At a time when the field of cardiac safety is going through important changes, this unique book provides the rationale for, and cutting-edge explanations of, new regulatory landscapes that will likely govern cardiac safety assessments globally for the foreseeable future. Exposure-response modeling is already being accepted by regulatory agencies in lieu of the traditional Thorough QT/QTc Study, and the Comprehensive in vitro Proarrhythmia Assay initiative is well under way. Developments in the field of cardiovascular safety are also described and discussed in the book. These include the search for more efficient ways to exonerate new drugs for type 2 diabetes from an unacceptable cardiovascular liability, how best to address off-target blood pressure increases induced by noncardiovascular drugs, and the continued evolution of the discipline of Cardio-oncology. “a resource that will likely serve as a standard for years to come” - Dr Jonathan Seltzer Therapeutic Innovation & Regulatory Science, 2017;51(2):180 “I have no hesitation in recommending this book as a valuable reference source” - Dr Rashmi Shah Journal for Clinical Studies, 2017;9(1):62-63
Providing practical, multidisciplinary coverage of the latest diagnostic and multidisciplinary therapeutic approaches for head and neck cancer, the 5th Edition of this award-winning text helps you achieve the best possible surgical outcomes and preserve and restore form and function. Internationally renowned surgeon Dr. Jatin P. Shah, joined by colleagues Snehal G. Patel, Bhuvanesh Singh, and Richard Wong, guides you step by step through every aspect of this challenging field, helping you take advantage of every multidisciplinary management approach available for your patients. - Offers complete coverage of the scalp, skull base, paranasal sinuses, oral cavity, pharynx, larynx, cervical lymph nodes, thyroid, salivary glands, and soft tissue and bone tumors - from incidence, diagnosis, and work up through treatment planning, operative techniques, rehabilitation, and outcomes. - Features new diagnostic approaches, staging, algorithmic thought processes for therapy selection, and outcomes of treatment for head and neck tumors, allowing for a better overall understanding of head and neck oncology. - Includes new information on multimodal management of head and neck cancer; a new Radiation Therapy Glossary; and hundreds of new surgical photographs presented in sequential order from the surgeon's point of view. - Provides outcomes of therapy data from the NCDB, institutional data from MSKCC, and evidence-based information throughout. - Covers key topics such as radiation oncology, medical oncology including targeted therapies, and maxillofacial prosthodontics and dental oncology. - Addresses the day-to-day, practical care of patients with basic operating room techniques and technology, intraoperative decisions, and post-operative care for patients undergoing head and neck surgery. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
At a time when the field of cardiac safety is going through important changes, this unique book provides the rationale for, and cutting-edge explanations of, new regulatory landscapes that will likely govern cardiac safety assessments globally for the foreseeable future. Exposure-response modeling is already being accepted by regulatory agencies in lieu of the traditional Thorough QT/QTc Study, and the Comprehensive in vitro Proarrhythmia Assay initiative is well under way. Developments in the field of cardiovascular safety are also described and discussed in the book. These include the search for more efficient ways to exonerate new drugs for type 2 diabetes from an unacceptable cardiovascular liability, how best to address off-target blood pressure increases induced by noncardiovascular drugs, and the continued evolution of the discipline of Cardio-oncology. “a resource that will likely serve as a standard for years to come” - Dr Jonathan Seltzer Therapeutic Innovation & Regulatory Science, 2017;51(2):180 “I have no hesitation in recommending this book as a valuable reference source” - Dr Rashmi Shah Journal for Clinical Studies, 2017;9(1):62-63
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