A proposal for a new model of the evolution of gene regulation networks and development that draws on work from artificial intelligence and philosophy of mind. Each of us is a collection of more than ten trillion cells, busy performing tasks crucial to our continued existence. Gene regulation networks, consisting of a subset of genes called transcription factors, control cellular activity, producing the right gene activities for the many situations that the multiplicity of cells in our bodies face. Genes working together make up a truly ingenious system. In this book, Roger Sansom investigates how gene regulation works and how such a refined but simple system evolved. Sansom describes in detail two frameworks for understanding gene regulation. The first, developed by the theoretical biologist Stuart Kauffman, holds that gene regulation networks are fundamentally systems that repeat patterns of gene expression. Sansom finds Kauffman's framework an inadequate explanation for how cells overcome the difficulty of development. Sansom proposes an alternative: the connectionist framework. Drawing on work from artificial intelligence and philosophy of mind, he argues that the key lies in how multiple transcription factors combine to regulate a single gene, acting in a way that is qualitatively consistent. This allows the expression of genes to be finely tuned to the variable microenvironments of cells. Because of the nature of both development and its evolution, we can gain insight into the developmental process when we identify gene regulation networks as the controllers of development. The ingenuity of genes is explained by how gene regulation networks evolve to control development.
In the expanded second edition of Fine Cuts, Roger Crittenden reveals the experiences of the greatest European film editors through his warm and perceptive interviews. This new edition builds on the foundations laid out in 2005, including interviews with the editors of films such as Day for Night, The Sacrifice, The Kid with a Bike, and Fanny and Alexander; new interviews with editors of such films as Tyrannosaur and The Other Side of Hope; and editors from a wider range of countries, including Austria, Belgium, Finland, Portugal, and Russia. The book now embraces all aspects of post-production, with insights into sound editing from Larry Sider, originator of the renowned School of Sound, and music composition from Oscar winner Dario Marianelli (Atonement). Editors relate their experiences with directors including: Claire Atherton [Chantal Akerman] Mick Audsley [Terry Gilliam, Stephen Frears] Yann Dedet [François Truffaut, Claire Denis, Maurice Pialat] Marie-Hélène Dozo [Dardenne Brothers] François Gédigier [Patrice Chéreau, Lars von Trier] Samu Heikkilä [Aki Kaurismäki] Sylvia Ingemarsdotter [Ingmar Bergman] Tony Lawson [Nicolas Roeg, Stanley Kubrick, Neil Jordan] Michal Leszczylowski [Andrei Tarkovsky, Lukas Moodysson] Roberto Perpignani [Orson Welles, Bernardo Bertolucci, Tavianni Brothers] Mary Stephen [Éric Rohmer] Each interview also includes a list of cited and notable films for further study. An online eResource contains additional interviews with editors Sabine Mamou, Agnès Guillemot, and Nino Baragli.
In The Japanese Mind, Roger Davies offers Westerners an invaluable key to the unique aspects of Japanese culture. Readers of this book will gain a clear understanding of what makes the Japanese, and their society, tick. Among the topics explored: aimai (ambiguity), amae (dependence upon others' benevolence), amakudari (the nation's descent from heaven), chinmoku (silence in communication), gambari (perseverance), giri (social obligation), haragei (literally, "belly art"; implicit, unspoken communication), kenkyo (the appearance of modesty), sempai-kohai (seniority), wabi-sabi (simplicity and elegance), and zoto (gift giving), as well as discussions of child-rearing, personal space, and the roles of women in Japanese society. It includes discussion topics and questions after each chapter. All in all, this book is an easy-to-use introduction to the distinguishing characteristics of Japanese society; an invaluable resource for anyone--business people, travelers, or students--perfect for course adoption, but also for anyone interested in Japanese culture. Next in this series: Now available separately, Japanese Culture: The Religious and Philosophical Foundations is a fascinating journey through Japan's rich cultural history.
This three-volume work presents a compendium of current and seminal papers on parallel/distributed processing offered at the 22nd International Conference on Parallel Processing, held August 16-20, 1993 in Chicago, Illinois. Topics include processor architectures; mapping algorithms to parallel systems, performance evaluations; fault diagnosis, recovery, and tolerance; cube networks; portable software; synchronization; compilers; hypercube computing; and image processing and graphics. Computer professionals in parallel processing, distributed systems, and software engineering will find this book essential to their complete computer reference library.
A bibliography of poetry composed in what is now the United States of America and printed in the form of books or pamphlets before 1821"--Provided by publisher.
From the earliest scratches on stone and bone to the languages of computers and the internet, A History of Writing offers an investigation into the origin and development of writing throughout the world. Illustrated with numerous examples, this book offers a global overview in a format that everyone can follow. Steven Roger Fischer also reveals his own discoveries made since the early 1980s, making it a useful reference for students and specialists as well as a delightful read for lovers of the written word everywhere.
Architectural historian Moss and photographer Crane set out to celebrate the surviving historic architecture of Philadelphia. This lavishly illustrated book celebrates Philadelphia's evolution from a modest mercantile outpost of a colonial power to a world-renowned cosmopolitan city.
