This issue of the Clinics in Laboratory Medicine on “Pharmacogenomics is being edited by Drs. Roland Valdes and Kristen Reynolds and will cover a wide variety of topics, including but not limited to, fundamentals of pharmacology, a review of pharmacogenetics guidelines, pharmacogenetic testing in pain management, pharmacogenetics of pain management, clinical and economic impact of pharmacogenetic genotyping analysis, exosome analysis in lab medicine, and implementation of pharmacogenetics in developing countries.
Applications in Pharmacogenetics are breaching the laboratory medicine and clinical environment. The testing of genetic variations in relation to differing response to drug metabolism and improvement of drug safety is an important and essential area in light of adverse drug reactions. This timely and comprehensive issue of the Clinics presents topics related to Pharmacology and Genetics, Pharmacogenetic Applications in Anticoagulation, Oncology, Pain Management, and Behavioral Disorders, Respiratory Disorders, as well as Education and Healthcare Economics of Pharmacogenetics.
This issue of the Clinics in Laboratory Medicine on “Pharmacogenomics is being edited by Drs. Roland Valdes and Kristen Reynolds and will cover a wide variety of topics, including but not limited to, fundamentals of pharmacology, a review of pharmacogenetics guidelines, pharmacogenetic testing in pain management, pharmacogenetics of pain management, clinical and economic impact of pharmacogenetic genotyping analysis, exosome analysis in lab medicine, and implementation of pharmacogenetics in developing countries.
The social organization of teaching and learning, particularly in classrooms, has not yet been recognized as a foundational element of education. However, social constructionist views of human development, cognition, and schooling, as well as the increasing challenges of cultural and linguistic diversity, make it a vital concern for teachers, researchers, and policymakers. This book introduces the concept of educational social organization, assembles the pertinent theory and evidence, and suggests future directions for training and policy. }The four goals of school reform--academic excellence, fairness, inclusion and harmony--can be achieved simultaneously, by transforming the final common pathway of all school reform--instructional activity. Teaching Transformed is a new vision for classrooms, based on consensus research findings and unified practice prescriptions, explained and justified by new developments in sociocultural theory, and clarified by an explicit five-phase developmental guide for achieving that transformation. Teaching Transformed is both visionary and practical, both theoretical and data-driven, and determined to create effective education for all students. Professional educators, parents, and any reader concerned with saving our schools will find this book necessary to understand our current plight, and to envision a realistic means of transformation.
Blood. Invention. Language. Resistance. World. Five ordinary words that do a great deal of conceptual work in everyday life and literature. In this original experiment in critical semantics, Roland Greene considers how these five words changed over the course of the sixteenth century and what their changes indicate about broader forces in science, politics, and other disciplines. Greene discusses a broad swath of Renaissance and transatlantic literature - including Shakespeare, Cervantes, Camoes, and Milton - in terms of the development of these words rather than works, careers, or histories. He creates a method for describing and understanding the semantic changes that occur, extending his argument to other words that operate in the same manner. Aiming to shift the conversation around Renaissance literature from current approaches to riskier enterprises, Greene also challenges semantic-historicist scholars, proposing a method that takes advantage of digital resources like full-text databases but still depends on the interpreter to fashion ideas out of ordinary language. "Five Words" is an innovative and accessible book that points the field of literary studies in an exciting new direction.--Page [4] of cover.
This book explores the impact of Latin America's political culture on the international politics of the region. It offers a general account of traditional Iberian political culture while examining how relations among states in the hemisphere — where the United States has been the central actor — have evolved over time. The authors assess the degree of consistency between domestic and international political behavior. The assessments are supported by case studies.
Blood. Invention. Language. Resistance. World. Five ordinary words that do a great deal of conceptual work in everyday life and literature. In this original experiment in critical semantics, Roland Greene considers how these words changed over the course of the sixteenth century and what their changes indicate about broader forces in science, politics, and other disciplines. Rather than analyzing works, careers, or histories, Greene discusses a broad swath of Renaissance and transatlantic literature—including Shakespeare, Cervantes, Camões, and Milton—in terms of the development of these five words. Aiming to shift the conversation around Renaissance literature from current approaches to riskier enterprises, Greene also proposes new methods that take advantage of digital resources like full-text databases, but still depend on the interpreter to fashion ideas out of ordinary language. Five Words is an innovative and accessible book that points the field of literary studies in an exciting new direction.
