Sabine Enenkel's Books

Antibiotics in the Tropics

Antibacterial Therapy with Limited Resources

By: Sabine Enenkel,Wolfgang Stille

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Antibiotics in the Tropics

Antibacterial Therapy with Limited Resources

By: Sabine Enenkel,Wolfgang Stille

International textbooks on infectious diseases and antibacterial chemotherapy are usually written for readers in North America and Europe. In many ways, they are not appropriate for the prob lems encountered in developing countries. This book, in contrast, intends to define the rules of antibacterial chemotherapy practised under conditions of limited resources. It is meant for everyone con cerned with the use of antibiotics in developing countries, includ ing doctors, medical assistants, pharmacists, officials in health mio isteries, and medical students. Throughout the book, treatment recommendations are made for 1 antibiotics from the WHO list of essential drugs. For example, em phasis has therefore been put upon chloramphenicol as a stable, unexpensive and widely available oral agent suitable for the treat ment of severe bacterial infections like septicemia and meningitis. So-called "international chemotherapy" with modem cephalospor ins and acylaminopenicillins has been outlined for comparison. Since it is the aim of the book to base treatment recommenda tions on data from developing countries, many data on the etiology of common bacterial infections in developing countries have also been included. Most of the data are from African, English-speak ing developing countries, but references have been made to the lit erature on South East Asia, India or Papua New Guinea, where appropriate. On the other hand, pertinent data were not available in every instance, so that several statements and recommendations had to be made as "best guess". The authors are aware of these imperfections and will welcome comments from the readers.

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Page Count

337

Publisher

Springer Science & Business Media

Published Date

ISBN 10

3642732763

ISBN 13

9783642732768

Modelling Proteasome Dynamics in a Bayesian Framework

By: Sabine Stübler

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Modelling Proteasome Dynamics in a Bayesian Framework

By: Sabine Stübler

Sabine Stübler compares different proteasome isoforms and subtypes in terms of their transport and active site-related parameters applying an existing computational model. In a second step, the author extends this model to be able to describe the influence of proteasome inhibitors in in vitro experiments. The computational model, which describes the hydrolysis of short fluorogenic peptides by the 20S proteasome, is calibrated to experimental data from different proteasome isoforms using an approximate Bayesian computation approach. The dynamics of proteasome inhibitors are included into the model in order to demonstrate how to modulate the inhibitor’s transport parameters for strong or isoform-specific inhibition.

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Page Count

108

Publisher

Springer

Published Date

ISBN 10

3658201673

ISBN 13

9783658201678

Antibiotics in the Tropics

Antibacterial Therapy with Limited Resources

By: Sabine Enenkel,Wolfgang Stille

Write a review Read reviews Take a Quiz Solve Book Puzzle

Antibiotics in the Tropics

Antibacterial Therapy with Limited Resources

By: Sabine Enenkel,Wolfgang Stille

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

337

Publisher

Springer Science & Business Media

Published Date

ISBN 10

3642732763

ISBN 13

9783642732768

Book's by Sabine Enenkel

Antibiotics in the Tropics

Antibiotics in the Tropics

Modelling Proteasome Dynamics in a Bayesian Framework

Modelling Proteasome Dynamics in a Bayesian Framework

Antibiotics in the Tropics

Antibiotics in the Tropics

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