Basic research of the pathobiology of diseases as well as of therapeutic strategies usually is carried out in rodents as animal models. Translational research that transfers novel results from basic research to clinical application often requires analyses in additional nonrodent models and/or large animal models that share specific pathophysiological characteristics with the human diseases in question. As prerequisites for the generation of appropriate disease models by genetic engineering, pigs exhibit suitable reproductive performance traits, pig genome analyses resulted in the availability of several resources of genomic data, and efficient and precise techniques for the genetic modification of pigs have been established. In the recent years, genetically engineered pigs were increasingly generated as biomedical research tools for specific human genetic diseases. Here, we review the current state of the techniques used for the production of genetically engineered pigs as well as the establishment of genetically engineered pigs as models for human diseases.
Simone Weil is one of the most profound and thought-provoking thinkers of the 20th century. A teacher, factory and farm labourer, a political activist at home and abroad, a loving friend, daughter and sister—all these manifest a life devoted to the good in its many forms. Her writings explore the good open to us and the various routes to it, spanning philosophy, politics, science and spirituality. While she saw her vocation primarily as a philosopher—examining questions concerning human faculties, action and thought, the limits of language and our need of mediation, suffering and beauty for contact with reality—her startlingly original thought is often obscured by her having been too readily categorized as a Christian mystic. Simone Weil: Basic Writings is an expertly edited anthology of Weil’s most important writings, presenting her philosophy as it relates to the architecture of human nature, politics, work, necessity, beauty, goodness and God. Working from the definitive French edition of Weil’s complete writings, D. K. Levy and Marina Barabas have translated the essays anew or for the first time, adding important notes and references absent from existing English language editions of Weil’s work. Following an extensive introduction that gives an overview of Weil's life and thought, each part opens with a short preface situating the selected essays within Weil’s oeuvre. Simone Weil: Basic Writings provides an excellent entry point to Weil’s philosophy, as well as a reference for students and scholars of Weil's thought in philosophy and related disciplines.
Simone Weil (1909-1943) was a philosopher, theologian, political activist, and mystic whose work endures among the greatest spiritual thinking in human history. Born and educated in Paris, she was devoted to advocating for disenfranchised citizens around the world. Called the 'saint of all outsiders' by Andre Gide, Weil's compassion for the plight of the working class and the armed forces fueled her enlightened treatises and existential inquiries.
Simone Weil (1909-1943) was a defining figure of the twentieth century; a philosopher, Christian, resistance fighter, anarchist, feminist, Labour activist and teacher. She was described by T. S. Eliot as 'a woman of genius, of a kind of genius akin to that of the saints', and by Albert Camus as 'the only great spirit of our time'. Originally published posthumously in two volumes, these newly reissued notebooks, are among the very few unedited personal writings of Weil's that still survive today. Containing her thoughts on art, love, science, God and the meaning of life, they give context and meaning to Weil's famous works, revealing an unique philosophy in development and offering a rare private glimpse of her singular personality.
Introducing the Selected Works of Simone Weil Throughout her life, Simone Weil was a constant letter writer and Seventy Letters contains a fair and important selection of them. Many of them are biographically important, as they are written to friends and to her family, especially to her brother, Andre. But they also give many important clues to Weil's own thinking on social and philosophical matters. In her later letters, her urgent concerns about her project for a frontline corps of nurses is obvious. In earlier ones, she not only shows her deep concern for social issues, but also raises issues about intellectual matters. These letters and others are particularly important for understanding her thinking on intellectual culture, philosophy, and science. SELECTED WORKS: First and Last Notebooks: Supernatural Knowledge / ISBN 978-1-4982-3919-6 Seventy Letters: Personal and Intellectual Windows on a Thinker / ISBN 978-1-4982-3920-2 Selected Essays, 1934-1943: Historical, Political and Moral Writings / ISBN 978-1-4982-3921-9
Although trained as a philosopher, Simone Weil (1909–43) contributed to a wide range of subjects, resulting in a rich field of interdisciplinary Weil studies. Yet those coming to her work from such disciplines as sociology, history, political science, religious studies, French studies, and women’s studies are often ignorant of or baffled by her philosophical investigations. In Simone Weil: Late Philosophical Writings, Eric O. Springsted presents a unique collection of Weil’s writings, one concentrating on her explicitly philosophical thinking. The essays are drawn chiefly from the time Weil spent in Marseille in 1940-42, as well as one written from London; most have been out of print for some time; three appear for the first time; all are newly translated. Beyond making important texts available, this selection provides the context for understanding Weil's thought as a whole. This volume is important not only for those with a general interest in Weil; it also specifically presents Weil as a philosopher, chiefly one interested in questions of the nature of value, moral thought, and the relation of faith and reason. What also appears through this judicious selection is an important confirmation that on many issues respecting the nature of philosophy, Weil, Wittgenstein, and Kierkegaard shared a great deal.
