Tumors that become clinically apparent have invariably developed ways to escape immune control. The mechanisms of escape are multiple and diverse and do not necessarily require the loss by tumor cells of expression of antigens recognized by the immune system. More commonly, tumor-specific T cells are rendered dysfunctional by a number of soluble and cell surface-bound molecules that are produced or modified by the action of cancer cells or suppressive and regulatory immune cells recruited to the tumor. Overall, the obstacles that prevent tumor rejection are active at several levels, affecting T-cell priming, functional differentiation, recruitment to the tumor, survival and effectors’ function inside the tumor. The multifaceted nature of these immunosuppressive networks represents a formidable obstacle to the success of immunotherapy. Nevertheless, the recent achievements of therapeutics targeting key checkpoint receptors highlight the great potential of strategies that are based on selective disruption of immunosuppressive networks.
Nursing Leadership covers contemporary concepts in leadership and management and their application to nursing practice. In addition to covering the fundamentals, a wide range of current topics are addressed including: change management, contemporary approaches to nursing care delivery & health outcomes evaluation; developing & enhancing quality in nursing practice; research based practice; cultural change processes; shared governance; development & leadership of staff; quality of work life issues; quality work environments; and industrial relations. Nursing Leadership provides a fresh innovative approach to the topic and is designed to stimulate interest in theory and concepts as well as providing the reader with strategies that can be readily tested and applied in practice.
This handy, practical guide provides clinicians with a comprehensive approach to the medical management of overweight children and adolescents. Coverage begins with the epidemiology, pathophysiology, and developmental aspects of child and adolescent obesity and a guide to evaluation of obese children. Subsequent chapters address respiratory, cardiovascular, endocrine, metabolic, orthopaedic, gastrointestinal, renal, and neurologic complications and comorbid conditions as well as mental health issues, acute obesity-related emergencies, and obesity as part of genetic syndromes. Pathophysiology is linked to clinical presentation, evaluation, and treatment, and lifestyle issues are discussed where appropriate. Highlighted boxes and algorithms help clinicians find and digest information quickly.
Kniha přináší přes čtyřicet příspěvků mezinárodního kolektivu autorů a jejím záměrem je především shromáždit a popsat střípky předchozích, zapomenutých způsobů života. Lidský život a evoluce překlenuje různé historické epochy i místa, osud člověka se však zdá neúprosný, protože svědkové, vzpomínky i hmatatelné důkazy lidské existence se nevyhnutelně vytrácejí. Kniha současně odráží výsledky široké, mezinárodní spolupráce Jiřího A. Svobody, významného vědce, s autory příspěvků, včetně těch, kteří se jeho dílem inspirují.
This volume brings forward a descriptive approach to the translation and reception of African American women’s literature in Spain. Drawing from a multidisciplinary theoretical and methodological framework, it traces the translation history of literature produced by African American women, seeking to uncover changing strategies in translation policies as well as shifts in interests in the target context, and it examines the topicality of this cohort of authors as frames of reference for Spanish critics and reviewers. Likewise, the reception of the source literature in the Spanish context is described by reconstructing the values that underlie judgements in different reception sources. Finally, this book addresses the specific problem of the translation of Black English into Spanish. More precisely, it pays attention to the ideological and the ethical implications of translation choices and the effect of the latter on the reception of literary texts.
A bigger and bigger part of the workforce is telecommuting. And managers need new skills to get the most out of this increasingly far-flung staff. This indispensable guide includes case studies, checklists, and sample forms and charts. It shows managers how to use teleconferencing technology to communicate with distanced workers, make the best use of scheduling software to monitor productivity, and even end the arrangement if it's not working. One of the best ways for companies to save money in lean times is to send their employees home to work. But that requires a different kind of workforce and a different kind of management. This book shows how to make the long-distance relationship work for everyone!
