A riveting, revelatory, and moving account of the author’s struggles with anxiety, and of the history of efforts by scientists, philosophers, and writers to understand the condition As recently as thirty-five years ago, anxiety did not exist as a diagnostic category. Today, it is the most common form of officially classified mental illness. Scott Stossel gracefully guides us across the terrain of an affliction that is pervasive yet too often misunderstood. Drawing on his own long-standing battle with anxiety, Stossel presents an astonishing history, at once intimate and authoritative, of the efforts to understand the condition from medical, cultural, philosophical, and experiential perspectives. He ranges from the earliest medical reports of Galen and Hippocrates, through later observations by Robert Burton and Søren Kierkegaard, to the investigations by great nineteenth-century scientists, such as Charles Darwin, William James, and Sigmund Freud, as they began to explore its sources and causes, to the latest research by neuroscientists and geneticists. Stossel reports on famous individuals who struggled with anxiety, as well as on the afflicted generations of his own family. His portrait of anxiety reveals not only the emotion’s myriad manifestations and the anguish anxiety produces but also the countless psychotherapies, medications, and other (often outlandish) treatments that have been developed to counteract it. Stossel vividly depicts anxiety’s human toll—its crippling impact, its devastating power to paralyze—while at the same time exploring how those who suffer from it find ways to manage and control it. My Age of Anxiety is learned and empathetic, humorous and inspirational, offering the reader great insight into the biological, cultural, and environmental factors that contribute to the affliction.
As founder of the Peace Corps, Head Start, the Special Olympics (with wife Eunice Kennedy Shriver), and other organizations, Sargent Shriver was a key social and political figure whose influence continues to the present day. This authorized biography, exhaustively researched and finely rendered by Scott Stossel (deputy editor of The Atlantic), reads like an epic novel, with “Sarge” marching through the historical events of the last century—the Great Depression, World War II, JFK’s assassination, the Cold War, and many more. Sarge gives us a complete account of Shriver’s life, as well as a thoughtful commentary on the Kennedy family, the Peace Corps, and United States and world history. It is a riveting and comprehensive reconstruction of a life that exemplifies what it means to be a true American.
Now more than ever, doctors are being targeted by government prosecutors and whistleblowers challenging the legality of their relationships with drug and device companies. With reputations at stake and the risk of civil and criminal liability, it is incumbent upon doctors to protect themselves. Managing Relationships with Industry: A Physician's Compliance Manual is an indispensable resource for doctors, professional societies, academic medical centers, community hospitals, and group practices struggling to understand the ever changing law and ethical standards on interactions with pharmaceutical and device companies. It is the first comprehensive summary of the law and ethics on physician relationships with industry written for the physician. Authored by a former state Attorney General, Harvard Medical School Professor, health care lawyer and professor of ethics, Managing Relationships approaches the topic from a balanced and reasoned perspective adding to the on-going national dialogue and debate on the proper limits to medicine's relationship with industry. - The first complete and up-to-date summary and analysis of the law and ethics on physician-industry relationships - Focuses on major enforcement actions and whistleblower lawsuits and the lessons learned for physicians - Provides options and guidance for maintaining compliant relationships and avoiding traps for the unwary - Covers both drug and device company relationships - Summarizes the types of industry relationships that are necessary and productive and those that are harmful and abusive - Details the law and ethics for each type of relationship including gifts, off-label uses and marketing, CME, speaker's bureaus, free samples, grants, consulting arrangements, etc. - Includes sample contracts for permissible consulting and CME speaker engagements