Introducing the Selected Works of Simone Weil Weil's many essays written over her short life cover a very wide range of topics. This important collection contains several that have been long unavailable. There is deep integrity in this diverse collection. Many are directed to social and political topics, written in Weil's distinctive way of commenting on contemporary issues through historical writing. Weil wrote in her great work The Need for Roots that humans beings need roots in the universe; this rootedness comes through their lived history. Often Weil is treated as if she were constantly trying to posit timeless truths, but as these essays make evident, Weil offers to her readers a sense of truth as we discover it and live with it in our concrete historical circumstances. This analogical and historical thinking is particularly clear in the several essays that come from her last days while working for the Free French in London, during which she meditated on the philosophical renewal of France after the war. SELECTED WORKS: First and Last Notebooks: Supernatural Knowledge / ISBN 978-1-4982-3919-6 Seventy Letters: Personal and Intellectual Windows on a Thinker / ISBN 978-1-4982-3920-2 Selected Essays, 1934-1943: Historical, Political and Moral Writings / ISBN 978-1-4982-3921-9
De briljante zangeres Nina Simone werd ondanks haar grote talent gedwarsboomd door haar eigen innerlijke tegenstellingen. Op het podium voelde en gedroeg Simone zich vrij en ongeremd. Tegelijkertijd had ze veel moeite haar artistieke ambitie te verenigen met haar toewijding aan de politieke burgerrechtenstrijd. In combinatie met haar grillige temperament leidde dit tot destructieve relaties, niet alleen met haar fans, maar ook met haar geliefde en dochter. Alan Light schreef op basis van jarenlange diepgaande research deze definitieve biografie. Hij gebruikte onder meer niet eerder gepubliceerde opnames van interviews. En zo ontstaat het beeld van de soms verdrietige en vaak verbijsterende wirwar van Nina Simones ware leven, een beeld dat Simone zelfs in haar eigen autobiografie nooit heeft willen tonen. Het resultaat is een aangrijpend, eerlijk en fascinerend portret.
Decarbonisation is the reduction of carbon dioxide emissions using low carbon power sources, lowering output of greenhouse gasses into the atmosphere. This is essential to meet global temperature standards set by international climate agreements. To limit global warming to 1.5°C, hence avoiding the worst-case scenarios predicted by climate science, the world economy must rapidly reduce its emissions and reach climate neutrality within the next three decades. This will not be an easy journey. Shifting away from carbon-intensive production will require a historic transformation of the structure of our economies. Written by a team of academics linked to the European think tank Bruegel, The Macroeconomics of Decarbonisation provides a guide to the macroeconomic fundamentals of decarbonisation. It identifies the major economic transformations, both over the long- and short-run, and the roadblocks requiring policy intervention. It proposes a macroeconomic policy agenda for decarbonisation to achieve the climate goals of the international community.
The Göttingen conference Systematics 2008 is the first joint meeting of the Gesellschaft für Biologische Systematik (GfBp. and the German Botanical Society, section Biodiversity and Evolutionary Biology (DBG), being the 10th Annual Meeting of the GfBS and the 18th International Symposium Biodiversity and Evolutionary Biology of the DBG. The conference programme covers biological systematics in the widest sense and provides ample opportunities for oral and poster presentations on new advances in plant, animal and microbial systematics. This volume brings together the abstracts of invited speaches from the plenary sessions on Progress in Deep Phylogeny, Speciation and Phylogeography, and New Trends in Biological Systematics as well as those of submitted talks and poster sessions.
