Ronald Korthuis's Books

Cell Survival Programs and Ischemia/Reperfusion

Hormesis, Preconditioning, and Cardioprotection

By: Maike Krenz,Christopher Baines,Theodore Kalogeris,Ronald Korthuis

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Cell Survival Programs and Ischemia/Reperfusion

Hormesis, Preconditioning, and Cardioprotection

By: Maike Krenz,Christopher Baines,Theodore Kalogeris,Ronald Korthuis

The major purpose of this book is to review the evidence supporting the concept that intrinsic cell survival programs can be activated by a variety of mildly noxious stimuli or pharmacologic agents to confer protection against the deleterious effects of ischemia/reperfusion (I/R). We begin with a discussion of the concept of hormesis (a term used most extensively in the toxicologic literature which refers to biphasic cellular responses that depend on concentration or intensity of a stimulus), review the seminal studies that led to the discovery of the cardioprotective effects of ischemic preconditioning, and outline its therapeutic potential (Chapter 1). This is followed by a summary of our current understanding of the mechanisms of I/R injury (Chapter 2), as this provides several points of intervention in limiting postischemic tissue injury that may be targeted by the adaptive programs invoked by conditioning stimuli. Chapters 3 and 4 focus on the mechanisms underlying ischemic pre-, post-, and remote conditioning, which establishes the mechanistic rationale for development of pharmacologic conditioning strategies that may mimic the remarkably powerful effects of ischemic conditioning (and are covered in Chapter 5). Lifestyle interventions, including exercise, caloric restriction, and consumption of alcoholic beverages and/or phytochemicals, that may induce hormetic responses will also be reviewed in this chapter. While the promise for conditioning as a therapeutic approach is enormous, there are obstacles to its practical application in patients, which are covered in Chapter 6. The final chapter (Chapter 7) examines the extension of our mechanistic understanding of the signaling pathways invoked by conditioning stimuli into the realm of gene therapy and to the preservation of stem cell viability in the harsh ischemic environment as natural translational outgrowths of preconditioning into therapeutics.

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132

Publisher

Biota Publishing

Published Date

ISBN 10

1615045856

ISBN 13

9781615045853

Skeletal Muscle Circulation

By: Ronald Korthuis

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Skeletal Muscle Circulation

By: Ronald Korthuis

The aim of this treatise is to summarize the current understanding of the mechanisms for blood flow control to skeletal muscle under resting conditions, how perfusion is elevated (exercise hyperemia) to meet the increased demand for oxygen and other substrates during exercise, mechanisms underlying the beneficial effects of regular physical activity on cardiovascular health, the regulation of transcapillary fluid filtration and protein flux across the microvascular exchange vessels, and the role of changes in the skeletal muscle circulation in pathologic states. Skeletal muscle is unique among organs in that its blood flow can change over a remarkably large range. Compared to blood flow at rest, muscle blood flow can increase by more than 20-fold on average during intense exercise, while perfusion of certain individual white muscles or portions of those muscles can increase by as much as 80-fold. This is compared to maximal increases of 4- to 6-fold in the coronary circulation during exercise. These increases in muscle perfusion are required to meet the enormous demands for oxygen and nutrients by the active muscles. Because of its large mass and the fact that skeletal muscles receive 25% of the cardiac output at rest, sympathetically mediated vasoconstriction in vessels supplying this tissue allows central hemodynamic variables (e.g., blood pressure) to be spared during stresses such as hypovolemic shock. Sympathetic vasoconstriction in skeletal muscle in such pathologic conditions also effectively shunts blood flow away from muscles to tissues that are more sensitive to reductions in their blood supply that might otherwise occur. Again, because of its large mass and percentage of cardiac output directed to skeletal muscle, alterations in blood vessel structure and function with chronic disease (e.g., hypertension) contribute significantly to the pathology of such disorders. Alterations in skeletal muscle vascular resistance and/or in the exchange properties of this vascular bed also modify transcapillary fluid filtration and solute movement across the microvascular barrier to influence muscle function and contribute to disease pathology. Finally, it is clear that exercise training induces an adaptive transformation to a protected phenotype in the vasculature supplying skeletal muscle and other tissues to promote overall cardiovascular health. Table of Contents: Introduction / Anatomy of Skeletal Muscle and Its Vascular Supply / Regulation of Vascular Tone in Skeletal Muscle / Exercise Hyperemia and Regulation of Tissue Oxygenation During Muscular Activity / Microvascular Fluid and Solute Exchange in Skeletal Muscle / Skeletal Muscle Circulation in Aging and Disease States: Protective Effects of Exercise / References

