This book focuses on group sequential methods for clinical trials with co-primary endpoints based on the decision-making frameworks for: (1) rejecting the null hypothesis (stopping for efficacy), (2) rejecting the alternative hypothesis (stopping for futility), and (3) rejecting the null or alternative hypothesis (stopping for either futility or efficacy), where the trial is designed to evaluate whether the intervention is superior to the control on all endpoints. For assessing futility, there are two fundamental approaches, i.e., the decision to stop for futility based on the conditional probability of rejecting the null hypothesis, and the other based on stopping boundaries using group sequential methods. In this book, the latter approach is discussed. The book also briefly deals with the group sequential methods for clinical trials designed to evaluate whether the intervention is superior to the control on at least one endpoint. In addition, the book describes sample size recalculation and the resulting effect on power and type I error rate. The book also describes group sequential strategies for three-arm clinical trials to demonstrate the non-inferiority of experimental intervention to actively control and to assess the assay sensitivity to placebo control.
This book integrates recent methodological developments for calculating the sample size and power in trials with more than one endpoint considered as multiple primary or co-primary, offering an important reference work for statisticians working in this area. The determination of sample size and the evaluation of power are fundamental and critical elements in the design of clinical trials. If the sample size is too small, important effects may go unnoticed; if the sample size is too large, it represents a waste of resources and unethically puts more participants at risk than necessary. Recently many clinical trials have been designed with more than one endpoint considered as multiple primary or co-primary, creating a need for new approaches to the design and analysis of these clinical trials. The book focuses on the evaluation of power and sample size determination when comparing the effects of two interventions in superiority clinical trials with multiple endpoints. Methods for sample size calculation in clinical trials where the alternative hypothesis is that there are effects on ALL endpoints are discussed in detail. The book also briefly examines trials designed with an alternative hypothesis of an effect on AT LEAST ONE endpoint with a prespecified non-ordering of endpoints.
Feminist writing has emerged in recent years as a major influence of twentieth-century European literature. Textual Liberation, first published in 1991, provides a timely and wide-ranging survey of twentieth-century feminist writing in Europe, presenting texts from a number of countries and highlighting some of the transnational parallels and contrasts. The contributors emphasize the wider contexts- political, social, economic- in which the texts were produced. They cover feminist literature in Britain, Scandinavia, Germany, Eastern Europe, Russia, France, Spain, Italy, and Turkey, and consider a range of genres, including the novel, poetry, drama, essays, and journalism. Each chapter contains an extensive bibliography with special emphasis on material available in English. A stimulating introduction to the development of European feminist writing, Textual Liberation will be an invaluable resource for students of women’s literature, women’s studies, and feminism.
S.U.I.T.E. PCISTM (Process-Centric Integrated System for Transformational Methodologies) is a Treatise for the Advancement of the Project Management Discipline. PCISTM is a tool designed to take out all of the guesswork involved, and remove the confusion inherent to Project process re-engineering. PCISTM utilizes specific, front-loading requirements that allows the Advanced PM to access each component independently, select and integrate methodologies, and, transition the Project result back into the revenue stream efficiently!
The last two decades have seen a dramatic growth in the proportion of families headed by women. Most of these families are poor and include dependent children--causing the development of a large underprivileged class across the western world. This book explores the causes and implications of this development. Because the increase in mother-headed families is an international trend, an international perspective has been adopted. The discussion centers on selected countries where certain trends are most visible. Among the western nations particular attention is given to the United States, Sweden, and the former U.S.S.R., because of their high prevalence of mother-headed families; and trends in some countries with a middling prevalence are also discussed. Japan is included, because of its combination of advanced industrialization with a non-western tradition and a low incidence of mother-headed families. Accordingly, the book considers broad supranational influences, and proposes some explanations that draw on material from history, anthropology, sociology, psychology, women's studies, economics, literature, and religious studies. The authors present definitive information on the incidence of mother-headed families across historical epochs and culture groups. This includes an exploration of the conditions under which such families have been many or few and have been treated well or poorly by their communities. They also offer some theoretical explanations for the increasing frequency of this family form and consider whether these interpretations fit the facts that have been gathered. Finally, there is a detailed discussion revealing what these explanations may imply for the future--that is, whether the number of mother-headed families is likely to increase, stabilize, or decrease.
