This graduate textbook imparts the fundamentals of reliability and risk that can be connected mathematically and applied to problems in engineering and medical science and practice. The book is divided into eight chapters, the first three of which deal with basic fundamentals of probability theory and reliability methods. The fourth chapter illustrates simulation methods needed to solve complex problems. Chapters 5-7 explain reliability codes and system reliability (which uses the component reliabilities discussed in previous chapters). The book concludes in chapter 8 with an examination of applications of reliability within engineering and medical fields. Presenting a highly relevant competency for graduates entering product research and development, or facilities operations sectors, this text includes many examples and end of chapter study questions to maximize student comprehension. Explains concepts of reliability and risk estimation techniques in the context of medicine and engineering; Elucidates the interplay between reliability and risk from design to operation phases; Uses real world examples from engineering structures and medical devices and protocols; Adopts a lucid yet rigorous presentation of reliability and risk calculations; Reinforces students understanding of concepts covered with end-of-chapter exercises.
The importance of the Himalayan state of Nepal has been obscured by the international campaign to free Tibet and the vicissitudes of the Sino-Indian rivalry. This book presents the history of Nepal’s domestic politics and foreign relations from ancient to modern times. Analysing newly declassified reports from the United States and Britain, published memoirs, oral recollections and interviews, the book presents the historical interactions between Nepal, China, Tibet and India. It discusses how the ageing and inevitable death of the 14th Dalai Lama, the radicalization of Tibetan diaspora and the ascendancy of the international campaign to free Tibet are of increasing importance to Nepal. With its position between China and India, the book notes how the focus could shift to Nepal, with it being home to some 20,000 Tibetan refugees and its chronic political turmoil, deepened by the Asian giants’ rivalry. Using a chronological approach, the past and present of the rivalry between China and India are studied, and attempts to chart the future are made. The book contributes to a new understanding of the intricate relationship of Nepal with these neighbouring countries, and is of interest to students and scholars of South Asian studies, politics and international relations.
Insulin is a protein hormone that is used as a medication to treat high blood glucose. This includes in diabetes mellitus type 1, diabetes mellitus type 2, gestational diabetes, and complications of diabetes. This book is a concise guide to the basics and clinical pharmacology of insulin, and the practical aspects of its use. Beginning with an overview of the development of insulins and normal physiology and metabolism, the next section examines different types of insulin (rapid-acting, short-acting, intermediate-acting, long-acting, and mixed). The following sections cover insulin therapy in type 1 diabetes, type 2 diabetes and in specific population groups. The book concludes with discussion on practical aspects of insulin therapy. Authored primarily for postgraduate medical students, the practical text is further enhanced by clinical images and diagrams to assist learning. Key points Concise guide to the prescription and use of insulin therapy for postgraduate students Explains different types of insulin and their specific uses Covers type 1 and type 2 diabetes mellitus, and specific population groups Clinical images and diagrams further enhance learning
Nanotechnology in Modern Animal Biotechnology: Concepts and Applications discusses the advancement of nanotechnologies in almost every field, ranging from materials science, to food, forensic, agriculture and life sciences, including biotechnology and medicine. Nanotechnology is already being harnessed to address many of the key problems in animal biotechnology, with future applications covering animal biotechnology (e.g. animal nutrition, health, disease diagnosis, and drug delivery). This book provides the tools, ideas and techniques of nanoscale principles to investigate, understand and transform biological systems. Nanotechnology provides the ability to manipulate materials at atomic and molecular levels and also arrange atom-by-atom on a scale of ~1–100 nm to create, new materials and devices with fundamentally new functions and properties arising due to their small scale. - Details the basics of nanotechnology, along with comprehensive information on the state-of-the-art and future perspectives of nanotechnology in biosensors - Provides recent perspectives and the challenges of nanomedicine - Provides new insights into the role nanomaterials can play in curing various diseases - Includes the most recent diagnostic methods, such as nanosensors
About the Book This book has been written with the twin goals of making the tax-payers aware about the compliances required for smooth conduct of GST audit of their business operations as well as to educate the tax auditors so as to enable them to conduct the audit in a fair, transparent and impartial way to ensure compliance of GST law as well as to prevent and plug in the leakage of revenue well in time. The book discusses the practical aspects which an auditor should concentrate on while doing GST audit and where the taxpayers need to be more careful and vigilant. The audit process has been explained from inception i.e. selection of taxpayer and intimation of conducting GST audit right upto the conclusion of the same. The knowledge of accounts is pre-requisite for the departmental officers who otherwise have diverse academic backgrounds. A separate chapter on accounting has been written not only to acquaint them with the elementary accounting process but also to provide further authentic resources to those interested in enhancing their accounting skills. The auditors must perform their duties with utmost sincerity, integrity and diligence; therefore, guidelines about overall conduct of the auditors have been included following which they will manifest the best professional ethics. Key Features · Analysis of GST Audit Process, Annual Returns (Form GSTR-9), Reconciliation Statement (GSTR-9C), Assessments under GST. · Includes GSTAM-2019 issued by CBIC with specific reference to checks to be undertaken during GST Audit. · Comprehensive guidance for conducting different types of audits under GST Act. · Includes practical tables giving Step-by-Step approach with Internal control questionnaires. · Detailed discussions on Key Reconciliation Statements including ITC, outward supplies etc. · Dedicated chapter on analysis of GST returns, giving itemized compliance requirement by the taxpayers as well as points for checks by the departmental auditors. · Explains key auditing and accounting terms relevant to GST.