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146

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Biota Publishing

Published Date

ISBN 10

1615041842

ISBN 13

9781615041848

Capillary Fluid Exchange

Regulation, Functions, and Pathology

By: Joshua Scallan,Virginia Heathorn Huxley,Ronald J. Korthuis

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Capillary Fluid Exchange

Regulation, Functions, and Pathology

By: Joshua Scallan,Virginia Heathorn Huxley,Ronald J. Korthuis

The partition of fluid between the vascular and interstitial compartments is regulated by forces (hydrostatic and oncotic) operating across the microvascular walls and the surface areas of permeable structures comprising the endothelial barrier to fluid and solute exchange, as well as within the extracellular matrix and lymphatics. In addition to its role in the regulation of vascular volume, transcapillary fluid filtration also allows for continuous turnover of water bathing tissue cells, providing the medium for diffusional flux of oxygen and nutrients required for cellular metabolism and removal of metabolic byproducts. Transendothelial volume flow has also been shown to influence vascular smooth muscle tone in arterioles, hydraulic conductivity in capillaries, and neutrophil transmigration across postcapillary venules, while the flow of this filtrate through the interstitial spaces functions to modify the activities of parenchymal, resident tissue, and metastasizing tumor cells. Likewise, the flow of lymph, which is driven by capillary filtration, is important for the transport of immune and tumor cells, antigen delivery to lymph nodes, and for return of filtered fluid and extravasated proteins to the blood. Given this background, the aims of this treatise are to summarize our current understanding of the factors involved in the regulation of transcapillary fluid movement, how fluid movements across the endothelial barrier and through the interstitium and lymphatic vessels influence cell function and behavior, and the pathophysiology of edema formation. Table of Contents: Fluid Movement Across the Endothelial Barrier / The Interstitium / The Lymphatic Vasculature / Pathophysiology of Edema Formation

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Morgan & Claypool Publishers

Published Date

ISBN 10

1615040668

ISBN 13

9781615040667

Chemical-Mechanical Polishing of Low Dielectric Constant Polymers and Organosilicate Glasses

Fundamental Mechanisms and Application to IC Interconnect Technology

By: Christopher Lyle Borst,William N. Gill,Ronald J. Gutmann

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Chemical-Mechanical Polishing of Low Dielectric Constant Polymers and Organosilicate Glasses

Fundamental Mechanisms and Application to IC Interconnect Technology

By: Christopher Lyle Borst,William N. Gill,Ronald J. Gutmann

As semiconductor manufacturers implement copper conductors in advanced interconnect schemes, research and development efforts shift toward the selection of an insulator that can take maximum advantage of the lower power and faster signal propagation allowed by copper interconnects. One of the main challenges to integrating a low-dielectric constant (low-kappa) insulator as a replacement for silicon dioxide is the behavior of such materials during the chemical-mechanical planarization (CMP) process used in Damascene patterning. Low-kappa dielectrics tend to be softer and less chemically reactive than silicon dioxide, providing significant challenges to successful removal and planarization of such materials. The focus of this book is to merge the complex CMP models and mechanisms that have evolved in the past decade with recent experimental results with copper and low-kappa CMP to develop a comprehensive mechanism for low- and high-removal-rate processes. The result is a more in-depth look into the fundamental reaction kinetics that alter, selectively consume, and ultimately planarize a multi-material structure during Damascene patterning.

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235

Publisher

Springer Science & Business Media

Published Date

ISBN 10

1461511658

ISBN 13

9781461511656

Attending

Medicine, Mindfulness, and Humanity

By: Ronald Epstein

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Attending

Medicine, Mindfulness, and Humanity

By: Ronald Epstein

A guide to mindfulness as part of a safe, patient-centered health-care and medical practice describes the author's perspective-changing experiences as a Harvard Medical student at the sides of doctors who practiced in very different ways.

