Hormonal carcinogenesis is an important and controversial area of current research. In addition to accelerating existing cancers, can hormones play the role of primary carcinogens? How do genetic factors influence hormone-related cancer risk? Hormones, Genes, and Cancer addresses these questions. Over the past few decades, cancer research has focused on external environmental causes(e.g., tobacco smoke, viruses, asbestos). With the advent of new genetic sequencing techniques, we are just now beginning to understand how the body's internal environment(i.e., the hormones and growth factors that determine normal development) influences cancer etiology and prevention. From molecular insights to clinical analyses, this volume provides state-of-the-art information on the complex interactions between hormones and genes and cancer. The epidemiology and molecular endocrinology of prostate, breast, uterine, ovarian and testicular cancer are detailed in this timely treatise.
When his troop transport ship left for Vietnam there were no patriotic farewells. It would continue to be so for the marines of Golf Company, 2nd Platoon, 2nd Battalion, 4th Marines as Goddard recounts their experiences in the rice paddies and jungles from DaNang to the DMZ.
Examines the role of multinational corporations in the economy of the world and their effect on governments, taxpayers, consumers, workers, and businessmen.
From fundamental principles to advanced subspecialty procedures, Miller’s Anesthesia covers the full scope of contemporary anesthesia practice. This go-to medical reference book offers masterful guidance on the technical, scientific, and clinical challenges you face each day, in addition to providing the most up-to-date information available for effective board preparation. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Address the unique needs of pediatric patients with guidance from an entire section on pediatric anesthesia. View more than 1,500 full-color illustrations for enhanced visual clarity. Access step-by-step instructions for patient management, as well as an in-depth analysis of ancillary responsibilities and problems. Quickly reference important concepts with ‘Key Points’ boxes integrated into every chapter. Stay current on today's most recent anesthetic drugs and guidelines/protocols for anesthetic practice and patient safety, and access expanded coverage on new techniques such as TEE and other monitoring procedures. Take advantage of the unique, international perspectives of prominent anesthesiologists from all over the world, including the UK, Australia, India, Brazil, and Germany. Remain at the forefront of new developments in anesthesia with coverage of hot topics including Non-OR Anesthesia; Role of the Anesthesiologist in Disasters; Sleep Medicine in Anesthesia; Perioperative and Anesthesia-related Neurotoxicity; Anesthetic Implications of Complementary and Alternative Medicine; and Robotics. Study brand-new chapters on Perioperative Fluid Management; Extracorporeal Support Therapies; Anesthesia for Organ Donation/Procurement; and Malignant Hyperthermia and other Genetic Disorders.
On occasion nearly everyone experiences short-term back pain from sore or strained muscles. But for many who come to treat their back gingerly because they fear further "injury," a cycle of worry and inactivity results; this aggravates existing muscle tightness and leads them to think of themselves as having a "bad back." Even worse is the understandable but usually counterproductive assumption that back pain is caused by "abnormalities"–bulging disks, a damaged spine, and so on. However, these abnormalities are frequently found in those who have absolutely no pain whatsoever. In reality, most backs are strong and resilient, built to support our bodies for a lifetime; truly "bad backs" are rare. Drawing on their work with patients and studies from major scientific journals and corporations, the authors of Back Sense–all three are former chronic back pain sufferers themselves–developed a revolutionary self-treatment approach targeting the true causes of chronic back pain. It is based on conclusive evidence proving that stress and inactivity are usually the prime offenders, and it allows patients to avoid the restrictions and expense of most other treatments. After showing readers how to rule out the possibility that a rare medical condition is the source of their problem, Back Sense clearly and convincingly explains the actual factors behind chronic back pain and systematically leads readers toward recapturing a life free of back pain.
The stories of the doctors, nurses and patients at the Union Army’s hospital in Gettysburg come to life in this unique Civil War history. Those who toiled and suffered at the Army of the Potomac’s XI Corps hospital at the George Spangler Farm in Gettysburg have long since departed. But Ronald D. Kirkwood, a journalist and George Spangler Farm expert, shares their stories—many of which have never been told before—in this gripping and scholarly narrative. Using a wealth of firsthand accounts, Kirkwood re-creates the XI Corps hospital complex and its people—especially George and Elizabeth Spangler, whose farm was nearly destroyed in the fateful summer of 1863. A host of notables make appearances, including Union officers George G. Meade, Henry J. Hunt, Edward E. Cross, Francis Barlow, Francis Mahler, Freeman McGilvery, and Samuel K. Zook. Pvt. George Nixon III, great-grandfather of President Richard M. Nixon, would die there, as would Confederate Gen. Lewis A. Armistead, who fell mortally wounded at the height of Pickett’s Charge. Kirkwood presents the most complete lists ever published of the dead, wounded, and surgeons at the Spanglers’ XI Corps hospital, and breaks new ground with stories of the First Division, II Corps hospital at the Spanglers’ Granite Schoolhouse. He also examines the strategic importance of the property itself, which was used as a staging area to get artillery and infantry to the embattled front line.