About the Book This book has been written with the twin goals of making the tax-payers aware about the compliances required for smooth conduct of GST audit of their business operations as well as to educate the tax auditors so as to enable them to conduct the audit in a fair, transparent and impartial way to ensure compliance of GST law as well as to prevent and plug in the leakage of revenue well in time. The book discusses the practical aspects which an auditor should concentrate on while doing GST audit and where the taxpayers need to be more careful and vigilant. The audit process has been explained from inception i.e. selection of taxpayer and intimation of conducting GST audit right upto the conclusion of the same. The knowledge of accounts is pre-requisite for the departmental officers who otherwise have diverse academic backgrounds. A separate chapter on accounting has been written not only to acquaint them with the elementary accounting process but also to provide further authentic resources to those interested in enhancing their accounting skills. The auditors must perform their duties with utmost sincerity, integrity and diligence; therefore, guidelines about overall conduct of the auditors have been included following which they will manifest the best professional ethics. Key Features Analysis of GST Audit Process, Annual Returns (Form GSTR-9), Reconciliation Statement (GSTR-9C), Assessments under GST. Includes GSTAM-2019 issued by CBIC with specific reference to checks to be undertaken during GST Audit. Comprehensive guidance for conducting different types of audits under GST Act. Includes practical tables giving Step-by-Step approach with Internal control questionnaires. Detailed discussions on Key Reconciliation Statements including ITC, outward supplies etc. Dedicated chapter on analysis of GST returns, giving itemized compliance requirement by the taxpayers as well as points for checks by the departmental auditors. Explains key auditing and accounting terms relevant to GST.
This atlas is a comprehensive guide to interventional pain management procedures. Divided into 11 sections, the book begins with an overview of the subject, covering radiological anatomy, common image-guided procedures, radiation protection, MRI, protocols, and more. Each of the following sections covers procedures for pain management in different parts on the body, including head and neck, cervical spine, chest and thorax, lumbosacral spine; as well as neuromodulation, and peripheral and sympathetic blocks. The final chapters examine ultrasound guided block and ultrasound guided dry needling. Presented in bullet point style, each topic follows a step by step approach, explaining indications, contraindications, equipment, and procedural techniques. Edited by recognised experts from India, the UK and the US, and with contributions from leading international experts, this book is highly illustrated with radiological images and figures. Access to procedural videos via a QR code is also included with the atlas.
Diabetes mellitus is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced. The latest edition of this reference provides endocrinologists with the latest advances in the diagnosis and management of diabetes. Beginning with an overview of epidemiology, pathophysiology and metabolism, the next sections discuss presentations of diabetes, therapeutic management, complications, and comorbidities. The following chapters cover diabetes in certain population groups, education and technology, nutrition, glucose monitoring, and research. The book concludes with a section dedicated to Type 1 diabetes, and a selection of journal reviews. Flow diagrams, tables and figures further enhance the comprehensive text. Key points Latest edition of comprehensive reference detailing latest advances in diagnosis and management of diabetes Covers numerous therapeutic methods Complete sections dedicated to Type 1 diabetes and journal reviews Highly illustrated with flow diagrams, tables and figures
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