There has recently been considerable discussion of a “replication crisis” in some areas of science. In this book, the authors argue that replication is not a necessary criterion for the validation of a scientific experiment. Five episodes from physics and genetics are used to substantiate this thesis: the Meselson-Stahl experiment on DNA replication, the discoveries of the positron and the omega minus hyperon, Mendel’s plant experiments, and the discovery of parity nonconservation. Two cases in which once wasn’t enough are also discussed, the nondiscovery of parity nonconservation and the search for magnetic monopoles. Reasons why once wasn’t enough are also discussed.
Description PDQ Medical Genetics challenges students to learn to think genetically, to recognize genetic factors, and to explain genetics to patients. The author presents an approach to solving clinical problems with genetic components rather than on the presentation of facts that would soon fall out of date. The text is problem-oriented. Each chapter opens with a case scenario designed to direct the student toward learning both the clinical and the basic biological science. The featured scenarios also provide direction in the dealing with a patient's, and family's, personal difficulties by listing genetic disease support groups. The informative text also emphasizes how to go about obtaining the latest information on such topics as molecular testing and imaging techniques. Key Features Features topics not found in most genetics texts designed primarily for medical students such as complex disorders, ambiguous genitalia, pharmacogenetics, and bone dyspasias. Includes a dual-platform mini-CD-ROM with the complete text and illustrations, in fully searchable PDF files Incorporates references and links to carefully selected websites for additional readings and a bonus self-assessment question and answer section for each chapter - all included on the accompanying CD-ROM This book will help students understand the nature of genetics and how its principles flow from those of evolution and natural selection. It provides to the medical student an approach to solving clinical probl ems and provides a conceptual framework within which to sort it all ou t. Davidson approaches the subject of medical genetics as students wil l encounter it - clinically. The book is problem-based, and each chapt er begins with a case scenario requiring a knowledge of genetics with which the practicing physician will have to come to grips fairly frequ ently with the emphasis on having the student recognize the applicatio ns of basic science data and solving the problem presented. It
The Biostatistics course is often found in the schools of public Health, medical schools, and, occasionally, in statistics and biology departments. The population of students in these courses is a diverse one, with varying preparedness. Introduction to Biostatistics assumes the reader has at least two years of high school algebra, but no previous exposure to statistics is required. Written for individuals who might be fearful of mathematics, this book minimizes the technical difficulties and emphasizes the importance of statistics in scientific investigation. An understanding of underlying design and analysis is stressed. The limitations of the research, design and analytical techniques are discussed, allowing the reader to accurately interpret results. Real data, both processed and raw, are used extensively in examples and exercises. Statistical computing packages - MINITAB, SAS and Stata - are integrated. The use of the computer and software allows a sharper focus on the concepts, letting the computer do the necessary number-crunching. - Emphasizes underlying statistical concepts more than competing texts - Focuses on experimental design and analysis, at an elementary level - Includes an introduction to linear correlation and regression - Statistics are central: probability is downplayed - Presents life tables and survival analysis - Appendix with solutions to many exercises - Special instructor's manual with solution to all exercises
The book presents a re-reading of H. G. Wells' novel "The Island of Doctor Moreau" as a key to addressing the controversies of our own humanity. It raises the issue: without human exceptionalism, where do ethics come from?
Neural and Brain Modeling reviews models used to study neural interactions. The book also discusses 54 computer programs that simulate the dynamics of neurons and neuronal networks to illustrate between unit and systemic levels of nervous system functions. The models of neural and brain operations are composed of three sections: models of generic mechanisms; models of specific neuronal systems; and models of generic operations, networks, and systems. The text discusses the computational problems related to galvanizing a neuronal population though an activity in the multifiber input system. The investigator can use a computer technique to simulate multiple interacting neuronal populations. For example, he can investigate the case of a single local region that contains two populations of neurons: namely, a parent population of excitatory cells, and a second set of inhibitory neurons. Computer simulation models predict the various dynamic activity occurring in the complicated structure and physiology of neuronal systems. Computer models can be used in "top-down" brain/mind research where the systemic, global, and emergent properties of nervous systems are generated. The book is recommended for behavioral scientists, psychiatrists, psychologists, computer programmers, students, and professors in human behavior.
