Pediatric Ophthalmology and Strabismus is your one-stop source for comprehensive coverage of all the pediatric ophthalmic conditions you are likely to encounter in practice. Extensively updated with expert contributions from leaders in the field and now featuring online instructional videos, this ophthalmology reference delivers all the state-of-the-art guidance you need to effectively diagnose and manage even the most challenging eye diseases and disorders seen in children. Take a holistic approach to patient management that considers the family and ensures optimal doctor-patient relationships.Get a balanced view of etiology, diagnosis, and management, and access unique guidance on the practical problems encountered in real-life clinical cases.Impresses the importance of systemic disease in diagnosis and management. Apply all the latest clinical advances through updated coverage of strabismus diagnosis, management and complications; retinal dystrophies; imaging & investigation; AIDS in children; developmental biology; cerebral visual impairment; child abuse; severe developmental glaucoma; and corneal dystrophies.Get rich visual guidance in diagnosis and management from over 1,700 full-color illustrations.Access advice from the experts with contributions from several new top researchers and clinicians.Find the answers you need quickly and easily through a consistent chapter organization and highly accessible clinical information. Browse the complete contents of Pediatric Ophthalmology and Strabismus online, download all the images, and watch brand-new procedural videos at www.expertconsult.com.
DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology, 10th edition has garnered universal acclaim as the world’s definitive, standard-setting oncology reference. More than 400 respected luminaries explore today’s most effective strategies for managing every type of cancer by stage of presentation - discussing the role of all appropriate therapeutic modalities as well as combined-modality treatments. This multidisciplinary approach will help your cancer team collaboratively face the toughest clinical challenges and provide the best possible care for every cancer patient. Access the complete contents online or on your mobile device, with quarterly updates reflecting late-breaking developments in cancer care, free for the first year on LWW Health Library. Take full advantage of the latest advances with brand-new chapters on Hallmarks of Cancer, Molecular Methods in Cancer, Oncogenic Viruses, Cancer Screening, and new sections on Genetic testing and counseling for cancer, plus comprehensive updates throughout – including coverage of the newest biologic therapies. Make optimal, well-coordinated use of all appropriate therapies with balanced, multidisciplinary advice from a surgeon, a medical oncologist, and a radiation oncologist in each major treatment chapter. Review the latest molecular biology knowledge for each type of cancer and its implications for improved management. Make the best decisions on cancer screening and prevention, palliative care, supportive oncology, and quality-of-life issues
Wiley-Blackwell's Clinical Cases series is designed to recognize the centrality of clinical cases to the profession by providing actual cases with an academic backbone. Clinical Cases in Orthodontics applies both theory and practice to real-life orthodontic cases in a clinically relevant format. This unique approach supports the new trend in case-based and problem-based learning, thoroughly covering topics ranging from Class I malocclusions to orthognathic surgery. Highly illustrated in full color, Clinical Cases in Orthodontics' format fosters independent learning and prepares the reader for case-based examinations.
Recent advances in technology have greatly impacted upon the practice of nuclear medicine in general, and the approach to hepatobiliary diseases in particular. Empha sis is now placed more on non-invasive functional imaging with quantification, a feature unique to nuclear medicine and not available from any other competing diag nostic imaging modality. By providing a measure of severity of disease, quantification aids not only in timing of therapy but also for testing whether or not the chosen therapy has achieved the intended goals and objectives. This is the first textbook of its kind in the new millennium on nuclear hepatology to fully integrate quantitative physiology with morphology in the diagnosis of hepatobiliary diseases. The conception of nuclear hepatology occurred in the late 1940s with the introduc tion of radiocolloids, whose rate of clearance from blood was used as a measure of hepatic blood flow. Radiocolloid imaging of the liver, introduced first in the mid 1950s, was the most popular nuclear medicine imaging procedure in the 1970s and early 1980s, accounting for nearly 50% of the total workload in many nuclear medicine departments.
