#PlaneBae meets Gilmore Girls in this hilarious and heartfelt story about the addictiveness of Internet fame and the harsh realities of going viral. Macy Evans dreams of earning enough income from her YouTube channel, R3ntal Wor1d, to leave her small, Midwestern town. But when she meets a boy named Eric at a baseball game, and accidently dumps her hotdog in his lap, her disastrous “meet-cute” becomes the topic of a viral thread. Now it’s not loyal subscribers flocking to her channel, it’s Internet trolls. And they aren’t interested in her reviews of VHS tapes—they only care about her relationship with Eric. Eric is overly eager to stretch out his fifteen minutes of fame, but Macy fears this unwanted attention could sabotage her “real-life” relationships—namely with the shy boy-next-door, Paxton, who she’s actually developing feelings for. Macy knows she should shut the lie down, though she can’t ignore the advertising money, or the spark she gets in her chest whenever someone clicks on her videos. Eric shouldn’t be the only one allowed to reap the viral benefits. But is faking a relationship for clicks and subscribers worth hurting actual people?
Saved!" meets To All the Boys I’ve Loved Before in this laugh-out-loud romantic comedy that takes a meaningful look at consent and what it means to give it. When CeCe’s born-again ex-boyfriend dumps her after they have sex, she follows him to Jesus camp in order to win him back. Problem: She knows nothing about Jesus. But her best friend Paul does. He accompanies CeCe to camp, and the plan—God’s or CeCe’s—goes immediately awry when her ex shows up with a new girlfriend, a True Believer at that. Scrambling to save face, CeCe ropes Paul into faking a relationship. But as deceptions stack up, she questions whether her ex is really the nice guy he seemed. And what about her strange new feelings for Paul—is this love, lust, or an illusion born of heartbreak? To figure it out, she’ll have to confront the reasons she chased her ex to camp in the first place, including the truth about the night she lost her virginity.
In this bright, laugh-out-loud rom-com, the grind of the millennial struggle is a lot more fun when you add falling in love to the mix, perfect for fans of Tessa Bailey and Beth O’Leary. Isla Jane is living the millennial nightmare. She’s got a shiny new MBA and no way to pay for it, thanks to her dead-end entry-level job, and nowhere to live, thanks to her miserable salary. Going home to her parents is not possible, but for once Isla’s brother may be her saving grace. He’s out of town on business for a month, meaning the guest room in his condo is blissfully empty. Or so Isla thinks, until she runs into Cade Greenley, her brother’s best friend—who’s crashing there while his own condo is undergoing renovations. When a desperate plan to sleep under her desk miraculously turns into a house-sitting job for one of the big bosses at her office, Isla is certain her luck has turned—with no one, Cade included, the wiser. It’s a perfect solution—until Cade catches her sunbathing at a mansion that is definitely not hers, and she admits she’s house-sitting because she can’t afford rent. The pair strike a deal—Cade will keep Isla’s secret from her overbearing parents if she agrees to pose as his girlfriend at a few upcoming corporate events. The fun and friendly vibe of his office is a surprise compared to hers, but the biggest shock is that each “date” with Cade feels less and less fake. Suddenly she’s looking forward to every minute they spend together while the chemistry between them sizzles. As Isla’s house-sitting scheme begins to unravel, she'll have to face the fact that her biggest lie of all is the one she's telling herself: that she's not falling in love with Cade.
