Born in the mid-nineteenth century, Sophie Lyons was a master thief, con artist, blackmailer and smuggler. Much of her success as a criminal was due to the fact that she was fearless, reckless, sharp and cunning--everything a woman of her time was not supposed to be. As a young child, Sophie's parents forced her to steal when she showed a talent for pickpocketing. Strong-willed and smart, she blossomed into a beautiful teenager who caught the eye of many men in the underworld of New York City. By the time Sophie reached her late teens she was married to her second husband--a notorious bank burglar named Ned Lyons--and was a professional criminal in her own right. Despite her prominent place in crime history, Sophie Lyons has never been the subject of a full-length biography. This book chronicles Sophie's fascinating and tragic life, from her beginnings as a criminal prodigy, through her ingenious escape from Sing Sing prison and her lifelong struggle with mental illness.
“Civil War Soldiers: Discovering the Men of the 25th United States Colored Troops” began as an exhibit of portraits and biographies of actual African-American men who served in the 25th USCT, Company G, during the Civil War. The show rated in the “Top 25” of over 1500 entries at ArtPrize 2013, an international art competition held annually in Grand Rapids, Michigan. Now the collection of 17 full color drawings, photos, updated biographies, an introduction with background details, color maps, and selected military records, appears in book form in this volume.The drawings are based on photos from a tiny, rare album, owned by the Captain of the men, William A. Prickitt, and physical descriptions from each man's Civil War military records. The men in the photos were identified with a hand-written name on the mat around their photo. The reason only 17 men of a much larger company were photographed is still a mystery.In addition to creating the portraits, the author did careful genealogical research on each man and wrote a short biography of him, including fascinating details about his life before and after the war. 1863 was the first time in American history that African-American men were allowed to serve in the U. S. Army. “Civil War Soldiers: Discovering the Men of the 25th United States Colored Troops” highlights 17 men who answered the call to serve their country at that pivotal moment.
Four of today's hottest authors--Maggie Shayne, MaryJanice Davidson, Jacey Ford, and Angela Knight--present a quartet of sexy tales about bold women who take no prisoners, either in a fight or in love. Original.
A classic tale of love and laughter with a touch of the Undead from the New York Times bestselling author of the Vampire Queen Betsy Taylor novels. A vampire hunter gets the surprise of her life when the man she saves from a bloodthirsty vampire is so grateful for her service that he decides to become her sidekick—much to her dismay.
“A diverse and thoughtful array of 16 stories written around the theme of endangered species—be they human or animal, mythical or alien.” —Publishers Weekly In this poignant yet uplifting anthology about extinction, science fiction stories draw you into compelling, adventurous, and even humorous tales that will make you think about the future of animals, humanity, and the world around us. You’ll find bugs and buffalo, humans and aliens, creatures that have never existed in our universe and genetically-engineered ones that shouldn’t. In “Seventy-Two Letters” by national bestselling author Ted Chiang—praised by Strange Horizons as “one of the finest representations of the SF subgenre of steampunk”—a discovery reveals that humanity has only a fixed number of generations to survive. A project is embarked upon that could save the species—or open it up to a most inhuman manipulation. A Joe Haldeman poem called “Endangered Species” encapsulates his concerns about war and its effect on the human race. And in “Listening to Brahms” by Suzy McKee Charnas, the last humans alive make first contact with an alien race of lizard-like creatures who appropriate Earth culture at their own peril. In Vanishing Acts, these tales and others “make the reader stop and think about endangered species—including humanity—which is, after all, the point” (Rambles.NET). “[A] splendid new original anthology.” —The Washington Post
Born in the mid-nineteenth century, Sophie Lyons was a master thief, con artist, blackmailer and smuggler. Much of her success as a criminal was due to the fact that she was fearless, reckless, sharp and cunning--everything a woman of her time was not supposed to be. As a young child, Sophie's parents forced her to steal when she showed a talent for pickpocketing. Strong-willed and smart, she blossomed into a beautiful teenager who caught the eye of many men in the underworld of New York City. By the time Sophie reached her late teens she was married to her second husband--a notorious bank burglar named Ned Lyons--and was a professional criminal in her own right. Despite her prominent place in crime history, Sophie Lyons has never been the subject of a full-length biography. This book chronicles Sophie's fascinating and tragic life, from her beginnings as a criminal prodigy, through her ingenious escape from Sing Sing prison and her lifelong struggle with mental illness.
A classic tale of love and laughter with a touch of the Undead from the New York Times bestselling author of the Vampire Queen Betsy Taylor novels. A vampire hunter gets the surprise of her life when the man she saves from a bloodthirsty vampire is so grateful for her service that he decides to become her sidekick—much to her dismay.