This book focuses on the data mining, systems biology, and bioinformatics computational methods that can be used to summarize biological networks. Specifically, it discusses an array of techniques related to biological network clustering, network summarization, and differential network analysis which enable readers to uncover the functional and topological organization hidden in a large biological network. The authors also examine crucial open research problems in this arena. Academics, researchers, and advanced-level students will find this book to be a comprehensive and exceptional resource for understanding computational techniques and their applications for a summary of biological networks.
A concise description of models and quantitative parameters in structural chemistry and their interrelations, with 280 tables and >3000 references giving the most up-to-date experimental data on energy characteristics of atoms, molecules and crystals (ionisation potentials, electron affinities, bond energies, heats of phase transitions, band and lattice energies), optical properties (refractive index, polarisability), spectroscopic characteristics and geometrical parameters (bond distances and angles, coordination numbers) of substances in gaseous, liquid and solid states, in glasses and melts, for various thermodynamic conditions. Systems of metallic, covalent, ionic and van der Waals radii, effective atomic charges and other empirical and semi-empirical models are critically revised. Special attention is given to new and growing areas: structural studies of solids under high pressures and van der Waals molecules in gases. The book is addressed to researchers, academics, postgraduates and advanced-course students in crystallography, materials science, physical chemistry of solids.
Topics include:Genetic Risk and Gynecologic Cancer, Current Management of Preinvasive Cervical Neoplasia, Current Surgical Management of Cervical Neoplasia, Current Surgical Management of Ovarian Cancer, Current Management of Trophoblastic Disease, and New Developments in Radiation Management and Gynecologic Cancers
All scientific disciplines prize predictive success. Conventional statistical analyses, however, treat prediction as secondary, instead focusing on modeling and hence estimation, testing, and detailed physical interpretation, tackling these tasks before the predictive adequacy of a model is established. This book outlines a fully predictive approach to statistical problems based on studying predictors; the approach does not require predictors correspond to a model although this important special case is included in the general approach. Throughout, the point is to examine predictive performance before considering conventional inference. These ideas are traced through five traditional subfields of statistics, helping readers to refocus and adopt a directly predictive outlook. The book also considers prediction via contemporary 'black box' techniques and emerging data types and methodologies where conventional modeling is so difficult that good prediction is the main criterion available for evaluating the performance of a statistical method. Well-documented open-source R code in a Github repository allows readers to replicate examples and apply techniques to other investigations.
This research monograph on circular data analysis covers some recent advances in the field, besides providing a brief introduction to, and a review of, existing methods and models. The primary focus is on recent research into topics such as change-point problems, predictive distributions, circular correlation and regression, etc. An important feature of this work is the S-plus subroutines provided for analyzing actual data sets. Coupled with the discussion of new theoretical research, the book should benefit both the researcher and the practitioner.
As we all know, weather radar came into existence during the Second World War when aircraft detection radars had their vision limited by echoes from rain bearing clouds. What was often considered to be of nuisance value by the air force personnel trying to locate enemy aircraft was seen as an opportunity by the weather men. Thus adversity in one field was converted into an opportunity in another. Since then weather radar has found myriad applications with the increased sophistication of technology and processing systems. It has now become an indispensable tool for the operational forecasters, cloud physicists and atmospheric scientists. The current generation radar is but a distant echo of the radars of the 1940s. As a result, its operation and maintenance have become very complex, like the technology it uses. Therefore, there is a definite requirement of focussing our special attention not only on the science of radar meteorology but also on its operational aspects. The present book, as pointed out by the author, attempts to fill this gap. The author has presented the subject with a balanced blend of science, technology and practice. The canvas is indeed very broad. Starting with the history of weather radar development the book goes on to discuss in a lucid style the physics of the atmosphere related to radar observation, radar technology, echo interpretation, different applications and finally attempts to look into the future to indicate potential new opportunities in this field.
