This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an introduction to skin physiology; the underlying theories of skin absorption; the physical laboratory-based processes used to generate skin absorption data, which is in turn used to construct mathematical models describing the skin permeation process; algorithms of skin permeability including quantitative structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between permeability and molecular properties; the development of formulation-focused approaches to models of skin permeability prediction; the use of artificial membranes, e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of novel Machine Learning methods in developing the next generation of predictive skin permeability models. The book will be of interest to all researchers in academia and industry working in pharmaceutical discovery and development, as well as readers from the field of occupational exposure and risk assessment, especially those whose work involves agrochemicals, bulk chemicals and cosmetics.
Most prisoners in the UK are required to work. Yet prison work is a relatively neglected subject in the existing literature on imprisonment and few studies have focused on the nature of prison work, prisoners' experience of it, and the extent to which it meets the need of rehabilitating prisoners. Prisoners' Work and Vocational Training sheds new light on this crucial area in the work of prisons and examines: *the nature of training received by prisoners *the actual work they undertake *how this relates to the world or work outside *the role it plays in helping to secure employment on release. Frances Simon employs a balance of qualitative and quantitative data, including first hand accounts from UK prisons, gathered during field research. Her book will be essential reading for all those studying criminology and prison studies and all professionals working with prisoners, including probation officers and social workers.
This book explores the British Army's response on the Western Front to a period of seminal change in warfare. In particular it examines the impact of the pre-war emphasis on worldwide garrison, occupation and policing duties for the Empire's defence of the mindset of the Army's leadership and its lack of preparation for a continental war involving a massive, unplanned increase in men and material. The reasons for the poor performance in the early years of the war, notably professionalism within the British Army, including poor staff work, 'trade unionism', careerism within the high command, and the tendency of an overconfident hierarchy to ignore the need for reform to tackle the tactical stalemate prior to 1916, are analysed. The high command rapidly learnt from the defeats of 1915-16 and performed much better in 1916-18, an especially formative period resulting in the promotion of a younger, more professional leadership and the development of the first truly modern system of tactics which has dominated wars ever since. During 1917-18 the Army's commanders and staff evolved and improved these new methods; developing a doctrine of combined arms to overcome the tactical stalemate bedevilling Allied offensives.
This electronic version has been made available under a Creative Commons (BY-NC-ND) open access license. The events of the Arab Uprisings posed an existential challenge to sovereign power across the Middle East. Whilst popular movements resulted in the toppling of authoritarian rule in Tunisia, Egypt and Yemen, other regimes were able to withstand these pressures. This book questions why some regimes fell whilst others were able to survive. Drawing on the work of political theorists such as Agamben and Arendt, Mabon explores the ways in which sovereign power is contested, resulting in the fragmentation of political projects across the region. Combining an innovative theoretical approach with interviews with people across the region and beyond, Mabon paints a picture of Middle Eastern politics dominated by elites seeking to maintain power and wealth, seemingly at whatever cost. This, for Mabon, is a consequence of the emergence and development of particular visions of political projects that harness or marginalise identities, communities, ideologies and faiths as mechanisms designed to ensure their survival. This book is essential reading for those interested in understanding why the uprisings took place, their geopolitical consequences, and why they are likely to happen again.
The last two decades have seen a renaissance in interest in the chemistry of the main group elements. In particular research on the metals of group 13 (aluminium, gallium, indium and thallium) has led to the synthesis and isolation of some very novel and unusual molecules, with implications for organometallic synthesis, new materials development, and with biological, medical and, environmental relevance. The Group 13 Metals Aluminium, Gallium, Indium and Thallium aims to cover new facts, developments and applications in the context of more general patterns of physical and chemical behaviour. Particular attention is paid to the main growth areas, including the chemistry of lower formal oxidation states, cluster chemistry, the investigation of solid oxides and hydroxides, advances in the formation of III-V and related compounds, the biological significance of Group 13 metal complexes, and the growing importance of the metals and their compounds in the mediation of organic reactions. Chapters cover: general features of the group 13 elements group 13 metals in the +3 oxidation state: simple inorganic compounds formal oxidation state +3: organometallic chemistry formal oxidation state +2: metal-metal bonded vs. mononuclear derivatives group 13 metals in the +1 oxidation state mixed or intermediate valence group 13 metal compounds aluminium and gallium clusters: metalloid clusters and their relation to the bulk phases, to naked clusters, and to nanoscaled materials simple and mixed metal oxides and hydroxides: solids with extended structures of different dimensionalities and porosities coordination and solution chemistry of the metals: biological, medical and, environmental relevance III-V and related semiconductor materials group 13 metal-mediated organic reactions The Group 13 Metals Aluminium, Gallium, Indium and Thallium provides a detailed, wide-ranging, and up-to-date review of the chemistry of this important group of metals. It will find a place on the bookshelves of practitioners, researchers and students working in inorganic, organometallic, and materials chemistry.
Berman’s Pediatric Decision Making uses an algorithmic, structured approach to lead you to the right diagnosis and treatment every time. Drs. Lalit Baja, Simon Hambidge, Ann-Christine Nyquist, and Gwendolyn Kerby use evidence-based research and flow charts for each presenting complaint or specific disorder to provide quick access to the information you need for effective decision making. With updated drug tables and revised algorithms, this streamlined new edition makes it even easier for you to diagnose and manage common clinical problems from infancy through adolescence. Rapidly access guidance on diagnosis and management from algorithms for each clinical disorder. Treat the full range of diseases and disorders with comprehensive coverage of diagnosis, assessment of severity, and clinical management. Choose the best treatment for each case thanks to indications for surgical interventions as well as expensive diagnostic procedures Stay current on recent developments and make effective decisions for movement disorders, physical abuse in children, sexual abuse in children, eating disorders, ADHD, and other hot topics. Find answers quickly and easily with a new table of contents organized into two sections—Presenting Complaints and Specific Disorders—that reduces the need to flip between chapters. Tap into the diverse perspectives of expert authors from all over the country. Get only the information you need in the streamlined new edition with shorter, more user-friendly flow diagrams and fewer specialized chapters.
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