A murderer "has somehow been able to breach Beltene's House's centuries-old wards and spells designed to keep out strangers," leaving one bloodless, embalmed corpse after another for "vampire" novelist Rhiannon Beltene to find
Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. A classic nursing reference, the fully updated Lippincott Manual for Nursing Practice, 11th Edition, offers expert nursing knowledge and much-needed practical guidance on patient care. Authoritative yet easy to follow, this comprehensive text guides you through the nursing concepts and skills particularly vital for medical-surgical assessment, care, and treatment. Essential for both in-the-classroom and on-the-unit guidance, this is the expertise that all students, new nurses, and medical-surgical nurses need to grasp essential nursing concepts, care management, and procedures.
This is the first book explicitly to compare extreme right-wing organizations, ideas, and actions in different national settings in Latin America. It shows how extreme rightist class and gender composition, motives, programs, and activities varied over time and between countries. It concludes by demonstrating the importance of the analysis for understanding present conditions.
The first English-language book to place the works of Elena Garro (1916–1998) and Octavio Paz (1914–1998) in dialogue with each other, Uncivil Wars evokes the lives of two celebrated literary figures who wrote about many of the same experiences and contributed to the formation of Mexican national identity but were judged quite differently, primarily because of gender. While Paz’s privileged, prize-winning legacy has endured worldwide, Garro’s literary gifts garnered no international prizes and received less attention in Latin American literary circles. Restoring a dual perspective on these two dynamic writers and their world, Uncivil Wars chronicles a collective memory of wars that shaped Mexico, and in turn shaped Garro and Paz, from the Conquest period to the Mexican Revolution; the Spanish Civil War, which the couple witnessed while traveling abroad; and the student massacre at Tlatelolco Plaza in 1968, which brought about social and political changes and further tensions in the battle of the sexes. The cultural contexts of machismo and ethnicity provide an equally rich ground for Sandra Cypess’s exploration of the tandem between the writers’ personal lives and their literary production. Uncivil Wars illuminates the complexities of Mexican society as seen through a tense marriage of two talented, often oppositional writers. The result is an alternative interpretation of the myths and realities that have shaped Mexican identity, and its literary soul, well into the twenty-first century.
Covering the evaluation and management of every key disease and condition affecting newborns, Avery's Diseases of the Newborn, by Drs. Christine A. Gleason and Sandra E. Juul, remains your #1 source for practical, clinically relevant information in this fast-changing field. You'll find the specific strategies you need to confidently diagnose and treat this unique patient population, in a full-color, easy-to-use single volume that focuses on key areas of practice. Now in a thoroughly revised 10th Edition, this highly respected reference is an authoritative clinical resource for neonatal practitioners. - Provides up-to-date information on every aspect of newborn evaluation and management in a new, visually improved format featuring more than 500 all-new, full-color illustrations integrated within each chapter - Includes greatly expanded Neurology and Hematology sections that highlight the knowledge and expertise of new co-editor, Dr. Sandra E. Juul - Features all-new chapters on Palliative Care, Gastroesophageal Reflux, Platelet Disorders, Transfusion Therapy, Hypertension, , and The Ear and Hearing Disorders, as well as expanded coverage of brain injury and neuroprotective strategies in the preterm and term infant - Contains new Key Points boxes at the beginning of every chapter - Brings you up to date on current topics such as the evolving epidemic of neonatal abstinence syndrome and the new clinical uses of ultrasound (including ultrasound videos online) - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices - Provides up-to-date information on every aspect of newborn evaluation and management in a new, visually improved format featuring more than 500 all-new, full-color illustrations integrated within each chapter. - Includes greatly expanded Neurology and Hematology sections that highlight the knowledge and expertise of new co-editor, Dr. Sandra E. Juul. - Features all-new chapters on Palliative Care, Gastroesophageal Reflux, Platelet Disorders, Transfusion Therapy, Hypertension, , and The Ear and Hearing Disorders, as well as expanded coverage of brain injury and neuroprotective strategies in the preterm and term infant. - Contains new Key Points boxes at the beginning of every chapter. - Brings you up to date on current topics such as the evolving epidemic of neonatal abstinence syndrome and the new clinical uses of ultrasound (including ultrasound videos online). - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
