Universally recognised as by far the most authoritative work ever published on the subject, The Birds of Africa is a superb multi-contributor reference work, with encyclopaedic species texts, stunning paintings of all species and numerous subspecies, informative line drawings, detailed range maps, and extensive bibliographies. Each volume contains an Introduction that brings the reader up to date with the latest developments in African ornithology, including the evolution and biogeography of African birds. Diagnoses of the families and genera, often with superspecies maps, are followed by the comprehensive species accounts themselves. These include descriptions of range and status, field characters, voice, general habits, food, and breeding habits. Full bibliographies, acoustic references, and indexes complete this scholarly work of reference. This eighth and final volume covers the Malagasy region which comprises Madagascar and the various islands and archipelagos of the Indian Ocean including the Seychelles, the Comoros, Mauritius and Réunion. Every resident and migrant species is covered in full detail, comparable to other volumes in the series, and with a colour map for each species. Vagrants are treated in less detail. All species are illustrated on a beautiful series of 64 colour plates, with original artwork from John Gale and Brian Small. This is a major work of reference on the birds of the region and will remain the standard text for many years to come.
An A-Z listing of drugs by generic name. Each monograph summarizes the known and/or possible effects of the drug on the fetus. It also summarizes the known/possible passage of the drug into the human breast milk. A careful and exhaustive summarization of the world literature as it relates to drugs in pregnancy and lacation. Each monograph contains six parts: generic US name, Pharmacologic class, Risk factor, Fetal risk summary, Breast feeding summary, References
Rory Luccombe has had a successful and prosperous life as an airline pilot and businessman . He moves in wealthy circles, and fancies himself as an investment advisor to the rich and powerful . However, prompted by greed, he goes too far and loses vast amounts of other peoples` money . Panicking, he snatches an opportunity to evade arrest and attempts to disappear, but this proves very difficult in the current climate of international security agencies monitoring every electronic transmission . He contrives to fake his death, but his deception fails due to the persistent pursuit by Gil Lamont, an ex-military policeman with aspirations of recovering his lost investment and his reputation as a top-rate detective . Driven by events, he tracks the fugitive from Florida to Paris and on to Scotland, but all his efforts and those of the force4s of Law and Order, fail to bring Luccombe to trial and to prevent his untimely death from an un-expected source .
What is Britain's future in Europe? This book revisits an old argument but for dramatically new times. The old argument is about Britain's 'semi-detachedness' from Europe and whether that posture could ever change. The new times are the crisis in the Eurozone and its wider impact on the European Union's future. While logic may point to deeper integration, the politics associated with the EU's problems make this a significant and possibly insurmountable challenge. Where should Britain stand? What future should Britain want for the EU? And how important is continued membership of the EU for Britain's future? This book offers new answers to these questions from the perspective of an author who has combined experience both at the heart of the British Government, as Tony Blair's European adviser and with years of understanding Europe from the inside - working at a senior level in the European Commission. This book will be essential reading for anyone interested in the future of British and European politics.
The only film critic to win the Pulitzer Prize, Roger Ebert collects his reviews from the last 30 months in Roger Ebert's Movie Yearbook 2012. Forbes Magazine described Ebert as the "most powerful pundit in America." In January 2011, he and his wife, Chaz, launched Ebert Presents at the Movies, a weekly public television program in the tradition that he and Gene Siskel began 35 years earlier. Since 1986, each edition of Roger Ebert's Movie Yearbook has presented full-length movie reviews, with interviews, essays, tributes, journal entries, and "Questions for the Movie Answer Man," and new entries in his popular Movie Glossary. Inside Roger Ebert's Movie Yearbook 2012, readers can expect to find every movie review Ebert has written from January 2009 to July 2011, including The Social Network, Waiting for Superman, Inception, The King's Speech, My Dog Tulip, The Human Centipede, and more. Also included in the Yearbook are: * In-depth interviews with newsmakers and celebrities, such as John Waters and Justin Timberlake. * Memorial tributes to those in the film industry who have passed away, such as Blake Edwards, Tony Curtis, and Arthur Penn. * Essays on the Oscars and reports from the Cannes and Toronto Film Festivals.