Tracking the degeneration of the Russian Revolution Red Flag Wounded brings together essays covering the controversies and debates over the fraught history of the Soviet Union from the revolution to its disintegration. Those monumental years were marked not only by violence, mass killing, and the brutal overturning of a peasant society but also by the modernisation and industrialisation of the largest country in the world, the victory over fascism, and the slow recovery of society after the nightmare of Stalinism. Ronald Grigor Suny is one of the most prominent experts on the revolution, the fate of the non-Russian peoples of the Soviet empire, and the twists and turns of Western historiography of the Soviet experience. As a biographer of Stalin and a long-time commentator on Russian and Soviet affairs, he brings novel insights to a history that has been misunderstood and deliberately distorted in the public sphere. For a fresh look at a story that affects our world today, this is the place to begin.
Expertly bridging the gap between basic science and clinical information, Williams Textbook of Endocrinology, 14th Edition, brings together an outstanding collection of world-renowned authors to provide authoritative discussions of the full spectrum of adult and pediatric endocrine system disorders. New chapters and significant revisions throughout keep you up to date with recent advances in medications, therapies, clinical trials, and more. This essential reference is a must-have resource for endocrinologists, endocrine surgeons, gynecologists, internists, pediatricians, and other clinicians who need current, comprehensive coverage of this multifaceted field. - Up to date with recent advances in medications, therapies, and clinical trials. - Provides state-of-the-art coverage of diabetes, metabolic syndrome, metabolic bones disorders, obesity, thyroid disease, testicular disorders, newly defined adrenal disorders and much more - all designed to help you provide optimal care to every patient. - Contains new chapters on Global Burden of Endocrine Disease, Navigation of Endocrine Guidelines, and Transgender Endocrinology. - Includes significant updates to the Diabetes section, including a new chapter on Physiology of Insulin Secretion and greater coverage of Type 2 Diabetes. - Presents current information in a highly illustrated, user-friendly format for quick reference. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Ronald L. Besser first learned to scribe from the celestial archives decades ago. In a revelatory presentation inspired by his ability to connect to medical professionals beyond the realm of Earth, he offers many unique insights into our history and medical conditions as our world continues to battle deadly contagions and a pandemic. Within easy-to-read text shared for the intelligent layman and those wishing to live a natural existence, Besser begins by exploring the start of AIDS, how it took millions of lives globally, and its treatments, and then examines the definition of autism and how to work with well. Included are his insights on a sure-fire treatment for Alzheimer’s disease which can be managed at home, how the brain colludes in the fetus to cause autism, and why all vaccines must have clinical trials before being distributed to the public. The Origins of AIDS and Autism is a unique presentation of ideas and insights from a retired civil engineer that examines several diseases, their effects on humankind and the world, and potential treatments to eradicate them from society forever.
Exploring a much neglected area, the relationship between food and nationalism, this book examines a number of case studies at various levels of political analysis to show how useful the food and nationalism axis can be in the study of politics.
What does rabbinical Judaism have to teach us about the way the mind works? How do the rabbis of the Talmud, Middle Ages, and our own time shed light on emotional disturbances, and on the cognitive-behavioral therapies used to treat them? In this panoramic view of rabbinical Judaism, psychiatrist Ronald Pies MD shows how cognitive-behavioral therapy (CBT) and rational emotive behavioral therapy (REBT) rely on psychological principles found in both ancient and modern Judaic writings. "The interplay between thought and deed is a central feature of Judaic affirmation. Control the thought and the deed will follow. Dr. Ronald Pies's book explores this connection in depth, and the inter-relationships that he weaves are at once illuminating and empowering." -Rabbi Dr. Reuven P. Bulka
Becoming a Mensch is a 'user's guide' to becoming a better person, taking readers through a process of personal growth by means of modern-day vignettes that draw upon the Talmud's ancient wisdom. By examining character traits such as 'kindness and compassion,' 'self-mastery and self discipline,' and 'humility and flexibility,' readers of any or no faith learn what it takes to become a 'mensch' —- a decent and honorable human being. Readers are introduced to the greatest sages of the Talmudic era and many modern masters of ethical behavior. Becoming a Mensch is not only a guidebook for personal growth —- it is also a useful guide for parents who want to foster the ethical development of their children.