Now in its 10th edition, Sleisenger and Fordtran?s Gastrointestinal and Liver Disease remains your indispensable source for definitive, state-of-the-art answers on every aspect of gastroenterology and hepatology. Overcome your most complex clinical challenges and make optimal use of the newest techniques, technologies, and treatments?with superb guidance from hundreds of world-renowned authorities. Meticulous updates throughout include the latest approaches and improvements in gastrointestinal and liver disease diagnosis and therapy as well as hundreds of images and 35 new procedural videos. "..one of the most valuable clinical resources in the dynamic field of gastroenterology and hepatology." Reviewed by Brindusa Diaconu on behalf of the Journal of Gastrointestinal and Liver Diseases, July 2015 "..an engaging, educational yet clinically orientated textbook which is relevant to modern clinical practice." Reviewed by Dr Harry Brown on behalf of glycosmedia.com, April 2015 "I can personally attest to the remarkable advances that have been made, as I was author of the chapter on eosinophilic gastroenteritis in the second edition of the textbook, and reading the same chapter in the tenth edition underscores the important advances that have been made in our understanding of the molecular basis as well as the pathophysiology of this and related disorders." Foreword by Norton J. Greenberger, MD Boston, Massachusetts, June 2015 Consult this title on your favorite e-reader. Get the essential gastroenterology information you need from one authoritative source with an outstanding global reputation for excellence. Zero in on the key information you need to know with a consistent, full-color chapter design. Stay up to date with emerging and challenging topics: enteric microbiota and probiotics; fecal microbiota transplantation; Clostridium difficile colitis; and factitious gastrointestinal diseases. Incorporate the latest findings and improvements in care for liver disease patients—from diagnosis and treatment through post-treatment strategies and management of complications. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, references, and videos from the book on a variety of devices.
Written by two leaders in the field of pediatric dermatology, this classic text provides both detailed content for the specialist and easily accessible information for the non-dermatologist and less experienced clinician. Paller and Mancini – Hurwitz Clinical Pediatric Dermatology, 6th Edition, comprehensively covers the full range of skin disorders in children, offering authoritative, practical guidance on diagnosis and treatment in a single volume. This award-winning, evidence-based text has been fully revised and updated, and is an essential resource for anyone who sees children with skin disorders. - Features new content outline boxes for faster navigation, hundreds more clinical images, and authors' tips for the diagnosis and treatment of pediatric skin diseases. - Contains updated, evidence-based guidance and the latest drug developments and disease classifications. - Provides a careful balance of narrative text, useful tables, and 1,300 high-quality clinical photographs, helping you recognize virtually any skin condition you're likely to see. - Includes a greatly expanded discussion of atopic dermatitis and psoriasis and new therapeutic approaches for treating genetic disorders and systemic diseases such as ichthyoses and rheumatologic disorders. - Discusses new tests for subclassifying disease, such as the myositis-specific antibodies of juvenile dermatomyositis, genotyping, and immunophenotypes of inflammatory skin disorders. - Contains new and updated tables on psoriasis co-morbidities, genetic syndrome classifications, acne therapies, pediatric histiocytoses, PHACE syndrome criteria, HSV therapies and juvenile dermatomyositis. - Features updated sections on infections, exanthems, vascular disorders, dermatoses and genodermatoses. - Discusses hot topics such as the use of stem cell and cell therapy, as well as recombinant protein, for treating epidermolysis bullosa; the resurgence of measles; congenital Zika virus infections; and much more.
Travel Writing and the Transnational Author explores the travel writing and transnational literature of four authors from the 'postcolonial canon': Michael Ondaatje, Vikram Seth, Amitav Ghosh, and Salman Rushdie.
