This unique volume presents an up-to-date review of one of the world's major health problems ? diseases caused by the four dengue viruses. It begins with an insightful story of the origin of dengue disease outbreaks, including the emergence of severe and fatal dengue hemorrhagic fever. The nature, structure and biology of the four dengue viruses are described, and a major portion of the book is focused on the epidemiology of dengue as a mosquito-borne disease. This is complemented by critiques of existing mosquito control programs by three groups of outstanding authorities. The strongest element of the volume is its comprehensive description of the current understanding of dengue disease pathogenesis, followed by an analysis of the pros and cons of five of the most controversial areas in the field: the WHO DEF case definition, secondary dengue infections, virulent viruses, the role of abnormal T cells and autoimmunity.
While the benefits of antibody responses are widely known, pathogens are also able to exploit antibodies to facilitate cell entry and potentially alter the cellular response via interactions with Fc receptors. This phenomenon, known as antibody-dependent enhancement (ADE) of disease, is a factor in numerous human and veterinary diseases. It is thought to result from innate cellular responses to Fcγ receptor-facilitated entry of infectious microbial immune complexes, and paradoxically results in increased production of pathogenic organisms. ADE has been described in vitro in numerous settings, but the strongest data regarding the in vivo impact of this mechanism on human disease come from human disease and animal models of dengue and leishmanial infections. This chapter reviews the literature of ADE in relation to the innate immune responses to Fcγ receptor ligation by infectious IgG immune complexes and discusses the research frontiers regarding this harmful antibody activity.
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