This book provides a comprehensive survey of the pharmacokinetic models used for the quantitative interpretation of contrast-enhanced imaging. It discusses all the available imaging technologies and the problems related to the calibration of the imaging system and accuracy of the estimated physiological parameters. Enhancing imaging modalities using contrast agents has opened up new opportunities for going beyond morphological information and enabling minimally invasive assessment of tissue and organ functionality down to the molecular level. In combination with mathematical modeling of the contrast agent kinetics, contrast- enhanced imaging has the potential to provide clinically valuable additional information by estimating quantitative physiological parameters. The book presents the broad spectrum of diagnostic possibilities provided by quantitative contrast-enhanced imaging, with a particular focus on cardiology and oncology, as well as novel developments in the area of quantitative molecular imaging along with their potential clinical applications. Given the variety of available techniques, the choice of the appropriate imaging modality and the most suitable pharmacokinetic model is often challenging. As such, the book provides a valuable technical guide for researchers, clinical scientists, and experts in the field who wish to better understand and properly apply tracer-kinetic modeling for quantitative contrast-enhanced imaging.
This book reviews the period from the unification of Italy to the fascist era through significant Neapolitan performers such as Gilda Mignonette and Enrico Caruso. It traces the transformation of a popular tradition written in dialect into a popular tradition, written in Italian, that contributed to the production of "American" identity.
This book challenges the Western contemporary “praise for Nature”. From food to body practices, from ecological discourses to the Covid-19 pandemic, contemporary imaginaries abound with representations of an ideal “pure Nature”, essentially defined according to a logic of denial of any artificial, modified, manipulated — in short, cultural — aspect. How should we contextualise and understand such an opposition, especially in light of the rich semantic scope of the term “nature” and its variability over time? And how can we — if we actually can — envisage alternative models and approaches capable of better accounting for such richness and variability? The author addresses these fundamental issues, combining an initial theoretical problematisation of the concept of nature and its evolution — from classical philosophy to the crucial changes occurred through the Middle Ages, the Renaissance, Romanticism and the modern era, finally considering recent insights in philosophy, sociology, cultural anthropology and semiotics — with the analysis of its discursivisation — from the iconography of Mother Nature between the past and the present to the representation of catastrophic events in fictional and non-fictional texts, from clean eating and other popular food trends to the ambivalence of the naked body between its supposed natural ascription and its multiple cultural characterisations. Thus she introduces a critique of pure Nature, providing a systematic study of the way nature is attributed meaning and value in some of today’s most relevant discourses and practices, and finally tracing a possible path towards an “internatural turn”.
This book provides a comprehensive survey of the pharmacokinetic models used for the quantitative interpretation of contrast-enhanced imaging. It discusses all the available imaging technologies and the problems related to the calibration of the imaging system and accuracy of the estimated physiological parameters. Enhancing imaging modalities using contrast agents has opened up new opportunities for going beyond morphological information and enabling minimally invasive assessment of tissue and organ functionality down to the molecular level. In combination with mathematical modeling of the contrast agent kinetics, contrast- enhanced imaging has the potential to provide clinically valuable additional information by estimating quantitative physiological parameters. The book presents the broad spectrum of diagnostic possibilities provided by quantitative contrast-enhanced imaging, with a particular focus on cardiology and oncology, as well as novel developments in the area of quantitative molecular imaging along with their potential clinical applications. Given the variety of available techniques, the choice of the appropriate imaging modality and the most suitable pharmacokinetic model is often challenging. As such, the book provides a valuable technical guide for researchers, clinical scientists, and experts in the field who wish to better understand and properly apply tracer-kinetic modeling for quantitative contrast-enhanced imaging.
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