Drs. Busuttil and Klintmalm present Transplantation of the Liver, 3rd Edition, which has been thoroughly revised to offer you the latest protocols, surgical approaches, and techniques used in this challenging procedure. Encompassing today's expert knowledge in the field, this medical reference book is an ideal single source for authoritative, up-to-date guidance on every imaginable aspect of liver transplantation. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Access valuable pearls, pitfalls, and insights from Dr. Ronald Busuttil and Dr. Goran Klintmalm, two of the world's preeminent experts in liver surgery. Understand today's full range of transplantation techniques with complete step-by-step descriptions of each, and access the background information and management options for each hepatic disease entity. Take advantage of detailed discussions of everything from pathophysiology and patient and donor selection, to transplantation anesthesia and operative procedures; immunosuppression; postoperative care; and ethical issues. Overcome your toughest challenges in liver transplantation. Many new and thoroughly revised chapters include: Deceased Organ Donation after Cardiac and Brain Death; Liver Transplantation for Non-Alcoholic Steatohepatitis; Extended Criteria Donors; Best Techniques for Biliary and Vascular Reconstruction in Living Donor Transplantation; Small for Size Syndrome; Dual Grafts for Transplantation; Arterial Reconstructions-Pitfalls; Transition of Pediatric Patients to Adulthood; Immunosuppressive Biologic Agents; Long Term Toxicity of Immunosuppressive Therapy; Stem Cell and Liver Regeneration; and Extracorporeal Perfusion for Resuscitation of Marginal Grafts. Stay current in your field and optimize patient outcomes with coverage of the most recent advances in living donor transplantation, pediatric transplantation, and gene and stem cell therapy. Access the latest information on anti-rejection/immunosuppressive drugs, as well as comprehensive discussions of each drug or combination of drugs used to suppress immune system. Effortlessly search the entire text online at Expert Consult.
Descriptive statistics for samples; Probability; Random variables and their distributions; Two random variables; Sampling; Estimation; Hypothesis testing; Analysis of variance; Introduction to regression; Regression theory; Multiple regression; Correlation; Bayesian decision theory; Nonparametric statistics; Chi square tests; Maximum likelihood estimation.
Ronald W. Schatz tells the story of the team of young economists and lawyers recruited to the National War Labor Board to resolve union-management conflicts during the Second World War. The crew (including Clark Kerr, John Dunlop, Jean McKelvey, and Marvin Miller) exerted broad influence on the U.S. economy and society for the next forty years. They handled thousands of grievances and strikes. They founded academic industrial relations programs. When the 1960s student movement erupted, universities appointed them as top administrators charged with quelling the conflicts. In the 1970s, they developed systems that advanced public sector unionization and revolutionized employment conditions in Major League Baseball. Schatz argues that the Labor Board vets, who saw themselves as disinterested technocrats, were in truth utopian reformers aiming to transform the world. Beginning in the 1970s stagflation era, they faced unforeseen opposition, and the cooperative relationships they had fostered withered. Yet their protégé George Shultz used mediation techniques learned from his mentors to assist in the integration of Southern public schools, institute affirmative action in industry, and conduct Cold War negotiations with Mikhail Gorbachev.
It has been 15 years since the original publication of Neuropsychology of Attention. At the time of its publication, attention was a construct that had long been of theoretical interest in the field of psychology and was receiving increased research by cognitive scientists. Yet, attention was typically viewed as a nuisance variable; a factor that needed to be accounted for when assessing brain function, but of limited importance in its own right. There is a need for a new edition of this book within Neuropsychology to present an updated and integrated review of what is know about attention, the disorders that affect it, and approaches to its clinical assessment and treatment. Such a book will provide perspectives for experimental neuropsychological study of attention and also provide clinicians with insights on how to approach this neuropsychological domain.
Five general areas are addressed in the 36 chapters: descriptive epidemiology of diabetes in the U.S., including prevalence, incidence, sociodemographic & metabolic characteristics, risk factors for developing diabetes, & mortality. Complications of diabetes (disability, vision disorders, heart disease, infection, etc.); medical care for diabetes; economic aspects, including health insurance & health care costs; & diabetes in special populations, including Blacks, Hispanics, Asian & Pacific Islanders, Native Americans & pregnant women. Index.