In this book, the author provides an hour-by-hour tactical history of the battle, beginning before dawn on September 17 and concluding with the immediate aftermath of the battle, including General McClellan's fateful decision to not pursue Lee's retreating forces back across the Potomac to Virginia. But this is not only an operational history of Antietam: the author also offers the reader insight into the experiences of enlisted soldiers, the terror of the fighting itself, and the emotional aftermath for those who survived"--
If you’ve set your sights on shaving minutes off your time, it’s time to ramp up your training with Advanced Marathoning, Third Edition. Find the plan that works best for you from the detailed day-by-day training schedules by choosing between 18- and 12-week preparation and selecting weekly distances of 55, 55 to 70, 70 to 85, or 85-plus miles. If you run marathons close together, you’ll find 6- to 12-week training plans to maximize your training time and recovery. For older marathoners, there is a full chapter dedicated to their unique training, nutrition, and recovery needs. Complement your running workouts with strength, core, and flexibility exercises to help keep injury at bay. Learn how current technologies such as GPS and online logs can help you analyze your training and performance and set goals for future races. Draw inspiration and insights from elite marathoners such as Galen Rupp, Eliud Kipchoge, and Molly Huddle. Implement cutting-edge nutrition and hydration strategies and recovery techniques to feel and run your best. Advanced Marathoning gives ambitious marathoners the information needed to train smarter, remain injury-free, and cross the next finish line stronger and faster than ever.
Behavioral Methods in Social Welfare" offers positive proof that behaviorism has come of age in social work. Steven Paul Schinke and the contributors to this volume are social work practitioners who document their attempts to extend the basic tenets of behavioral psychology from the laboratory, clinic, and classroom to the full range of client groups and social problems that make up the practice of social work. In social work education, traditionally to the extent it appeared in the curriculum at all, behavioral content appeared in electives or in courses not focused on practice. It is a true measure of progress that behavioral methods are now visible, integral component of social work education and practice.The authors of each piece in this collection indicate progress in developing an empirically based approach to social work practice. Despite the impressive documentation contained in the present volume, no conclusive evidence as to the effectiveness of behavioral methods exists. What behavioral methods do offer, however, is a systematic format for both problem intervention and evaluation that, over time, should produce a more empirically based practice. A promising sign, well documented in the present effort, is the facility with which this book has subjected practice procedures to the rigor of research and evaluation.This blending of clinical practice and research develops the sense of competence that student-practitioners acquire in understanding and controlling both the art and science of their clinical practice. Steven Schinke and his colleagues offer a series of "snapshots" of important work in process. Their collective portrait provides a fresh perspective and new stimulus for all social work practice, as well as an affirmation that disciplined, responsive, and sensitive social work intervention can make a difference in the lives of people.
Insall & Scott Surgery of the Knee by Dr. W. Norman Scott remains the definitive choice for guidance on the most effective approaches for the diagnosis and management of the entire scope of knee disorders. This edition reflects a complete content overhaul, with more than 50 new chapters and over 400 contributors from around the world. The video program includes 70 new video clips, while new and expanded material covers a range of hot topics, including same-day surgery and hospital management of knee arthroplasty patients and anesthesia specific for knee surgery. - Extensive visual elements and video program include nearly 70 new videos -- over 230 in total – as well as a Glossary of Implants featuring 160 demonstrative pictures. - Over 50 new chapters and brand-new sections on Same Day Surgery and Hospital Management of Knee Arthroplasty Patients; Quality and Payment Paradigms for TKA; Anesthesia Specific for Knee Surgery; and Preoperative Assessment, Perioperative Management, and Postoperative Pain Control. - An expanded Adult Reconstruction Section informs readers about Enhanced Primary Revision and the treatment of Peri-prosthetic fractures in TKA. - Includes enhanced worldwide approaches for all aspects of disorders of the knee from nearly 400 contributors worldwide. - Boasts updated pediatric knee considerations and updated tumor surgery principles for the treatment of tumors about the knee. - Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos (including video updates), glossary, and references from the book on a variety of devices.
Although this revised edition of the text takes a traditional functional approach to management, it is organzied around four modern themes: cost, quality, speed and innovation.