Japanese Culture: The Religious and Philosophical Foundations takes readers on a thoroughly researched and extremely readable journey through Japan's cultural history. This much-anticipated sequel to Roger Davies's best-selling The Japanese Mind provides a comprehensive overview of the religion and philosophy of Japan. This cultural history of Japan explains the diverse cultural traditions that underlie modern Japan and offers readers deep insights into Japanese manners and etiquette. Davies begins with an investigation of the origins of the Japanese, followed by an analysis of the most important approaches used by scholars to describe the essential elements of Japanese culture. From there, each chapter focuses on one of the formative elements: Shintoism, Buddhism, Taoism, Zen, Confucianism, and Western influences in the modern era. Each chapter is concluded with extensive endnotes along with thought-provoking discussion activities, making this volume ideal for individual readers and for classroom instruction. Anyone interested in pursuing a deeper understanding of this complex and fascinating nation will find Davies's work an invaluable resource.
In 1797 the bloodiest mutiny ever suffered by the Royal Navy took place on the British frigate HMS Hermione off the coast of Puerto Rico. Jonathan Robbins, a reputed American sailor who had been impressed into service, made his way to American shores. President John Adams bowed to Britain’s request for his extradition. Convicted of murder and piracy by a court-martial in Jamaica, Robbins was hanged. Adams’s catastrophic miscalculation ignited a political firestorm, only to be fanned by Robbins’s failure to receive his constitutional rights of due process and trial by jury by an American court. American Sanctuary brilliantly lays out in riveting detail the story of how the Robbins affair, amid the turbulent presidential campaign of 1800, inflamed the new nation and set in motion a constitutional crisis, resulting in Adams’s defeat and Thomas Jefferson’s election as the third president of the United States. Robbins’s martyrdom led directly to the country’s historic decision to grant political asylum to foreign refugees—a major achievement in fulfilling the promise of American independence.
‘If poems were gifts, and in many ways they are, children will find plenty to absorb and amuse them in this bulging stocking of an anthology.’ Roger McGough From traditional verses by Christina Rossetti and William Blake to modern classics by Julia Donaldson and Benjamin Zephaniah, this heart-warming Christmas anthology will delight children and adults of all ages. All the wonders of the season are captured in 100 Best Christmas Poems for Children. Perfect for reading aloud with all the family or for children aged 8-12 to read to themselves, there are verses that will encourage you to reflect on the Christmas themes of joy, hope and peace for all the world, while also savouring the festive fun of everything else that Christmas brings – from the opening of the first Advent window to the tidying away of all the decorations on Twelfth Night. Edited and introduced by beloved poet Roger McGough, this enchanting children’s poetry book make a wonderful gift and keepsake and will be cherished by all who read it. Children will gain an appreciation for language and storytelling as the magic of Christmas is brought to life by this anthology that they’ll return to over and over again each year.
Roger Crittenden reveals the experiences of many of the greatest living European film editors through his warm and perceptive interviews which offer a unique insight into the art of editing - direct from masters of the craft. In their interviews the editors relate their experience to the directors they have worked with, including: Agnes Guillemot- (Godard, Truffaut, Catherine Breillat) Roberto Perpignani- (Welles, Bertolucci, Tavianni Brothers) Sylvia Ingemarsson- (Ingmar Bergman) Michal Leszczylowski- (Andrei Tarkovsky, Lukas Moodysson) Tony Lawson (Nic Roeg, Stanley Kubrick, Neil Jordan) and many more. Foreword by Walter Murch - three-time Oscar-winning Editor of 'Apocalypse Now', 'The English Patient', 'American Graffiti', 'The Conversation' and 'The Godfather Part II and III'.
How does snow form? Why are we always depressed after Christmas? How does Santa manage to deliver all those presents in one night? (He has, in fact, little over two ten-thousandths of a second to get between each of the 842 million households he must visit.) This book contains information on how drugs might make us see flying reindeer, how pollution is affecting the shape of Christmas trees, and the intriguing correlation between the length of our Christmas card list and brain size.
On the eve of its centennial, Carol Dawson and Roger Allen Polson present almost 100 years of history and never-before-seen photographs that track the development of the Texas Highway Department. An agency originally created “to get the farmer out of the mud,” it has gone on to build the vast network of roads that now connects every corner of the state. When the Texas Highway Department (now called the Texas Department of Transportation or TxDOT) was created in 1917, there were only about 200,000 cars in Texas traveling on fewer than a thousand miles of paved roads. Today, after 100 years of the Texas Highway Department, the state boasts over 80,000 miles of paved, state-maintained roads that accommodate more than 25 million vehicles. Sure to interest history enthusiasts and casual readers alike, decades of progress and turmoil, development and disaster, and politics and corruption come together once more in these pages, which tell the remarkable story of an infrastructure 100 years in the making.
