The first book to focus on comprehensive systems biology as applied to drug discovery and development Drawing on real-life examples, Systems Biology in Drug Discovery and Development presents practical applications of systems biology to the multiple phases of drug discovery and development. This book explains how the integration of knowledge from multiple sources, and the models that best represent that integration, inform the drug research processes that are most relevant to the pharmaceutical and biotechnology industries. The first book to focus on comprehensive systems biology and its applications in drug discovery and development, it offers comprehensive and multidisciplinary coverage of all phases of discovery and design, including target identification and validation, lead identification and optimization, and clinical trial design and execution, as well as the complementary systems approaches that make these processes more efficient. It also provides models for applying systems biology to pharmacokinetics, pharmacodynamics, and candidate biomarker identification. Introducing and explaining key methods and technical approaches to the use of comprehensive systems biology on drug development, the book addresses the challenges currently facing the pharmaceutical industry. As a result, it is essential reading for pharmaceutical and biotech scientists, pharmacologists, computational modelers, bioinformaticians, and graduate students in systems biology, pharmaceutical science, and other related fields.
The US is currently well ahead of the rest of the world in the development and application of SB and its principles especially as they pertain to basic medical research and development. This lead is largely due to its earlier start in the academic arena. However, there is evidence of rapid development in both the UK/EU and Japan, and the gap is narrowing, particularly in the UK. From an industrial point of view, the Pharmaceutical Industry based in the US and UK can capitalize on these opportunities and gain the benefits of this technology. Many educational institutions (particularly their medical divisions) at present are heavily business-oriented, realize that in this particular industrial environment, that every dollar counts.
This collection of case studies is designed for use in both undergraduate and graduate courses in health care administration. With contributions from a range of experts including present and former CEOs, consultants, public health officials, systems executives, departmental managers, architects, planners and entrepreneurs, this robust classroom resource brings together practical, real world examples of issues and topics that are critical to understanding the complex field of health care management.
The world’s leading textbook on astrobiology—ideal for an introductory one-semester course and now fully revised and updated Are we alone in the cosmos? How are scientists seeking signs of life beyond our home planet? Could we colonize other planets, moons, or even other star systems? This introductory textbook, written by a team of four renowned science communicators, educators, and researchers, tells the amazing story of how modern science is seeking the answers to these and other fascinating questions. They are the questions that are at the heart of the highly interdisciplinary field of astrobiology, the study of life in the universe. Written in an accessible, conversational style for anyone intrigued by the possibilities of life in the solar system and beyond, Life in the Universe is an ideal place to start learning about the latest discoveries and unsolved mysteries in the field. From the most recent missions to Saturn’s moons and our neighboring planet Mars to revolutionary discoveries of thousands of exoplanets, from the puzzle of life’s beginning on Earth to the latest efforts in the search for intelligent life elsewhere, this book captures the imagination and enriches the reader’s understanding of how astronomers, planetary scientists, biologists, and other scientists make progress at the cutting edge of this dynamic field. Enriched with a wealth of engaging features, this textbook brings any citizen of the cosmos up to speed with the scientific quest to discover whether we are alone or part of a universe full of life. An acclaimed text designed to inspire students of all backgrounds to explore foundational questions about life in the cosmos Completely revised and updated to include the latest developments in the field, including recent exploratory space missions to Mars, frontier exoplanet science, research on the origin of life on Earth, and more Enriched with helpful learning aids, including in-chapter Think about It questions, optional Do the Math and Special Topic boxes, Movie Madness boxes, end-of-chapter exercises and problems, quick quizzes, and much more Supported by instructor’s resources, including an illustration package and test bank, available upon request
Why do polished stones look wet? How does the Twin Paradox work? What if Jupiter were a star? How can we be sure that pi never repeats? How does a quantum computer break encryption? Discover the answers to these, and other profound physics questions! This fascinating book presents a collection of articles based on conversations and correspondences between the author and complete strangers about physics and math. The author, a researcher in mathematical physics, responds to dozens of questions posed by inquiring minds from all over the world, ranging from the everyday to the profound. Rather than unnecessarily complex explanations mired in mysterious terminology and symbols, the reader is presented with the reasoning, experiments, and mathematics in a casual, conversational, and often comical style. Neither over-simplified nor over-technical, the lucid and entertaining writing will guide the reader from each innocent question to a better understanding of the weird and beautiful universe around us. Advance praise for Do Colors Exist?: “Every high school science teacher should have a copy of this book. The individual articles offer enrichment to those students who wish to go beyond a typical ‘dry curriculum’. The articles are very fun. I probably laughed out loud every 2-3 minutes. This is not easy to do. In fact, my children are interested in the book because they heard me laughing so much.” – Ken Ono, Emory University