Born in 1882 to a family of recent immigrants to America, Alfred Plowman dreamed of becoming a writer. Between 1907 and 1913 he wrote at least 20 short stories that were published in pulp fiction magazines. They appear together here for the first time, along with correspondence, from editors and others, relating to the work. Al Plowman's stories provide a fascinating look into turn of the century St. Louis, Missouri, where he grew up. With only an eighth grade education Al entered the working world to help support his family while simultaneously writing stories and submitting them to publishers in New York. These pulp fiction stories are tales of the moral questions of the time, filled with characters placed in troubling circumstances that require them to make difficult, often painful, decisions. These tales provide a glimpse into the past, into the world of working class people aspiring to better lives at the turn of the twentieth century in a rapidly growing American city.
Biomaterials, Medical Devices, and Combination Products is a single-volume guide for those responsible for-or concerned with-developing and ensuring patient safety in the use and manufacture of medical devices.The book provides a clear presentation of the global regulatory requirements and challenges in evaluating the biocompatibility and clinical
This volume provides a complete update of all the materials in prior volumes on the subject (including current directories to testing labs and other support establishments worldwide), while adding substantial new material on the following topics: · The history of CROs, including snapshots of CROs and a genealogy chart making clear where they came from and where they went. · Study directors and principal investigators. · The nuts and bolts of study performance. · Electronic reporting requirements – SEND and eCTD (required for NDA, BLA, ANDA, and IND submissions). · Consultants and their roles. · An expanded examination of common problems and their solutions. This book boasts complete directories to the global universe of operating labs – where they are, how to contact them, and what they do (including special capabilities). Additionally, checklists for qualifying labs and manufacturing facilities – and for auditing studies and projects at such facilities – are included. It is directed at those in industry (specifically directed at those working for companies using CRO services) but will also be of interest to scientists or administrators working in research organizations themselves. In this case, the contents of this new work are essential to the target reader because the work, regulations, and actors (CROs) have evolved and changed at a rapid pace in the 10 years since the earlier volume that the author published. Likewise, the companies using these services have come to all be almost completely dependent on outsourcing. The earlier texts remain the only source of their kind (paper or electronic) on the field and the only noncommercial guide to the global industry and this volume provides a complete update.
Capturing the growth of the global medical device market in recent years, this practical new guide is essential for all who are responsible for ensuring safety in the use and manufacture of medical devices. It has been extensively updated to reflect significant advances, incorporating combination products and helpful case examples of current real-life problems in the field. The Third Edition explores these key current trends: global device markets continually advancing technology the increasing harmonization of device safety regulation worldwide Each aspect of safety evaluation is considered in terms of International Standards Organization (ISO), US Food and Drug Administration (FDA), European Union (EU), and Japanese Ministry of Health and Welfare (MHW) perspectives. In addition, the book reflects the role of the continuing growth of technology in the incorporation of science, particularly in the areas of immunotoxicology and toxicokinetics.
The sixth edition of this comprehensive yet concise Rosen & Barkin’s 5 Minute Emergency Medicine Consult pulls together up-to-date and evidence-based practice guidelines for easy use in a busy emergency department. In just two brief, bullet-friendly, clutter-free pages, you can quickly decipher the information you need to confirm your diagnosis, order tests, manage treatment and more!
Non-Animal Techniques in Biomedical and Behavioral Research and Testing features the contributions of noted experts describing the application of non-animal methods in a wide variety of research and testing situations, including computer modeling/graphics, protein sequence analysis, behavioral analysis, drug design/testing, cosmetic and household products testing, toxicological testing, clinical testing, chemical identification and analysis, and disease investigations. Many of the alternatives covered have applications in behavioral as well as biomedical research and testing. Topics examined include in vitro techniques, molecular genetics, structure-activity relationships, physicochemical methods, computer-assisted drug designs, nutrition, epidemiology, autopsies, neural networks, ethology, image scanning devices, and medical microbiology. Future applications for non-animal methods are also explored. The book will appeal to toxicologists, pharmacologists, cosmetic and household product researchers, epidemiologists, medical microbiologists, biopsychiatrists, biomedical and psychological educators, biochemists, molecular geneticists, and other scientists interested in alternative testing methods.
Construction Pathways is a comprehensive competency-based text, fulfilling the requirements of the latest Certificate II in Construction Pathways (CPC20220) qualification with extensive practice activities, exercises and illustrations/images. The text offers students comprehensive coverage of all the core competencies required, along with the main high-volume trade electives such as Carpentry, Bricklaying and Wall and Floor Tiling all in one book. Instructor resources pack includes solutions manual, mapping grids and downloadable worksheets. Premium resources like PowerPoints and test banks provide additional teaching support, saving time and adding more depth to classes.
