The application of bioinformatics approaches in drug design involves an interdisciplinary array of sophisticated techniques and software tools to elucidate hidden or complex biological data. This work reviews the latest bioinformatics approaches used for drug discovery. The text covers ligand-based and structure-based approaches for computer-aided drug design, 3D pharmacophore modeling, molecular dynamics simulation, the thermodynamics of ligand−receptor and ligand−enzyme association, thermodynamic characterization and optimization, and techniques for computational genomics and proteomics.
Capt. Lumba has been a pilot, union leader and airline executive. He is one of Indian aviation’s legends. His memoir will take you through the by-lanes of Indian Civil Aviation in all its glory. The book explains the Pilot Strike of 1992, the creation and success of Alliance Air (possibly India’s first low-cost carrier), the operational start-up of IndiGo, India’s premier and most successful low-cost carrier. Finally, it covers the safe landing at Laksh Farms, a place termed as a piece of heaven on earth! Readers will find this book more than just a memoir. There are valuable lessons of personal behaviour and integrity that are invaluable to ruminate about. In addition, the historically accurate perspectives of starting and running an airline provide valuable tips for students studying aviation management or even for executives operating in that space today.
The story circumscribe mainly around three characters, who are friends in the profession & personal life. They struggle hard to carve a niche for themselves in the society. The book talks about what journalists undergo in any organization and how the one time noble job of journalism, synonymous with the word mission in India, has now been converted into meagre job. To reach the top editorial post, a journalist needs to sit on the lap of management, write or present things as per their wish. Its knowledge sharing experiences that is filled with humour, thrill, miseries and rejoice.The book is a story of three friends reflecting the state of journalism in the Indian society. How the media houses plays havoc with lives of journalists have been marvelously brought out in the Indian context. Trend suggest in this country how politicians used criminals to win elections. Later, the criminals instead of working for anyone started contesting elections on their own, thus the advent of criminalization in Indian politics took place. Similarly, big media houses used journalists for their liaison activities to serve their business interest and at the later stage, the same lot of journalists started serving their vested interest by grabbing top posts in the corrodors of power...
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