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304

Publisher

Simon and Schuster

Published Date

ISBN 10

1501121715

ISBN 13

9781501121715

Anesthesia E-Book

By: Ronald D. Miller,Lars I. Eriksson,Lee A Fleisher,Jeanine P. Wiener-Kronish,William L. Young

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Anesthesia E-Book

By: Ronald D. Miller,Lars I. Eriksson,Lee A Fleisher,Jeanine P. Wiener-Kronish,William L. Young

From fundamental principles to advanced subspecialty procedures, Miller’s Anesthesia covers the full scope of contemporary anesthesia practice. It is the go-to reference for masterful guidance on the technical, scientific, and clinical challenges you face. Now new chapters, new authors, meticulous updates, an increased international presence, and a new full-color design ensure that the 7th edition continues the tradition of excellence that you depend on. Covers the full scope of contemporary anesthesia practice. Offers step-by-step instructions for patient management and an in-depth analysis of ancillary responsibilities and problems. Incorporates ‘Key Points’ boxes in every chapter that highlight important concepts. Extends the breadth of international coverage with contributions from prominent anesthesiologists from all over the world, including China, India, and Sweden. Features 30 new authors and 13 new chapters such as Sleep, Memory and Consciousness; Perioperative Cognitive Dysfunction; Ultrasound Guidance for Regional Anesthesia; Anesthesia for Correction of Cardiac Arrhythmias; Anesthesia for Bariatric Surgery; Prehospital Emergency and Trauma Care; Critical Care Protocols; Neurocritical Care; and Renal Replacement Therapy. Dedicates an entire section to pediatric anesthesia, to help you address the unique needs of pediatric patients. Presents a new full-color design -- complete with more than 1,500 full-color illustrations -- for enhanced visual guidance.

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3220

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

1437720617

ISBN 13

9781437720617

Cell Survival Programs and Ischemia/Reperfusion

Hormesis, Preconditioning, and Cardioprotection

By: Maike Krenz,Christopher Baines,Theodore Kalogeris,Ronald Korthuis

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Cell Survival Programs and Ischemia/Reperfusion

Hormesis, Preconditioning, and Cardioprotection

By: Maike Krenz,Christopher Baines,Theodore Kalogeris,Ronald Korthuis

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Page Count

132

Publisher

Biota Publishing

Published Date

ISBN 10

1615045856

ISBN 13

9781615045853

Skeletal Muscle Circulation

By: Ronald Korthuis

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Skeletal Muscle Circulation

By: Ronald Korthuis

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Solve jigsaw puzzle

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146

Publisher

Biota Publishing

Published Date

ISBN 10

1615041842

ISBN 13

9781615041848

Capillary Fluid Exchange

Regulation, Functions, and Pathology

By: Joshua Scallan,Virginia Heathorn Huxley,Ronald J. Korthuis

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Capillary Fluid Exchange

Regulation, Functions, and Pathology

By: Joshua Scallan,Virginia Heathorn Huxley,Ronald J. Korthuis

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Solve jigsaw puzzle

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Publisher

Morgan & Claypool Publishers

Published Date

ISBN 10

1615040668

ISBN 13

9781615040667

Book's by Ronald Korthuis

Cell Survival Programs and Ischemia/Reperfusion

Cell Survival Programs and Ischemia/Reperfusion

Skeletal Muscle Circulation

Skeletal Muscle Circulation

Capillary Fluid Exchange

Capillary Fluid Exchange

Chemical-Mechanical Polishing of Low Dielectric Constant Polymers and Organosilicate Glasses

Chemical-Mechanical Polishing of Low Dielectric Constant Polymers and Organosilicate Glasses

Attending

Attending

Anesthesia E-Book

Anesthesia E-Book

Cell Survival Programs and Ischemia/Reperfusion

Cell Survival Programs and Ischemia/Reperfusion

Skeletal Muscle Circulation

Skeletal Muscle Circulation

Capillary Fluid Exchange

Capillary Fluid Exchange

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