A bracing confluence of adventure, murder, and breathtaking scenery." — Kirkus "Fans of backwoods suspense will find this thriller strikes the perfect balance of tense excitement and opportunities for testing their deductive skills." —BookLife "...a fabulous read. I’d love to see more of Richard Carlyle and will be watching this author for more works of this caliber. The Gorge is most highly recommended." — Readers' Favorite "...a fabulous read. I’d love to see more of Richard Carlyle and will be watching this author for more works of this caliber. The Gorge is most highly recommended." — Readers' Favorite Perfect for fans of Peter Heller’s The River and Karen Dionne’s The Marsh King’s Daughter. It is not yet spring in the Adirondack Mountains of upstate New York. Whitewater rafting season has already begun, however. Streams filled with snowmelt are pouring into the Hudson Gorge, an almost inaccessible twelve-mile canyon. But someone who knows every foot of the backcountry is stalking those who are attempting to run the Gorge as the river reaches flood stage. Richard Carlyle, a former raft guide and veteran criminologist working with state and local police, is desperately searching for the person who has murdered two people already. Tracking the killer to a remote cabin in the Gorge, Carlyle confronts an ecoterrorist with a grudge against anyone who dares to invade his territory.
Between the twelfth and seventeenth centuries, gilds were the basis of industrial and commercial organization in England. Surprisingly, however, the disappearance of gilds has been neglected by historians. In The Most Necessary Luxuries, Ronald Berger uses the Mercers' Company of Coventry to follow the eclipse of an entire trading community in one of England's premier medieval cities and manufacturing centers. Berger charts the difficulties faced by mercers and grocers in a growing capitalist economy and discusses their unsuccessful efforts to maintain their prosperity. The book helps to explain both the development of a new urban system and the rise of shops in Midland England. It shows how shops replaced markets and fairs and uses the economics of the fashion trades to explain why provincial shops could not overcome the competition put forward by the metropolis. The Most Necessary Luxuries unites the fields of social, urban, and economic history to explain the decline of a medieval city, the evolution of the English urban middle class, and the transformation from an amalgam of wealthy wholesalers and distributors of luxury goods to an association of mere shopkeepers. It demonstrates that the rise of commercial capitalism between 1550 and 1700 in England undermined the medieval economy that was based on protected markets, restrictive trading practices, and entrenched oligarchies that dominated towns.
Extensive updating throughout and a dramatically enhanced media and supplements package, including all new video case studies, makes this new edition of Abnormal Psychology the most effective yet.
Product Description: We stand on the brink of unprecedented growth in our ability to understand and change the human genome. New reproductive technologies now enable parents to select some genetic traits for their children, and soon it will be possible to begin to shape ourselves as a species. Despite the loud cries of alarm that such a prospect inspires, Ronald Green argues that we will, and we should, undertake the direction of our own evolution. A leader in the bioethics community, Green offers a scientifically and ethically informed view of human genetic self-modification and the possibilities it opens up for a better future. Fears of a terrible Brave New World or a new eugenics movement are overblown, he maintains, and in the more likely future, genetic modifications may improve parents' ability to enhance children's lives and may even promote social justice. The author outlines the new capabilities of genomic science, addresses urgent questions of safety that genetic interventions pose, and explores questions of parenting and justice. He also examines the religious implications of gene modification. Babies by design are assuredly in the future, Green concludes, and by making responsible choices as we enter that future, we can incorporate gene technology in a new age of human adventure.
Alcoholism, the oldest addictive illness, remains a serious problem because of its major modifications of many physiological systems. The genetic and neurological origins and mechanisms are complex and only partly understood. However, it is clear that alcohol use modifies the production of most hormones, directly and indirectly modulating the systems that hormones regulate. Acute and chronic alcohol consumption affects virtually all cellular functions of tissues like brain, liver, immune system, and reproductive and endocrine organs. The latter have major regula tory roles, affecting many functions from development to repro duction. Although stress can further modify alcohol's effects on hormone production, it significantly causes most of alcohol's modi fications of the body to occur via changes in hormone production and secretion. Ronald R. Watson vii Contributors Michael L. Adams • Department of Psychiatry, Washington University School of Medicine, St. Louis, MO Robert A. Anderson, Jr .• Ob/Gyn Research, Rush-Presbyterian-St. Luke's Medical Center, Chicago,IL Kasibhatla Bhavani • Molecular Heptology Laboratory, Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA Theodore J. Cicero • Department of Psychiatry, Washington University School of Medicine, St.