This volume contains papers presented at the Second Symposium on Ordered Fluids and Liquid Crystals held at the 158th National Meeting of the American Chemical Society, New York, Sep tember, 1969. The Symposium was sponsored by the Division of Colloid and Surface Chemistry. The proceedings for the first symposium on this subject were published by the American Chemical Society in the Advances in Chemistry Series. In the preface to the volume for the first meet ing held four years ago, we noted that research on liquid crystals had gone through tremendous fluctuations, with peaks of activity around 1900 and again in the early 1930's. The present period of high activity which started about 1960 has continued to exhibit acceleration. The reason for the persistent growth in the field is due to the increasing recognition of the important role played by liquid crystals in both biological systems and in items of commerce as diverse as detergents and electronic components. Addi tionally, more powerful and sophisticated instrumentation is pro viding a basis for understanding the properties of the liquid crystalline state as weIl as yielding inc~s~ve tests for the theories of mesophase structure which are only now reaching astate of maturity. Julian F. Johnson Roger S. Porter v CONTENTS Thermal Phase Transitions in Biomembranes • . • • • • • . • • 1 Joseph M. Steim Conditions of Stability for Liquid-Crystalline Phospholipid Membranes .
Wondering if the world is really going to hell in a handbasket? Then consider Roger Ebert's e-book original 33 Movies to Restore Your Faith in Humanity. Read Roger's full-length reviews of movies and rekindle your belief in the human spirit. From the out-of-the-world experience of E.T. to the outer space drama of Apollo 13 to the personal insights into ordinary people in Cinema Paradiso and Everlasting Moments, you'll be reassured that maybe there is hope for us all. Mix in historical dramas like The Bridge on the River Kwai and Gandhi, stories of personal heroism like Hotel Rwanda and Schindler's List, and the irresistible Up, and things will be looking, well, up!
This study uses early Jewish sources to analyze the significance of Day of Atonement and High Priest imagery in the narrative of Simon Peter’s threefold denial of Jesus. It then describes the influence of other early Jewish sources on Jesus’ commissioning his main disciple Simon Peter as his own successor in John 21:15-19. Aus relates this event to Moses’ commissioning his main disciple Joshua as his successor.
Rock Blasting and Explosives Engineering covers the practical engineering aspects of many different kinds of rock blasting. It includes a thorough analysis of the cost of the entire process of tunneling by drilling and blasting in comparison with full-face boring. Also covered are the fundamental sciences of rock mass and material strength, the thermal decomposition, burning, shock initiation, and detonation behavior of commercial and military explosives, and systems for charging explosives into drillholes. Functional descriptions of all current detonators and initiation systems are provided. The book includes chapters on flyrock, toxic fumes, the safety of explosives, and even explosives applied in metal working as a fine art. Fundamental in its approach, the text is based on the practical industrial experience of its authors. It is supported by an abundance of tables, diagrams, and figures. This combined textbook and handbook provides students, practitioners, and researchers in mining, mechanical, building construction, geological, and petroleum engineering with a source from which to gain a thorough understanding of the constructive use of explosives.
Marshalling facts and the latest research findings, the author systematically refutes the adversaries of globalization, markets, and progress. This book will change the debate on globalization in this country and make believers of skeptics.
The aim of Sit on Our Hands, or Stand on Our Feet is not to present a theology that explains disasters. In fact there is no such theology. Nor is this work primarily for those who are responded to; it is not part of the theological 'grab bag' that Christian responders carry with them to use for the benefit of casualties. It is more a part of the Christian's engaged practical theological apprenticeship prior to, and during, a response. This book represents the role of the practical theologian, who empowers the church community's legitimation and contribution in disaster response, and who encourages individual Christians--whose calling into particularly relevant professions, whose natural skills and/or professional training, could find them placed in a major incident responding status (paid or voluntary)--doing their work as unto the Lord. It is a serious must-read for any Christians who have hearts heavy with compassion but who are not sure what to do or why when disaster strikes.