This book will refresh and revive you to the beginning stages of a new revolution!" JEREMY LOPEZ, D.D. Identity Network, Inc., President "I recommend this book to everyone who is concerned about truth and justice being smothered and suppressed within the U.S." MARYAL BOUMANN Pray California, Director DO NOT go to court without FIRST reading this book! Reading it could save you BIG money! Not Reading it will cost you more! Rev. Scott Wallis, a leading pro se litigator, has represented himself in 50+ cases worth $5+ billion dollars before Illinois state and federal courts against top law firms. To date, his largest victory, the reversal of his $500+ million dollars lawsuit against parties that bankrupted USA Baby(R), Inc., America's Leading Specialty Retailer of Infant and Children's Furniture and Accessories(R). Court Street, a Multi-Trillion dollar industry, routinely dispenses injustice in justices' name. The attorney "fraternity" has ordained a black-robed wall of silent perdition, an inseparable barrier preventing what America and Main Street needs most - justice. Why? Money! Court Street is overseeing the greatest redistribution of wealth in mankind's history - from Main Street to Wall Street. Secret Corruption exposes hidden corruption taking place daily behind the walls of Court Street. Court Street's corruption is impacting your life; it is literally bankrupting America. Take a revealing look at our nation's most secretive and corrupt enterprise! Buy this book! "I urge everyone who desires that America returns to its Just Foundation to purchase this book and let your voice be heard!" MARK SILJANDER Member of Congress (ret.), 1977-81 United States Ambassador, 1987-88 Mohandas K. Gandhi Peace Award, 1996 Author, A Deadly Misunderstanding, 2008 "I commend this book to you, if you can keep your blood pressure under control: as you read it, you will share the outrage Scott expresses." GENE REDLIN Business Owner
This comprehensive analysis of Boris Karloff's life and career incorporates criticism, in-depth production information and discussions of cinematic themes and characters, with an account of the historical periods and events depicted in the films and the Hollywood era in which they were produced. Each of Karloff's horror films is examined at length, as well as his contributions to other media. Over 100 posters, portraits, film scenes and candid photos illustrate the text, and numerous contemporaries (Evelyn Karloff, Laurence Olivier, Henry Brandon, Ian Wolfe, Zita Johann, others) are quoted throughout.
At the tense intersection of biblical interpretation and contemporary politics, this book stands out as an imagined political campaign guide based on a creative deep dive into Luke’s vibrant evangelical account of Jesus’s messianic mission. It seeks to challenge any group that blithely claims Jesus’s endorsement of their partisan agendas today, but especially those trumpeting authoritarian rule. Close attention to Luke’s narrative discloses a distinctive figure who strikingly ill fits standard strongman profiles and straitjacket labels. Warning: If Luke’s Jesus doesn’t change your vote, he might well change your mind, challenge your life, and shake up your politics along the way.
Would you like to do your part in saving America? Grass Roots is a no-nonsense instruction manual that explains exactly what you can do. Scott Hennen—host and founder of the innovative Common Sense Club radio program—shows how everyday Americans just like you are making a difference for our country’s future. This down-to-earth handbook gives you clear, practical, effective actions you can take to preserve the American dream for your children and grandchildren. President Ronald Reagan once said, “All great change in America begins at the dinner table.” Today, most Americans struggle just to keep food on the dinner table. We are staggering under a crushing burden of big government, out-of-control spending, and towering federal debt. We have become tax slaves—and the people we sent to Washington to represent us are the very ones who sold us there. We’re angry—and rightly so. But ruling-class politicians have shrugged off our grassroots anger, calling it “Astroturf.” We’re tired of being ignored, patronized, and lied to by the very people who are supposed to be our “public servants.” Not since the original Boston Tea Party of 1773 have so many everyday Americans participated in such a significant display of righteous indignation and freedom-loving patriotism. For the first time in generations, ordinary hardworking, church-going Americans are carrying signs, gathering in large numbers, and making their voices heard. Big government, beware. A sleeping giant has awakened. Scott Hennen has drawn up a practical blueprint for change, a handbook for all of us who are ready to roll up our sleeves and do our part to restore America’s goodness—and greatness. Grass Roots is a political manifesto for every American who loves liberty and cares enough to get involved.