This book deals with the typical equipment, materials, processes, monitoring, and control used in the practical fabrication/production of optical thin films. It focuses on the practical elements needed to actually produce optical coatings.
From fundamental principles to advanced subspecialty procedures, Miller’s Anesthesia covers the full scope of contemporary anesthesia practice. This go-to medical reference book offers masterful guidance on the technical, scientific, and clinical challenges you face each day, in addition to providing the most up-to-date information available for effective board preparation. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Address the unique needs of pediatric patients with guidance from an entire section on pediatric anesthesia. View more than 1,500 full-color illustrations for enhanced visual clarity. Access step-by-step instructions for patient management, as well as an in-depth analysis of ancillary responsibilities and problems. Quickly reference important concepts with ‘Key Points’ boxes integrated into every chapter. Stay current on today's most recent anesthetic drugs and guidelines/protocols for anesthetic practice and patient safety, and access expanded coverage on new techniques such as TEE and other monitoring procedures. Take advantage of the unique, international perspectives of prominent anesthesiologists from all over the world, including the UK, Australia, India, Brazil, and Germany. Remain at the forefront of new developments in anesthesia with coverage of hot topics including Non-OR Anesthesia; Role of the Anesthesiologist in Disasters; Sleep Medicine in Anesthesia; Perioperative and Anesthesia-related Neurotoxicity; Anesthetic Implications of Complementary and Alternative Medicine; and Robotics. Study brand-new chapters on Perioperative Fluid Management; Extracorporeal Support Therapies; Anesthesia for Organ Donation/Procurement; and Malignant Hyperthermia and other Genetic Disorders.
From fundamental principles to advanced subspecialty procedures, Miller’s Anesthesia covers the full scope of contemporary anesthesia practice. It is the go-to reference for masterful guidance on the technical, scientific, and clinical challenges you face. Now new chapters, new authors, meticulous updates, an increased international presence, and a new full-color design ensure that the 7th edition continues the tradition of excellence that you depend on. Covers the full scope of contemporary anesthesia practice. Offers step-by-step instructions for patient management and an in-depth analysis of ancillary responsibilities and problems. Incorporates ‘Key Points’ boxes in every chapter that highlight important concepts. Extends the breadth of international coverage with contributions from prominent anesthesiologists from all over the world, including China, India, and Sweden. Features 30 new authors and 13 new chapters such as Sleep, Memory and Consciousness; Perioperative Cognitive Dysfunction; Ultrasound Guidance for Regional Anesthesia; Anesthesia for Correction of Cardiac Arrhythmias; Anesthesia for Bariatric Surgery; Prehospital Emergency and Trauma Care; Critical Care Protocols; Neurocritical Care; and Renal Replacement Therapy. Dedicates an entire section to pediatric anesthesia, to help you address the unique needs of pediatric patients. Presents a new full-color design -- complete with more than 1,500 full-color illustrations -- for enhanced visual guidance.
This is a concise textbook on abnormal psychology that integrates various theoretical models, sociocultural factors, research, clinical experiences, and therapies. The author encourages critical thinking about the science and study of mental disorders and also reveals the humanity behind them.
Taphonomy: A Process Approach is the first book to review the entire field of taphonomy, or the science of fossil preservation. It describes the formation of animal and plant fossils in marine and terrestrial settings and how this affects deciphering the ecology and extinction of past lifeforms and the environments in which they lived. The volume emphasises a process approach to taphonomy and reviews the taphonomic behaviour of all important taxa, plant and animal. It will be useful to anyone interested in the preservation of fossils and the formation of fossil assemblages, but it is aimed primarily at advanced students and professionals working in paleontology, stratigraphy, sedimentology, climate modeling and biogeochemistry.