Brinkley Saunders has a secret. To everyone in the academic world she left behind, she lost it all when she dropped out of grad school. Once a rising star following in her mother's footsteps, she's now an administrative assistant at an insurance agency--or so they think. In reality, Brinkley works at Heartbreak for Hire, a secret service that specializes in revenge for jilted lovers, frenemies, and long-suffering coworkers with a little cash to spare and a man who needs to be taken down a notch. It might not be as prestigious as academia, but it helps Brinkley save for her dream of opening an art gallery and lets her exorcise a few demons, all while helping to empower women. But when her boss announces she's hiring male heartbreakers for the first time, Brinkley's no longer so sure she's doing the right thing--especially when her new coworker turns out to be a target she was paid to take down. Though Mark spends his days struggling up the academic ladder, he seems to be the opposite of a backstabbing adjunct: a nerd at heart in criminally sexy sweater vests who's attentive both in and out of the bedroom. But as Brinkley finds it increasingly more difficult to focus on anything but Mark, she soon realizes that like herself, people aren't always who they appear to be"--
Getting over Your Vampire Ex is as Easy as Killing Him and Stealing His Girlfriend Holly Liddell has been stuck with crimped hair since 1987 when she agreed to let her boyfriend, Elton, turn her into a vampire. But when he ditches her at a gas station a few decades into their eternity together, she realizes that being young forever actually means working graveyard shifts at Taco Bell, sleeping in seedy motels, and being supernaturally compelled to follow your ex from town to town—at least until Holly meets Elton’s other exes. It seems that Holly isn’t the only girl Elton seduced into this wretched existence. He turned Ida in 1921, then Rose in 1954, and he abandoned them both before Holly was even born. Now Rose and Ida want to kill him before he can trick another girl into eternal adolescence, and they’ll need Holly’s help to do it. And once Holly starts falling for Elton’s vulnerable new conquest, Parker, she’ll do anything to save her. To kill Elton for good, Holly and her friends will have to dig up their pasts, rob a bank, and reconcile with the people they’ve hurt in their search for eternal love. And to win the girl, Holly will have to convince Parker that she’s more than just Elton’s crazy ex—even though she is trying to kill him.
Brinkley Saunders has a secret. To everyone in the academic world she left behind, she lost it all when she dropped out of grad school. Once a rising star following in her mother's footsteps, she's now an administrative assistant at an insurance agency--or so they think. In reality, Brinkley works at Heartbreak for Hire, a secret service that specializes in revenge for jilted lovers, frenemies, and long-suffering coworkers with a little cash to spare and a man who needs to be taken down a notch. It might not be as prestigious as academia, but it helps Brinkley save for her dream of opening an art gallery and lets her exorcise a few demons, all while helping to empower women. But when her boss announces she's hiring male heartbreakers for the first time, Brinkley's no longer so sure she's doing the right thing--especially when her new coworker turns out to be a target she was paid to take down. Though Mark spends his days struggling up the academic ladder, he seems to be the opposite of a backstabbing adjunct: a nerd at heart in criminally sexy sweater vests who's attentive both in and out of the bedroom. But as Brinkley finds it increasingly more difficult to focus on anything but Mark, she soon realizes that like herself, people aren't always who they appear to be"--
Saved!" meets To All the Boys I’ve Loved Before in this laugh-out-loud romantic comedy that takes a meaningful look at consent and what it means to give it. When CeCe’s born-again ex-boyfriend dumps her after they have sex, she follows him to Jesus camp in order to win him back. Problem: She knows nothing about Jesus. But her best friend Paul does. He accompanies CeCe to camp, and the plan—God’s or CeCe’s—goes immediately awry when her ex shows up with a new girlfriend, a True Believer at that. Scrambling to save face, CeCe ropes Paul into faking a relationship. But as deceptions stack up, she questions whether her ex is really the nice guy he seemed. And what about her strange new feelings for Paul—is this love, lust, or an illusion born of heartbreak? To figure it out, she’ll have to confront the reasons she chased her ex to camp in the first place, including the truth about the night she lost her virginity.
In this bright, laugh-out-loud rom-com, the grind of the millennial struggle is a lot more fun when you add falling in love to the mix, perfect for fans of Tessa Bailey and Beth O’Leary. Isla Jane is living the millennial nightmare. She’s got a shiny new MBA and no way to pay for it, thanks to her dead-end entry-level job, and nowhere to live, thanks to her miserable salary. Going home to her parents is not possible, but for once Isla’s brother may be her saving grace. He’s out of town on business for a month, meaning the guest room in his condo is blissfully empty. Or so Isla thinks, until she runs into Cade Greenley, her brother’s best friend—who’s crashing there while his own condo is undergoing renovations. When a desperate plan to sleep under her desk miraculously turns into a house-sitting job for one of the big bosses at her office, Isla is certain her luck has turned—with no one, Cade included, the wiser. It’s a perfect solution—until Cade catches her sunbathing at a mansion that is definitely not hers, and she admits she’s house-sitting because she can’t afford rent. The pair strike a deal—Cade will keep Isla’s secret from her overbearing parents if she agrees to pose as his girlfriend at a few upcoming corporate events. The fun and friendly vibe of his office is a surprise compared to hers, but the biggest shock is that each “date” with Cade feels less and less fake. Suddenly she’s looking forward to every minute they spend together while the chemistry between them sizzles. As Isla’s house-sitting scheme begins to unravel, she'll have to face the fact that her biggest lie of all is the one she's telling herself: that she's not falling in love with Cade.