Acute toxicology testing provides the first line of defense against potentially dangerous chemicals. This book is a complete and practical guide to conducting and interpreting all regulatory required and commonly used acute toxicity tests. It presents detailed protocols for all of the common test designs and reviews their development and objectives. Acute Toxicology Testing, Second Edition will interest not only workers in the pharmaceutical industry, but also researchers and students in toxicology and public health. Key Features * Over 100 tables summarizing and interpreting results * Complete coverage of all major test designs and their limitations and advantages * Current status of alternative test designs and models
Safety pharmacology is the evaluation and study of the pharmacological effects of a potential drug that are unrelated to the desired therapeutic effect. These effects often present a hazard—particularly in individuals with compromised or limited organ system functions. Safety Pharmacology in Pharmaceutical Development: Approval and Post Marketing Surveillance, Second Edition covers safety pharmacology from the regulatory requirements down to the studies that must be done to justify them. Using the author’s more than 30 years of direct experience, the book incorporates tricks and practical insights for making studies work and understanding why they fail. The second edition includes current regulations, including USFDA and those from Europe and Japan. Presenting a clear description of what is needed and why for supporting drug development, the book focuses on updated test methods, interpretation, and science. It covers the core and supplemental batteries of test procedures and how to do them and provides an overview of available facilities and contract organizations for performing studies.
This best-selling emergency department reference is now in its thoroughly updated Fifth Edition. The foremost authorities provide practical information on over 600 clinical problems in a fast-access two-page outline format that's perfect for on-the-spot consultation during care in the emergency department. Coverage of each disorder includes clinical presentation, pre-hospital, diagnosis, treatment, disposition, and ICD-9 coding. Icons enable practitioners to quickly spot the information they need. This edition provides up-to-date information on topics such as emerging infections, new protocols, and new treatments.
Joel Osteen, Paula White, T. D. Jakes, Rick Warren, and Brian McLaren pastor some the largest churches in the nation, lead vast spiritual networks, write best-selling books, and are among the most influential preachers in American Protestantism today. Spurred by the phenomenal appeal of these religious innovators, sociologist Shayne Lee and historian Phillip Luke Sinitiere investigate how they operate and how their style of religious expression fits into America’s cultural landscape. Drawing from the theory of religious economy, the authors offer new perspectives on evangelical leadership and key insights into why some religious movements thrive while others decline. Holy Mavericks provides a useful overview of contemporary evangelicalism while emphasizing the importance of "supply-side thinking" in understanding shifts in American religion. It reveals how the Christian world hosts a culture of celebrity very similar to the secular realm, particularly in terms of marketing, branding, and publicity. Holy Mavericks reaffirms that religion is always in conversation with the larger society in which it is embedded, and that it is imperative to understand how those religious suppliers who are able to change with the times will outlast those who are not.
This book serves as a primary text for students of pharmacology, toxicology, and biology, and as a practical handbook to support the daily operations of the toxicology laboratory and researcher. This edition retains the structure of earlier editions, but has been extensively revised to provide both the student and the working toxicologist with the necessary tools for the rigorous and critical design of studies and analysis of experimental data. Assuming only basic mathematical skills as a starting point, Statistics and Experimental Design for Toxicologists provides a thorough and exhaustive introduction to the statistical methods available to and used in the discipline. A worked, practical example from the field is provided for each technique presented. Written from a toxicologist's perspective, this book provides both the methodological tools necessary to analyze experimental toxicology data and the insight to know when to use them.
While the safety assessment (“biocompatibility”) of medical devices has been focused on issues of local tissue tolerance (irritation, sensitization, cytotoxicity) and selected quantal effects (genotoxicity and acute lethality) since first being regulated in the late 1950s, this has changed as devices assumed a much more important role in healthcare and became more complex in both composition and in their design and operation. Add to this that devices now frequently serve as delivery systems for drugs, and that drugs may be combined with devices to improve device performance, and the problems of ensuring patient safety with devices has become significantly more complex. A part of this, requirements for ensuring safety (once based on use of previously acceptable materials – largely polymers and metals) have come to requiring determining which chemical entities are potentially released from a device into patients (and how much is released). Then an appropriate and relevant (yet also conservative) risk assessment must be performed for each identified chemical structure. The challenges inherent in meeting the current requirements are multifold, and this text seeks to identify, understand, and solve all of them. • Identify and verify the most appropriate available data. • As in most cases such data is for a different route of exposure, transform it for use in assessing exposure by the route of interest. • As the duration (and rate) of exposure to moieties released from a device are most frequently different (longer) than what available data speaks to, transformation across tissue is required. • As innate and adaptive immune responses are a central part of device/patient interaction, assessing potential risks on this basis are required. • Incorporating assessments for special populations such as neonates. • Use of (Q)SAR (Quantitative Structure Activity Relationships) modeling in assessments. • Performance and presentation of integrative assessments covering all potential biologic risks. Appendices will contain summarized available biocompatibility data for commonly used device materials (polymers and metals) and safety assessments on the frequently seen moieties in extractions from devices.