Representing the latest data from active research groups, The Neurobiology of Cocaine is designed to educate students and inform experts in a rapidly changing field. This volume presents current research regarding the mechanisms of cocaine's action in the brain. Recent developments of cellular, molecular, and brain imaging methods provide new evidence that chemical and molecular substrates underlie cocaine reinforcement, dependence, and withdrawal. This book explores the biological bases of such effects, describing the brain circuits affected by cocaine, neuroendocrine and neurophysiological actions of cocaine, neurochemistry and pharmacology of cocaine, and cocaine effects on signal transduction, gene expression, and protein phosphorylation. This up-to-date text also describes the recently cloned class of neurotransporters affected by cocaine and characterizes their interaction with the drug. These reports focus on the effects of chronic exposure and subsequent withdrawal, which are differentiated from acute cocaine actions. Thus, they provide information on brain mechanisms likely active during long-term use and abuse in humans. Such commonalities are illustrated by a discussion of cocaine action in the human brain as visualized by positron emission tomography. This volume is a must for anyone interested in the mechanisms underlying cocaine abuse.
Addressing the history of the earth in terms of geological process and the resolution of the fossil record, Martin presents a lucid report on the current state of knowledge of a group of interconnected themes--process, scale and hierarchy, and methodologies of historical sciences.
This book systematically addresses all the major available direct and enabling technologies which have contributed to the revolutionized research and development, thus improvements to existing vaccines. Its target audience is both research and development workers in the field, as well as health-care personnel who use vaccines. It should serve as an
This volume is based in part upon the proceedings of the Calcium Theme held during the 67th Annual Meeting of the Federation of American Societies for Experimental Biology, which took place in Chicago, AprillO-lS, 1983. The American Society for Pharmacology and Experimental Therapeutics had the primary responsibility for organizing the scientific program with the assistance of other member societies, including the American Physiology Society, American Association of Pathologists, and American Institute of Nutrition. The purpose of the Calcium Theme was to review progress in the diverse areas of investigation bearing on the ubiquitous role of calcium in biological systems. In addition to contributions from those participating in the Theme, this volume also includes a number of invited papers that were added to fill certain voids in topics covered. The authors were selected because they are investigators active in the mainstream of their particular research area, possessing the acumen to analyze cogently not only their own recent findings but also to relate these findings to their respective area. New information as well as reviews of current concepts generally highlight the individual contributions. Undoubtedly, some readers may argue with the emphasis made and/or the conclusions reached on individual topics. In such cases, other volumes will hopefully provide a forum for alternative points of view. Due to the broad scope of subjects covered and the large number of contributions, the papers have been arranged in three sections.
This issue of the Cardiology Clinics entitled "Pulmonary Hypertension" is an in-depth review on the subject edited by Dr. Ronald J. Oudiz. The topics covered will include: classification of pulmonary hypertension, epidemiology and pathophysiology, diagnosis, and management in Groups I-V. There are also sections devoted to issues faced in pediatrics and pregnancy, as well as a section on patient support, among other topics.
Coupled with its sequel, this book gives a connected, unified exposition of Approximation Theory for functions of one real variable. It describes spaces of functions such as Sobolev, Lipschitz, Besov rearrangement-invariant function spaces and interpolation of operators. Other topics include Weierstrauss and best approximation theorems, properties of polynomials and splines. It contains history and proofs with an emphasis on principal results.
Handbook of Mass Spectra of Environmental Contaminants, Second Edition is a collection of the electron impact mass spectra of 533 commonly encountered environmental pollutants. The compounds were selected from an analysis of several U.S. Environmental Protection Agency and World Health Organization databases. All data have been reviewed by a panel of experienced mass spectrometrists. To help identify unknown compounds, all spectra have been indexed by common chemical name, CAS registry number, exact molecular weight, and intense peaks. Completely revised and expanded, the Handbook of Mass Spectra of Environmental Contaminants, Second Edition, provides information essential to environmental laboratory specialists world-wide. This handbook is a collection of the electron impact mass spectra of 533 commonly encountered environmental pollutants, selected from U.S. Environmental Protection Agency and World Health Organization databases.
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