Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function. Antibacterial Agents is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated “lab-to-clinic” approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects (including links to current guidelines, significant drug interactions, cautions and contraindications), prodrugs and future improvements. Agents covered include: agents targeting DNA - quinolone, rifamycin, and nitroimidazole antibacterial agents agents targeting metabolic processes - sulfonamide antibacterial agents and trimethoprim agents targeting protein synthesis - aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones agents targeting cell wall synthesis - β-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin Antibacterial Agents will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.
This illuminating book critically examines multicultural language politics and policymaking in the Andean-Amazonian countries of Ecuador, Peru, and Bolivia, demonstrating how issues of language and power throw light on the relationship between Indigenous peoples and the state. Based on the author’s research in Ecuador, Peru, and Bolivia over several decades, Howard draws comparisons over time and space. With due attention to history, the book’s focus is situated in the years following the turn of the millennium, a period in which ideological shifts have affected continuity in official policy delivery even as processes of language shift from Indigenous languages such as Aymara and Quechua, to Spanish, have accelerated. The book combines in-depth description and analysis of state-level activity with ethnographic description of responses to policy on the ground. The author works with concepts of technologies of power and language regimentation to draw out the hegemonic workings of power as exercised through language policy creation at multiple scales. This book will be key reading for students and scholars of critical sociolinguistic ethnography, the history, society and politics of the Andean region, and linguistic anthropology, language policy and planning, and Latin American studies more broadly.
A unique textbook, aimed at undergraduate students, containing large numbers of spectra, problems and marginal notes, specifically chosen to highlight the points being discussed.
Nature Unbound' is an examination of the rise of protected areas and their current social and economic position in our world. It examines the social impacts of protected areas, the conflicts that surround them, the alternatives to them and the conceptual categories they impose.
Drawing upon a variety of important philosophical traditions, this book develops an original perspective on the relations between ethical, economic and aesthetic values in a tourism context. It considers the ethical/political issues arising in many areas of tourism development, including: the profound cultural and environmental impacts on tourist destinations the reciprocity (or lack of) in host-guest relations the (un)fair distribution of benefits and revenues the moral implications of issues such as sex tourism, staged authenticity and travel to oppressive regimes. The book concludes with a detailed investigation of the potential and pitfalls of ecotourism, sustainable tourism and community-based tourism, as examples of what is sometimes termed 'ethical tourism.' Until now, the ethical issues that surround tourism development have received little academic attention. Explaining philosophical arguments without the use of excessive jargon, this fascinating book interweaves theory and practice, aided by the use of text boxes to explain key terms in ethics, politics, and tourism development, and drawing on contemporary case studies from South Africa, Mexico, Zambia, Honduras, Ethiopia and Madagascar.
We share a history, we share a memory and they both share my heart. It's that time of the year. A time that Eoin, Mary Anne and Jack all remember. Having grown up together in various care homes for the disabled, they now rely on each other in adulthood for support, friendship and love. But when young film-maker Eleanor arrives, struggling with hidden issues and agendas of her own, to make a documentary about their lives together, the examination and attention she brings threatens to disrupt the long-term relationships and friendships at the heart of their group. Mainstream is a complex drama about truth, lies and the mainstreaming of Travellers with disabilities. It was produced in November 2016 in a co-production between Fishamble Theatre Company and Project Arts Centre, Dublin.
Lads, when it comes to your time for pickin' women, you're not going to have my kind of luck. The best one is taken. All Julia and John want is to live their lives with their two sons, on their own terms. But despite their hopes, the outside world and its racism puts paid to their plans. A world premiere of a new play from Rosaleen McDonagh, this tender, complex and beautiful love story examines how external circumstances pull us apart, when all we really want is to be together. This edition was published to coincide with the world premiere at Abbey Theatre, Dublin, in August 2021
Environmentally-sustainable tourism or ecotourism has become a major area of interest for governments, the private sector and international lending institutions. It is regarded as a way of allowing economic development whilst protecting against environmental degradation, especially in those countries with fragile ecosystems. However, despite the beneficial intentions of ecotourism, it tends to be regarded uncritically by environmental organizations, governments and the private sector alike. Rosaleen Duffy presents this analysis of ecotourism, linking it with environmental ideologies and the politics of North-South relations. By the extensive use of case study and interview material, she formulates ideas and proposals that should be important for the development of ecotourism around the globe.