Originally published in 1993, this book provides an excellent analysis of commodity policies internationally during the late 20th Century. It discusses 2 major methods of market regulation: price stabilization – based on buffer stocks or export quotas – and compensatory finance. The authors analyse whether major commodity policies have reached their primary objectives and to what extent they have had economic side effects. Discussion of more general policy issues centres around three international commodity agreements for coffee, rubber and cocoa. The authors also look at the policies adopted by individual nations to regulate commodity trading and assess to what extent they have reached their objectives. A discussion of the intervention of the International Monetary Fund and STABEX assesses the degree of stability they can provide in a highly volatile and variable environment. Nearly 30 years later, volatile world commodity markets are still a major issue in the policy dialogue. Although topics, policy instruments and concepts have changed, this book remains a fundamental contribution to the study of international commodity policy. It will be of great interest to students of commodity policy and economic development and economists in national and international organizations dealing with market stabilization.
Considering the interrelations between sight, touch, and imagination, this book surveys classical, late antique, and medieval theories of vision to elaborate on how various spheres of the Byzantine world categorized and comprehended sensation and perception. Revisiting scholarly assumptions about the tactility of sight in the Byzantine world, it demonstrates how the haptic language associated with vision referred to the cognitive actions of the viewer as they grasped sensory data in the mind in order to comprehend and produce working imaginations of objects for thought and memory. At stake is how the affordances and limitations of the senses came to delineate and cultivate the manner in which art and rhetoric was understood as mediating the realities they wished to convey. This would similarly come to contour how Byzantine religious culture could also go about accessing the sacred, the image serving as a site of desire for the mediated representation of the Divine.
All of us, whatever our individual beliefs, belong to a society shaped by the Christian tradition. It is an extraordinary history. Over the centuries since the death of Christ, his followers have known adversity and defeat as well as glory and power – the victories of Charlemagne, or the Crusades, matched by those of Hun, Moor, or Turk. Christianity has borne persecution and division, each taking its terrible toll martyrs. It has assumed unexpected forms, from fourth-century Arianism to seventeenth-century Quakerism. It has been the cause and the victim of war and holocaust. It has been challenged by the findings of such scientists as Galileo and Darwin and – never more markedly than our own 21st century – by a progressive secularism. Yet in every sphere of Western life and achievement – in our art and literature, our politics and our law, our philosophy – we find the enduring legacy of the Christian experience. Here is a sound, readable guide to Christianity as a whole – its origins, its revolutionary impact on human affairs, its development over twenty-one centuries, its role as a fundamental, powerful force in our world and our lives.
A critical portrait of Christianity follows its beginnings two thousand years ago to today, documenting such areas as the life of Christ, the rise of cathedrals and kings, the political climate of Rome, and the flight of the Puritans to the New World. Reprint.
The present volume deals with specific aspects of neuropathology for forensic and clinical neuropathologists, with particular emphasis on their relevance to everyday practice. Each chapter includes an overview of the literature as well as specific references and features a wealth of figures, graphs, and tables.
To select the most suitable simulation algorithm for a given task is often difficult. This is due to intricate interactions between model features, implementation details, and runtime environment, which may strongly affect the overall performance. An automated selection of simulation algorithms supports users in setting up simulation experiments without demanding expert knowledge on simulation. Roland Ewald analyzes and discusses existing approaches to solve the algorithm selection problem in the context of simulation. He introduces a framework for automatic simulation algorithm selection and describes its integration into the open-source modelling and simulation framework James II. Its selection mechanisms are able to cope with three situations: no prior knowledge is available, the impact of problem features on simulator performance is unknown, and a relationship between problem features and algorithm performance can be established empirically. The author concludes with an experimental evaluation of the developed methods.