Donna Reed has been called everyone's favorite mother and her recognition as such has stood the test of time. But before she became known as the ultimate mom for her role on The Donna Reed Show, Miss Reed was already a veteran film actress with almost forty films to her credit. Among these are her performances in It's a Wonderful Life and From Here to Eternity. Her role in the latter garnered her a Best Supporting Actress Oscar. This book is a comprehensive reference to the life and work of Donna Reed for use by researchers as well as fans. Performing arts researcher Brenda Scott Royce has compiled a self-contained reference work to Donna Reed's career and life. A brief biography begins the book, followed by detailed examinations of Miss Reed's work in motion pictures, television, and radio. Also listed are media reviews of her work, a listing of awards and nominations, and a chronology of major events in her life. An annotated bibliography follows these sections, and it lists all articles and other items about Donna Reed that appeared in major magazines, fan magazines, books, and newspapers. The entries in each section are cross-referenced for easy referral by the reader. This bio-bibliography will be an important addition to libraries with a performing arts collection, students of media arts, and Donna Reed fans.
For complete, authoritative coverage of every aspect of thoracic and cardiac surgery, turn to the unparalleled guidance found in Sabiston and Spencer Surgery of the Chest, 9th Edition. Now in full-color for the first time, Drs. Frank W. Sellke, Pedro J. del Nido, and Scott J. Swanson’s standard-setting set is meticulously organized so that you can quickly find expert information on open and endoscopic surgical techniques performed in the operating room. With its comprehensive coverage of thoracic as well as adult and pediatric cardiac surgery, this 9th Edition is an essential resource not only for all thoracic surgeons, but also for physicians, residents, and students concerned with diseases of the chest. Find what you need quickly with short, focused chapters divided into three major sections: Adult Cardiac Surgery, Pediatric Cardiac Surgery, and Thoracic Surgery. Benefit from the knowledge and expertise of global experts who provide a comprehensive view of the entire specialty. Master all of the most important current knowledge and techniques in cardiac and thoracic surgery—whether for specialty board review or day-to-day surgical practice. Visualize challenging surgical techniques and procedures and navigate the text more efficiently thanks to an all-new, full-color design. Stay up to date with revised or all-new chapters including Critical Care for War-related Thoracic Surgery; Neuromonitoring and Neurodevelopment Outcomes in Congenital Heart Surgery; and Quality Improvement: Surgical Performance. Keep abreast of cutting-edge topics such as endovascular stenting and cell-based therapies, as well as the latest innovations in imaging and diagnosis, minimally invasive cardiothoracic surgery, and percutaneous devices. Sharpen your surgical skills with access to 21 procedural videos online, including 3 new videos covering Surgical Technique-VATS Sympathetic Block; Open pneumothorax; and Extent II repair of thoracoabdominal aortic aneurysm.
The only text to cover the full range of adult cardiac, thoracic, and pediatric chest surgery, Sabiston and Spencer Surgery of the Chest provides unparalleled guidance in a single, two-volume resource. This gold standard reference, edited by Drs. Frank Sellke, Pedro del Nido, and Scott Swanson, covers today's most important knowledge and techniques in cardiac and thoracic surgery—the information you need for specialty board review and for day-to-day surgical practice. Meticulously organized so that you can quickly find expert information on open and endoscopic surgical techniques, this 10th Edition is an essential resource not only for all cardiothoracic surgeons, but also for physicians, residents, and students concerned with diseases of the chest. - Features short, focused chapters divided into three major sections: Adult Cardiac Surgery, Pediatric Cardiac Surgery, and Thoracic Surgery. - Presents the knowledge and expertise of global experts who provide a comprehensive view of the entire specialty. - Provides full-color coverage throughout, helping you visualize challenging surgical techniques and procedures and navigate the text efficiently. - Includes new chapters on dissection complications and percutaneous treatment of mitral and tricuspid valve disease. - Offers extensively revised or rewritten chapters on surgical revascularization, acute dissection, vascular physiology, the latest innovations in minimally invasive cardiothoracic surgery and percutaneous devices, the molecular biology of thoracic malignancy, robotics in chest surgery, congenital valve reconstructions, novel hybrid procedures in pediatric cardiac surgery, and 3D visualization of cardiac anatomy for surgical procedure planning. - Keeps you up to date with the latest developments in cardiothoracic imaging and diagnosis. - Provides access to more than 30 surgical videos online, and features new figures, tables, and illustrations throughout. - An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
Is business just a way to make money? Or can the marketplace be a venue for service to others? Scott B. Rae and Kenman L. Wong seek to explore this and other critical business issues from a uniquely Christian perspective, offering up a vision for work and service that is theologically grounded and practically oriented.