The thrilling and definitive history of World War I in the Middle East By 1914 the powers of Europe were sliding inexorably toward war, and they pulled the Middle East along with them into one of the most destructive conflicts in human history. In The Fall of the Ottomans, award-winning historian Eugene Rogan brings the First World War and its immediate aftermath in the Middle East to vivid life, uncovering the often ignored story of the region's crucial role in the conflict. Unlike the static killing fields of the Western Front, the war in the Middle East was fast-moving and unpredictable, with the Turks inflicting decisive defeats on the Entente in Gallipoli, Mesopotamia, and Gaza before the tide of battle turned in the Allies' favor. The postwar settlement led to the partition of Ottoman lands, laying the groundwork for the ongoing conflicts that continue to plague the modern Arab world. A sweeping narrative of battles and political intrigue from Gallipoli to Arabia, The Fall of the Ottomans is essential reading for anyone seeking to understand the Great War and the making of the modern Middle East.
Featuring 127 new drug entries, the eighth edition of this popular reference provides practical, reliable information on more than 1,175 drugs that may be used by pregnant and lactating women.
As the irreversible effects of glaucoma can lead to blindness, there is high demand for early diagnosis and an ongoing need for practitioners to adopt new and evolving medical and surgical treatment options to improve patient outcomes. Glaucoma, Second Edition is the most comprehensive resource in the field delivering expert guidance for the most timely and effective diagnosis and treatment of glaucoma – aimed at specialists, fellows and general ophthalmologists. More than 300 contributors from six continents provide a truly global perspective and explore new approaches in this user friendly reference which has been updated with enhanced images, more spotlights, new videos, and more. - Get all the accuracy, expertise, and dependability you could ask for from leading specialists across six continents, for expert guidance and a fresh understanding of the subject. - Develop a thorough, clinically relevant understanding of all aspects of adult and pediatric glaucoma in Volume One, and the latest diagnostic imaging techniques including ultrasound biomicroscopy and optical coherence tomography. - Stay at the forefront of your field with 10 brand new chapters on trending topics including: new surgical approaches such as trabeculotomy and canaloplasty; glaucoma implications in cataract and ocular surface disease; and, updates in the cost-effectiveness of medical management. - Avoid pitfalls and achieve the best outcomes thanks to more than 40 brand new spotlight commentaries from key leaders providing added insight, tips and pearls of wisdom across varying hot topics and advances in the field. - Refine and improve your surgical skills by watching over 50 video clips depicting the latest techniques and procedures including: new trabeculectomy methods, needling, implants, valve complications, and more. - Prevent and plan for complications in advance by examining over 1,600 illustrations, photos and graphics (1,250 in color) capturing essential diagnostics techniques, imaging methods and surgical approaches. - Grasp each procedure and review key steps quickly with chapter summary boxes that provide at-a-glance quick comprehension of the key take away points. - Broaden your surgical repertoire with the latest surgical techniques - such as trabeculectomy, gonio-surgery, combined surgeries, and implant procedures - in Volume Two. - Glean all essential, up-to-date, need-to-know information about stem cell research, gene transfer, and implants. - Find answers fast thanks to a well-organized, user-friendly full-color layout. - eBook version included with purchase.
This compact volume covers the main developments in the social sciences since the Second World War. Chapters on economics, human geography, political science, psychology, social anthropology, and sociology will interest anyone wanting short, accessible histories of those disciplines, all written by experts in the relevant field; they will also make it easy for readers to make comparisons between disciplines. A final chapter proposes a blueprint for a history of the social sciences as a whole. Whereas most of the existing literature considers the social sciences in isolation from one other, this volume shows that they have much in common; for example, they have responded to common problems using overlapping methods, and cross-disciplinary activities have been widespread.