Basic research of the pathobiology of diseases as well as of therapeutic strategies usually is carried out in rodents as animal models. Translational research that transfers novel results from basic research to clinical application often requires analyses in additional nonrodent models and/or large animal models that share specific pathophysiological characteristics with the human diseases in question. As prerequisites for the generation of appropriate disease models by genetic engineering, pigs exhibit suitable reproductive performance traits, pig genome analyses resulted in the availability of several resources of genomic data, and efficient and precise techniques for the genetic modification of pigs have been established. In the recent years, genetically engineered pigs were increasingly generated as biomedical research tools for specific human genetic diseases. Here, we review the current state of the techniques used for the production of genetically engineered pigs as well as the establishment of genetically engineered pigs as models for human diseases.
Over the past decades, the field commonly known as comparative law has significantly expanded. The multiplication of journals, the proliferation of scholarship and the creation of courses or summer schools specifically devoted to comparative law attest to its increasing popularity. Within the Western legal tradition, a traditional, black-letter approach to law has proved particularly authoritative. This co-authored book rethinks comparative law’s mainstream model by providing both students and lawyers with the intellectual equipment allowing them to approach any foreign law in a more meaningful way.
This book pinpoints continuities and changes in U.S. foreign economic policy from the fixed exchange rate system of the 1960s through to the period between the two oil crises of the 1970s. Chapters pay close attention to the interconnectedness between the long lasting decline of the U.S. Dollar on foreign exchange markets and the U.S. balance of payments, transformations in international capital markets, and international oil developments. The book charts the prolonged failure of Washington’s foreign economic policies to restore U.S. financial and monetary leadership through to the Carter Administration.
incl. Bonus – Psychology of persuasion influence & NLP, learn the power of rhetoric body language & virtual attraction, social skills for online communication
incl. Bonus – Psychology of persuasion influence & NLP, learn the power of rhetoric body language & virtual attraction, social skills for online communication
Also in the 6th revised and improved edition, published by a government-funded publisher involved in EU programs and a partner of the Federal Ministry of Education, you receive the concentrated expertise of renowned experts (overview in the book preview), as well as tailored premium content and access to travel deals with discounts of up to 75%. At the same time, you do good and support sustainable projects. Because digitalization has decisively changed our communication behavior. Not only since Donald Trump, Fake News has gained importance in social media and has taken the Machiavellian art of manipulation to a new dimension. It is increasingly difficult to distinguish between what is true and false because we lack the appropriate tools to do so. This makes it all the more important to see through these interpersonal digital power games and the communicative tricks and tactics of other people and to classify them correctly. After all, whoever has the power determines the direction of travel and can enforce their goals. Seeing through manipulative communication strategies in the digital world is therefore of crucial importance. And this book shows you what is important. With its "Info on Demand" concept, the publisher not only participated in an EU-funded program but was also awarded the Global Business Award as Publisher of the Year. Therefore, by purchasing this book, you are also doing good: The publisher is financially and personally involved in socially relevant projects such as tree planting campaigns, the establishment of scholarships, sustainable living arrangements, and many other innovative ideas. The goal of providing you with the best possible content on topics such as career, finance, management, recruiting, or psychology goes far beyond the static nature of traditional books: The interactive book not only imparts expert knowledge but also allows you to ask individual questions and receive personal advice. In doing so, expertise and technical innovation go hand in hand, as we take the responsibility of delivering well-researched and reliable content, as well as the trust you place in us, very seriously. Therefore, all texts are written by experts in their field. Only for better accessibility of information do we rely on AI-supported data analysis, which assists you in your search for knowledge. You also gain extensive premium services: Each book includes detailed explanations and examples, making it easier for you to successfully use the consultation services, freeky available only to book buyers. Additionally, you can download e-courses, work with workbooks, or engage with an active community. This way, you gain valuable resources that enhance your knowledge, stimulate creativity, and make your personal and professional goals achievable and successes tangible. That's why, as part of the reader community, you have the unique opportunity to make your journey to personal success even more unforgettable with travel deals of up to 75% off. Because we know that true success is not just a matter of the mind, but is primarily the result of personal impressions and experiences. Publisher and editor Simone Janson is also a bestselling author and one of the 10 most important German bloggers according to the Blogger Relevance Index. Additionally, she has been a columnist and author for renowned media such as WELT, Wirtschaftswoche, and ZEIT - you can learn more about her on Wikipedia.
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