Sergio Rosales-Mendoza's Books

Algae-Based Biopharmaceuticals

By: Sergio Rosales-Mendoza

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Algae-Based Biopharmaceuticals

By: Sergio Rosales-Mendoza

This book constitutes a key reference on the use of algae in the biopharmaceuticals production field; providing an updated outlook on the achievements accomplished thus far and transmitting a prospective view for this biotechnological application. This book provides a detailed description of the technology as well as an updated outlook of the strides achieved thus far in the field of algae-based biopharmaceuticals. Algae constitute attractive expression hosts for the production of recombinant proteins with medical applications. Among the features that make them attractive candidates are: low cost, fast growth, wide biosynthetic capacity, and absence of human pathogens; which constitute substantial advantages with respect to bacterial and mammalian systems. First, the features of algae as convenient hosts for the production of BFs are analyzed in terms of production costs, biosynthetic capacity, and safety (Chapter 1). Second, the genetic engineering tools for algae-species are described. Nuclear and chloroplast-based expression approaches are analyzed and compared in terms of biosynthetic advantages, gene expression complexity, and DNA transfer approaches (Chapter 2). In the following sections, chapters 3 to 7, the state of the art on producing distinct types of BFs in algae species is presented. Although this book is mainly focused on BFs, considering that the production of compounds with health-promoting properties are achieved using genetically-engineered algae strains, chapter 8 deals with nutraceuticals. In the ninth chapter, the developments reported thus far are placed in perspective and challenges for the field are discussed. Critical future prospects comprise the following: optimizing large-scale production in bioreactors, implementing glycoengineering approaches, optimizing nuclear expression, exploring new approaches for oral delivery, and implementing regulatory frameworks to accomplish technology transfer and regulatory approval of algae-made BFs.

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Page Count

172

Publisher

Springer

Published Date

ISBN 10

331932232X

ISBN 13

9783319322322

Algae-Based Biopharmaceuticals

By: Sergio Rosales-Mendoza

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Algae-Based Biopharmaceuticals

By: Sergio Rosales-Mendoza

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Page Count

172

Publisher

Springer

Published Date

ISBN 10

331932232X

ISBN 13

9783319322322

Nanovaccines

An Innovative Technology to Fight Human and Animal Diseases

By: Sergio Rosales-Mendoza,Omar González-Ortega

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Nanovaccines

An Innovative Technology to Fight Human and Animal Diseases

By: Sergio Rosales-Mendoza,Omar González-Ortega

This book provides a compilation of the current developments in mucosal nanovaccines, which are an attractive approach to fight against infectious and non-communicable diseases. Since nanomaterials possess unique properties; many of them have a positive effect on vaccine efficacy when used as antigen carriers and have been applied in vaccinology with significant advances over the past years. This book addresses the methodologies for mucosal nanovaccines synthesis; based on the following nanomaterials: gold, PLGA, silica, and chitosan nanoparticles; as well as nanogels, carbon nanotubes, liposomes, and Virus-like particles. A description of the immunogenic properties of the mucosal nanovaccines is presented, highlighting the improvements achieved with this approach when compared to conventional formulations. Mucosal vaccines constitute the most practical immunization approach since they are easy to administer (promoting patient ́s comfort and increasing compliance), allow triggering relevant immune responses at both the site of administration and distant compartments, and thus may protect the main entry portal for pathogens (oral, nasal, and genital mucosae). In this context, the potential of nanovaccines to result in new mucosal formulations in the benefit of global health is analyzed. Covers the synthesis and functionalization of nanomaterials for the development of nanovaccines; Discusses the underlying mechanisms involved in the induction of immune responses through mucosal compartments and the advantages of nanomaterials in the formulation of nanovaccines; Transmits the state of the art for the development of mucosal nanovaccines; Provides routes for the design and evaluation of mucosal nanovaccines; Presents key perspectives for the field of mucosal vaccine development.

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Page Count

347

Publisher

Springer Nature

Published Date

ISBN 10

3030316688

ISBN 13

9783030316686

Book's by Sergio Rosales-Mendoza

Algae-Based Biopharmaceuticals

Algae-Based Biopharmaceuticals

Algae-Based Biopharmaceuticals

Algae-Based Biopharmaceuticals

Nanovaccines

Nanovaccines

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