Roger Ebert's Movie Yearbook 2010 is the ultimate source for movies, movie reviews, and much more. For nearly 25 years, Roger Ebert's annual collection has been recognized as the preeminent source for full-length critical movie reviews, and his 2010 yearbook does not disappoint. The yearbook includes every review Ebert has written from January 2007 to July 2009. It also includes interviews, essays, tributes, and all-new questions and answers from his Questions for the Movie Answer Man columns. Fans get a bonus feature, too, with new entries to Ebert's Little Movie Glossary. This is the must-have go-to guide for movie fanatics.
Pulmonary rehabilitation programmes are now a fundamental part of the clinical management of patients with chronic respiratory diseases. This comprehensive reference book places pulmonary rehabilitation within the wider framework of respiratory disease, and the health burden that this now poses worldwide. Part one of the book examines the evidence
Neuromechanics of Human Movement, Fourth Edition, provides a scientific foundation to the study of human movement by exploring how the nervous system controls the actions of muscles to produce human motion in relation to biomechanical principles.
Stem cells provide for life-long cell replacement in tissues and organs, and have inherent homing abilities that are critical in therapeutic applications. Stem cells are also the driving force of cancer where genetic/epigenetic alterations culminate in tumorigenesis either in tissue stem cells or in some of their derivatives. As a rare subset of the tumor, cancer stem cells are the only drive of tumor initiation/propagation. Autologous and cancer stem cells are thus the key targets of 1) long-term and transient-regenerative/epigenetic gene therapy and 2) of recurrence-free anticancer therapy, respectively. While cancer stem cell gene therapy still needs time to accomplish, autologous stem cells have been instrumental in the first unequivocal successes for gene therapy whereby ex vivo retrovirally corrected hematopoietic stem cells have been returned to the patients. This timely book presents 1) the aforementioned stem cell gene therapy achievements that rely on random-integration of therapeutic transgenes into host chromosomes and 2) emerging experimental approaches aimed at eliminating random-integration oncogenic hazards through site-specific integration or gene targeting. Breakthrough endonuclease-boosted gene targeting for gene correction (inherited diseases) or targeted integration of therapeutic transgenes (other disorders) culminating in an efficiency compatible with clinical trials is one of the highlights of the book. Highlights also include the pioneering transplantation of adult pluripotent stem cells as a substitute for tissue-specific stem cells, thereby pinpointing the invaluable potential for stem cell gene therapy applications of autologous cells able to contribute to all three germ layers. Stem cell gene therapy is thus discussed in terms of 1) magnifying stem cell therapeutic homing through transient regenerative gene therapy and 2) of tackling most pathologies (including mitochondrial DNA diseases and ageing disorders) through stem cell repopulation dynamics into appropriate niches (long-term engraftment) and tissues (cell turn-over). Regarding cancer stem cell gene therapy, focus is on both the increasing number of identified tissue-specific cancer stem cells as the ultimate therapeutic targets and on the development of armed stem cells as tumor-homing vectors for targeted anticancer therapy. Sample Chapter(s). Introduction: Toward a Universal Platform for Autologous Stem Cell Gene Therapy (335 KB). Chapter 1: Stem Cell Gene Therapy for ADA-Deficiency without Myelopreparative Conditioning (318 KB). Contents: Introduction: Toward a Universal Platform for Autologous Stem Cell Gene Therapy; Long-term Stem Cell Gene Therapy: From Current Clinical Random-Integration Achievements to Stem Cell Gene Targeting/Cybridization: From Pioneering Clinical Retroviral Gene Therapy to Experimental Site-Specific Integrative Gene Therapy; Stem Cell Gene Targeting/Cybridization: Toward Endonuclease-Boosted Gene Repair/Alteration, Custom Site-Specific Integrative Gene Therapy and Transmitochondrial Therapy/Rejuvenation; Adult Pluripotent Stem Cells: Emerging Stem Cell/Gene Therapy Breakthrough; Cancer Stem Cell Gene Therapy: Cancer Stem Cells as Breakthrough Targets of Cancer Gene Therapy; Armed Stem Cells as Tumor-Homing Vectors for Cancer Gene Therapy. Readership: Clinicians, scientists, physicians, veterinarians, dentists, pharmacists/chemists, interested in an ongoing medical/veterinarian breakthrough that is expected to revolutionize the practice of Medicine/Dentistry and that relies on cell biology, molecular biology/genetics, developmental biology, biochemistry, molecular pathology and animal science.
