Biology of Aging, Second Edition presents the biological principles that have led to a new understanding of the causes of aging and describes how these basic principles help one to understand the human experience of biological aging, longevity, and age-related disease. Intended for undergraduate biology students, it describes how the rate of biological aging is measured; explores the mechanisms underlying cellular aging; discusses the genetic pathways that affect longevity in various organisms; outlines the normal age-related changes and the functional decline that occurs in physiological systems over the lifespan; and considers the implications of modulating the rate of aging and longevity. The book also includes end-of-chapter discussion questions to help students assess their knowledge of the material. Roger McDonald received his Ph.D. from the University of Southern California and is Professor Emeritus in the Department of Nutrition at the University of California, Davis. Dr. McDonald’s research focused on mechanisms of cellular aging and the interaction between nutrition and aging. His research addressed two key topics in the field: the relationship between dietary restriction and lifespan, and the effect of aging on circadian rhythms and hypothalamic regulation. You can contact Dr. McDonald at rbmcdonald@ucdavis.edu. Related Titles Ahmad, S. I., ed. Aging: Exploring a Complex Phenomenon (ISBN 978-1-1381-9697-1) Moody, H. R. & J. Sasser. Gerontology: The Basics (ISBN 978-1-1387-7582-4) Timiras, P. S. Physiological Basis of Aging and Geriatrics (ISBN 978-0-8493-7305-3)
Remarkable.… Ekirch has emptied night's pockets, and laid the contents out before us." —Arthur Krystal, The New Yorker Bringing light to the shadows of history through a "rich weave of citation and archival evidence" (Publishers Weekly), scholar A. Roger Ekirch illuminates the aspects of life most often overlooked by other historians—those that unfold at night. In this "triumph of social history" (Mail on Sunday), Ekirch's "enthralling anthropology" (Harper's) exposes the nightlife that spawned a distinct culture and a refuge from daily life. Fear of crime, of fire, and of the supernatural; the importance of moonlight; the increased incidence of sickness and death at night; evening gatherings to spin wool and stories; masqued balls; inns, taverns, and brothels; the strategies of thieves, assassins, and conspirators; the protective uses of incantations, meditations, and prayers; the nature of our predecessors' sleep and dreams—Ekirch reveals all these and more in his "monumental study" (The Nation) of sociocultural history, "maintaining throughout an infectious sense of wonder" (Booklist).
Facing the possibility of being drafted and sent to Vietnam, Roger Durham secured a deferment when he enrolled in college. Devoting more time to anti-war protests than to studies, he became immersed in the late 1960s counterculture, flunked out and was drafted anyway. Deployed to Vietnam with the U.S. Army's 18th Engineer Brigade Headquarters, he was assigned to a helicopter base "behind the wire," far from the action. Or so he thought--the action came to him as the base drew mortar, rocket and sapper attacks. Durham's clear-eyed memoir relates an often untold experience of the Vietnam War--that of the counterculture soldier whose opposition to war did not end when he was inducted. Adjusting to life in-country, he finds a thriving drug culture and a brotherhood of like-minded warriors, who resist both the enemy and the culture of zealous militarism that prosecutes what they see as an immoral war, against American national interests. Durham undergoes changes in perspective, extending his tour of duty when the thought of going home fills him with anxiety and anticipation.
Most towns did not have hospitals of their own before the mid-twentieth century, and Kentucky towns were no exception. KentuckyÕs first real hospital opened in 1823, but it was in LouisvilleÑtoo far away to serve many Kentucky communities, especially in cases of emergency. For this and other reasons, the lifespan of the average Kentuckian in the 1800s was only 40 years. Today it has grown to 75, and trained medical professionals are available to most communities throughout the state. Healing Kentucky tells how medical care changed in Kentucky over 200 years and became the much safer and better system we know today. It also describes early healing practices and methods used to care for the sick in the days before safe hospitals, even on Civil War battlefields. From cholera epidemics to polio and plastic surgery, readers will learn much about the people who shaped medicine in Kentucky.
This edition of the economic history classic One Kind of Freedom reprints the entire text of the first edition together with an introduction by the authors and an extensive bibliography of works in Southern history published since the appearance of the first edition. The book examines the economic institutions that replaced slavery and the conditions under which ex-slaves were allowed to enter the economic life of the United States following the Civil War. The authors contend that although the kind of freedom permitted to black Americans allowed substantial increases in their economic welfare, it effectively curtailed further black advancement and retarded Southern economic development. Quantitative data are used to describe the historical setting but also shape the authors' economic analysis and test the appropriateness of their interpretations. Ransom and Sutch's revised findings enrich the picture of the era and offer directions for future research.