Since it was first published in 1987, Galactic Dynamics has become the most widely used advanced textbook on the structure and dynamics of galaxies and one of the most cited references in astrophysics. Now, in this extensively revised and updated edition, James Binney and Scott Tremaine describe the dramatic recent advances in this subject, making Galactic Dynamics the most authoritative introduction to galactic astrophysics available to advanced undergraduate students, graduate students, and researchers. Every part of the book has been thoroughly overhauled, and many sections have been completely rewritten. Many new topics are covered, including N-body simulation methods, black holes in stellar systems, linear stability and response theory, and galaxy formation in the cosmological context. Binney and Tremaine, two of the world's leading astrophysicists, use the tools of theoretical physics to describe how galaxies and other stellar systems work, succinctly and lucidly explaining theoretical principles and their applications to observational phenomena. They provide readers with an understanding of stellar dynamics at the level needed to reach the frontiers of the subject. This new edition of the classic text is the definitive introduction to the field. ? A complete revision and update of one of the most cited references in astrophysics Provides a comprehensive description of the dynamical structure and evolution of galaxies and other stellar systems Serves as both a graduate textbook and a resource for researchers Includes 20 color illustrations, 205 figures, and more than 200 problems Covers the gravitational N-body problem, hierarchical galaxy formation, galaxy mergers, dark matter, spiral structure, numerical simulations, orbits and chaos, equilibrium and stability of stellar systems, evolution of binary stars and star clusters, and much more Companion volume to Galactic Astronomy, the definitive book on the phenomenology of galaxies and star clusters
An evolutionary biologist provides surprising insights into the changing nature of Homo sapiens in this “important and an entertaining read" (Choice). In Future Humans, evolutionary biologist Scott Solomon draws on recent discoveries to examine the future evolution of our species. Combining knowledge of our past with current trends, Solomon offers convincing evidence that evolutionary forces are still affecting us today. But how will modernization—including longer lifespans, changing diets, global travel, and widespread use of medicine and contraceptives—affect our evolutionary future? Solomon presents an entertaining and accessible review of the latest research on human evolution in modern times, drawing on fields from genomics to medicine and the study of our microbiome. Drawing together topics ranging from the rise of online dating and Cesarean sections to the spread of diseases such as HIV and Ebola, Solomon suggests that we are entering a new phase in human evolutionary history—one that makes the future less predictable and more interesting than ever before.
Any alteration of the natural processes occurring on a piece of land will have expected as well as unanticipated effects, and those effects have little regard for arbitrary human boundaries. Consequently, it is not enough for land managers to consider only how they might maintain the parcels for which they are responsible; they must also anticipate
Introduction to Education provides pre-service teachers with an overview of the context, craft and practice of teaching in Australian schools as they commence the journey from learner to classroom teacher. Each chapter poses questions about the nature of teaching students, and guides readers though the Australian Professional Standards for Teachers. Incorporating recent research and theoretical literature, Introduction to Education presents a critical consideration of the professional, policy and curriculum contexts of teaching in Australia. The book covers theoretical topics in chapters addressing assessment, planning, safe learning environments, and working with colleagues, families, carers and communities. More practical chapters discuss professional experience and building a career after graduation. Rigorous in conception and practical in scope, Introduction to Education welcomes new educators to the theory and practical elements of teaching, learning, and professional practice.
Digital technology has become integral in the fields of health and care, and a number of recent reports have stressed the importance of equipping health and care staff with the skills and knowledge they need to use such technology effectively. Numerous failures of digital projects in the health and care sectors have demonstrated that simply relocating IT generalists into these specialist fields is not a guaranteed formula for success; the unique complexities of the typically under-resourced legacy infrastructures of health and care create challenges that demand specific education and training. This book presents the proceedings of the European Federation for Medical Informatics (EFMI) 2022 Special Topic Conference (STC), held in Cardiff, Wales, on 7-8 September 2022. The theme of STC 2022 was Digital Professionalism in Health and Care: Developing the Workforce, Building the Future, which emphasized the vital need for professional education, training and continuing development of the health and care informatics workforce. The 30 full papers and 5 posters in this book cover a broad range of topics and methods in informatics education and training, and include a small selection from the wider sub-domains of biomedical informatics. Providing a valuable overview of current methods and training, the book will be of interest to a wide range of professionals working in healthcare today, especially those involved in equipping the workforce with the skills they will need for the digital future.
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