The theory of U-statistics goes back to the fundamental work of Hoeffding [1], in which he proved the central limit theorem. During last forty years the interest to this class of random variables has been permanently increasing, and thus, the new intensively developing branch of probability theory has been formed. The U-statistics are one of the universal objects of the modem probability theory of summation. On the one hand, they are more complicated "algebraically" than sums of independent random variables and vectors, and on the other hand, they contain essential elements of dependence which display themselves in the martingale properties. In addition, the U -statistics as an object of mathematical statistics occupy one of the central places in statistical problems. The development of the theory of U-statistics is stipulated by the influence of the classical theory of summation of independent random variables: The law of large num bers, central limit theorem, invariance principle, and the law of the iterated logarithm we re proved, the estimates of convergence rate were obtained, etc.
This book provides clinicians and trainees with the latest advances and procedures in the management of paediatric and neonatal emergencies. Divided into 16 sections, the text begins with discussion on the concept of intensive care, resuscitation, and diagnosis of an acutely sick child. The following chapters cover the treatment of emergency scenarios in different systems of the body – respiratory, cardiovascular, nervous, endocrine, renal and gastrointestinal. The book concludes with sections on infectious diseases, oncology, accidents and poisoning, and neonatology. A chapter on drug dosages is also included. Topics are presented in a step by step, systematic approach, further enhanced by photographs, diagrams, flowcharts and tables to assist learning. Key points Comprehensive guide to latest advances in management of paediatric and neonatal emergencies Covers emergency scenarios in all anatomical systems Includes section on paediatric drug dosages Highly illustrated with photographs, diagrams, flowcharts and tables
Device testing represents the single largest manufacturing expense in the semiconductor industry, costing over $40 billion a year. The most comprehensive and wide ranging book of its kind, Testing of Digital Systems covers everything you need to know about this vitally important subject. Starting right from the basics, the authors take the reader through automatic test pattern generation, design for testability and built-in self-test of digital circuits before moving on to more advanced topics such as IDDQ testing, functional testing, delay fault testing, memory testing, and fault diagnosis. The book includes detailed treatment of the latest techniques including test generation for various fault models, discussion of testing techniques at different levels of integrated circuit hierarchy and a chapter on system-on-a-chip test synthesis. Written for students and engineers, it is both an excellent senior/graduate level textbook and a valuable reference.
Addresses the Question Frequently Proposed to the Designer by Architects: "Can We Do This? Offering guidance on how to use code-based procedures while at the same time providing an understanding of why provisions are necessary, Tall Building Design: Steel, Concrete, and Composite Systems methodically explores the structural behavior of steel, concrete, and composite members and systems. This text establishes the notion that design is a creative process, and not just an execution of framing proposals. It cultivates imaginative approaches by presenting examples specifically related to essential building codes and standards. Tying together precision and accuracy—it also bridges the gap between two design approaches—one based on initiative skill and the other based on computer skill. The book explains loads and load combinations typically used in building design, explores methods for determining design wind loads using the provisions of ASCE 7-10, and examines wind tunnel procedures. It defines conceptual seismic design, as the avoidance or minimization of problems created by the effects of seismic excitation. It introduces the concept of performance-based design (PBD). It also addresses serviceability considerations, prediction of tall building motions, damping devices, seismic isolation, blast-resistant design, and progressive collapse. The final chapters explain gravity and lateral systems for steel, concrete, and composite buildings. The Book Also Considers: Preliminary analysis and design techniques The structural rehabilitation of seismically vulnerable steel and concrete buildings Design differences between code-sponsored approaches The concept of ductility trade-off for strength Tall Building Design: Steel, Concrete, and Composite Systems is a structural design guide and reference for practicing engineers and educators, as well as recent graduates entering the structural engineering profession. This text examines all major concrete, steel, and composite building systems, and uses the most up-to-date building codes.
Human face is very important cosmetically as it is the first part of the body noticed by anyone in th world whether it is a baby, male, female or professionals. It is therefore important that a blemishless face attracts anybody. Similarly any dissimilarities over the face has a direct impact on the self image and confidence. This book precisely and comprehensively highlights all the important dermatoses over the human face covering the various pathogenesis, clinical features and its management.