This book takes as its theme the related issues of calendar, chronology and worship, as they were conceived and practised in ancient Jewish and early Christian times. After a general discussion of the way the three issues are related, there follow six chapters on the calendar, first the standard Jewish calendar, then the Qumran calendar (giving particular attention to the Book of Enoch and the Temple Scroll) and finally the Christian calendar - both the standard Christian calendar and that observed by the Montanists. Three chapters on chronology come next, one of them offering a chronological solution to a puzzling calendrical problem in the Dead Sea Scrolls, another relating Jewish eschatological expectations to New Testament teaching, and a third examining the chronological calculations of the Hellenistic Jew Demetrius, the Testaments of the Twelve Patriarchs, and the Book of Jubilees. The three concluding chapters, on worship, include an investigation of the historical development of the Psalter and a careful survey of the relationship between ancient Jewish worship and early Christian. The book discusses a variety of issues that arise in modern biblical, intertestamental and patristic study, some neglected, some very controversial, and throws new light upon them.
Amid the trend towards decentralized industrial relations, various new and modified systems of employee representation are taking hold in many countries worldwide. In this highly informative examination of this field of international labour law – originally presented as a series of papers for the 11th JILPT Comparative Labor Law Seminar held in Tokyo in February 2012 – twelve distinguished scholars from Australia, China, France, Germany, Japan, Korea, Sweden, Taiwan, the United Kingdom, and the United States describe their countries’ current perspectives on this issue, along with their own analysis and commentary. Among the specific questions addressed for each jurisdiction are the following: What is the legal framework for an employee representation system? How is the representative body formed and what are its declared powers? Are there legal mechanisms preventing intervention by the employer? Are non-standard employees involved? What methods of deliberation and decision-making are used? How are the activities of representatives protected? Who bears the costs? What is the relationship with collective bargaining? With labour unions? Each contributor also describes typical ways in which the employee representative system works, offering concrete examples such as dismissal, wage determination, and equal treatment. Some deal with situations in which employee representation is in fact nonexistent or malfunctioning in real workplaces. There is also pervasive attention paid to the fundamental matter of what ‘representation’ is for, and the probable future direction of employee representation. Given the need to secure representation for non-union and non-standard employees at the workplace, these reports on the conditions and new developments in this important field provide ample basis on which to build a better system of employee representation in this era of diversified workforces in the globalized market. Accordingly, this book will prove of inestimable value to practitioners and policymakers in labour and employment law anywhere in the world.
Target Literacy offers a structured programme of units designed to support and develop the skills of students who currently fail to rise above Level 3 at KS3. The key focus is on language skills - particularly those highlighted in the recent National Literacy Strategy Objectives for KS3. Each unit is built around a core text, drawn from a range of fiction and non-fiction sources; accompanying activities (a) encourage discussion on the text's content and themes; (b) develop students' understanding of the language features of the texts, through plenty of accessible activities; (c) allow students to practise what they have learned through extended writing activities, supported by hints and tips, and writing frames. The accompanying teachers' book offers photocopiable versions of the writing frames, plus further reinforcement activities.