The popular and successful rhetorical textbooks produced by the 18th century Scottish philosophical tradition, such as George Campbell's The Philosophy of Rhetoric (1776), Hugh Blair's Lectures on Rhetoric and Belles Lettres (1783), and Alexander Bain's English Composition and Rhetoric (1877) have been widely accorded a role in the trajectories of 19th and 20th century literary theory. Scholars have generally overlooked them, however, as philosophical works. The selected writings chosen for this volume show how these rhetorical textbooks were a practical extension of the philosophy of language developed by 18th century Scottish philosophers. Francis Hutcheson, Adam Smith, Thomas Reid, Adam Ferguson, Alexander Gerard, and Henry Home, Lord Kames, advanced a radically new paradigm of language as an inherently mediated practice, directed simultaneously to personal and social, moral and aesthetic uses. This Scottish philosophy of rhetoric powerfully influenced the teaching of language and literacy as tools for social and educational innovation. This volume - the first of its kind - offers a wide variety of writings on rhetoric and rhetorical theory, selected in a way that reveals their intimate connection with the Scottish philosophical tradition.
Kawsay Vida is a course book and interactive multimedia program on DVD for the teaching and learning of the Quechua language from beginner to advanced levels. The course book is based on contemporary Bolivian Quechua, while the multimedia program contains a section on Bolivian Quechua (beginner to intermediate levels) and a section on southern Peruvian Quechua (advanced level). The book provides a practical introduction to spoken Quechua through the medium of English, while the multimedia program offers a choice of English or Spanish as the medium of instruction. The video clips introduce us to Quechua speakers in the valleys of Northern Potosí (Bolivia) and Cuzco (Peru), giving a sense of immediacy that the printed page cannot achieve, and highlighting the social and cultural settings in which the language is spoken. The DVD is available for both PC and Macintosh platforms. The book contains twenty-two units of study. As students work through these, cross-references take them to relevant sections of the DVD. The Bolivian and Peruvian Quechua sections of the multimedia program are divided into thematically and grammatically ordered modules, which introduce users to different aspects of Andean life, while progressing language learning in a structured way. Users engage with the audio, video, and visual material contained in the DVD through a range of interactive exercises, which reinforce listening and comprehension skills. Once familiarity with the language is acquired, the multimedia program may be used independently from the book.
Drawing upon a variety of important philosophical traditions, this book develops an original perspective on the relations between ethical, economic and aesthetic values in a tourism context. It considers the ethical/political issues arising in many areas of tourism development, including: the profound cultural and environmental impacts on tourist destinations the reciprocity (or lack of) in host-guest relations the (un)fair distribution of benefits and revenues the moral implications of issues such as sex tourism, staged authenticity and travel to oppressive regimes. The book concludes with a detailed investigation of the potential and pitfalls of ecotourism, sustainable tourism and community-based tourism, as examples of what is sometimes termed 'ethical tourism.' Until now, the ethical issues that surround tourism development have received little academic attention. Explaining philosophical arguments without the use of excessive jargon, this fascinating book interweaves theory and practice, aided by the use of text boxes to explain key terms in ethics, politics, and tourism development, and drawing on contemporary case studies from South Africa, Mexico, Zambia, Honduras, Ethiopia and Madagascar.
This book gives equal weight to the psychological and neurological approaches to the study of cognitive deficits in patients with brain lesions. The result is an analysis of cognitive skills and abilities that departs from the more usual syndrome approach.
Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function. Antibacterial Agents is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated “lab-to-clinic” approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects (including links to current guidelines, significant drug interactions, cautions and contraindications), prodrugs and future improvements. Agents covered include: agents targeting DNA - quinolone, rifamycin, and nitroimidazole antibacterial agents agents targeting metabolic processes - sulfonamide antibacterial agents and trimethoprim agents targeting protein synthesis - aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones agents targeting cell wall synthesis - β-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin Antibacterial Agents will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.
A unique textbook, aimed at undergraduate students, containing large numbers of spectra, problems and marginal notes, specifically chosen to highlight the points being discussed.
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