Getting over Your Vampire Ex is as Easy as Killing Him and Stealing His Girlfriend Holly Liddell has been stuck with crimped hair since 1987 when she agreed to let her boyfriend, Elton, turn her into a vampire. But when he ditches her at a gas station a few decades into their eternity together, she realizes that being young forever actually means working graveyard shifts at Taco Bell, sleeping in seedy motels, and being supernaturally compelled to follow your ex from town to town—at least until Holly meets Elton’s other exes. It seems that Holly isn’t the only girl Elton seduced into this wretched existence. He turned Ida in 1921, then Rose in 1954, and he abandoned them both before Holly was even born. Now Rose and Ida want to kill him before he can trick another girl into eternal adolescence, and they’ll need Holly’s help to do it. And once Holly starts falling for Elton’s vulnerable new conquest, Parker, she’ll do anything to save her. To kill Elton for good, Holly and her friends will have to dig up their pasts, rob a bank, and reconcile with the people they’ve hurt in their search for eternal love. And to win the girl, Holly will have to convince Parker that she’s more than just Elton’s crazy ex—even though she is trying to kill him.
#PlaneBae meets Gilmore Girls in this hilarious and heartfelt story about the addictiveness of Internet fame and the harsh realities of going viral. Macy Evans dreams of earning enough income from her YouTube channel, R3ntal Wor1d, to leave her small, Midwestern town. But when she meets a boy named Eric at a baseball game, and accidently dumps her hotdog in his lap, her disastrous “meet-cute” becomes the topic of a viral thread. Now it’s not loyal subscribers flocking to her channel, it’s Internet trolls. And they aren’t interested in her reviews of VHS tapes—they only care about her relationship with Eric. Eric is overly eager to stretch out his fifteen minutes of fame, but Macy fears this unwanted attention could sabotage her “real-life” relationships—namely with the shy boy-next-door, Paxton, who she’s actually developing feelings for. Macy knows she should shut the lie down, though she can’t ignore the advertising money, or the spark she gets in her chest whenever someone clicks on her videos. Eric shouldn’t be the only one allowed to reap the viral benefits. But is faking a relationship for clicks and subscribers worth hurting actual people?
Recent progress in the field of wildlife disease ecology demonstrates that infectious disease plays a crucial role in the lives of wild animals. Parasites and pathogens should be especially important for social animals in which high contact among individuals increases the potential for disease spread. As one of the best studied mammalian groups, primates offer a unique opportunity to examine how complex behaviours (including social organization) influence the risk of acquiring infectious diseases, and the defences used by animals to avoid infection. This book explores the correlates of disease risk in primates, including not only social and mating behaviour but also diet, habitat use, life history, geography and phylogeny. The authors examine how a core set of host and parasite traits influence patterns of parasitism at three levels of biological organization: among individuals, among populations, and across species. A major goal is to synthesize, for the first time, four disparate areas of research: primate behavioural ecology, parasite biology, wildlife epidemiology, and the behavioural and immune defences employed by animals to counter infectious disease. Throughout, the authors provide an overview of the remarkable diversity of infectious agents found in wild primate populations. Additional chapters consider how knowledge of infectious diseases in wild primates can inform efforts focused on primate conservation and human health. More generally, this book identifies infectious disease as an important frontier in our understanding of primate behaviour and ecology. It highlights future challenges for testing the links between host and parasite traits, including hypotheses for the effects of disease on primate social and mating systems.