Sustainable development will not happen without substantial contributions from and leading roles of companies and business organizations. This requires the provision of adequate information on corporate social and ecological impacts and performance. For the last decade, progress has been made in developing and adapting accounting mechanisms to these needs but significant work is still needed to tackle the problems associated with conventional accounting. Until recently, research on environmental management accounting (EMA) has concentrated on developed countries and on cost–benefit analysis of implementing individual EMA tools. Using a comparative case study design, this book seeks to redress the balance and improve the understanding of EMA in management decision-making in emerging countries, focussing specifically on South-East Asian companies. Drawing on 12 case studies, taken from a variety of industries, Environmental Management Accounting: Case Studies of South-East Asian Companies explores the relationship between decision situations and the motivation for, and barriers to, the application of clusters of EMA tools as well as the implementation process itself. This book will be useful to scholars interested in the environmental and sustainability management accounting research field and those considering specific approaches to EMA within emerging economies.
Children with brain and spinal tumors account for 20-25% of childhood cancers. Until the early 1990s there had been little progress in the development of new treatments, and outcomes were not improving despite advances seen in other childhood cancers. During the past 10 years, however, there has been a dramatic increase in interest in the subject a
A renowned biologist's cutting-edge and unconventional examination of human reproduction and embryo research Scientists have long struggled to make pregnancy easier, safer, and more successful. In The Dance of Life, developmental and stem-cell biologist Magdalena Zernicka-Goetz takes us to the front lines of efforts to understand the creation of a human life. She has spent two decades unraveling the mysteries of development, as a simple fertilized egg becomes a complex human being of forty trillion cells. Zernicka-Goetz's work is both incredibly practical and astonishingly vast: her groundbreaking experiments with mouse, human, and artificial embryo models give hope to how more women can sustain viable pregnancies. Set at the intersection of science's greatest powers and humanity's greatest concern, The Dance of Life is a revelatory account of the future of fertility -- and life itself.
As Trade Union membership has declined, union mergers have been prominent features in strategies of revitalization. Yet, there is very little systematic and empirical research into the effects of union mergers on the unions actually merging or of their impact on the wider union movement. This ground-breaking study fills this gap with its in-depth analysis of British unions' mergers since 1978: the point at which British unions moved from growth into decline, primarily due to adverse and damaging changes in the British industrial relations climate. Initially the book describes the merger processes (transfers and amalgamations) and the extent of British unions' merger activities. This is placed in context by an examination of the generally hostile environment in which such mergers were sought and concluded. The different non-merger strategies adopted by unions to mitigate their membership loss and reduced political status are also assessed. In the body of the text the focus is on: the factors shaping unions' merger searches; the consequent merger negotiations; and the merged unions' subsequent performance. Because of the distinctly different opportunities for reform offered by transfers, as against amalgamations, the book examines each, in turn, in Parts 2 and 3. The interpretative framework adopted for analysing transfers and amalgamations addresses the following elements of unions' interests: members' job territories; political objectives and means; democratic ethos and government; administration (including finance); and leaders' imperatives. Drawing on a wealth of material gathered over the past 20 years via surveys, interviews and action research the different purposes and performances of the merged unions are critically assessed. It is concluded that transfers served to generate a limited range of improvements, generally of advantage to the minor partner union. In contrast, amalgamations are found to have the potential to transform many aspects of union organisation. However, in practice, they also tended to generate a number of unintended and unwelcome consequences. In conclusion mergers' contributions to the revitalization of the wider British trade union movement are also discussed. This authoritative study of British unions' merger strategies is essential reading for all those interested in the future of trade unions and the potential mergers offer for generating significant reforms. Academics and students in employee relations, industrial relations, HRM and labour history should also find it useful for increasing their understanding of how unions have responded to changes in the economic and political context. Policy makers and union practitioners should also gain insights into the kinds of problems associated with unions'structural reforms.