Purposefully designed as a resource for practicing and student toxicologists, Statistics and Experimental Design for Toxicologists and Pharmacologists, Fourth Edition equips you for the regular statistical analysis of experimental data. Starting with the assumption of basic mathematical skills and knowledge, the author supplies a complete and systematic yet practical introduction to the statistical methodologists available for, and used in, the discipline. For every technique presented, a worked example from toxicology is also presented. See what's new in the Fourth Edition: The first practical guide to performing meta analysis allowing for using the power inherent in multiple similar studies Coverage of Bayesian analysis and data analysis in pharmacology and toxicology Almost 200 problems with solutions Discussion of analysis of receptor binding assays, safety pharmacology assays and other standard types conducted in pharmacology A new chapter explaining the basics of Good Laboratory Practices (GLPs) For those with computer skills, this edition has been enhanced with the addition of basic SAS Written specifically for toxicologists and pharmacologists, the author draws on more than 30 years of experience to provide understanding of the philosophical underpinnings for the overall structure of analysis. The book's organization fosters the ordered development of skills and yet still facilitates ease of access to information as needed. This Fourth Edition gives you the tools necessary to perform rigorous and critical analysis of experimental data and the insight to know when to use them.
2017 Silver Nautilus Winner 2018 Indie Book Award Finalist Take your ego out of the equation, and watch your company thrive! “I’ve got a solution,” Encore’s CFO tells Brandon, “but it’s unorthodox.” It’s 2005 and Brandon Black has just been promoted to CEO of Encore Capital, a company struggling to navigate an increasingly difficult business environment. Faced with a rapidly declining stock price and low workplace morale, Brandon knows he needs change—and fast. Following his CFO’s advice, he and his executive team start working with Learning as Leadership (LaL) and its president, Shayne Hughes. Through their partnership, Encore’s executive team learns to root out the unproductive ego habits that undermine collaboration and performance. As they instill these more effective behaviors throughout the organization, Encore begins to solve problems collectively, prioritize resources without infighting, and focus on the initiatives with the greatest strategic value. When the financial crisis of 2008–09 forces 90 percent of its competitors out of business, Encore thrives, with its profits increasing by 300 percent and its stock price by 1200 percent. Told from two lively first-person perspectives, Ego Free Leadership brings readers along for Encore’s incredible success story. They’ll see a CEO overcome his unconscious resistance to modeling the change he wants in his team and discover a time-tested roadmap for eliminating the destructive effects of the ego in teams and organizations.
Toxicology has made tremendous strides in the sophistication of the models used to identify and understand the mechanisms of agents that can harm or kill humand and other higher organisms. Non-animals or in vitro models started to gain significant use in the 1960s. As a result of the increased concern over animal welfare, economic factors, and the need for greater sensitivity and understanding of mechanisms, interest in in vitro^n models has risen. This volume demonstrates that there now exists a broad range of in vitro models for use in either identifying or understanding most forms of toxicity. The availability of in vitro models spans both the full range of endpoints (irritation, sensitization, lethality, mutagenicity, and devlopmental toxicity) and the full spectrum of target organ systems (skin, eye, heart, liver, kidney, nervous system, etc.). Chapters are devoted to each of these speciality areas from a perspective of presenting the principal models and their uses and limitations. Chapters that overview the principles involved in the general selection and use of models, and that address the issues of safety concerns and regulatory acceptance of these methods are also included.
This practical guide presents a road map for safety assessment as an integral part of the development of new drugs and therapeutics. Helps readers solve scientific, technical, and regulatory issues in preclinical safety assessment and early clinical drug development Explains scientific and philosophical bases for evaluation of specific concerns – including local tissue tolerance, target organ toxicity and carcinogenicity, developmental toxicity, immunogenicity, and immunotoxicity Covers the development of new small and large molecules, generics, 505(b)(2) route NDAs, and biosimilars Revises material to reflect new drug products (small synthetic, large proteins and cells, and tissues), harmonized global and national regulations, and new technologies for safety evaluation Adds almost 20% new and thoroughly updates existing content from the last edition
Capturing the growth of the global medical device market in recent years, this practical new guide is essential for all who are responsible for ensuring safety in the use and manufacture of medical devices. It has been extensively updated to reflect significant advances, incorporating combination products and helpful case examples of current real-l
Four of today's hottest authors--Maggie Shayne, MaryJanice Davidson, Jacey Ford, and Angela Knight--present a quartet of sexy tales about bold women who take no prisoners, either in a fight or in love. Original.
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