Overgrowth Syndromes is a comprehensive clinical guide to the well-defined genetic disorders (and others that are less well-defined) for which somatic overgrowth is a major manifestation. It details the unique characteristics and known causative genes for this class of disorders, offering clinicians an expert resource for both clinical diagnosis and laboratory confirmation. Assembled by the world's leading experts on overgrowth, this volume maximizes clinical utility without sacrificing nuance or rigor. It codifies the last decade's sweeping advances in understanding general and segmental overgrowth, including the latter's mosaic nature and phenotypic variability. It is an essential resource for clinicians navigating this set of conditions from clinical presentation all the way to counseling and anticipatory management.
Contemporary Social Theory helps students explore, describe, and discuss how social theory relates to their own experiences, popular culture, and the world in which they live. It advances the view that new theory can be effectively used to assess social and cultural phenomena. The text identifies the important intellectual movements, categories, and paradigms that have occurred in the study of social theory. It also looks at issues closely related to contemporary social theory, such as: the postmodern condition, globalization, postcolonialism, inequality, gender, race, and human sexuality.
Perhaps no topic is more heated, and the sources more tendentious, than that of Civil War prisons and the treatment of prisoners of war (POWs). Partisans of each side, then and now, have vilified the other for maltreatment of their POWs, while seeking to excuse their own distressing record of prisoner of war camp mismanagement, brutality, and incompetence. It is only recently that historians have turned their attention to this contentious topic in an attempt to sort the wheat of truth from the chaff of partisan rancor. Roger Pickenpaugh has previously studied a Union prison camp in careful detail (Camp Chase) and now turns his attention to the Union record in its entirety, to investigate variations between camps and overall prison policy and to determine as nearly as possible what actually happened in the admittedly over-crowded, under-supplied, and poorly-administered camps. He also attempts to determine what conditions resulted from conscious government policy or were the product of local officials and situations. A companion to Pickenpaugh's Captives in Blue.
Roger A. Bruns's immensely entertaining biography, now available in paperback, throws a spotlight on a colorful, influential, but long-obscured Chicago character. This is the true story of Ben Reitman, ally of hobos, personal physician to scores of Al Capone's prostitutes, author, womanizer, founder of Chicago's Hobo College, and longtime lover of Emma Goldman.
The use of the chemical modification of proteins has evolved over the past 80 years, benefiting from advances in analytical, physical, and organic chemistry. Over the past 30 years, the use of chemical reagents to modify proteins has been crucial in determining the function and structure of purified proteins. This groundbreaking work is part of the
Dip into this illustrated account of key inventions and discoveries, listed year by year, with intriguing facts about each invention and the person (or people) who invented it. From the prehistoric hunting tools our early ancestors used to the modern-day smartphones that connect the entire planet, this book provides a fascinating tour through the history of humankind's inventions and discoveries. Fully revised and updated for 2020, 1,000 Inventions and Discoveries explores recent inventions and discoveries - from the Amazon Echo to the first photograph of a black hole - as well as showcasing revolutionary historical inventions such as the wheel. Whether you're a budding inventor, a history buff, or both, this amazing guide is packed with the inventions and discoveries in science, technology, transport, medicine, and mathematics that changed the course of human existence.
This final book in the series focuses on the atheistic or humanistic type of religions. It would be one of the most valuable for the church in the Western World where anti-god and pro-evolution religions are beginning to explode, for it was written to refute those religions and show how they fail. Unlike most books on world religions, this title dives into the secular humanistic religions. The book starts with God’s Word as the absolute authority. In doing so, God becomes our guide to refute false religions. Humanistic religions are all around us and we need to be able to spot their tenets and oppose them instead of allowing them to subtly infiltrate our Christianity and undermine us from within We need to know how to refute these humanistic religions We need to know how to effectively present the gospel to people who have been deceived by humanistic religions
Roger Koppl develops a theory of experts and expert failure, and illustrates his theory with wide-ranging examples, including that of state regulation of economic activity.
From cops who are paragons of virtue, to cops who are as bad as the bad guys...from surly loners, to upbeat partners...from detectives who pursue painstaking investigation, to loose cannons who just want to kick down the door, the heroes and anti-heroes of TV police dramas are part of who we are. They enter our living rooms and tell us tall tales about the social contract that exists between the citizen and the police. Love them or loathe them--according to the ratings, we love them--they serve a function. They've entertained, informed and sometimes infuriated audiences for more than 60 years. This book examines Dragnet, Highway Patrol, Naked City, The Untouchables, The F.B.I., Columbo, Hawaii Five-O, Kojak, Starsky & Hutch, Hill Street Blues, Cagney & Lacey, Miami Vice, Law & Order, Homicide: Life on the Street, NYPD Blue, CSI, The Shield, The Wire, and Justified. It's time to take another look at the "perps," the "vics" and the boys and girls in blue, and ask how their representation intersects with questions of class, gender, sexuality, and "race." What is their socio-cultural agenda? What is their relation to genre and televisuality? And why is it that when a TV cop gives a witness his card and says, "call me," that witness always ends up on a slab?
