Scott Berthelette's Books

Heirs of an Ambivalent Empire

French-Indigenous Relations and the Rise of the Métis in the Hudson Bay Watershed

By: Scott Berthelette

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Heirs of an Ambivalent Empire

French-Indigenous Relations and the Rise of the Métis in the Hudson Bay Watershed

By: Scott Berthelette

The fur trade was the heart of the French empire in early North America. The French-Canadian (Canadien) men who traversed the vast hinterlands of the Hudson Bay watershed, trading for furs from Indigenous trappers and hunters, were its cornerstone. Though the Canadiens worked for French colonial authorities, they were not unwavering agents of imperial power. Increasingly they found themselves between two worlds as they built relationships with Indigenous communities, sometimes joining them through adoption or marriage, raising families of their own. The result was an ambivalent empire that grew in fits and starts. It was guided by imperfect information, built upon a contested Indigenous borderland, fragmented by local interests, and periodically neglected by government administrators. Heirs of an Ambivalent Empire explores the lives of the Canadiens who used family and kinship ties to navigate between sovereign Indigenous nations and the French colonial government from the early 1660s to the 1780s. Acting as cultural intermediaries, the Canadiens made it possible for France to extend its presence into northwest North America. Over time, however, their uncertain relationships with the French colonial state splintered imperial authority, leading to an outcome that few could have foreseen – the emergence of a new Indigenous culture, language, people, and nation: the Métis.

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Page Count

355

Publisher

McGill-Queen's Press - MQUP

Published Date

ISBN 10

0228012503

ISBN 13

9780228012504

Heirs of an Ambivalent Empire

French-Indigenous Relations and the Rise of the Métis in the Hudson Bay Watershed

By: Scott Berthelette

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Heirs of an Ambivalent Empire

French-Indigenous Relations and the Rise of the Métis in the Hudson Bay Watershed

By: Scott Berthelette

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355

Publisher

McGill-Queen's Press - MQUP

Published Date

ISBN 10

0228012503

ISBN 13

9780228012504

Comprehensive Disability Management

By: Henry G. Harder,Liz R. Scott

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Comprehensive Disability Management

By: Henry G. Harder,Liz R. Scott

Comprehensive Disability Management explores current knowledge of disability management and provides insight into new concepts. This book documents proven techniques for reducing the financial and human costs of disability. It introduces the first theoretical model in this developing profession and provides practical examples of how to implement and manage an effective disability management program. Formulates the business case for disability management in an organization, helping the reader understand how disability management fits into the overall functioning of a corporation. Presents a theoretical model that recognizes the influence of multiple issues on a disability outcome. Reviews proven disability management techniques for ensuring evidence-based best practice treatments.

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Page Count

220

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

0443101132

ISBN 13

9780443101137

Reactive Drug Metabolites

By: Amit S. Kalgutkar,Deepak Dalvie,R. Scott Obach,Dennis A. Smith

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Reactive Drug Metabolites

By: Amit S. Kalgutkar,Deepak Dalvie,R. Scott Obach,Dennis A. Smith

Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.

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Page Count

445

Publisher

John Wiley & Sons

Published Date

ISBN 10

352765576X

ISBN 13

9783527655762

Book's by Scott Berthelette

Heirs of an Ambivalent Empire

Heirs of an Ambivalent Empire

Heirs of an Ambivalent Empire

Heirs of an Ambivalent Empire

Comprehensive Disability Management

Comprehensive Disability Management

Reactive Drug Metabolites

Reactive Drug Metabolites

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