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Therapeutic Targeting of RAS Mutant Cancers

By: Edward C. Stites,Kendra Paskvan,Shumei Kato

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Therapeutic Targeting of RAS Mutant Cancers

By: Edward C. Stites,Kendra Paskvan,Shumei Kato

The KRAS oncogene is believed to be the most common single nucleotide variant oncogene in human cancer. Historically, efforts to target KRAS and the other RAS GTPases have struggled. More recently, efforts have focused on identifying and exploiting features unique to specific oncogenic mutations. This has led to the first FDA approval for a RAS targeted therapy. This new agent is a covalent inhibitor that reacts with the cysteine residue created by a codon 12 glycine to cysteine (G12C) mutation within KRAS. Mutant-specific strategies may also exist for other KRAS single nucleotide variants, and recent studies provide examples and mechanisms.

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59

Publisher

Cambridge University Press

Published Date

ISBN 10

1009081020

ISBN 13

9781009081023

Therapeutic Targeting of RAS Mutant Cancers

By: Edward C. Stites,Kendra Paskvan,Shumei Kato

Write a review Read reviews Take a Quiz Solve Book Puzzle

Therapeutic Targeting of RAS Mutant Cancers

By: Edward C. Stites,Kendra Paskvan,Shumei Kato

The KRAS oncogene is believed to be the most common single nucleotide variant oncogene in human cancer. Historically, efforts to target KRAS and the other RAS GTPases have struggled. More recently, efforts have focused on identifying and exploiting features unique to specific oncogenic mutations. This has led to the first FDA approval for a RAS targeted therapy. This new agent is a covalent inhibitor that reacts with the cysteine residue created by a codon 12 glycine to cysteine (G12C) mutation within KRAS. Mutant-specific strategies may also exist for other KRAS single nucleotide variants, and recent studies provide examples and mechanisms.

Average ratings

N/A

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0%

4

0%

3

0%

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0%

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0%

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Solve jigsaw puzzle

Age

Page Count

59

Publisher

Cambridge University Press

Published Date

ISBN 10

1009081020

ISBN 13

9781009081023

Book's by Shumei Kato

Therapeutic Targeting of RAS Mutant Cancers

Therapeutic Targeting of RAS Mutant Cancers

Therapeutic Targeting of RAS Mutant Cancers

Therapeutic Targeting of RAS Mutant Cancers

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