The pages of history are filled with stories of men and women burned at the stake, exiled, and ostracized in the name of religion. Thus Roland Bainton explains the struggle within the Christian Church to achieve religious liberty by telling, in popular biographical style, nine stories of sincere people--both persecutors and persecuted--who took part in the struggle. Bainton's biographies begin with Thomas of Torquemada, instrument of the Roman Catholic Inquisition, and with John Calvin who active in the burning of Michael Servetus. He then covers how such persecution brought about the toleration controversy of the sixteenth century, when SŽbastian Castellio struck his blow for religious liberty, when Hollander David Joris made a mystical approach to tolerance, and when Franciscan Bernardino Ochino believed in the cultivation of the inner life. Finally he concentrates on the champions of religious liberty in the 17th Century: John Milton, Roger Williams and John Locke.
In this comprehensive reference and background book, Dr. Roland Holou highlights the lives, visions, achievements, policies, and strategies of exceptional contemporary African Diaspora leaders across the globe. This inspirational collection of biographies motivates, challenges, and encourages current and future generations of people of African descent to take initiative and offers guidance to those interested in Africas development. It enlightens and empowers readers with stories that showcase the diversity, complexity, and richness of the ongoing global African Diaspora engagement efforts. It also presents powerful accounts of experiences, growth, struggle, failure, and success that will provoke interest in the field of Diaspora engagement and inspire readers to stand up and face lifes many challenges. The featured leaders are known for their long-lasting achievements. Their impressive actions both contributed to important historical movements that significantly shaped and transformed the lives and history of people of African descent and removed major roadblocks preventing the prosperity of Africa and its Diaspora. They have brought about enormous and rare progress that would have been impossible without their leadership; their contributions have greatly improved the freedom and economic and political development of Africa and its Diaspora. If you are interested in learning the secrets of these modern leaders who have accomplished outstanding tasks and demonstrated professional excellence and character while performing duties related to Africa and its Diaspora, then this is the book for you. Since influence can have negative effects as well, this book also addresses destructive actions of certain leaders that are pulling down both Africa and its people. To learn more about this book, please visit www.AfricanDiasporaLeaders.com.
Bainton presents the many strands that made up the Reformation in a single, brilliantly coherent account. He discusses the background for Luther's irreparable breach with the Church and its ramifications for 16th Century Europe, giving thorough accounts of the Diet of Worms, the institution of the Holy Commonwealth of Geneva, Henry VIII's break with Rome, and William the Silent's struggle for Dutch independence.
Knowledge of the juxtaglomerular apparatus (JGA) of the kidney and of the synthesis and secretion of renin has increased to such an extent over the past few years that it is now appropriate to summarize this knowledge in a monograph on the JGA, the first of its kind. It was the authors' special concern to demonstrate the association between structure and function for renin secretion, not only within the juxtaglomerular region, but also in the region of the renal cortex beyond the JGA. The description of the pathology of the human JGA, studded with references to experimental findings but nevertheless fully self-contained, should help to make this monograph also useful for clinicians.
Having devoted my life to the study of history, I am prompted in my latter days to ask whether one can make sense of it all." --from the Introduction In this book, Bainton pauses to reflect on the importance of studying history because of what it can teach us about human nature. The study of history, then, is the study of human behavior and therefore it helps us understand ourselves. And with this greater self-understanding comes the further inquiry beyond the human--to God, Christ, and Christian ideals. Readers who think history is as dry as dust have never read Bainton! In this book, Bainton shows that history is not only interesting, it's also important. One can indeed "make sense of it all.
Love poetry dominated European literature during the Renaissance. Its attitudes, conventions, and values appeared not only in courtly settings but also in the transatlantic world, where cultures were being built, power exercised, and policies made. In this major contribution to our understanding of both the Age of Exploration and early modern lyric, Roland Greene argues that love poetry was not simply a reflection of the times but a means of cultural transformation. European encounters with the Americas awakened many forms of desire, which pervaded the writings of explorers like Columbus and his contemporaries. These experiences in turn shaped colonial society in Brazil, Peru, and elsewhere. The New World, while it could be explored, conquered, and exploited, could never really be "known"—leaving Europe's desire continually unrequited and the project of empire unfulfilled. Using numerous poetic examples and extensive historical documentation, Unrequited Conquests rewrites the relations between the Renaissance and colonial Latin America and between poetry and history.