In Human Dimensions of Cyber Security, Terry Bossomaier, Steven D’Alessandro, and Roger Bradbury have produced a book that ... shows how it is indeed possible to achieve what we all need; a multidisciplinary, rigorously researched and argued, and above all accessible account of cybersecurity — what it is, why it matters, and how to do it." --Professor Paul Cornish, Visiting Professor, LSE IDEAS, London School of Economics Human Dimensions of Cybersecurity explores social science influences on cybersecurity. It demonstrates how social science perspectives can enable the ability to see many hazards in cybersecurity. It emphasizes the need for a multidisciplinary approach, as cybersecurity has become a fundamental issue of risk management for individuals, at work, and with government and nation states. This book explains the issues of cybersecurity with rigor, but also in simple language, so individuals can see how they can address these issues and risks. The book provides simple suggestions, or cybernuggets, that individuals can follow to learn the dos and don’ts of cybersecurity. The book also identifies the most important human and social factors that affect cybersecurity. It illustrates each factor, using case studies, and examines possible solutions from both technical and human acceptability viewpoints.
Atmospheric chemistry is central to understanding global changes ? ozone depletion, appearance of the polar ozone holes, and compositional changes which worsen the greenhouse effect. Because of its importance, work is progressing on many fronts.This volume emphasizes the troposhere and stratosphere and has chapters on gas phase, condensed phase, and heterogeneous chemistry. Present progress is emphasized, and important future directions are also described.This book fills a need not satisfied by any others and will be popular for some years to come. It informs students and newcomers to the field of the many facets of atmospheric chemistry and can be used as a text for advanced students. It is also a valuable desk reference summarizing activities by quite a number of the most active research groups.Chapter 18 by Kolb et al. on heterogeneous chemistry is especially noteworthy because it represents a unique joint effort by several groups working on a very timely subject; they describe a conceptual framework and establish conventions which will be standard in future papers on this subject.
This best-selling emergency department reference is now in its thoroughly updated Fourth Edition. The foremost authorities provide practical information on over 600 clinical problems in a fast-access two-page outline format that's perfect for on-the-spot consultation during care in the emergency department. Coverage of each disorder includes clinical presentation, pre-hospital, diagnosis, treatment, disposition, and ICD-9 coding. Icons enable practitioners to quickly spot the information they need. This edition provides up-to-date information on topics such as emerging infections, new protocols, and new treatments.
Most clinical laboratory tests utilize interstitial and extravascular such as blood, urine, cerebral spinal fluid (CSF), and saliva. For example, CSF is monitored in the context of cancer for both diagnostic and therapeutic reasons. And yet, our understanding of the makeup of interstitial fluids, their relationships to disease, as well as their commercial importance in therapeutics and diagnostics remains rudimentary. Although sometimes perceived as static, interstitial and extravascular fluids are surprisingly dynamic. More than half of serum albumin is in the extravascular space. These fluids move rapidly between the intravascular and extravascular spaces - one entire plasma volume is exchanged very nine hours. In the first half of the book, the authors cover fundamental concepts of interstitial fluids, including their composition and function. They then further review the mechanisms by which interstitial fluids are regulated, characterizing the importance of hyaluronan – a major constituent of interstitial spaces and an a component of synovial fluid; and, outlining the regulation of proteolysis in the interstitial space. In the second half of the book, the authors focus on the coagulation system. This system has been studied extensively in the context of vascular spaces. But many of its components exist in the interstitial spaces. Chapters are devoted to the fibrinolytic system, kallikrein, matrix metalloproteinases, coagulation factors, and protease inhibitors – all are interstitial. By covering a unique array of topics with broad application to biomedical scientists, this book expands our understanding of the importance of interstitial spaces and the fluids that move through and reside in this extravascular environment.
The Second Edition of A-Z of Neurological Practice builds on the previous edition with revised and updated information in a high density but easily accessible format to provide a quick and ready reference for busy clinicians of all degrees of experience. Entries for specific neurological conditions are uniformly structured indicating: Pathophysiology; Clinical Features; Investigations and Diagnosis; Differential Diagnosis; Treatment and Prognosis. Key references are cited throughout and all entries are cross referenced. A-Z of Neurological Practice, Second Edition is a practical, authoritative guide that will become an invaluable resource for neurologists in clinical practice, neurology trainees and all those involved with the treatment of neurological disorders.