In the past two centuries hundreds of apparitions of the Virgin Mary have been reported, drawing crowds to the seers and the sites and constituting events of great religious significance for millions of people worldwide. Here Sandra Zimdars-Swartz provides a detective-like investigation of the experiences and interpretations of six major apparitions, including those at La Salette and Lourdes in France during the mid-nineteenth century; at Fatima, Portugal, in 1917; and the more recent ones at San Damiano, Italy; Garabandal, Spain; and Medjugorje, Yugoslavia, where the apparitions continue. Adopting a phenomenological approach to these "encounters with Mary"--one that is neither apologetic nor antagonistic--the author explores the tension between the personal meaning of the events for their subjects and the public appropriation of this meaning by a larger religious community. Along the way she examines the backgrounds of the seers, their willingness or reluctance to talk about the apparitions and their messages, the amount of emotional support they received from family and community as news of the apparitions spread, the reports of miracles at apparition sites, the reactions of local authorities, and the steps taken by the Roman Catholic Church in officially recognizing or rejecting the apparitions as worthy of belief. The author concludes with a survey of religious worldviews based on Marian apparitions, focusing especially on the now-popular transcultural apocalyptic nature of these messages to the modern world. Originally published in 1991. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
A practical clinically relevant introduction to diagnostic radiology Introduction to Basic Radiology is written to provide non-radiologists with the level of knowledge necessary to order correct radiological examinations, improve image interpretation, and enhance their interpretation of various radiological manifestations. The book focuses on the clinical scenarios most often encountered in daily practice and discusses practical imaging techniques and protocols used to address common problems. Relevant case scenarios are included to demonstrate how to reach a specific diagnosis. Introduction to Basic Radiology is divided into ten chapters. The first two chapters provide basic information on various diagnostic imaging techniques and control agents. Each of the following chapters discuss imaging of specific organ systems and begin with a description of the imaging modality of choice and illustrates the relevant features to help simplify the differential diagnosis. You will also find important chapters on pediatric radiology and women's imaging. Unlike other introductory texts on the subject, this book treats diagnosis from a practical point of view. Rather than discuss various diseases and classify them from the pathologic standpoint, Introduction to Basic Radiology utilizes cases from the emergency room and physician's offices and uses a practical approach to reach a diagnosis. The cases walk you through a radiology expert’s analysis of imaging patterns. These cases are presented progressively, with the expert's thinking process described in detail. The cases highlight clinical presentation, clinical suspicion, modality of choice, radiologic technique, and pertinent imaging features of common disease processes.
This work is the first book-length scholarly treatment of Nnedi Okorafor's critically acclaimed fiction. Written for an audience that includes serious fans as well as scholars, it is an introduction to Okorafor's work and major influences. The scope of the text is ambitious, featuring detailed analyses of her novels, short story collection, memoir, comics and graphic novel. Particular emphasis is given to Okorafor's most enduring themes, which include healthy young adult development and decision making, the interweaving of fantasy and science fiction, flight as a unifying force and the use of innovative biotechnology in ecological utopian communities. Influences examined include feminism, Afrofuturist and Africanfuturist movements and African mythology. Chapters also detail Okorafor's examinations of colonialism and corporate neocolonialism in Africa and Africa's potential to become a major world power.
The Year Book of Pulmonary Disease brings you abstracts of the articles that reported the year's breakthrough developments in pulmonary disease carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. Topics such as Asthma and Cystic Fibrosis, Chronic Obstructive Pulmonary Disease, Lung Cancer, Community-Acquired Pneumonia, Lung Transplantation, Sleep Disorders, and Critical Care Medicine are represented highlighting the most current and relevant articles in the field.
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