Roland Thaxter Bird, universally and affectionately known to friends and associates as R. T., achieved a kind of Horatio Alger success in the scientific world of dinosaur studies. Forced to drop out of school at a young age by ill health, he was a cowboy who traveled from job to job by motorcycle until he met Barnum Brown, Curator of Vertebrae Paleontology at the American Museum of Natural History in New York and a leader in the study of dinosaurs. Beginning in 1934, Bird spent many years as an employee of the museum and as Brown's right-hand man in the field. His chart of the Howe Quarry in Wyoming, a massive sauropod boneyard, is one of the most complex paleontological charts ever produced and a work of art in its own right. His crowning achievement was the discovery, collection, and interpretation of gigantic Cretaceous dinosaur trackways along the Paluxy River near Glen Rose and at Bandera, Texas. A trackway from Glen Rose is on exhibit at the American Museum and at the Texas Memorial Museum in Austin. His interpretation of these trackways demonstrated that a large carnosaur had pursued and attacked a sauropod, that sauropods migrated in herds, and that, contrary to then-current belief, sauropods were able to support their own weight out of deep water. These behavioral interpretations anticipated later dinosaur studies by at least two decades. From his first meeting with Barnum Brown to his discoveries at Glen Rose and Bandera, this very human account tells the story of Bird's remarkable work on dinosaurs. In a vibrantly descriptive style, Bird recorded both the intensity and excitement of field work and the careful and painstaking detail of laboratory reconstruction. His memoir presents a vivid picture of camp life with Brown and the inner workings of the famous American Museum of Natural History, and it offers a new and humanizing account of Brown himself, one of the giants of his field. Bird's memoir has been supplemented with a clear and concise introduction to the field of dinosaur study and with generous illustrations which delineate the various types of dinosaurs.
This comprehensive text/reference presents an in-depth review of the state of the art of automotive connectivity and cybersecurity with regard to trends, technologies, innovations, and applications. The text describes the challenges of the global automotive market, clearly showing where the multitude of innovative activities fit within the overall effort of cutting-edge automotive innovations, and provides an ideal framework for understanding the complexity of automotive connectivity and cybersecurity. Topics and features: discusses the automotive market, automotive research and development, and automotive electrical/electronic and software technology; examines connected cars and autonomous vehicles, and methodological approaches to cybersecurity to avoid cyber-attacks against vehicles; provides an overview on the automotive industry that introduces the trends driving the automotive industry towards smart mobility and autonomous driving; reviews automotive research and development, offering background on the complexity involved in developing new vehicle models; describes the technologies essential for the evolution of connected cars, such as cyber-physical systems and the Internet of Things; presents case studies on Car2Go and car sharing, car hailing and ridesharing, connected parking, and advanced driver assistance systems; includes review questions and exercises at the end of each chapter. The insights offered by this practical guide will be of great value to graduate students, academic researchers and professionals in industry seeking to learn about the advanced methodologies in automotive connectivity and cybersecurity.
This fundamental book presents the most comprehensive summary of the current state of the art in the chemistry of cage compounds. It introduces different ways of how ions and molecules can be encapsulated by three-dimensional caging ligands to form molecular and polymeric species: covalent, supramolecular, and coordination capsules. The authors introduce their classification, reactivity, and selected practical applications. Because encapsulation can isolate caged ions and molecules from external factors, the encapsulated species can exhibit unique physical and chemical properties. The resulting specific reactivity and selectivity can open up a range of applications, including chemical separation, recognition, chiral separation, catalysis, applications as sensors or probes, as molecular or supramolecular devices, or molecular carriers (cargo).A particularly strong emphasis in this book is on the summary and review of the synthesis of various types of cage compounds. Readers will find over 850 literature references summarized and clearly represented in over 600 schemes and illustrations. The book is structured by the types of caging ligands (covalent, supramolecular, or coordination capsules). The authors further arranged the chapters by ligand classes and types of encapsulated species (neutral molecules, anions, or cations). Readers will hence find an exhaustive reference resource and summary of the current state of research into encapsulated species, nowadays almost a separated realm of modern chemistry.
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