An Introduction to Seismology, Earthquakes and Earth Structures is an introduction to seismology and its role in the earth sciences, and is written for advanced undergraduate and beginning graduate students. The fundamentals of seismic wave propagation are developed using a physical approach and then applied to show how refraction, reflection, and teleseismic techniques are used to study the structure and thus the composition and evolution of the earth. The book shows how seismic waves are used to study earthquakes and are integrated with other data to investigate the plate tectonic processes that cause earthquakes. Figures, examples, problems, and computer exercises teach students about seismology in a creative and intuitive manner. Necessary mathematical tools including vector and tensor analysis, matrix algebra, Fourier analysis, statistics of errors, signal processing, and data inversion are introduced with many relevant examples. The text also addresses the fundamentals of seismometry and applications of seismology to societal issues. Special attention is paid to help students visualize connections between different topics and view seismology as an integrated science. An Introduction to Seismology, Earthquakes, and Earth Structure gives an excellent overview for students of geophysics and tectonics, and provides a strong foundation for further studies in seismology. Multidisciplinary examples throughout the text - catering to students in varied disciplines (geology, mineralogy, petrology, physics, etc.). Most up to date book on the market - includes recent seismic events such as the 1999 Earthquakes in Turkey, Greece, and Taiwan). Chapter outlines - each chapter begins with an outline and a list of learning objectives to help students focus and study. Essential math review - an entire section reviews the essential math needed to understand seismology. This can be covered in class or left to students to review as needed. End of chapter problem sets - homework problems that cover the material presented in the chapter. Solutions to all odd numbered problem sets are listed in the back so that students can track their progress. Extensive References - classic references and more current references are listed at the end of each chapter. A set of instructor's resources containing downloadable versions of all the figures in the book, errata and answers to homework problems is available at: http://levee.wustl.edu/seismology/book/. Also available on this website are PowerPoint lecture slides corresponding to the first 5 chapters of the book.
What happened to musical modernism? When did it end? Did it end? In this unorthodox Lacanian account of European New Music, Seth Brodsky focuses on the unlikely year 1989, when New Music hardly takes center stage. Instead one finds Rostropovich playing Bach at Checkpoint Charlie; or Bernstein changing “Joy” to “Freedom” in Beethoven’s Ninth; or David Hasselhoff lip-synching “Looking for Freedom” to thousands on New Year’s Eve. But if such spectacles claim to master their historical moment, New Music unconsciously takes the role of analyst. In so doing, it restages earlier scenes of modernism. As world politics witnesses a turning away from the possibility of revolution, musical modernism revolves in place, performing century-old tasks of losing, failing, and beginning again, in preparation for a revolution to come.
A revolutionary, personalized psychotherapy approach for the treatment of Axis I clinical disorders, by renowned expert Dr. Theodore Millon Acknowledging the primacy of the whole person, Resolving Difficult Clinical Syndromes: A Personalized Psychotherapy Approach takes into account all of the complexities of human nature--family influences, culture, neurobiological processes, unconscious memories, and so on--illustrating that no part of human nature should lie outside the scope of a clinician's regard. Part of a three-book series, Resolving Difficult Clinical Syndromes: A Personalized Psychotherapy Approach provides you with a unique combination of conceptual background and step-by-step practical advice to guide your treatment of Axis I clinical disorders. Detailed case studies are provided throughout the text to illustrate the strategies of personalized psychotherapy for: * Mood-Related Syndromes: Dysthymic, Major Depressive, and Bipolar Disorders * Acute, Post-Traumatic, and Generalized Anxiety Syndromes * Anxiety-Related Psychological Syndromes: Phobic, Dissociative, and Obsessive-Compulsive Disorders * Anxiety-Related Physical Syndromes: Somatoform and Conversion Disorders * Cognitive Dysfunction Syndromes: Substance-Related and Schizophrenia-Spectrum Disorders Destined to become an essential reference for trainees and professionals, this book makes a revolutionary call to return therapy to the natural reality of each patient's life, seamlessly guiding you in understanding the personality and treatment of the whole, unique, yet complex person who exhibits a notable clinical syndrome.