How should living things and our own human nature be changed in the hands of those who can alter them genetically? How do we set limits, and what goals are legitimate pursuits? This book's contribution to a theological understanding of science and technology helps in showing how Christian theology can provide a solid framework for considering these issues.
In the course of this compact and insightful work, Dr. Ronald Pies, tells us a little about what happiness is, and a lot about how to achieve it. The first chapter begins with a reminder from the great Roman emperor Marcus Aurelius, that "things do not touch the soul." This, explains Pies, "is the keystone in the arch of Stoic philosophy." In a sense, then, the rest of the book is an extended meditation on how we might avoid letting things touch our souls too much. But, it is much more than simply a meditation. From here, Pies goes on to offer readers a well-researched, often witty explanation of how Stoic philosophy—as it resonates not only with Christian and Judaic, but also with Buddhist and Hindu worldviews—can guide and improve their lives. In the process, he draws on his own considerable clinical experience to offer composite case vignettes, both positive and negative, that illustrate the principles he is discussing.
With the author's intimate knowledge of the suffering caused by this disease, Schizophrenia emphasizes research strategies, the importance of sound scientific approaches, and the challenges that remain.
The over-riding premise for biotechnology in this book is bringing novel products to market to substantially advance patient care and disease mitigation. Biotechnology, over its relatively brief existence of 40 years, has experienced a mercurial growth. The vast educational need for biotechnology information in this rapidly burgeoning field is a basic rationale here. However a more prominent underpinning is that, bringing biotech products to market for patient care involves success in the following four areas of engagement simultaneously - scientific advances for healthcare technologies, novel and varied products for untreated diseases, regulatory authorities, and biotech companies. Features Comprehensive coverage of biotechnology science topics used in development and manufacturing Addresses all the scientific technologies within biotechnology responsible for products on the market and the pipeline Presents business issues such as marketing and sales of the products, as well as companies engaged, and how biotech business has evolved
Begun formally in 1990, the U.S. Human Genome Project's (HGP) goals were to identify all the 20,000 to 25,000 genes in human DNA, determine the sequences of the three billion chemical base pairs that make up human DNA, store this information in databases, improve tools for data analysis, and transfer related technologies to the private sector. It was the first large scientific undertaking to address potential issues that arose from project data, and opened up vast possibilities for the use of genetic data and the alteration of our genetic makeup. This volume is the first to address the diverse range of ethical issues arising from the HGP, and enables professors to bring this critically important topic to life in the classroom. ';
Intelligent systems are required to enhance the capacities being made available to us by the internet and other computer based technologies. The theory necessary to help providing solutions to difficult problems in the construction of intelligent systems are discussed. In particular, attention is paid to situations in which the available information and data may be imprecise, uncertain, incomplete or of a linguistic nature. Various methodologies to manage such information are discussed. Among these are the probabilistic, possibilistic, fuzzy, logical, evidential and network-based frameworks.One purpose of the book is not to consider these methodologies separately, but rather to consider how they can be used cooperatively to better represent the multiplicity of modes of information. Topics in the book include representation of imperfect knowledge, fundamental issues in uncertainty, reasoning, information retrieval, learning and mining, as well as various applications.Key Features:• Tools for construction of intelligent systems • Contributions by world leading experts • Fundamental issues and applications • New technologies for web searching • Methods for modeling uncertain information • Future directions in web technologies • Transversal to methods and domains
Renowned for its richness, depth, and authorship, Cases and Materials on Corporations offers broad coverage of both public and closely held corporations. A powerful introductory chapter sets out the defining characteristics of a corporation. A thematic framework frames corporate law in terms of the corporation’s responsibilities to its employees, its investors, and society. New to the Ninth Edition: The introductory Chapter recognizes that issues of race and systemic discrimination have dominated recent headlines and political discourse. This has re-focused attention on the long-standing debate between proponents of the dominant shareholders primacy model of corporate governance and proponents of a more stakeholder-oriented model. Without taking sides on this issue, this Chapter notes that this debate has continued throughout American legal history, and it focuses on recent efforts by some states and Nasdaq