Since its first edition in 1975, this extraordinary textbook has helped shape the way biochemistry is taught, offering exceptionally clear writing, innovative graphics, coverage of the latest research techniques and advances, and a signature emphasis on physiological and medical relevance. Those defining features are at the heart of this edition.
This book is an accessible resource offering practical information not found in more database-oriented resources. The first chapter lists acronyms with definitions, and a glossary of terms and subjects used in biochemistry, molecular biology, biotechnology, proteomics, genomics, and systems biology. There follows chapters on chemicals employed in biochemistry and molecular biology, complete with properties and structure drawings. Researchers will find this book to be a valuable tool that will save them time, as well as provide essential links to the roots of their science. Key selling features: Contains an extensive list of commonly used acronyms with definitions Offers a highly readable glossary for systems and techniques Provides comprehensive information for the validation of biotechnology assays and manufacturing processes Includes a list of Log P values, water solubility, and molecular weight for selected chemicals Gives a detailed listing of protease inhibitors and cocktails, as well as a list of buffers
A collection of letters from a cross-section of Japanese citizens to a leading Japanese newspaper, relating their experiences and thoughts of the Pacific War.
The seminal text Plant Virology is now in its fifth edition. It has been 10 years since the publication of the fourth edition, during which there has been an explosion of conceptual and factual advances. The fifth edition of Plant Virology updates and revises many details of the previous edition while retaining the important earlier results that constitute the field's conceptual foundation. Revamped art, along with fully updated references and increased focus on molecular biology, transgenic resistance, aphid transmission, and new, cutting-edge topics, bring the volume up to date and maintain its value as an essential reference for researchers and students in the field. - Thumbnail sketches of each genera and family groups - Genome maps of all genera for which they are known - Genetic engineered resistance strategies for virus disease control - Latest understanding of virus interactions with plants, including gene silencing - Interactions between viruses and insect, fungal, and nematode vectors - Contains over 300 full-color illustrations
Documents the Army massacre of 150 Native Americans in December, 1890, along Wounded Knee Creek in the Lakota reservation, detailing its link to an assassination and the murders of three Native Americans that rallied politicians, soldiers, and citizens to condemn the events at Wounded Knee and fight for Native American rights during two sensationalized trials. Reprint. 15,000 first printing.
“A riveting account that reaches beyond the market landscape to say something universal about risk and triumph, about hubris and failure.”—The New York Times NAMED ONE OF THE BEST BOOKS OF THE YEAR BY BUSINESSWEEK In this business classic—now with a new Afterword in which the author draws parallels to the recent financial crisis—Roger Lowenstein captures the gripping roller-coaster ride of Long-Term Capital Management. Drawing on confidential internal memos and interviews with dozens of key players, Lowenstein explains not just how the fund made and lost its money but also how the personalities of Long-Term’s partners, the arrogance of their mathematical certainties, and the culture of Wall Street itself contributed to both their rise and their fall. When it was founded in 1993, Long-Term was hailed as the most impressive hedge fund in history. But after four years in which the firm dazzled Wall Street as a $100 billion moneymaking juggernaut, it suddenly suffered catastrophic losses that jeopardized not only the biggest banks on Wall Street but the stability of the financial system itself. The dramatic story of Long-Term’s fall is now a chilling harbinger of the crisis that would strike all of Wall Street, from Lehman Brothers to AIG, a decade later. In his new Afterword, Lowenstein shows that LTCM’s implosion should be seen not as a one-off drama but as a template for market meltdowns in an age of instability—and as a wake-up call that Wall Street and government alike tragically ignored. Praise for When Genius Failed “[Roger] Lowenstein has written a squalid and fascinating tale of world-class greed and, above all, hubris.”—BusinessWeek “Compelling . . . The fund was long cloaked in secrecy, making the story of its rise . . . and its ultimate destruction that much more fascinating.”—The Washington Post “Story-telling journalism at its best.”—The Economist
Provides readers with the methods, algorithms, and means to perform text mining tasks This book is devoted to the fundamentals of text mining using Perl, an open-source programming tool that is freely available via the Internet (www.perl.org). It covers mining ideas from several perspectives--statistics, data mining, linguistics, and information retrieval--and provides readers with the means to successfully complete text mining tasks on their own. The book begins with an introduction to regular expressions, a text pattern methodology, and quantitative text summaries, all of which are fundamental tools of analyzing text. Then, it builds upon this foundation to explore: Probability and texts, including the bag-of-words model Information retrieval techniques such as the TF-IDF similarity measure Concordance lines and corpus linguistics Multivariate techniques such as correlation, principal components analysis, and clustering Perl modules, German, and permutation tests Each chapter is devoted to a single key topic, and the author carefully and thoughtfully introduces mathematical concepts as they arise, allowing readers to learn as they go without having to refer to additional books. The inclusion of numerous exercises and worked-out examples further complements the book's student-friendly format. Practical Text Mining with Perl is ideal as a textbook for undergraduate and graduate courses in text mining and as a reference for a variety of professionals who are interested in extracting information from text documents.