Shanti S. Gupta has made pioneering contributions to ranking and selection theory; in particular, to subset selection theory. His list of publications and the numerous citations his publications have received over the last forty years will amply testify to this fact. Besides ranking and selection, his interests include order statistics and reliability theory. The first editor's association with Shanti Gupta goes back to 1965 when he came to Purdue to do his Ph.D. He has the good fortune of being a student, a colleague and a long-standing collaborator of Shanti Gupta. The second editor's association with Shanti Gupta began in 1978 when he started his research in the area of order statistics. During the past twenty years, he has collaborated with Shanti Gupta on several publications. We both feel that our lives have been enriched by our association with him. He has indeed been a friend, philosopher and guide to us.
Vertebrate pests cause considerable damage to environment, agriculture and biodiversity apart from transmitting diseases. The problem is more pronounced in tropical Asia and Africa with non-human primates, elephants, several species of ungulates, rodents, frugivorous and grainivorous birds causing agricultural losses. In Europe and America the damage is due to carnivore predation on livestock, bird damage in cereal crops and rodent problem in urban and agricultural situations. Although there are several excellent books on rodent pest management both in India and at global level, there is a conspicuous lacuna of published books on vertebrate pest management. Even the few publications on the subject mostly deal with birds, rodents, bears, rabbits, foxes, etc because they are written by Americans or Britishers. Because their emphasis is on the problem prevalent in their countries and evaluation of management options available to them. In contrast the problem in tropics especially in India is unique. Rodents of course, are the most destructive. But what rodents do over twelve months of year is matched by a few nights of devastating crop raids by elephants or week long foraging by monkeys. Sporadic and localized damage is inflicted by several species of birds, bats, wild boar, blue bull, bears, hares, peacock etc. The damage is sometimes so high, it is impossible for a subsistence farmer to accept stoically the loss of his entire food source over a couple of days and nights. However, his options are limited in view of conservations and protection status enjoyed by some of these animals. The problem is compounded by religious sentiments associated with a few of them. This book is an attempt to find an acceptable solution to the problem of crop losses of these less studied but economically important groups of vertebrate pests. Sincere efforts have gone into formulation of recommendations keeping in mind the biological needs of vertebrate pests, their conservation status and suffering of the poor farmer. Many a time the sympathies deservedly go to the speechless marauders of crops as it is man who has shrunk, degraded and destroyed their habitat, deprived them of their natural source of food. There are no choices for vertebrate pests but raid the crops in their range but we, humans have several to survive. The book is an attempt to understand this dilemma.
Astronomy and Astrophysics Abstracts, which has appeared in semi-annual volumes since 1969, is devoted to the recording, summarizing and indexing of astronomical publications throughout the world. It is prepared under the auspices of the International Astronomical Union (according to a resolution adopted at the 14th General Assembly in 1970). Astronomy and Astrophysics Abstracts aims to present a comprehensive documenta tion of literature in all fields of astronomy and astrophysics. Every effort will be made to ensure that the average time interval between the date of receipt of the original literature and publication of the abstracts will not exceed eight months. This time interval is near to that achieved by monthly abstracting journals, compared to which our system of accumu lating abstracts for about six months offers the advantage of greater convenience for the user. Volume 31 contains literature published in 1982 and received before July 15, 1982; some older literature which was received late and which is not recorded in earlier volumes is also included. We acknowledge with thanks contributions to this volume by Dr. J. Bouska, Prague, who surveyed journals and publications in Czech and supplied us with abstracts in English .