We've all heard that, "you learn more from failure than you do from success." Which means that all those hours spent watching crappy movies wasn't a waste of your precious and ever-dwindling life span; it was an education! And Better Living Through Bad Movies can show you how to extract the profound, life-affirming lessons from films like Battlefield Earth, Coyote Ugly, and Indecent Proposal. In over 50 hilarious reviews, the authors show how you can use the worst movies ever made to improve your sex life (it involves cardboard cutouts and clog dancing), Apocalypse-proof your home (using the following materials: John Travolta, Kevin Costner, Sylvester Stallone and more Kevin Costner), and win omnipotence and a Happy Meal by solving Satan's Junior Jumble. You will also discover how to forge a love that will last a lifetime (by dating the moribund), use films like Batman and Robin and Star Wars: The Phantom Menace as grief counseling, and conquer the world using common fruit bats and dry cleaning fluid. And most important of all, you'll learn Hollywood's Ultimate Secret: Why Beaches and Armageddon are actually the exact same movie.
Field Guide to Bedside Diagnosis, Second Edition enables students and physicians to navigate from the patient's symptoms and presenting signs to the diagnosis. The book covers 139 chief complaints and signs and is organized to parallel the diagnostic reasoning process: a differential overview of probable causes, a diagnostic approach for each differential, and the specific clinical findings that point to diagnosis. A collection of 192 full-color illustrations show diagnostically important observable signs. This edition includes thoroughly updated diagnostic approaches and quick-access Evidence-Based Medicine Physical Diagnosis tables indicating sensitivity, specificity, and likelihood ratios for findings.
As three of the most prominent actors of the early studio system, James Cagney, Edward G. Robinson, and Humphrey Bogart played an unparalleled role in the rise of the Warner Brothers Studio. These "Warners Wiseguys" are now virtually synonymous with the studio's era of gritty gangster films. This study of their interwoven studio-contract careers highlights the similarities of their personalities and their struggles with harsh typecasting. It details and comments critically on each of their combined 112 Warners films. Complete with commentary from the author and other film buffs. An appendix provides a filmographic guide to the films discussed, including lists of primary actors, release dates, directorial credits, and running times for each film.
“To know thyself is the beginning of wisdom.” —Socrates What’s the secret to lasting happiness? How do you gain the resilience needed to weather life’s inevitable storms? What can you do when you’re feeling anxious, depressed, stressed, or burned out by life? For ancient philosophers like Socrates, Marcus Aurelius, Zeno, and Epictetus, these questions were more than mere musings—they were key elements of a school of thought called Stoicism. In The Stoicism Workbook, you’ll learn how thinking like Socrates—and using the Socratic method of questioning or self-inquiry—can help you identify what truly matters in your life, and build the resilience needed to go out and get it! Combining ancient philosophical wisdom with modern psychology, this practical self-help workbook will help you think flexibly, maintain inner peace, adapt to difficult situations, and improve your overall mental health and well-being. You’ll also discover how the core Stoic virtues—wisdom, justice, courage, and temperance—can be your compass as you navigate an increasingly uncertain world. Stoicism isn’t about being emotionless in the face of pain or suffering. It’s about giving yourself space for reflection before reacting. It’s about seeing opportunities in everyday challenges, which in turn makes you stronger and more resilient. It’s about wielding the power to decide to what extent sadness, pain, and anger affect you. These are the keys to lasting happiness. Let this workbook guide you to learn more, and put this ancient wisdom into practice every day.
