The development of new medications for pain and drug abuse is a serious and pressing issue in the medical world of addiction treatments. Edited by Stanley Glick and Isabelle Maisonneuve, this book focuses on collected studies performed and recorded by leading doctors and researchers in the field of drug research. Research on the problems associated with pharmacology of drug abuse demands not only the determination of the mechanisms of cellular action of the addictive substances, but also short- and long-term physiological effects of addiction and of treatment, including the course of withdrawal symptoms. This volume focuses on protocols for development of new pharmacotherapies for drug abuse, including alcoholism and smoking; bridging animal and human models; preclinical assessment models; new approaches to treatment of pain during withdrawal; new treatments for stimulant and opioid addictions. Larger-scale social issues posed by this seemingly refractory problem, such as prenatal cocaine exposure and the legacy of methadone, are also examined. Presenting their results with worldwide public health issues in mind, this distinguished group of contributors tackle the present and potential problems concerning drug abuse medications. Contributors include Jean Bidlack, Frank Porreca, Lindsay Hough, Gerald Gebhart, Thomas Kosten, Nancy Mello, Stevens Negus, David Self, David Roberts, Donald Landry, George Koob, Mary Jeanne Kreek, Richard Keller, Edward Sellers, and Jack Henningfield.