This books documents the salient characters of the tectonic evolution of the Indian subcontinent. It showcases the well investigated subcontinent of Gondwana. The book is linked to an updated geological and tectonic map of this region on 1:12,000,000 in scale. The Indian subcontinent displays almost uninterrupted and unique the geological history since about Eo-Archean (~3800 Ma) to recent, with the development of many Proterozoic deformed and metamorphosed fold belts around Archean nuclei, and enormously thick undeformed platform deposits. After their stabilization during late Proterozoic, the subcontinent underwent Paleozoic rifting and deposition of coal-bearing thick sequences, followed by enormously-thick outpouring of Deccan volcanics as a consequence of huge mantle plume. The youngest event in its evolution is the Cenozoic Himalayan Orogenic Mountains, spanning the area between Nanga Parbat and Namcha Barwah; a part of which extends both in Pakistan and Myanmar.
This handbook covers a wealth of topics from number theory, special attention being given to estimates and inequalities. As a rule, the most important results are presented, together with their refinements, extensions or generalisations. These may be applied to other aspects of number theory, or to a wide range of mathematical disciplines. Cross-references provide new insight into fundamental research. Audience: This is an indispensable reference work for specialists in number theory and other mathematicians who need access to some of these results in their own fields of research.
A clear, engaging writing style, hundreds of full-color images, and new information throughout make Volpe's Neurology of the Newborn, 6th Edition, an indispensable resource for those who provide care for neonates with neurological conditions. World authority Dr. Joseph Volpe, along with Dr. Terrie E. Inder and other distinguished editors, continue the unparalleled clarity and guidance you've come to expect from the leading reference in the field – keeping you up to date with today's latest advances in diagnosis and management, as well as the many scientific and technological advances that are revolutionizing neonatal neurology. - Provides comprehensive coverage of neonatal neurology, solely written by the field's founding expert, Dr. Joseph Volpe - for a masterful, cohesive source of answers to any question that arises in your practice. - Focuses on clinical evaluation and management, while also examining the many scientific and technological advances that are revolutionizing neonatal neurology. - Organizes disease-focused chapters by affected body region for ease of reference. - Features a brand new, full-color design with hundreds of new figures, tables, algorithms, and micrographs. - Includes two entirely new chapters: Neurodevelopmental Follow-Up and Stroke in the Newborn; a new section on Neonatal Seizures; and an extensively expanded section on Hypoxic-Ischemia and Other Disorders. - Showcases the experience and knowledge of a new editorial team, led by Dr. Joseph Volpe and Dr. Terrie E. Inder, Chair of the Department of Pediatric Newborn Medicine at Brigham and Women's Hospital, all of whom bring a wealth of insight to this classic text. - Offers comprehensive updates from cover to cover to reflect all of the latest information regarding the development of the neural tube; prosencephalic development; congenital hydrocephalus; cerebellar hemorrhage; neuromuscular disorders and genetic testing; and much more. - Uses an improved organization to enhance navigation. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.
Against All Odds: The IT Story of India is an insider's account and an anecdote-rich history of Indian IT over the last six decades. It taps into the first-hand experiences of Kris Gopalakrishnan and fifty other stalwarts who built and shaped the IT industry. This is a tale of persistence and resilience, of foresight, of planning and being ready when luck knocks on the door, of a spirit of adventure and, above all, of an abiding sense of faith in technology and the belief that it would do good for India. It is a tale of triumph, and the best is yet to come!
Coordination chemistry is the study of compounds formed between metal ions and other neutral or negatively charged molecules. Coordination chemistry includes areas of inorganic solid state chemistry, organometallic chemistry and bioinorganic chemistry, as well as applications to analytical chemistry, catalysis, industrial chemistry and materials science.
Nucleotide Sequences 1986/1987, Volume VII: Structural RNA, Synthetic, and Unannotated Sequences presents data that reflect the information found in GenBank Release 44.0 of August 1986. This book provides information pertinent to the unique international collaboration between two leading nucleotide sequence data libraries, one based in Europe and one in the United States. Organized into three sections, this volume begins with an overview of the sequences, some basic identifying information, and some of the biological annotations. This text then discusses the EMBL Nucleotide Sequence Data Library, an international center of fundamental research with its main focus in the fields of cell biology, molecular structures, instrumentation, and differentiation. This book discusses as well the GenBank database established in 1982 by the National Institute of General Medical Sciences (NIGMS) of the U.S National Institutes of Health (NIH). This book is a valuable resource for molecular biologists and other investigators collecting the large number of reported DNA and RNA sequences and making them available in computer-readable form.
