Long respected as a manufacturer of sturdy agricultural machinery, the John Deere Company began in the 1960s to build a line of consumer products in a dedicated factory in Horicon, Wisconsin. Starting with a lawn and garden tractor in 1963, Deere soon entered the fast-growing snowmobile market, introducing two models in 1971. The next 13 years would see a succession of models as Deere vied against tough competitors in a weather-dependent market. This detailed history, written by two key participants in the snowmobile program, describes the development of John Deere snowmobiles from start to finish: the design and engineering decisions that shaped each important model; reception of the snowmobiles by consumers; the factory race teams; the introduction of front-engine and water-cooled models; the process of selecting engines and negotiating with suppliers, including when problems developed; and the snowmobiles' impact on product engineering. The text provides an inside view of Deere's Consumer Products Division at a time of rapid growth, and of the people and processes that made it all happen.
This important publication provides up-to-date reviews using data from human patients and animal models. The goal is to understand the relationship between immunological modification by drugs of abuse and disease resistance. Examined are the major drugs of abuse and their effects on lymphoid cell function, numbers, development, and interactions. Also addressed are reviews of how ethanol, cocaine, morphine, and marijuana effect the immune function. The book includes evaluations of the relationship of immunomodulation by drugs of abuse on resistance to infectious diseases. This is critical to understanding how drugs modulate diseases and cancer development. This invaluable publication is important to those in biochemistry, physiology, chemistry, biology, immunology, cancer, medicine, pharmacology, microbiology, psychology, psychiatry, and additive studies. It is also of value to those in nutrition, pathology, pediatrics, family medicine, gerontology, surgery, sociology, and anatomy. Specialty groups, such as those in tropical medicine and public policy, will have a strong interest in the book. It is also of significant interest to organizations that deal with major numbers of patients using drugs of abuse and with their associated diseases including AIDS.
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