This remarkably insightful book gives true meaning to the apocryphal moan from the pharmaceutical CEO as he traveled home after an FDA slap down: Drug development aint for sissies. Peter Kowey, MD, author of LETHAL RHYTHM, DEADLY RHYTHM and THE EMPTY NET When Roger Mills, a medical school professor, made a late-career move from academic cardiology to the pharmaceutical industry, he had no idea what the next decade would bring. At the University of Florida in the late 1990s, he had been a clinical investigator in a phase 2 trial studying the dosing and efficacy of nesiritide, which Scios Inc. was attempting to bring to the market. He joined the company in 2005, and soon became its vice president for medical affairs. Nesiritide was the biotechnology companys only product in clinical development, and after a stunning turn of events at a Food and Drug Administration meeting in 1999, company president Dick Brewer had to use all his smarts to keep the company together and reverse its fortunes. Johnson & Johnson would eventually acquire the company in 2003 for $2.4 billion, but then found it would have to decide how to deal with safety concerns raised about the drug after two scientific publications claimed it could cause kidney failure and death. Get a revealing look at what it really takes to develop and introduce a drug to market and all the things that can go wrong in Nesiritide.
“Ever wanted to continue a conversation with a lifelong friend who has died? Impossible, you say! Not for cardiologist and author Roger Mills and his Amherst College classmate and rowing partner from fifty years ago—the accomplished European research biologist Bernard Witholt. This book was born two years after Witholt’s death, when his widow shared his journal about living with an “unruly heart” (that occasionally raced at 240 beats per minute) with Mills. 240 Beats per Minute recounts an extraordinary conversation—the combination of Bernie’s journal and Roger’s commentary. It’s a read of such continuing surprise, discovery, triumph, and, in the end, mutual understanding and respect, that we readers become the luckiest of eavesdroppers: Long after we finish Life with an Unruly Heart, Bernie and Roger’s conversation will live in our minds.” —Paul Dimond, lawyer and author of The Belle of Two Arbors and Beyond Busing, winner of the Ralph J. Bunche Book of the Year Award
The various classes of medications employed in the treatment of heart failure are reviewed as well as the clinical trials shaping heart failure therapeutics. Appropriate staging of therapeutics is discussed along with rational poly-pharmacy. Treatment options for advanced heart failure are concisely presented.
This best-selling emergency department reference is now in its thoroughly updated Fifth Edition. The foremost authorities provide practical information on over 600 clinical problems in a fast-access two-page outline format that's perfect for on-the-spot consultation during care in the emergency department. Coverage of each disorder includes clinical presentation, pre-hospital, diagnosis, treatment, disposition, and ICD-9 coding. Icons enable practitioners to quickly spot the information they need. This edition provides up-to-date information on topics such as emerging infections, new protocols, and new treatments.
The sixth edition of this comprehensive yet concise Rosen & Barkin’s 5 Minute Emergency Medicine Consult pulls together up-to-date and evidence-based practice guidelines for easy use in a busy emergency department. In just two brief, bullet-friendly, clutter-free pages, you can quickly decipher the information you need to confirm your diagnosis, order tests, manage treatment and more!
In this final volume of his best-selling 'Inner' trilogy, Roger Neighbour explores the relationship between a doctor's professional and private selves. He suggests that the mind of every doctor retains an untrained 'ordinary human being' part - their Inner Physician - which makes an important, though often neglected, contribution to medical practice. This 'Inner Physician', which he also describes as the 'amateur within' or the 'expert minus the expertise', plays a major role in diagnosis and treatment, and is the chief source of insight, empathy and clinical acumen. Roger shows that skilled use of the Inner Physician is one thing that distinguishes the generalist from the specialist.
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