Samuel Dagogo-Jack's Books

Prediabetes: A Fundamental Text

Pathophysiology, Complications, Management & Reversal

By: Samuel Dagogo-Jack

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Prediabetes: A Fundamental Text

Pathophysiology, Complications, Management & Reversal

By: Samuel Dagogo-Jack

Prediabetes affects nearly 90 million U.S. adults and more than 374 million people worldwide. But what exactly is prediabetes, and how should it be treated? Individuals with prediabetes have a high risk of progressing to type 2 diabetes. Diabetes currently affects approximately 30 million adults in the U.S. and 463 million people worldwide, and type 2 diabetes represents 90-95% of the diabetes burden. Individuals with prediabetes also face increased risks of developing several complications including heart disease. Intervention at the prediabetes stage can help prevent progression to type 2 diabetes, and even lead to remission of prediabetes and a return to normal blood glucose regulation (NGR). However, a deeper understanding of the pathobiology of prediabetes is critical to the discovery and delivery of programs for preventing of diabetes. Focusing on prediabetes is compelling: Understanding the numerous risk factors that trigger the initial escape from NGR toward prediabetes provides critical information that enables the precise and timely targeting of preventive interventions to at-risk persons. This book is for clinicians, researchers, public health practitioners and policy makers. It begins with an overview of the demographic, anthropometric, biobehavioral and biochemical factors that drive the transition from normal blood glucose to prediabetes. Emerging knowledge from the fields of genomics, transcriptomics, microRNAs, metabolomics and microbiomics is incorporated into a comprehensive treatise on the pathobiology of prediabetes. Next, the focus shifts to evidence-based management of prediabetes and prevention of type 2 diabetes. Prediabetes seldom remits spontaneously. Lifestyle modification and certain medications can prevent progression from prediabetes to type 2 diabetes and may even induce remission of prediabetes in some people. Landmark diabetes prevention trials are discussed through the prism of their successful translatability in communities around the world. Emphasis is placed on practical adaptations that would enable cost-effective community diabetes prevention initiatives. Interventions utilizing lifestyle modification are prioritized over medications, but novel approaches (including cyclical medication strategy, designer nutraceuticals and metabolic surgery) are also discussed. Current lifestyle intervention protocols have been more effective at preventing progression from prediabetes to type 2 diabetes than they have been at restoring NGR. This book makes the case that reversal of prediabetes and restoration of normal blood glucose levels carries numerous benefits and ought to be the primary goal of intervention in people with prediabetes.

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Page Count

268

Publisher

American Diabetes Association

Published Date

ISBN 10

158040779X

ISBN 13

9781580407793

Medications and Diabetes Risk

Mechanisms and Approach to Risk Reduction

By: Samuel Dagogo-Jack

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Medications and Diabetes Risk

Mechanisms and Approach to Risk Reduction

By: Samuel Dagogo-Jack

More than 23 million Americans currently have diabetes and approximately 54 million have pre-diabetes. People with diabetes often also require medications for several co-morbid conditions (including hypertension, dyslipidemia, depression, heart disease, pain syndromes). Yet, a vast literature abounds on the potential adverse effects of numerous medications on glucose metabolism. Thus, genuine clinical concern exists that certain medications used for treatment of co-morbid conditions and other indications (such as hormone replacement, contraception, infections) might worsen glycemic control in diabetic patients or trigger diabetes in others. These concerns influence therapeutic decisions in a manner that sometimes emphasizes avoidance of possible dysglycemia over effective control of the co-morbid conditions. The same concerns may also weigh against the otherwise appropriate use of necessary medications. The purpose of this concise book is to provide clinicians with actionable knowledge regarding the effects of various medications on glucose regulation and diabetes risk. Beginning with a brief overview of diabetes pathophysiology, the different drugs have been organized by class, and the scientific evidence for the diabetes risk and possible mechanisms have been presented for each drug. The agents discussed include widely prescribed medication classes: antibiotics, antidepressants, antihypertensives, bronchodilators, estrogens and oral contraceptives, glucocorticoids, lipid-lowering agents, NSAIDs, and thyroid hormone. Although less widely prescribed than the foregoing list, atypical antipsychotics, HIV antiretrovirals, immunomodulatory agents, and human growth hormone, have also been included because of the interest generated by their link to diabetes risk. In addition to medications used in ambulatory practice, this work includes a discussion of total parenteral nutrition (TPN)-induced hyperglycemia, which is associated with increased morbidity and mortality among hospitalized patients. For completeness, an account of the growing link between use of recreational drugs (alcohol, nicotine, cannabinoids, opioids, cocaine) and glucose abnormalities has been included, because of the possible intersection between these addictive agents and the growing diabetes epidemic. With some medications, the data presented should help debunk myths, clarify misperceptions and provide reassurance to the practicing clinicians. Wherever the evidence supports increased diabetes risk, clear suggestions are given on how to reduce the risk. This book serves two essential functions: to enable clinicians to confidently prescribe therapeutic regimens that embody the best risk-benefit profile with regard to glycemia, and to equip them with the know-how for preventing and managing drug-induced hyperglycemia

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Page Count

106

Publisher

Oxford University Press

Published Date

ISBN 10

0199749558

ISBN 13

9780199749553

Diabetes Risks from Prescription and Nonprescription Drugs

Mechanisms and Approaches to Risk Reduction

By: Samuel Dagogo-Jack

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Diabetes Risks from Prescription and Nonprescription Drugs

Mechanisms and Approaches to Risk Reduction

By: Samuel Dagogo-Jack

Over 29 million Americans have diabetes. Of those millions of people, the majority take at least one medication to treat their diabetes, but also take additional medications or supplements for other conditions. With this complex array of medications across such a broad and diverse population, potential contraindications are a real possibility. Diabetes Risks from Prescription and Nonprescription Drugs surveys the medication landscape and provides brief yet illuminating information on the potential effects any medication may have on people currently treating diabetes or whether any particular medication may increase the risk that someone will develop diabetes. Designed with the busy clinician in mind, Dr. Dagogo-Jack provides succinct descriptions of the drugs that may interact with diabetes medications or increase the risk of developing diabetes. He includes information from the latest clinical studies and the most recent literature to present a comprehensive, authoritative text on an elusive and troubling clinical conundrum.

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Page Count

134

Publisher

American Diabetes Association

Published Date

ISBN 10

158040653X

ISBN 13

9781580406536

Book's by Samuel Dagogo-Jack

Prediabetes: A Fundamental Text

Prediabetes: A Fundamental Text

Medications and Diabetes Risk

Medications and Diabetes Risk

Diabetes Risks from Prescription and Nonprescription Drugs

Diabetes Risks from Prescription and Nonprescription Drugs

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