Maize is one of the versatile emerging crops with wider adaptability under varied agro-climatic conditions. Globally, maize is known as queen of cereals because it has the highest genetic yield potential among the cereals. It is cultivated on nearly 150 m/ha in about 160 countries having wider diversity of soil, climate, biodiversity and management practices that contributes 36 % (782 m/t) in the global grain production. The United States of America (USA) is the largest producer of maize contributes nearly 35 % of the total production in the world. It is the driver of the US economy. This book talks about the improvement, production, protection and post harvest technology of the maize crop. Note: T& F does not sell or distribute the Hardback in India, Pakistan, Nepal, Bhutan, Bangladesh and Sri Lanka.
This book focusses on power quality improvement and enhancement techniques with aid of intelligent controllers and experimental results. It covers topics ranging from the fundamentals of power quality indices, mitigation methods, advanced controller design and its step by step approach, simulation of the proposed controllers for real time applications and its corresponding experimental results, performance improvement paradigms and its overall analysis, which helps readers understand power quality from its fundamental to experimental implementations. The book also covers implementation of power quality improvement practices. Key Features Provides solution for the power quality improvement with intelligent techniques Incorporated and Illustrated with simulation and experimental results Discusses renewable energy integration and multiple case studies pertaining to various loads Combines the power quality literature with power electronics based solutions Includes implementation examples, datasets, experimental and simulation procedures
A hands-on approach to statistical inference that addresses the latest developments in this ever-growing field This clear and accessible book for beginning graduate students offers a practical and detailed approach to the field of statistical inference, providing complete derivations of results, discussions, and MATLAB programs for computation. It emphasizes details of the relevance of the material, intuition, and discussions with a view towards very modern statistical inference. In addition to classic subjects associated with mathematical statistics, topics include an intuitive presentation of the (single and double) bootstrap for confidence interval calculations, shrinkage estimation, tail (maximal moment) estimation, and a variety of methods of point estimation besides maximum likelihood, including use of characteristic functions, and indirect inference. Practical examples of all methods are given. Estimation issues associated with the discrete mixtures of normal distribution, and their solutions, are developed in detail. Much emphasis throughout is on non-Gaussian distributions, including details on working with the stable Paretian distribution and fast calculation of the noncentral Student's t. An entire chapter is dedicated to optimization, including development of Hessian-based methods, as well as heuristic/genetic algorithms that do not require continuity, with MATLAB codes provided. The book includes both theory and nontechnical discussions, along with a substantial reference to the literature, with an emphasis on alternative, more modern approaches. The recent literature on the misuse of hypothesis testing and p-values for model selection is discussed, and emphasis is given to alternative model selection methods, though hypothesis testing of distributional assumptions is covered in detail, notably for the normal distribution. Presented in three parts—Essential Concepts in Statistics; Further Fundamental Concepts in Statistics; and Additional Topics—Fundamental Statistical Inference: A Computational Approach offers comprehensive chapters on: Introducing Point and Interval Estimation; Goodness of Fit and Hypothesis Testing; Likelihood; Numerical Optimization; Methods of Point Estimation; Q-Q Plots and Distribution Testing; Unbiased Point Estimation and Bias Reduction; Analytic Interval Estimation; Inference in a Heavy-Tailed Context; The Method of Indirect Inference; and, as an appendix, A Review of Fundamental Concepts in Probability Theory, the latter to keep the book self-contained, and giving material on some advanced subjects such as saddlepoint approximations, expected shortfall in finance, calculation with the stable Paretian distribution, and convergence theorems and proofs.
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