Synoptic and Dynamic Climatology provides the first comprehensive account of the dynamical behaviour and mechanisms of the global climate system and its components, together with a modern survey of synoptic-scale weather systems in the tropics and extratropics, and of the methods and applications of synoptic climate classification. It is unrivalled in the scope and detail of its contents. The work is thoroughly up to date, with extensive bibliographies by chapter. It is illustrated with nearly 300 figures and plates. *Part 1 provides an introduction to the global climate system and the space-time scales of weather and climate processes, followed by a chapter on climate data and their analysis *Part 2 describes and explains the characteristics of the general circulation of the global atmosphere and includes the nature and causes of global teleconnection patterns *Part 3 discusses synoptic weather systems in the extratropics and tropics and satellite-based climatologies of synoptic features. It also describes the applications of synoptic climatology and summarises current climatic research and its directions.
Routledge English Language Introductions cover core areas of language study and are one-stop resources for students. Assuming no prior knowledge, books in the series offer an accessible overview of the subject, with activities, study questions, sample analyses, commentaries and key readings - all in the same volume. The innovative and flexible 'two-dimensional' structure is built around four sections - introduction, development, exploration and extension - which offer self-contained stages for study. Each topic can also be read across these sections, enabling the reader to build gradually on the knowledge gained. English Grammar: presents the basic concepts and key terms of English grammar in a clear and systematic way encourages readers to evaluate critically the knowledge they already have, particularly in areas that are problematic for them as learners, and to build up and trust their own intuitions about the language uses a range of international authentic texts to illustrate concepts and theories, from sources such as newspapers, novels and academic texts discussing English grammar is accompanied by a companion website featuring audio files of authentic spoken English, and further activities. Written by an experienced teacher and researcher, this accessible textbook is an essential resource for all students of English language and linguistics.
In this lively and stimulating study, Roger Magraw examines how the 19th-century French bourgeoisie struggled and eventually succeeded in consolidating the gains it made in 1789. The book describes the attempts of the bourgeoisie to remold France in its own image and its strategy for overcoming the resistance from the old aristocratic and clerical elites and the popular classes. Incorporating the most recent research on religion and anticlericalism, the development of the economy, the role of women in society, and the educational system, this work is the first to draw extensively on the new social history in its interpretation of events in 19th-century France.
Len Lye: A Biography tells for the first time the story of a unique, charismatic artist who was an innovator in many areas&– film, kinetic sculpture, painting, photography and poetry. Born in New Zealand in 1901, Len Lye gained an international reputation in the arts and had friendships with many famous people&– including Dylan Thomas, Robert Graves, Gertrude Stein, John Grierson, Norman McLaren, Oskar Fischinger, John Cage, Robert Creeley, Laura Riding, Stan Brakhage, and the artists of the New York School. A colorful bohemian, Lye lived in London from 1926 to 1944 (where he made highly original hand-painted films for John Grierson's GPO Film Unit), then moved to New York for the last 36 years of his life. Describing Len Lye as a "trailblazer" and a "one-man modern art movement" in Sight & Sound, Ian Francis also celebrated this superb biography as "the definitive piece of Lye scholarship.
A History of World Societies introduces students to the global past through social history and the stories and voices of the people who lived it. Now published by Bedford/St. Martin's, and informed by the latest scholarship, the book has been thoroughly revised with students in mind to meet the needs of the evolving course. Proven to work in the classroom, the book’s regional and comparative approach helps students understand the connections of global history while providing a manageable organization. With more global connections and comparisons, more documents, special features and activities that teach historical analysis, and an entirely new look, the ninth edition is the most teachable and accessible edition yet. Test drive a chapter today. Find out how.
A History of World Societies introduces students to the global past through social history and the stories and voices of the people who lived it. The book’s regional and comparative approach helps students understand the connections of global history while providing a manageable organization. With global connections and comparisons, documents, features and activities that teach historical analysis.
Why might Rudolph's nose have been red? Why do we actually give Christmas gifts? Why has smell become an important component in the Christmas shopping experience? Roger Highfield, science editor of London's Daily Telegraph and co-author of the highly acclaimed The Arrow of Time, has taken a long-overdue look at our most cherished holiday from the rigorous (but highly entertaining) viewpoint of a scientist. What are the thermodynamics involved in cooking a turkey? What are the likely celestial candidates for the Star of Bethlehem? Is the concept of a virgin birth scientifically feasible? What happens to us physically when we overindulge in alcohol? How does snow form? Why are we always depressed after Christmas? How does Santa manage to deliver all those presents in one night? (He has, in fact, little over two ten- thousands of a second to get between each of the 842 million households he must visit.) The Physics of Christmas is that rare science book that manages to be as delightful as it is informative.
First introduced to biomedical research in 1980, the term biomarker has taken on a life of its own in recent years and has come to mean a number of things. In biomedical science, biomarker has evolved to most commonly mean a characteristic that can be used either as a diagnostic or a prognostic, but most significantly as a screening indicator for p
Over 30,000 Japanese children are in the care of the state. This study describes what happens to them in a country that has no professional social workers and little tradition of adopting or fostering children in need of care.
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