This book describes and analyzes the demographic changes that took place in Taiwan between 1945 and 1995. It uses an interdisciplinary methodology so that different approaches to demographic change can be compared and contrasted. It attempts to evaluate Taiwan's experience so that lessons for the Third World can be extracted. The content and presentation of the material are deliberately designed to replicate the 1954 work of Barclay, Demographic Change and Colonial Development in Taiwan. As such the book seeks to provide the reasons that economic development without demographic change took place under the Japanese while development with demographic change took place under the Chinese. The volume is richly illustrated with some 82 original maps and graphs.
Congress and Its Members has been the gold standard for Congress courses for thirty years. Now in its 18th edition, this bestseller offers comprehensive coverage of the U.S. Congress and the legislative process by examining the tension between Congress as a lawmaking institution and as a collection of politicians constantly seeking re-election.
As the twentieth century began, oil in Texas was easy to find, but the quantities were too small to attract industrial capital and production. Then, on January 10, 1901, the Spindletop gusher blew in. Over the next fifty years, oil transformed Texas, creating a booming economy that built cities, attracted out-of-state workers and companies, funded schools and universities, and generated wealth that raised the overall standard of living--even for blue-collar workers. No other twentieth-century development had a more profound effect upon the state. In this book, Roger M. Olien and Diana Davids Olien chronicle the explosive growth of the Texas oil industry from the first commercial production at Corsicana in the 1890s through the vital role of Texas oil in World War II. Using both archival records and oral histories, they follow the wildcatters and the gushers as the oil industry spread into almost every region of the state. The authors trace the development of many branches of the petroleum industry--pipelines, refining, petrochemicals, and natural gas. They also explore how overproduction and volatile prices led to increasing regulation and gave broad regulatory powers to the Texas Railroad Commission.
Examining the chemical modification of biological polymers and the emerging applications of this technology, Chemical Modification of Biological Polymers reflects the change in emphasis in this subsection of biotechnology from the study of protein structure and function toward applications in therapeutics and diagnostics. HighlightsThe basic organi
This textbook introduces students to the critical role of the US intelligence community within the wider national security decision-making and political process. Intelligence in the National Security Enterprise defines what intelligence is and what intelligence agencies do, but the emphasis is on showing how intelligence serves the policymaker. Roger Z. George draws on his thirty-year CIA career and more than a decade of teaching at both the undergraduate and graduate level to reveal the real world of intelligence. Intelligence support is examined from a variety of perspectives to include providing strategic intelligence, warning, daily tactical support to policy actions as well as covert action. The book includes useful features for students and instructors such as excerpts and links to primary-source documents, suggestions for further reading, and a glossary.
It has been ten years since the publication of the third edition of this seminal text on plant virology, during which there has been an explosion of conceptual and factual advances. The fourth edition updates and revises many details of the previous editon, while retaining the important older results that constitute the field's conceptual foundation. Key features of the fourth edition include: * Thumbnail sketches of each genera and family groups * Genome maps of all genera for which they are known * Genetic engineered resistance strategies for virus disease control * Latest understanding of virus interactions with plants, including gene silencing * Interactions between viruses and insect, fungal, and nematode vectors * New plate section containing over 50 full-color illustrations.
Genetically Modified Plants, Second Edition, provides an updated roadmap and science-based methodology for assessing the safety of genetic modification technologies, as well as risk assessment approaches from regulators across different agroecosystems. This new edition also includes expanded coverage of technologies used in plant improvement, such as RNA-dependent DNA methylation, reverse breeding, agroinfiltration, and gene-editing technologies such as CRISPR and TALENS. This book is an essential resource for anyone interested in crop improvement, including students and researchers, practitioners in regulatory agencies, and policymakers involved in plant biotechnology risk assessment. - Provides a roadmap for assessing the safety of genetically modified plants - Expands coverage of technologies used in plant improvement, such as RNA-dependent DNA methylation, Reverse Breeding and Agro-infiltration - Introduces new chapters addressing the potential applications and associated risks of new gene editing technologies such as CRISPR and TALENS
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