to require greater diversity (both in terms of race and gender) on corporate boards. Current data is provided. In addition, this Chapter adds a new section to introduce the “public benefit corporation,” a new corporate form that is a hybrid of a profit-making corporation and a not-for-profit entity now recognized by a majority of the states. New material on the emerging line of good faith cases in the context of director oversight where a corporation is subject to “mission critical” regulation. This new line of cases opens up potential avenues to assign monetary liability to directors for failure to manage corporate risks. New Supreme Court decisions (including Lorenzo and Omnicare) are assessed, and the continuing struggle to define insider trading is reviewed. The chapter on shareholder voting and proxy gives special attention to recent efforts by activist hedge funds to influence and constrain corporate management. The revised chapter on takeovers takes up the legal rules governing friendly and unfriendly acquisitions. The chapter tracks the unique experience of Delaware law over this period: an ongoing and openly—but respectful–disagreement between the Delaware Chancery Court and the Delaware Supreme Court about the allocation of authority between the board of directors and shareholders. The chapter also examines the new texture of the takeover market where activists play a central role. Professors and students will benefit from: Richness and depth: A range of thoroughly developed topics allows instructors to delve into topics with as much depth as they wish. The text is strong in material on both public and closely held corporations. Traditional casebook pedagogy: Text notes, statutory material, excerpted commentary, problems, questions, and edited cases. Strong introductory chapter: Sets out the defining characteristics of a corporation: limited liability, perpetual existence, free transferability, and centralized management. Thematic framework: Examines corporate law in the context of the corporation’s responsibilities to its own constituents and investors, as well as to society.
Earth’s Evolving Systems: The History of Planet Earth, Second Edition is an introductory text designed for popular courses in undergraduate Earth history. Written from a “systems perspective,” it provides coverage of the lithosphere, hydrosphere, atmosphere, and biosphere, and discussion of how those systems interacted over the course of geologic time.
Nearly all major planets and moons in our Solar System have been visited by spacecraft and the data they have returned has revealed the incredible diversity of planetary surfaces. Featuring a wealth of images, this textbook explores the geological evolution of the planets and moons. Introductory chapters discuss how information gathered from spacecraft is used to unravel the geological complexities of our Solar System. Subsequent chapters focus on current understandings of planetary systems. The textbook shows how planetary images and remote sensing data are analyzed through the application of fundamental geological principles. It draws on results from spacecraft sent throughout the Solar System by NASA and other space agencies. Aimed at undergraduate students in planetary geology, geoscience, astronomy and solar system science, it highlights the differences and similarities of the surfaces at a level that can be readily understood by non-specialists.
Biology is a source of fascination for most scientists, whether their training is in the life sciences or not. In particular, there is a special satisfaction in discovering an understanding of biology in the context of another science like mathematics. Fortunately there are plenty of interesting (and fun) problems in biology, and virtually all scientific disciplines have become the richer for it. For example, two major journals, Mathematical Biosciences and Journal of Mathematical Biology, have tripled in size since their inceptions 20-25 years ago. The various sciences have a great deal to give to one another, but there are still too many fences separating them. In writing this book we have adopted the philosophy that mathematical biology is not merely the intrusion of one science into another, but has a unity of its own, in which both the biology and the math ematics should be equal and complete, and should flow smoothly into and out of one another. We have taught mathematical biology with this philosophy in mind and have seen profound changes in the outlooks of our science and engineering students: The attitude of "Oh no, another pendulum on a spring problem!," or "Yet one more LCD circuit!" completely disappeared in the face of applications of mathematics in biology. There is a timeliness in calculating a protocol for ad ministering a drug.
Center of Military History Publication 51-3-1. By J. Ronald Fox, et al. Discusses reform initiatives from 1960 to the present and concludes with prescriptions for future changes to the acquisition culture of the services, DoD, and industry.
This is the definitive edition of R.A. Fisher's classic work--probably the best known book in evolutionary biology after Darwin's Origin of Species. The book was the first attempt to assess and explain Darwin's evolutionary theories in terms of genetic evolution. Based on the original 1930 edition, the book incorporates the many changes Fisher made for the second edition as well as unpublished material taken from Fisher's own copy.