The Fifth Edition of Greenfield's Surgery has been thoroughly revised, updated, and refocused to conform to changes in surgical education and practice. Reflecting the increasingly clinical emphasis of residency programs, this edition features expanded coverage of clinical material and increased use of clinical algorithms. Key Points open each chapter, and icons in the text indicate where Key Points are fully discussed. Many of the black-and-white images from the previous edition have been replaced by full-color images. This edition has new chapters on quality assessment, surgical education, and surgical processes in the hospital. Coverage of surgical subspecialty areas is more sharply focused on topics that are encountered by general surgeons and included in the current general surgery curriculum and ABSITE exam. The vascular section has been further consolidated. A new editor, Diane M. Simeone, MD, PhD, has joined the editorial team. This edition is available either in one hardbound volume or in a four-volume softbound set. The lightweight four-volume option offers easy portability and quick access. Each volume is organized by organ system so you can find the facts you need within seconds. The companion website presents the fully searchable text, an instant-feedback test bank featuring over 800 questions and answers, and a comprehensive image bank. Unique to this new edition's website are 100 "Morbidity and Mortality" case discussions. Each case reviews a specific surgical complication, how the complication was addressed, and reviews the literature on approaches and outcomes.
Takaki traces the economic and political history of Indians, African Americans, Mexicans, Japanese, Chinese, Irish, and Jewish people in America, with considerable attention given to instances and consequences of racism. The narrative is laced with short quotations, cameos of personal experiences, and excerpts from folk music and literature. Well-known occurrences, such as the Triangle Shirtwaist Factory Fire, the Trail of Tears, the Harlem Renaissance, and the Japanese internment are included. Students may be surprised by some of the revelations, but will recognize a constant thread of rampant racism. The author concludes with a summary of today's changing economic climate and offers Rodney King's challenge to all of us to try to get along. Readers will find this overview to be an accessible, cogent jumping-off place for American history and political science plus a guide to the myriad other sources identified in the notes.
Reasoning about knowledge—particularly the knowledge of agents who reason about the world and each other's knowledge—was once the exclusive province of philosophers and puzzle solvers. More recently, this type of reasoning has been shown to play a key role in a surprising number of contexts, from understanding conversations to the analysis of distributed computer algorithms. Reasoning About Knowledge is the first book to provide a general discussion of approaches to reasoning about knowledge and its applications to distributed systems, artificial intelligence, and game theory. It brings eight years of work by the authors into a cohesive framework for understanding and analyzing reasoning about knowledge that is intuitive, mathematically well founded, useful in practice, and widely applicable. The book is almost completely self-contained and should be accessible to readers in a variety of disciplines, including computer science, artificial intelligence, linguistics, philosophy, cognitive science, and game theory. Each chapter includes exercises and bibliographic notes.
The globally important nature of wetland ecosystems has led to their increased protection and restoration as well as their use in engineered systems. Underpinning the beneficial functions of wetlands are a unique suite of physical, chemical, and biological processes that regulate elemental cycling in soils and the water column. This book provides an in-depth coverage of these wetland biogeochemical processes related to the cycling of macroelements including carbon, nitrogen, phosphorus, and sulfur, secondary and trace elements, and toxic organic compounds. In this synthesis, the authors combine more than 100 years of experience studying wetlands and biogeochemistry to look inside the black box of elemental transformations in wetland ecosystems. This new edition is updated throughout to include more topics and provide an integrated view of the coupled nature of biogeochemical cycles in wetland systems. The influence of the elemental cycles is discussed at a range of scales in the context of environmental change including climate, sea level rise, and water quality. Frequent examples of key methods and major case studies are also included to help the reader extend the basic theories for application in their own system. Some of the major topics discussed are: Flooded soil and sediment characteristics Aerobic-anaerobic interfaces Redox chemistry in flooded soil and sediment systems Anaerobic microbial metabolism Plant adaptations to reducing conditions Regulators of organic matter decomposition and accretion Major nutrient sources and sinks Greenhouse gas production and emission Elemental flux processes Remediation of contaminated soils and sediments Coupled C-N-P-S processes Consequences of environmental change in wetlands# The book provides the foundation for a basic understanding of key biogeochemical processes and its applications to solve real world problems. It is detailed, but also assists the reader with box inserts, artfully designed diagrams, and summary tables all supported by numerous current references. This book is an excellent resource for senior undergraduates and graduate students studying ecosystem biogeochemistry with a focus in wetlands and aquatic systems.