More than fifty million Americans suffer today from chronic pain. Dr. Scott Brady was one of them. Doctors told him he would live with his back pain for the rest of his life. Having exhausted all options offered by conventional medicine, Dr. Brady overcame his pain using a mind-body-spirit approach'in an incredible four weeks. In 2000, he founded the Brady Institute, where more than 80 percent of his patients have achieved 80-100 percent pain relief, without surgery or drugs. In Pain Free For Life, Dr. Brady sets a clear course for readers to diagnose what is really causing their pain 'autonomic overload syndrome, which is brought on by the repression of harmful negative emotions with profiles of pain-prone personalities and an innovative spiritual health inventory. He reveals the techniques behind his remarkably effective recovery plan, including the practice of depth journaling and prescriptions to boost the power of personal belief. Dr. Brady's approach has helped his patients overcome such conditions as chronic back pain, nagging neck and shoulder pain, migraine or tension headaches, muscle pain, irritable bowel syndrome, insomnia, and many other chronic pain-associated ailments. The principles and techniques described in Pain Free For Life will be illustrated by in-depth case studies. His proven 6-week program produces results in as little as thirty minutes a day.
50 Great Myths of Popular Psychology uses popular myths as a vehicle for helping students and laypersons to distinguish science from pseudoscience. Uses common myths as a vehicle for exploring how to distinguish factual from fictional claims in popular psychology Explores topics that readers will relate to, but often misunderstand, such as 'opposites attract', 'people use only 10% of their brains', and 'handwriting reveals your personality' Provides a 'mythbusting kit' for evaluating folk psychology claims in everyday life Teaches essential critical thinking skills through detailed discussions of each myth Includes over 200 additional psychological myths for readers to explore Contains an Appendix of useful Web Sites for examining psychological myths Features a postscript of remarkable psychological findings that sound like myths but that are true Engaging and accessible writing style that appeals to students and lay readers alike
As two of the most popular entertainers of the mid-century film industry, comic greats Bud Abbott and Lou Costello offered an essential balm to the American public following the sorrows of the Great Depression and during the trauma of World War II. This is the first book to focus in detail on the immensely popular wartime films of Abbott and Costello, discussing the production, content, and reception of 18 films within the context of wartime events on the home front and abroad. The films covered include the service comedies Buck Privates, In the Navy, and Keep 'Em Flying; more mainstream comic relief films such as Pardon My Sarong and Who Done It?; and post-war experiments such as Little Giant and The Time of Their Lives. More than 120 stills and lobby cards from the author's personal collection illustrate the text, including many showing outtakes or deleted scenes.
Preserving the Promise: Improving the Culture of Biotech Investment critically examines why most biotech startups fail, as they emerge from universities into an ecosystem that inhibits rather than encourages innovation. This "Valley of Death" squanders our public investments in medical research and with them, the promise of longer and healthier lives. The authors explicate the Translation Gap faced by early stage biotech companies, the result of problematic technology transfer and investment practices, and provide specific prescriptions for improving translation of important discoveries into safe and effective therapies. In Preserving the Promise, Dessain and Fishman build on their collective experience as company founders, healthcare investor (Fishman) and physician/scientist (Dessain). The book offers a forward-looking, critical analysis of "conventional wisdom" that encumbers commercialization practices. It exposes the self-defeating habits of drug development in the Valley of Death, that waste money and extinguish innovative technologies through distorted financial incentives. - Explains why translation of biotech discovery into medicine succeeds so infrequently that it's been dubbed the Valley of Death - Uncovers specific decision-making strategies that more effectively align incentives, improving clinical and financial outcomes for investors, inventor/entrepreneurs, and patients - Examines the critical, early stages of commercialization, where technology transfer offices and Angels act as gatekeepers to development, and where tension between short-term financial and long-term clinical aspirations sinks important technologies - Deconstructs the forces driving biotech, recasts them in a proven conceptual framework, and offers practical guidance for making the system better
These were unique, complex, personal and professional relationships between master director John Ford and his two favorite actors, John Wayne and Ward Bond. The book provides a biography of each and a detailed exploration of Ford's work as it was intertwined with the lives and work of both Wayne and Bond (whose biography here is the first ever published). The book reveals fascinating accounts of ingenuity, creativity, toil, perseverance, bravery, debauchery, futility, abuse, masochism, mayhem, violence, warfare, open- and closed-mindedness, control and chaos, brilliance and stupidity, rationality and insanity, friendship and a testing of its limits, love and hate--all committed by a "half-genius, half-Irish" cinematic visionary and his two surrogate sons: Three Bad Men.
