The study of mental health disorders and the genetics behind these disorders can be greatly enhanced by the use of induced pluripotent stem cells (iPSC). Since many mental health disorders develop after puberty, the only way in which to study the genetic mechanism of these diseases previously was through cellular surrogates, such as blood or cultured fibroblasts. Having the ability to reprogram adult cells to the pluripotent stage provides the capacity to study the onset of these disorders during a culture model of neural development and to include the impact of genetic risk factors and potential environmental triggers. Working with the National Institute of Mental Health (NIMH), the Rutgers Cell and DNA Repository (RUCDR) has begun banking iPSC source cells and converting those source cells into iPSC for distribution to the scientific community. Although initial protocols were developed to reprogram fibroblasts, the ability to reprogram blood cells has several advantages including less invasive collection, less post collection manipulation, and the large number of samples in existing collections. Here, we provide detailed protocols for reprogramming either fibroblasts with retroviral vectors or cryopreserved lymphocytes with Sendai viral vectors. Our goal is to support the discovery of effective treatments for mental health disorders. Table of Contents: Acknowledgments / Introduction / Appendix / General Protocols / References / Author Biographies
The study of mental health disorders and the genetics behind these disorders can be greatly enhanced by the use of induced pluripotent stem cells (iPSC). Since many mental health disorders develop after puberty, the only way in which to study the genetic mechanism of these diseases previously was through cellular surrogates, such as blood or cultured fibroblasts. Having the ability to reprogram adult cells to the pluripotent stage provides the capacity to study the onset of these disorders during a culture model of neural development and to include the impact of genetic risk factors and potential environmental triggers. Working with the National Institute of Mental Health (NIMH), the Rutgers Cell and DNA Repository (RUCDR) has begun banking iPSC source cells and converting those source cells into iPSC for distribution to the scientific community. Although initial protocols were developed to reprogram fibroblasts, the ability to reprogram blood cells has several advantages including less invasive collection, less post collection manipulation, and the large number of samples in existing collections. Here, we provide detailed protocols for reprogramming either fibroblasts with retroviral vectors or cryopreserved lymphocytes with Sendai viral vectors. Our goal is to support the discovery of effective treatments for mental health disorders. Table of Contents: Acknowledgments / Introduction / Appendix / General Protocols / References / Author Biographies
First Published in 1993. This volume is based upon an April 1990 Carl Albert Center conference commemorating the bicentennial of the United States Congress and the centennial of the University of Oklahoma. The conference was entitled, Back to the Future: the United States Congress in the Twenty-first Century. Its focus was on the nature of change in Congress and on the likely direction of congressional change as the new century approaches.
Ronald Kessler’s explosive bestseller, The FBI, brought down FBI Director William S. Sessions. Now, in this unparalleled work of investigative journalism, Kessler reveals the inner world of the CIA. Based on extensive research and hundreds of interviews, including several with former Directors of Central Intelligence, Inside the CIA is the first in-depth, unbiased account of the Agency’s core operations, its abject failures, and its resounding successes. Kessler reveals how: -CIA analysts botched the job of foreseeing the Soviet economy’s collapse -The Agency spies on every country in the world except Great Britain, Australia, and Canada -The CIA undertakes covert action to influence or overthrow foreign governments or political parties -The Agency trains its officers to break the laws of other countries Inside the CIA is an extraordinary guide to the world’s most successful house of spies.
Arthur McIvor and Ronald Johnston explore the experience of coal miners' lung diseases and the attempts at voluntary and legal control of dusty conditions in British mining from the late nineteenth century to the present. In this way, the book addresses the important issues of occupational health and safety within the mining industry; issues that have been severely neglected in studies of health and safety in general. The authors examine the prevalent diseases, notably pneumoconiosis, emphysema and bronchitis, and evaluate the roles of key players such as the doctors, management and employers, the state and the trade unions. Throughout the book, the integration of oral testimony helps to elucidate the attitudes of workers and victims of disease, their 'machismo' work culture and socialisation to very high levels of risk on the job, as well as how and why ideas and health mentalities changed over time. This research, taken together with extensive archive material, provides a unique perspective on the nature of work, industrial relations, the meaning of masculinity in the workplace and the wider social impact of industrial disease, disability and death. The effects of contracting dust disease are shown to result invariably in seriously prescribed lifestyles and encroaching isolation. The book will appeal to those working on the history of medicine, industrial relations, social history and business history as well as labour history.
