Standing Committee on Risk Analysis Issues and Reviews's Books

Toxicity-Pathway-Based Risk Assessment

Preparing for Paradigm Change: A Symposium Summary

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Standing Committee on Risk Analysis Issues and Reviews

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Toxicity-Pathway-Based Risk Assessment

Preparing for Paradigm Change: A Symposium Summary

By: National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Standing Committee on Risk Analysis Issues and Reviews

In 2007, the National Research Council envisioned a new paradigm in which biologically important perturbations in key toxicity pathways would be evaluated with new methods in molecular biology, bioinformatics, computational toxicology, and a comprehensive array of in vitro tests based primarily on human biology. Although some considered the vision too optimistic with respect to the promise of the new science, no one can deny that a revolution in toxicity testing is under way. New approaches are being developed, and data are being generated. As a result, the U.S. Environmental Protection Agency (EPA) expects a large influx of data that will need to be evaluated. EPA also is faced with tens of thousands of chemicals on which toxicity information is incomplete and emerging chemicals and substances that will need risk assessment and possible regulation. Therefore, the agency asked the National Research Council to convene a symposium to stimulate discussion on the application of the new approaches and data in risk assessment. The symposium was held on May 11-13, 2009, in Washington, DC, and included presentations and discussion sessions on pathway-based approaches for hazard identification, applications of new approaches to mode-of-action analyses, the challenges to and opportunities for risk assessment in the changing paradigm, and future directions.

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Page Count

134

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National Academies Press

Published Date

ISBN 10

0309154227

ISBN 13

9780309154222

Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids

By: Institute of Medicine,Food and Nutrition Board,Standing Committee on the Scientific Evaluation of Dietary Reference Intakes,Subcommittee on Interpretation and Uses of Dietary Reference Intakes,Subcommittee on Upper Reference Levels of Nutrients,Panel on Dietary Antioxidants and Related Compounds

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Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids

This volume is the newest release in the authoritative series of quantitative estimates of nutrient intakes to be used for planning and assessing diets for healthy people. Dietary Reference Intakes (DRIs) is the newest framework for an expanded approach developed by U.S. and Canadian scientists. This book discusses in detail the role of vitamin C, vitamin E, selenium, and the carotenoids in human physiology and health. For each nutrient the committee presents what is known about how it functions in the human body, which factors may affect how it works, and how the nutrient may be related to chronic disease. Dietary Reference Intakes provides reference intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for different groups based on age and gender, along with a new reference intake, the Tolerable Upper Intake Level (UL), designed to assist an individual in knowing how much is "too much" of a nutrient.

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530

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National Academies Press

Published Date

ISBN 10

0309069491

ISBN 13

9780309069496

Review of the Research Program of the Partnership for a New Generation of Vehicles

Fifth Report

By: National Research Council,Division on Engineering and Physical Sciences,Commission on Engineering and Technical Systems,Standing Committee to Review the Research Program of the Partnership for a New Generation of Vehicles

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Review of the Research Program of the Partnership for a New Generation of Vehicles

Fifth Report

This fifth review of the Partnership for a New Generation of Vehicles assesses progress made in the program towards the development of high fuel economy vehicles. One of the goals of the program is to develop midsize sedans with up to three times the fuel economy of today's vehicles. Concept vehicles are slated for 2000 and production prototypes for 2004. The book addresses engine technologies, batteries for energy storage, fuel cells, lightweight materials, fuels, emissions control systems, power electronics, and vehicle systems engineering.

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123

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National Academies Press

Published Date

ISBN 10

0309184231

ISBN 13

9780309184236

Review of the Research Program of the Partnership for a New Generation of Vehicles

Sixth Report

By: Transportation Research Board,Commission on Engineering and Technical Systems,Board on Energy and Environmental Systems,Standing Committee to Review the Research Program of the Partnership for a New Generation of Vehicles

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Review of the Research Program of the Partnership for a New Generation of Vehicles

Sixth Report

Review of the Research Program of the Partnership for a New Generation of Vehicles reviews the Partnership for a New Generation of Vehicles (PNGV). The PNGV program is a cooperative research and development (R&D) program between the federal government and the United States Council for Automotive Research (USCAR). A major objective of the PNGV program is to develop technologies for a new generation of vehicles with fuel economies up to three times (80 miles per gallon [mpg]) those of comparable 1994 family sedans. At the same time, these vehicles must be comparable in terms of performance, size, utility, and cost of ownership and operation and must meet or exceed federal safety and emissions requirements. The intent of the PNGV program is to develop concept vehicles by 2000 and production prototype vehicles by 2004. This report examines the overall adequacy and balance of the PNGV research program to meet the program goals and requirements (i.e., technical objectives, schedules, and rates of progress). The report also discusses ongoing research on fuels, propulsion engines, and emission controls to meet emission requirements and reviews the USCAR partners' progress on PNGV concept vehicles for 2000.

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Page Count

131

Publisher

National Academies Press

Published Date

ISBN 10

0309070945

ISBN 13

9780309070942

Book's by Standing Committee on Risk Analysis Issues and Reviews

Toxicity-Pathway-Based Risk Assessment

Toxicity-Pathway-Based Risk Assessment

Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids

Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids

Review of the Research Program of the Partnership for a New Generation of Vehicles

Review of the Research Program of the Partnership for a New Generation of Vehicles

Review of the Research Program of the Partnership for a New Generation of Vehicles

Review of the Research Program of the Partnership for a New Generation of Vehicles

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