A "bravely intimate [and] dazzlingly comprehensive" history (The New York Times Book Review) of efforts by scientists, philosophers, and writers to understand anxiety—from an acclaimed journalist with his own longstanding battle with this often misunderstood affliction. Drawing on his own experience with anxiety, Scott Stossel presents a moving and revelatory account of a condition that affects some 40 million Americans. Stossel offers an intimate and authoritative history. We discover the well-known who have struggled with the condition, as well as the afflicted generations of Stossel's own family. Revealing anxiety's myriad manifestations and the anguish it causes, he also surveys the countless psychotherapies, medications, and often outlandish treatments that have been developed to relieve it. Stossel vividly depicts anxiety’s human toll—its crippling impact, its devastating power to paralyze. He also explores how individual sufferers—including himself—have managed and controlled symptoms. By turns erudite and compassionate, amusing and inspirational, My Age of Anxiety is the essential account of a pervasive affliction.
Louis Armstrong was not only a virtuoso musician, singer, composer and actor, but also a dedicated writer who typed hundreds of letters and reminiscences, carrying a typewriter with him on his constant travels around the globe. The man never stopped creating, and constantly communicated with friends and acquaintances. His unique verbal, musical and visual content and style permeated everything he touched. Included in this extensive career biography are the major events of his life, his artistic innovations and cultural achievements, a detailed survey of his recordings and live performances, and in-depth discussions of his screen performances--not only his Hollywood feature film appearances, but his performances in short films, European concert films, and dozens of television shows broadcast from Hollywood, New York and Europe.
Through seven successful editions, Sabiston & Spencer Surgery of the Chest has set the standard in cardiothoracic surgery references. Now, the new 8th Edition, edited by Frank W. Sellke, MD, Pedro J. del Nido, MD, and Scott J. Swanson, MD, carries on this tradition with updated coverage of today's essential clinical knowledge from leaders worldwide. Guidance divided into three major sections—Adult Cardiac Surgery, Congenital Heart Surgery, and Thoracic Surgery—lets you quickly find what you need, while new and revised chapters reflect all of the important changes within this rapidly evolving specialty. Expert Consult functionality—new to this edition—enables you to access the complete contents of the 2-volume set from anyplace with an Internet connection for convenient consultation where and when you need it. This is an ideal source for mastering all of the most important current knowledge and techniques in cardiac and thoracic surgery—whether for specialty board review or day-to-day practice. Features short, focused chapters that help you find exactly what you need. Presents the work of international contributors who offer a global view of the entire specialty. Covers thoracic surgery as well as adult and pediatric cardiac surgery for a practical and powerful single source. Includes nearly 1,100 illustrations that help to clarify key concepts. Features online access to the complete contents of the 2-volume text at expertconsult.com for convenient anytime, anywhere reference. Covers the hottest topics shaping today's practice, including the latest theory and surgical techniques for mitral valve disease, advances in the treatment of congenital heart disease, minimally invasive surgical approaches to the treatment of adult and congenital cardiac disease and thoracic disease, stent grafting for aortic disease, and cell-based therapies. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.