For the first time, readers are given insights into Hart's somewhat lonely and tragic personal life, his quarrels with exploitive studios, and his association with such latter-day frontier legends as Charles M. Russell, Bat Masterson, and Wyatt Earp, who regarded him as a kindred spirit.
Bringing together authorities on the history, historiography and methodology of recent and contemporary science, this book reviews the problems facing historians of technology, contemporary science and medicine and explores new ways forward.
Steven J. Brams is one of the leading game theorists of his generation. This new edition includes brand new material on topics such as fallback bargaining and principles of rational negotiation.
Mrs. Lane is a descendant of the author of the "Star Spangled Banner," Francis Scott Key. Her book traces Key's ancestry back to the American immigrant, Philip Key of London, who settled in St. Mary's County, Maryland in 1720, and forward to a number of Key lines in the U.S. of her own era.
Perhaps the most spectacular reaction to court-ordered busing in the 1970s occurred in Boston, where there was intense and protracted protest. Ron Formisano explores the sources of white opposition to school desegregation. Racism was a key factor, Formisa
In Stations of the Sun and The Triumph of the Moon Ronald Hutton established himself as a leading authority on the historian of Paganism. His wealth of unusual knowledge, complemented by a deep and sympathetic understanding of past and present beliefs that are often dismissed as strange or marginal, and an ability to write lucidly and wittily, gives his work a unique flavour. The essays which make up Witches, Druids and King Arthur cover elegantly and entertainingly a wide range of beliefs, myths and practices.
THE STORY: As Walter Kerr of the New York Herald-Tribune describes the play and its central character: He's a producer and writer of television serials, except that he doesn't really write any serials, they're written by frostbitten spastics he ke
Drawing upon extensive experience in law, government service, teaching, and research, Ronald Cass offers a contribution to the ongoing public discussion on law and society. After opening his discussion with chapters on the rule of law in American society, Cass turns to the hard case of its application to the president of the United States. Through this prism Cass examines the behavior of judges who may not always act according to a "perfect model." This book provides a corrective to criticism of the American legal system raised all too frequently by some members of the academy. Rather than concentrating on relatively minor inconsistencies in the law and slight departures from the ideal of perfectly constrained decision making, Cass argues that the energies of his fellow scholars could be better spent on more serious defects in the legal system. With a special section on the 2000 presidential election, including the Florida recount and Supreme Court decision, The rule of law in America offers a look at a subject of interest to legal scholars and general readers alike.
Lawrence Police Department: Heroes Wear Blue pictorially chronicles the history of the department from its inception through its first century to the present day. A compelling visual tour, not only for police and local historians, this collection offers a glimpse of society and how it has changed. Featuring the first known police officer in Lawrence, Massachusetts, as well as the Lawrence police officers who served in the Civil War in uniform, this volume also provides a rare glimpse of vintage police equipment that is now unlawful to use.
The New York Times said of Ronald H. Spector’s classic account of the American struggle against the Japanese in World War II, “No future book on the Pacific War will be written without paying due tribute to Eagle Against the Sun.” Now Spector has returned with a book that is even more revealing. In the Ruins of Empire chronicles the startling aftermath of this crucial twentieth-century conflict. With access to recently available firsthand accounts by Chinese, Japanese, British, and American witnesses and previously top secret U.S. intelligence records, Spector tells for the first time the fascinating story of the deadly confrontations that broke out–or merely continued–in Asia after peace was proclaimed at the end of World War II. Under occupation by the victorious Allies, this part of the world was plunged into new power struggles or back into old feuds that in some ways were worse than the war itself. In the Ruins of Empire also shows how the U.S. and Soviet governments, as they secretly vied for influence in liberated lands, were soon at odds. At the time of the peace declaration, international suspicions were still strong. Joseph Stalin warned that “crazy cutthroats” might disrupt the surrender ceremony in Tokyo Bay. Die-hard Japanese officers plotted to seize the emperor’s palace to prevent an announcement of surrender, and clandestine relief forces were sent to rescue thousands of Allied POWs to prevent their being massacred. In the Ruins of Empire paints a vivid picture of the postwar intrigues and violence. In Manchuria, Russian “liberators” looted, raped, and killed innocent civilians, and a fratricidal rivalry continued between Chiang Kai-shek’s regime and Mao’s revolutionaries. Communist resistance forces in Malaya settled old scores and terrorized the indigenous population, while mujahideen holy warriors staged reprisals and terror killings against the Chinese–hundreds of innocent civilians were killed on both sides. In Indochina, a nativist political movement rose up to oppose the resumption of French colonial rule; one of the factions that struggled for supremacy was the Communist Viet Minh led by Ho Chi Minh. Korea became a powder keg with the Russians and Americans entangled in its north and south. And in Java, as the Indonesian novelist Idrus wrote, people brutalized by years of Japanese occupation “worshipped a new God in the form of bombs, submachine guns, and mortars.” Through impeccable research and provocative analysis, as well as compelling accounts of American, British, Indian, and Australian soldiers charged with overseeing the surrender and repatriation of millions of Japanese in the heart of dangerous territory, Spector casts new and startling light on this pivotal time–and sets the record straight about this contested and important period in history.