Between 1905 and 1913, French physicist Jean Perrin's experiments on Brownian motion ostensibly put a definitive end to the long debate regarding the real existence of molecules, proving the atomic theory of matter. While Perrin's results had a significant impact at the time, later examination of his experiments questioned whether he really gained experimental access to the molecular realm. The experiments were successful in determining the mean kinetic energy of the granules of Brownian motion; however, the values for molecular magnitudes Perrin inferred from them simply presupposed that the granule mean kinetic energy was the same as the mean molecular kinetic energy in the fluid in which the granules move. This stipulation became increasingly questionable in the years between 1908 and 1913, as significantly lower values for these magnitudes were obtained from other experimental results like alpha-particle emissions, ionization, and Planck's blackbody radiation equation. In this case study in the history and philosophy of science, George E. Smith and Raghav Seth here argue that despite doubts, Perrin's measurements were nevertheless exemplars of theory-mediated measurement-the practice of obtaining values for an inaccessible quantity by inferring them from an accessible proxy via theoretical relationships between them. They argue that it was actually Perrin more than any of his contemporaries who championed this approach during the years in question. The practice of theory-mediated measurement in physics had a long history before 1900, but the concerted efforts of Perrin, Rutherford, Millikan, Planck, and their colleagues led to the central role this form of evidence has had in microphysical research ever since. Seth and Smith's study thus replaces an untenable legend with an account that is not only tenable, but more instructive about what the evidence did and did not show.
Gale Researcher Guide for: Jimmy Santiago Baca and New Prison Writing is selected from Gale's academic platform Gale Researcher. These study guides provide peer-reviewed articles that allow students early success in finding scholarly materials and to gain the confidence and vocabulary needed to pursue deeper research.
Twenty years ago, Nashville singing star Rae Willie Chappell died gruesomely. Since then, a serial slayer has been killing Rae Willie look-alikes in a way that even hardened cops find shocking. Rider Chappell had been a teenager when his mother had died. Now he is a Nashville detective. But can Rider face the most monstrous legacy a mother ever left a son?
Gale Researcher Guide for: Jimmy Santiago Baca and New Prison Writing is selected from Gale's academic platform Gale Researcher. These study guides provide peer-reviewed articles that allow students early success in finding scholarly materials and to gain the confidence and vocabulary needed to pursue deeper research.
The US is currently well ahead of the rest of the world in the development and application of SB and its principles especially as they pertain to basic medical research and development. This lead is largely due to its earlier start in the academic arena. However, there is evidence of rapid development in both the UK/EU and Japan, and the gap is narrowing, particularly in the UK. From an industrial point of view, the Pharmaceutical Industry based in the US and UK can capitalize on these opportunities and gain the benefits of this technology. Many educational institutions (particularly their medical divisions) at present are heavily business-oriented, realize that in this particular industrial environment, that every dollar counts.
The first book to focus on comprehensive systems biology as applied to drug discovery and development Drawing on real-life examples, Systems Biology in Drug Discovery and Development presents practical applications of systems biology to the multiple phases of drug discovery and development. This book explains how the integration of knowledge from multiple sources, and the models that best represent that integration, inform the drug research processes that are most relevant to the pharmaceutical and biotechnology industries. The first book to focus on comprehensive systems biology and its applications in drug discovery and development, it offers comprehensive and multidisciplinary coverage of all phases of discovery and design, including target identification and validation, lead identification and optimization, and clinical trial design and execution, as well as the complementary systems approaches that make these processes more efficient. It also provides models for applying systems biology to pharmacokinetics, pharmacodynamics, and candidate biomarker identification. Introducing and explaining key methods and technical approaches to the use of comprehensive systems biology on drug development, the book addresses the challenges currently facing the pharmaceutical industry. As a result, it is essential reading for pharmaceutical and biotech scientists, pharmacologists, computational modelers, bioinformaticians, and graduate students in systems biology, pharmaceutical science, and other related fields.
The US is currently well ahead of the rest of the world in the development and application of SB and its principles especially as they pertain to basic medical research and development. This lead is largely due to its earlier start in the academic arena. However, there is evidence of rapid development in both the UK/EU and Japan, and the gap is narrowing, particularly in the UK. From an industrial point of view, the Pharmaceutical Industry based in the US and UK can capitalize on these opportunities and gain the benefits of this technology. Many educational institutions (particularly their medical divisions) at present are heavily business-oriented, realize that in this particular industrial environment, that every dollar counts.
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