In its third edition, this massive reference work lists the final resting places of more than 14,000 people from a wide range of fields, including politics, the military, the arts, crime, sports and popular culture. Many entries are new to this edition. Each listing provides birth and death dates, a brief summary of the subject's claim to fame and their burial site location or as much as is known. Grave location within a cemetery is provided in many cases, as well as places of cremation and sites where ashes were scattered. Source information is provided.
As founder of the Peace Corps, Head Start, the Special Olympics (with wife Eunice Kennedy Shriver), and other organizations, Sargent Shriver was a key social and political figure whose influence continues to the present day. This authorized biography, exhaustively researched and finely rendered by Scott Stossel (deputy editor of The Atlantic), reads like an epic novel, with “Sarge” marching through the historical events of the last century—the Great Depression, World War II, JFK’s assassination, the Cold War, and many more. Sarge gives us a complete account of Shriver’s life, as well as a thoughtful commentary on the Kennedy family, the Peace Corps, and United States and world history. It is a riveting and comprehensive reconstruction of a life that exemplifies what it means to be a true American.
This graphic novella presents a critical history of the U.S. War on Drugs, using a modernized parody of the Charles Dickens classic "A Christmas Carol" as a story framework.
Molecular Cell Biology presents the key concepts in cell biology and their experimental underpinnings. The authors, all world-class researchers and teachers, incorporate medically relevant examples where appropriate to help illustrate the connections between cell biology and health and human disease. As always, a hallmark of Molecular Cell Biology is the use of experiments to engage students in the history of cell biology and the research that has contributed to the field. New Co-Author, Angelika Amon: The new edition of Molecular Cell Biology introduces a new member to our author team, respected researcher and teacher Angelika Amon of the Massachusetts Institute of Technology. Dr. Amon is an Investigator at the Howard Hughes Medical Institute as well as a member of the Koch Institute for Integrative Cancer Research and the National Academy of Sciences. Her laboratory studies the molecular mechanisms that govern chromosome segregation during mitosis and meiosis and the consequences when these mechanisms fail during normal cell proliferation and cancer development. Increased Clarity, Improved Pedagogy: In the new edition, the authors have scrutinized every chapter with an eye toward bringing out key concepts and making connections easier to follow. Perennially challenging topics, such as cellular energetics, cell signaling and immunology, have been revised to improve student understanding. Coverage of developmental biology has been streamlined to focus on just those key areas central to cell biology courses. Every figure in the book was reconsidered and, if possible, simplified to highlight key lessons. Revised end-of-chapter materials include new questions, including additional Analyze the Data problems to give students added practice at interpreting experimental evidence. The result is a book that balances currency and experimental focus with attention to clarity, organization, and pedagogy. Highlights of the New Edition: - Chapter 1 Molecules, Cells, and Evolution now frames cell biology in the light of evolution: because we all come from the same ancestor cell, the molecules and processes of cell biology are similar in all forms of life. We can use model organisms to study aspects of cell structure and function that have been conserved across millions of years of evolution. - Chapter 9 Culturing, Visualizing, and Perturbing Cells has been rewritten to include cutting edge methods including FRAP, FRET, siRNA, and chemical biology, making it a state-of-the art methods chapter. - Cell signaling chapters (Chapters 15 & 16) have been reorganized and illustrated with simplified overview figures, to help students navigate the complexity of signaling pathways. - Fully Reconceived, Thoroughly Updated Chapter 19 The Eukaryotic Cell Cycle now begins with the concept of "START" (a cell's commitment to entering the cell cycle starting with DNA synthesis) and then progresses through the cycle stages. The chapter focuses on yeast and mammals and uses general names for cell cycle components as much as possible. New Discoveries, Methodologies and Medical Examples: New discoveries, new methodologies and new medical examples are included throughout.
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