With its clear, straightforward presentation, this text enables you to grasp all the fundamental concepts of pharmacokinetics and pharmacodynamics. This will allow you to understand the time course of drug response and dosing regimen design. Clinical models for concentration and response are described and built from the basic concepts presented in earlier chapters. Your understanding of the material will be enhanced by guided computer exercises conducted on a companion website. Simulations will allow you to visualize drug behavior, experiment with different dosing regimens, and observe the influence of patient characteristics and model parameters. This makes the book ideal for self-study. By including clinical models of agonism, indirect drug effects, tolerance, signal transduction, and disease progression, author Sara Rosenbaum has created a work that stands out among introductory-level textbooks in this area.You'll find several features throughout the text to help you better understand and apply key concepts: Three fictitious drugs are used throughout the text to progressively illustrate the development and application of pharmacokinetic and pharmacodynamic principles Exercises at the end of each chapter reinforce the concepts and provide the opportunity to perform and solve common dosing problems Detailed instructions let you create custom Excel worksheets to perform simple pharmacokinetic analyses Because this is an introductory textbook, the material is presented as simply as possible. As a result, you'll find it easy to gain an accurate, working knowledge of all the core principles, apply them to optimize dosing regimens, and evaluate the clinical pharmacokinetic and pharmacodynamic literature.
With its clear, straightforward presentation, this text enables you to grasp all the fundamental concepts of pharmacokinetics and pharmacodynamics. This will allow you to understand the time course of drug response and dosing regimen design. Clinical models for concentration and response are described and built from the basic concepts presented in earlier chapters. Your understanding of the material will be enhanced by guided computer exercises conducted on a companion website. Simulations will allow you to visualize drug behavior, experiment with different dosing regimens, and observe the influence of patient characteristics and model parameters. This makes the book ideal for self-study. By including clinical models of agonism, indirect drug effects, tolerance, signal transduction, and disease progression, author Sara Rosenbaum has created a work that stands out among introductory-level textbooks in this area.You'll find several features throughout the text to help you better understand and apply key concepts: Three fictitious drugs are used throughout the text to progressively illustrate the development and application of pharmacokinetic and pharmacodynamic principles Exercises at the end of each chapter reinforce the concepts and provide the opportunity to perform and solve common dosing problems Detailed instructions let you create custom Excel worksheets to perform simple pharmacokinetic analyses Because this is an introductory textbook, the material is presented as simply as possible. As a result, you'll find it easy to gain an accurate, working knowledge of all the core principles, apply them to optimize dosing regimens, and evaluate the clinical pharmacokinetic and pharmacodynamic literature.
Teaching Tolerance is an invitation to parents and teachers: an invitation to examine their own habits and attitudes toward the community around them. Sara Bullard believes that once a parent is aware of the attitudes they were raised with, it is easier for them to teach their children true tolerance toward others. The first chapters of Teaching Tolerance focus on the humanness of intolerance-no one is truly exempt from the habit of judging others. The fourth chapter outlines the work required to alter intolerant instincts. The last four chapters walk parents through children's need for security, self-expression and moral guidance; needs which, if respectfully met, will free them to be comfortable both with themselves and with people of different backgrounds. Bullard concludes each chapter with questions and suggestions for journal writing to help parents further explore their own attitudes. Also included is an extensive list of books, toys, games and music that explore ethnicity and promote tolerance.
How can egalitarian ideals be put into action? This ground-breaking book sets out a new interdisciplinary model for equality studies. Integrating normative questions about the ideal of equality with empirical issues about the nature of inequality, it applies a new framework to a wide range of contemporary inequalities. Proposing far-reaching changes in the economy, politics, law, education and research practices, it sets out innovative political strategies for achieving those aims. It is an invaluable resource for both academics and activists.
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