Metabolic and Cellular Engineering (MCE) is more than an exciting scientific enterprise. It has become the cornerstone for coping with the challenges ahead of mankind. Continuous developments, new concepts, and technological innovations will enable us to deal with emerging challenges, and solve problems once thought impossible ten years ago. Challenges in MCE are broad- from unraveling fundamental aspects of cellular function to meeting unsatiated energy and food demands that are rising in parallel with population growth.In charting the progress of MCE during the last decade, we could not help but feel in awe of the enormous strides of progress made from the nascent Metabolic Engineering to the Systems Bioengineering of today. The burgeoning availability of genomic sequences from diverse species has been spectacular. It has become the engine that drives the genetic means for the modification of existing organisms and the generation of synthetic, man-made ones. From the initial attempts at purposeful genetic modification of a cell for the production of valuable compounds, we have now moved on to changing microbes genetically or metabolically.The arsenal of experimental and theoretical tools available for Metabolic and Cellular Engineering has expanded enormously, driven by the re-emergence of Physiology as Systems Biology. The revival of the concept of networks fueled by new developments has become central to Systems Biology. Networks represent an integrative vision of how processes of disparate nature relate to each other, and as such is becoming a key analytical and conceptual tool for MCE. This book reflects and addresses all these ongoing changes while providing the essential conceptual and analytical tools needed to understand and work in the MCE research field.
Over the past decade, advances in both molecular developmental biology and evolutionary ecology have made possible a new understanding of organisms as dynamic systems interacting with their environments. This innovative book synthesizes a wealth of recent research findings to examine how environments influence phenotypic expression in individual organisms (ecological development or 'eco-devo'), and how organisms in turn alter their environments (niche construction). A key argument explored throughout the book is that ecological interactions as well as natural selection are shaped by these dual organism-environment effects. This synthesis is particularly timely as biologists seek a unified contemporary framework in which to investigate the developmental outcomes, ecological success, and evolutionary prospects of organisms in rapidly changing environments. Organism and Environment is an advanced text suitable for graduate level students taking seminar courses in ecology, evolution, and developmental biology, as well as academics and researchers in these fields.
Measles virus possesses a non segmented, single stranded, negative sense RNA genome that is encapsidated by the nucleoprotein to form a helical nucleocapsid. This ribonucleoproteic complex is the substrate for both transcription and replication. The RNA-dependent RNA polymerase binds to the nucleocapsid template via its co-factor, the phosphoprotein. This book focuses on the main structural information available on the nucleoprotein, showing that it consists of a structured core (NCORE) and of an intrinsically disordered C-terminal domain (NTAIL). The functional implications of the disordered nature of NTAIL are discussed in light of the ability of disordered regions to establish interactions with multiple partners, thus leading to multiple biological effects. Indeed, beyond the phosphoprotein, NTAIL also interacts with cellular partners, including the major heat shock protein, hsp72, the interferon regulator factor 3, IRF3, and a yet unidentified cellular receptor referred to as NR. This book consists of two chapters devoted to the general functions of the nucleoprotein in transcription and replication and to a detailed overview of its structural properties, and of three chapters focused on the functional relevance of the interaction between NTAIL and its various intracellular and extracellular partners.
Instrumental techniques for analyzing intrinsically disordered proteins The recently recognized phenomenon of protein intrinsic disorder is gaining significant interest among researchers, especially as the number of proteins and protein domains that have been shown to be intrinsically disordered rapidly grows. The first reference to tackle this little-documented area, Instrumental Analysis of Intrinsically Disordered Proteins: Assessing Structure and Conformation provides researchers with a much-needed, comprehensive summary of recent achievements in the methods for structural characterization of intrinsically disordered proteins (IDPs). Chapters discuss: Assessment of IDPs in the living cell Spectroscopic techniques for the analysis of IDPs, including NMR and EPR spectroscopies, FTIR, circular dichroism, fluorescence spectroscopy, vibrational methods, and single-molecule analysis Single-molecule techniques applied to the study of IDPs Assessment of IDP size and shape Tools for the analysis of IDP conformational stability Mass spectrometry Approaches for expression and purification of IDPs With contributions from an international selection of leading researchers, Instrumental Analysis of Intrinsically Disordered Proteins: Assessing Structure and Conformation fills an important need in a rapidly growing field. It is required reading for biochemists, biophysicists, molecular biologists, geneticists, cell biologists, physiologists, and specialists in drug design and development, proteomics, and molecular medicine with an interest in proteins and peptides.
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