and chronic disease. Written by a team of expert reviewers, the book provides clear and concise coverage of the core foundations of Wnt signaling before advancing to discussion of cutting-edge scientific research. Focused on the biological insights and current scientific questions of Wnt signaling, this book will be a comprehensive and definitive resource for a wide range of researchers and students in cell signaling, cell physiology, developmental biology, and biomedical engineering, as well as anyone interested in learning more about this important and complex protein network. • A definitive source of information on Wnt signaling and its role in development and disease, written by leaders in the field. • Explores the role of Wnt signaling in chronic disease such as melanoma, colorectal cancer, dementia, and psychiatric diseases • Reviews the complex processes of signal integration and regulation • Features broad discussion of Wnt signaling biology as well as detailed discussion of the pathway’s role in diseases and potential clinical applications.
The implicit questions that inevitably underlie German bioethics are the same ones that have pervaded all of German public life for decades: How could the Holocaust have happened? And how can Germans make sure that it will never happen again? In Reasons of Conscience, Stefan Sperling considers the bioethical debates surrounding embryonic stem cell research in Germany at the turn of the twenty-first century, highlighting how the country’s ongoing struggle to come to terms with its past informs the decisions it makes today. Sperling brings the reader unmatched access to the offices of the German parliament to convey the role that morality and ethics play in contemporary Germany. He describes the separate and interactive workings of the two bodies assigned to shape German bioethics—the parliamentary Enquiry Commission on Law and Ethics in Modern Medicine and the executive branch’s National Ethics Council—tracing each institution’s genesis, projected image, and operations, and revealing that the content of bioethics cannot be separated from the workings of these institutions. Sperling then focuses his discussion around three core categories—transparency, conscience, and Germany itself—arguing that without fully considering these, we fail to understand German bioethics. He concludes with an assessment of German legislators and regulators’ attempts to incorporate criteria of ethical research into the German Stem Cell Law.
This book explores the view that impoverishment and Agree operations are part of a single grammatical component. The architecture set forth here gives rise tocomplex but highly systematic interactions between the two operations. This interaction is shown to provide a unified and general account of apparentlydiverse and unrelated intances of eccentric argument encoding that so far haveremained elusive to a unified theoretical account. The proposed view of the grammatical architecture achieves an integration of these phenomena withinbetter-studied languages and thus gives rise to a more general theory of caseand agreement phenomena. The empirical evidence on the basis of which the proposal is developed drawsfrom a wide range of typologically non-related languages, including Basque, Hindi, Icelandic, Itelmen, Marathi, Nez Perce, Niuean, Punjabi, Sahaptin, Selayarese, Yukaghir, and Yurok . The proposal has far-reaching consequences for the study of grammatical architecture, linguistic interfaces, derivational locality in apparently non-local dependencies and the role of functional considerations in formal approaches tothe human language faculty.
Presents a collection of questions to help readers determine where they are in their life and career, formulate goals, and how to achieve them, along with questions and answers from a variety of writers, musicians, and artists that they were asked on their way to success.
Fintech Dictionary - What is a blockchain framework? What is crowdlending or an ICO? The Fintech Dictionary helps readers in clarifying key terms that have emerged in the vivid field of financial technology (fintech). It links keywords from banking and insurance, from information technology as well as from innovation management – similar to the „melting pot“ of terms in reality. The collection of over 830 keywords presents the reader concise and up-to-date definitions of terms in an alphabetical order. It should serve students and interested parties from academia and practice alike.
Fintech Dictionary - What is a blockchain framework? What is crowdlending or an ICO? The Fintech Dictionary helps readers in clarifying key terms that have emerged in the vivid field of financial technology (fintech). It links keywords from banking and insurance, from information technology as well as from innovation management – similar to the „melting pot“ of terms in reality. The collection of over 830 keywords presents the reader concise and up-to-date definitions of terms in an alphabetical order. It should serve students and interested parties from academia and practice alike.
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