Cytochromes are proteins that catalyze electron transfer reactions of well-known metabolic pathways and are classified in various superfamilies. The CYP, or P450, superfamily accounts for 90% of the oxidative metabolism of clinical drugs. One member of this superfamily, P450 2D6 (or CYP2D6), singlehandedly metabolizes about 25% of all medications in the human liver. Cytochrome P450 2D6: Structure, Function, Regulation, and Polymorphism reviews the current knowledge of CYP2D6 as well as the maturing body of evidence indicating its significance to clinical and pharmacological researchers and practitioners. This book focuses on the critical role CYP2D6 plays in the human liver. It examines the genetic, epigenetic, physiological, pathological, and structural factors of the gene that govern the highly variable metabolism of a number of drugs in clinical use. It highlights the impact of the functional roles of CYP2D6 on clinical practice and drug development and also discusses implications for precise medicine, strategies to avoid adverse drug reactions, and paths for future research. Cytochrome P450 2D6 is a unique, valuable book focusing on a single but immensely powerful human gene. It provides the first single source of comprehensive information on CYP2D6 that serves as an important reference for medical, biomedical, pharmaceutical, and nursing researchers, practitioners, and students.
The Early Permian Tarim Large Igneous Province in Northwest China: Tectonics, Petrology, Geochemistry, and Geophysics is the first book to introduce the Early Permian Tarim Large Igneous Province. Based on more than twenty years of study, this book systematically presents time-spatial, geochemical and geodynamic features, along with the metallogenesis and magma evolution of the Early Permian Tarim Large Igneous Province. Furthermore, it provides a new geodynamic model for Large Igneous Provinces. It is intended for researchers and graduate students in tectonics, igneous petrology, geochemistry, geophysics, earth evolution and planetary geology in addition to mining industry professionals. - Provides the temporal-spatial features of the Early Permian Tarim Large Igneous Province using seismic and borehole data - Presents petrological and geochemical features and magma evolution of the rock units in Early Permian Tarim Large Igneous Province - Builds up a new model for Large Igneous Provinces based on the information from the Early Permian Tarim Large Igneous Province
The Early Permian Tarim Large Igneous Province in Northwest China: Tectonics, Petrology, Geochemistry, and Geophysics is the first book to introduce the Early Permian Tarim Large Igneous Province. Based on more than twenty years of study, this book systematically presents time-spatial, geochemical and geodynamic features, along with the metallogenesis and magma evolution of the Early Permian Tarim Large Igneous Province. Furthermore, it provides a new geodynamic model for Large Igneous Provinces. It is intended for researchers and graduate students in tectonics, igneous petrology, geochemistry, geophysics, earth evolution and planetary geology in addition to mining industry professionals. - Provides the temporal-spatial features of the Early Permian Tarim Large Igneous Province using seismic and borehole data - Presents petrological and geochemical features and magma evolution of the rock units in Early Permian Tarim Large Igneous Province - Builds up a new model for Large Igneous Provinces based on the information from the Early Permian Tarim Large Igneous Province
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