Building and expanding on the first edition, the second edition of Food, National Identity and Nationalism continues to explore a much-neglected area study: the relationship between food and nationalism. With a preface written by Michaela DeSoucey and using a wide range of case studies, it demonstrates that food and nationalism is an important area to study, and that the food-nationalism axis provides a useful prism through which to explore and analyse the world around us, from the everyday to the global, and the ways in which it affects us. The second edition includes a number of new case studies, including the demise and resurrection of pie as a ‘national dish’ in post-Brexit Britain; the use of netnography; the role of diasporas in maintaining and reinventing national food; the gastrodiplomatic potential of the New Nordic Cuisine; the potential of veganism to transcend nationalism; and the relationship between gastronationalism and populism.
Toxic Plants of North America, Second Edition is an up-to-date, comprehensive reference for both wild and cultivated toxic plants on the North American continent. In addition to compiling and presenting information about the toxicology and classification of these plants published in the years since the appearance of the first edition, this edition significantly expands coverage of human and wildlife—both free-roaming and captive—intoxications and the roles of secondary compounds and fungal endophytes in plant intoxications. More than 2,700 new literature citations document identification of previously unknown toxicants, mechanisms of intoxication, additional reports of intoxication problems, and significant changes in the classification of plant families and genera and associated changes in plant nomenclature. Toxic Plants of North America, Second Edition is a comprehensive, essential resource for veterinarians, toxicologists, agricultural extension agents, animal scientists, and poison control professionals.
Walker's vision, the text smoothly combines in-depth scholarship with a popular, readable style to preserve and enhance what the Washington Post called a landmark of zoological literature.
An up-to-date guide to the winding, wonderful, whimsical streets of the greatest city on earth, Jerusalem. Whether you are visiting Jerusalem, live in this Golden City, or just want to learn the history of the crossroads of the world, you'll find this volume indispensable.
How are genetically modified plants produced? Which breeding goals are worthwhile, and which are not? Can the escape of transferred genes be controlled? Why have the first transgenic plants been released without full appreciation of the consequences? How dangerous are bacterial proteins produced in plant foods? Is anyone monitoring the unexpected effects of gene transfer? Will genetically modified plants ever be acceptable to organic growers? These are some of the important questions canvassed in this book, written with the insight of an experienced Australian plant scientist and conservationist.
Psychology: The Science of Mind and Behaviour is here with a new, fully updated and revised third edition. Bringing new developments in the field and its renowned pedagogical design, the third edition offers an exciting and engaging introduction to the study of psychology.This book’s scientific approach, which brings together international research, practical application and the levels of analysis framework, encourages critical thinking about psychology and its impact on our daily lives. Key features: Fully updated research and data throughout the book as well as increased cross cultural referencesRestructured Chapter 3 on Genes, Environment and Behaviour, which now starts with a discussion of Darwinian theory before moving on to Mendelian geneticsCore subject updates such as DSM-5 for psychological disorders and imaging techniques on the brain are fully integratedRevised and updated Research Close Up boxesCurrent Issues and hot topics such as, the study of happiness and schizophrenia, intelligence testing, the influence of the media and conflict and terrorism are discussed to prompt debates and questions facing psychologists todayNew to this edition is Recommended Reading of both classic and contemporary studies at the end of chapters Connect™ Psychology: a digital teaching and learning environment that improves performance over a variety of critical outcomes; easy to use and proven effective. LearnSmart™: the most widely used and intelligent adaptive learning resource that is proven to strengthen memory recall, improve course retention and boost grades. SmartBook™: Fuelled by LearnSmart, SmartBook is the first and only adaptive reading experience available today.
In the first decades of the 1800s, white Americans entered the rugged lands of Arkansas, which they had little explored before. They established new towns and developed commercial enterprises alongside Native Americans indigenous to Arkansas and other tribes and nations that had relocated there from the East. This history is also the story of Arkansas's people, and is told through numerous biographies, highlighting early life in frontier Arkansas over a period of 200 years. The book provides a categorical look at commerce and portrays the social diversity represented by both prominent and common Arkansans--all grappling for success against extraordinary circumstances.
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