Essential for ob/gyn physicians, primary care physicians, and any health care provider working with pregnant or postpartum women, Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, 12th Edition, puts must-know information at your fingertips in seconds. An easy A-to-Z format lists more than 1,400 of the most commonly prescribed drugs taken during pregnancy and lactation, with detailed monographs designed to provide the most essential information on possible effects on the mother, embryo, fetus, and nursing infant.
Special Edition Using Access 2002 is a reader's authoritative guide to mastering the essential facets of this powerful database development platform. Detailed, step-by-step instructions guide the reader through the process of designing and using Access tables, queries, forms and reports. Special Edition Using Access 2002 will include comprehensive coverage of the transition to MSDE/SQL Server for all multi-user applications, expanded coverage of Web Applications, and expanded coverage of XML. This book contains elements such as Tips, Notes, cautions, cross-references and Troubleshooting information, giving the text a "Layered" quality that meets the needs of readers with different learning styles.
Part of the Oxford Psychiatry Library (OPL) series, Cognition in Major Depressive Disorder provides a succinct summary of cognitive deficits reported in patients with major depressive disorder (MDD) with a particular focus on aspects of measurement, underlying disease pathophysiology, implications for treatment and prevention. This book also provides readers an opportunity for clinical-based assessment of cognition and recommendations for how cognitive measurement and treatment is positioned in the management of individuals with mood disorders.
The cloning of two G protein-coupled cannabinoid receptors, termed CB1 and CB2, in the early 1990s has stimulated and facilitated research conducted on the physiological function of cannabinoid actions in the brain and throughout the body. In the twenty years since the identification of these two receptors, endogenous ligands (endocannabinoids) for these receptors have been identified, their biosynthetic and metabolic pathways have been discerned, and their functional and regulatory action for signalling through CB1 and CB2 receptors have been described. More recently, it has become has become evident that cannabinoids exert actions at non-CB1, non-CB2 receptors. Much less is understood about these actions. Many of these novel?targets? are in the process of being characterized functionally and physiologically, and the therapeutic value of targeting these non-CB1, non-CB2 receptors is being evaluated. The purpose of this volume is to present the current knowledge on the atypical actions of cannabinoids on these new targets. This book is intended as a scientific resource for cannabinoid researchers carrying out animal and human experiments, and for those who are interested in learning about future directions in cannabinoid research. Additionally, this book may be of value to investigators currently working outside the field of cannabinoid research who have an interest in learning about these compounds and their atypical cannabinoid signalling. This book provides insight into the potential medical application of cannabinoids and their therapeutic development for the treatment of human disease.
The fractionation of human blood plasma can be considered to be a mature industry, with the basic technology, alcohol fractionation, dating back at least to the 1940s. Many of the products described in the current work have been approved biologics since the 1950s. The information gathered from the development of plasma proteins has proved vital to the development of recombinant therapeutic proteins. Discussing the role of plasma proteins in current biotechnology, Biotechnology of Plasma Proteins describes the protein composition of human plasma, the fractionation of plasma to obtain therapeutic proteins, and the analysis of these products. It delineates the path from plasma products to recombinant products, and highlights products from albumin, intravenous immunoglobins, and coagulation. It offers a comprehensive review of current techniques for the analysis of proteins including electrophoresis, chromatography, spectrophotometry, mass spectrometry, and updates not published since 1975. Key Topics Protein Composition of Plasma Proteomic methods for plasma protein analysis Plasma protein biomarkers Validation of biomarkers Assays for plasma biomarkers Methods for the Analysis of Protein Products Assay development and validation Electrophoresis Chromatography Immunoassay Mass spectrometry Raman spectroscopy Plasma Fractionation: Historical and Modern Methods Development of Cohn alcohol fractionation Industrial methods Development of chromatographic methods Plasma Protein Products of Therapeutic Value Albumin Intravenous immunoglobulin Coagulation products Growth factors Wound management
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