Psychology: The Science of Mind and Behaviour is here with a new, fully updated and revised third edition. Bringing new developments in the field and its renowned pedagogical design, the third edition offers an exciting and engaging introduction to the study of psychology.This book’s scientific approach, which brings together international research, practical application and the levels of analysis framework, encourages critical thinking about psychology and its impact on our daily lives. Key features: Fully updated research and data throughout the book as well as increased cross cultural referencesRestructured Chapter 3 on Genes, Environment and Behaviour, which now starts with a discussion of Darwinian theory before moving on to Mendelian geneticsCore subject updates such as DSM-5 for psychological disorders and imaging techniques on the brain are fully integratedRevised and updated Research Close Up boxesCurrent Issues and hot topics such as, the study of happiness and schizophrenia, intelligence testing, the influence of the media and conflict and terrorism are discussed to prompt debates and questions facing psychologists todayNew to this edition is Recommended Reading of both classic and contemporary studies at the end of chapters Connect™ Psychology: a digital teaching and learning environment that improves performance over a variety of critical outcomes; easy to use and proven effective. LearnSmart™: the most widely used and intelligent adaptive learning resource that is proven to strengthen memory recall, improve course retention and boost grades. SmartBook™: Fuelled by LearnSmart, SmartBook is the first and only adaptive reading experience available today.
As with the beginning of the twentieth century, when food safety standards and the therapeutic benefits of certain foods and supplements first caught the public’s attention, the dawn of the twenty-first century finds a great social priority placed on the science of food safety. Ronald Schmidt and Gary Rodrick’s Food Safety Handbook provides a single, comprehensive reference on all major food safety issues. This expansive volume covers current United States and international regulatory information, food safety in biotechnology, myriad food hazards, food safety surveillance, and risk prevention. Approaching food safety from retail, commercial, and institutional angles, this authoritative resource analyzes every step of the food production process, from processing and packaging to handling and distribution. The Handbook categorizes and defines real and perceived safety issues surrounding food, providing scientifically non-biased perspectives on issues for professional and general readers. Each part is divided into chapters, which are then organized into the following structure: Introduction and Definition of Issues; Background and Historical Significance; Scientific Basis and Implications; Regulatory, Industrial, and International Implications; and Current and Future Implications. Topics covered include: Risk assessment and epidemiology Biological, chemical, and physical hazards Control systems and intervention strategies for reducing risk or preventing food hazards, such as Hazard Analysis Critical Control Point (HACCP) Diet, health, and safety issues, with emphasis on food fortification, dietary supplements, and functional foods Worldwide food safety issues, including European Union perspectives on genetic modification Food and beverage processors, manufacturers, transporters, and government regulators will find the Food Safety Handbook to be the premier reference in its field.
From fundamental principles to advanced subspecialty procedures, Miller’s Anesthesia covers the full scope of contemporary anesthesia practice. It is the go-to reference for masterful guidance on the technical, scientific, and clinical challenges you face. Now new chapters, new authors, meticulous updates, an increased international presence, and a new full-color design ensure that the 7th edition continues the tradition of excellence that you depend on. Covers the full scope of contemporary anesthesia practice. Offers step-by-step instructions for patient management and an in-depth analysis of ancillary responsibilities and problems. Incorporates ‘Key Points’ boxes in every chapter that highlight important concepts. Extends the breadth of international coverage with contributions from prominent anesthesiologists from all over the world, including China, India, and Sweden. Features 30 new authors and 13 new chapters such as Sleep, Memory and Consciousness; Perioperative Cognitive Dysfunction; Ultrasound Guidance for Regional Anesthesia; Anesthesia for Correction of Cardiac Arrhythmias; Anesthesia for Bariatric Surgery; Prehospital Emergency and Trauma Care; Critical Care Protocols; Neurocritical Care; and Renal Replacement Therapy. Dedicates an entire section to pediatric anesthesia, to help you address the unique needs of pediatric patients. Presents a new full-color design -- complete with more than 1,500 full-color illustrations -- for enhanced visual guidance.
This leading text reflects both the new direction and explosive growth of the field of hematology. Edited and written by practitioners who are the leaders in the field, the book covers basic scientific foundations of hematology while focusing on its clinical aspects. This edition has been thoroughly updated and includes ten new chapters on cellular biology, haploidentical transplantation, hematologic manifestations of parasitic diseases, and more. The table of contents itself has been thoroughly revised to reflect the rapidly changing nature of the molecular and cellular areas of the specialty. Over 1,000 vivid images, now all presented in full color for the first time, include a collection of detailed photomicrographs in every chapter, selected by a hematopathology image consultant. What's more, this Expert Consult Premium Edition includes access to the complete contents of the book online, fully searchable and updated quarterly by Dr. Hoffman himself. - Publisher.
Presenting the fundamentals of microeconomics, the Fourth Edition retains the strengths of the previous editions, but now integrates economic principles with their policy implications, in many cases using a specific illustration to introduce an abstract idea. Naturally, the authors emphasize the importance of ``switching'' in explaining demand and supply; however, it goes beyond most others to provide more detail and tighter explanation of what the aggregate demand and aggregate supply curves look like and why, making an introduction to macroeconomics much easier. In addition, the Fourth Edition places a greater emphasis on the international aspects of modern economies. Includes examples, applications, graphs, table, and exercises.
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