Bold Privateers is a collection of fascinating stories of the era's notorious privateers. It recalls the exploits of privateer captains, their fortunes and failures, reveals the importance of booty hunting during war.
From the dramatic rescue attempt of the passengers of the S.S. Atlantic in 1873 to the sinking of the bulk carrier MV Flare in 1982, disaster at sea is a continual reminder of the ocean's annihilating power. This book recounts the compelling stories of many of the most exciting shipwrecks on Canada's east coast: S.S. Atlantic, HMS Tribune, the Chameau, the offshore oil rig Ocean Ranger. The narratives highlight the cause of each wreck, attempts at rescue and, in many cases, the present-day preservation of the wreck sites. These sites, once the playthings of treasure hunters, are now recognized as unparalleled sources of knowledge about our past. Illustrated in colour with artifacts, underwater photography and historical visuals, Shipwreck Treasurestracks four centuries of marine disasters on Canada's eastern seaboard.
Bold Privateers is a collection of fascinating stories of the era's notorious privateers. It recalls the exploits of privateer captains, their fortunes and failures, reveals the importance of booty hunting during war.
In this warm and engaging book, the late, great Sir Roger Moore reflects on life and ageing. He shares the joys he experienced every day along with the tiny triumphs that life brings to us all at the most unexpected times.
They were college kids and young soldiers who wanted to fly, and they knew little about Vietnam other than what they read in the newspapers before going there. But Ia Drang, Kontum, Bong Son, Pleiku, Dak To, and dozens of other places soon became their trials by fire as they flew the grunts into and out of hot LZs and exposed themselves to some of the most intense combat of the war. Their mission was to fly into isolated jungle hilltops and muddy rice fields often without knowing what they'd face. Consequently, the crewmen who flew the helicopters and manned the door guns suffered some of the highest percentages of dead and wounded in the history of American warfare.
Stem cells provide for life-long cell replacement in tissues and organs, and have inherent homing abilities that are critical in therapeutic applications. Stem cells are also the driving force of cancer where genetic/epigenetic alterations culminate in tumorigenesis either in tissue stem cells or in some of their derivatives. As a rare subset of the tumor, cancer stem cells are the only drive of tumor initiation/propagation. Autologous and cancer stem cells are thus the key targets of 1) long-term and transient-regenerative/epigenetic gene therapy and 2) of recurrence-free anticancer therapy, respectively. While cancer stem cell gene therapy still needs time to accomplish, autologous stem cells have been instrumental in the first unequivocal successes for gene therapy whereby ex vivo retrovirally corrected hematopoietic stem cells have been returned to the patients. This timely book presents 1) the aforementioned stem cell gene therapy achievements that rely on random-integration of therapeutic transgenes into host chromosomes and 2) emerging experimental approaches aimed at eliminating random-integration oncogenic hazards through site-specific integration or gene targeting. Breakthrough endonuclease-boosted gene targeting for gene correction (inherited diseases) or targeted integration of therapeutic transgenes (other disorders) culminating in an efficiency compatible with clinical trials is one of the highlights of the book. Highlights also include the pioneering transplantation of adult pluripotent stem cells as a substitute for tissue-specific stem cells, thereby pinpointing the invaluable potential for stem cell gene therapy applications of autologous cells able to contribute to all three germ layers. Stem cell gene therapy is thus discussed in terms of 1) magnifying stem cell therapeutic homing through transient regenerative gene therapy and 2) of tackling most pathologies (including mitochondrial DNA diseases and ageing disorders) through stem cell repopulation dynamics into appropriate niches (long-term engraftment) and tissues (cell turn-over). Regarding cancer stem cell gene therapy, focus is on both the increasing number of identified tissue-specific cancer stem cells as the ultimate therapeutic targets and on the development of armed stem cells as tumor-homing vectors for targeted anticancer therapy. Sample Chapter(s). Introduction: Toward a Universal Platform for Autologous Stem Cell Gene Therapy (335 KB). Chapter 1: Stem Cell Gene Therapy for ADA-Deficiency without Myelopreparative Conditioning (318 KB). Contents: Introduction: Toward a Universal Platform for Autologous Stem Cell Gene Therapy; Long-term Stem Cell Gene Therapy: From Current Clinical Random-Integration Achievements to Stem Cell Gene Targeting/Cybridization: From Pioneering Clinical Retroviral Gene Therapy to Experimental Site-Specific Integrative Gene Therapy; Stem Cell Gene Targeting/Cybridization: Toward Endonuclease-Boosted Gene Repair/Alteration, Custom Site-Specific Integrative Gene Therapy and Transmitochondrial Therapy/Rejuvenation; Adult Pluripotent Stem Cells: Emerging Stem Cell/Gene Therapy Breakthrough; Cancer Stem Cell Gene Therapy: Cancer Stem Cells as Breakthrough Targets of Cancer Gene Therapy; Armed Stem Cells as Tumor-Homing Vectors for Cancer Gene Therapy. Readership: Clinicians, scientists, physicians, veterinarians, dentists, pharmacists/chemists, interested in an ongoing medical/veterinarian breakthrough that is expected to revolutionize the practice of Medicine/Dentistry and that relies on cell biology, molecular biology/genetics, developmental biology, biochemistry, molecular pathology and animal science.
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