This book discusses recent advances in theoretical–computational studies on the biosynthesis of melanin pigment (melanogenesis). These advances are being driven by the development of high-performance computers, new experimental findings, and extensive work on medical applications involving the control of pigmentation and the treatment of challenging dermatological diseases. Understanding the elementary processes involved in chemical reactions at the atomic scale is important in biochemical reaction design for effective control of the pigmentary system. Accordingly, the book focuses on the elementary steps involved in melanogenesis, which crucially affect the composition of the resulting melanin pigment by means of competitive reactions. The book also addresses reactions analogous to melanogenesis, with a focus on o-quinone reactions, which are especially important for understanding melanogenesis-associated cytotoxicity.
Democratic leaders around the world are finding it increasingly difficult to exercise strong leadership and maintain public support. However, there is nowhere that this has proven to be as challenging of a task as Japan, which has seen its top leaders change more often over the past 25 years than any other major country in the world. The current prime minister has strived to put an end to this pattern, but can he buck this historical trend? More fundamentally, why do Japan's prime ministers find it so difficult to project strong leadership, or even stay in office? And what are the ramifications for Japan's partners and for the world? This volume, authored by contributors who straddle the scholarly and policymaking worlds in Japan, explores the obstacles facing Japan as it looks for greater leadership and explains why this matters for the rest of the world.
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