Particle image velocimetry, or PIV, refers to a class of methods used in experimental fluid mechanics to determine instantaneous fields of the vector velocity by measuring the displacements of numerous fine particles that accurately follow the motion of the fluid. Although the concept of measuring particle displacements is simple in essence, the factors that need to be addressed to design and implement PIV systems that achieve reliable, accurate, and fast measurements and to interpret the results are surprisingly numerous. The aim of this book is to analyze and explain them comprehensively.
MONEY, SEX, AND SELF-INTEREST TAKEN CONTROL OF CAPITOL HILL Now more than ever, Congress runs the country. But who is running Congress? New York Times bestselling author and award-winning journalist Ronald Kessler takes you behind the scenes, conducting unprecedented interviews with more than 350 insiders to reveal the shocking answer to that question. Here are the sex scandals, the dirty financial deals, the abuses of power -- the deepest, darkest secrets of Congress -- exposed for the first time, including: How congressional members -- including the entire House Republican leadership -- used taxpayer dollars to lavishly redecorate their offices with custom-made furniture, including $20,000 chairs. Eyewitness accounts of members engaging in adulterous affairs and wild orgies in the parking lots, back rooms, and hidden chambers of Capitol Hill. Evidence of special-interest money-laundering schemes that put millions into the pockets of our elected officials. Meticulously documented and chock-full of sizzling revelations, Inside Congress is making headlines across the country. Read it -- and find out what your senators and representatives don't want you to know.
France and England are often seen as monarchies standing at opposite ends of the spectrum of seventeenth-century European political culture. On the one hand the Bourbon monarchy took the high road to absolutism, while on the other the Stuarts never quite recovered from the diminution of their royal authority following the regicide of Charles I in 1649. However, both monarchies shared a common medieval heritage of sacral kingship, and their histories remained deeply entangled throughout the century. This study focuses on the interaction between ideas of monarchy and images of power in the two countries between the execution of Mary Queen of Scots and the Glorious Revolution. It demonstrates that even in periods when politics were seemingly secularized, as in France at the end of the Wars of Religion, and in latter seventeenth- century England, the appeal to religious images and values still lent legitimacy to royal authority by emphasizing the sacral aura or providential role which church and religion conferred on monarchs.
The material in this book reviews work dating back to the vocabulary control movement in the 1930s and also refers to more recent work on the role of lexis in language learning. Two chapters describe the main foundations of lexical semantics and relevant research and pedagogical studies in vocabulary and lexicography; and a further chapter discusses recent advances in the field of lexis and discourse analysis. There is also a series of specially commissioned articles which investigate the structure and functions of the modern English lexicon in relation to its exploitation for classroom vocabulary teaching.
V. 1. "This gorgeous book, the first of a four-volume definitive catalogue, features Chase's stunning paintings in pastel, which constitute a major and previously understudied body of work by the artist; monotypes; painted tiles and plates; watercolors; and prints. Reconstructing Chase's oeuvre is a daunting task, as the artist left few records of any kind, and no documentation of his individual works exists. Furthermore, Chase's paintings and pastels have been forged in great numbers throughout the years, and many of these works still surface on the art market. Making this long-awaited volume even more valuable is a list of every known exhibition of Chase's work during the artist's lifetime, selected examples of major post-1917 exhibitions, and an essay on Chase's innovative pastel technique"--Jacket.
Many books have been written regarding Ronald Reagan, but this collection of his letters must certainly be among the most varied and revealing aspect of the man. Organized by themes such as "Old Friends", "Running for Office ", "Core Beliefs" the book contains over 1,000 letters stretching from 1922 to 1994 . Whether discussing economic policy with a political for, dispensing marital advice, or sharing a joke with a pen pal.
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