Dead Man's Chest is a classic pirate yarn that begins with long John Silver's escape from the merchantman Hispaniola at Peurta Plata and culminates with the American Revolution more than a decade later. It describes in rich detail the unholy alliance formed between this soft-hearted cut-throut, his teenage nephew, David Noble, and the slaver-turned-merchant captain, John Paul Jones to retrieve a king's ransom of Spanish gold and jewels from Dead Man's Chest; the other two-thirds of the treasure described in Stevenson's novel, and the inspiration for the sailor's ballad by the same name. Dead Man's Chest explains how the Scottish fugitive John Paul Jones earned a naval commission. More importantly, the novel illuminates a hitherto unknown thirty-month period in John Paul's career. From November 1773 when he killed a mutineer to June 1775 when he received his naval commission in Philadelphia from Thomas Jefferson. Learn how the contract that he and John Silver made with the American founding fathers impacted the lives of the Colonists and ultimately helped win America's freedom from Mother England.
John Paul Jones became one of the greatest naval heroes of the American Revolution, but much of his life remains shrouded in mystery...until now. The Treasure of Dead Man’s Chest explains how this Scottish fugitive earned a naval commission. More importantly, the novel illuminates a hitherto unknown thirty-month period in John Paul’s career. From November 1773 when he killed a mutineer to June 1775 when he received his naval commission in Philadelphia from Thomas Jefferson. Learn how the contract that he and John Silver made with the American founding fathers impacted the lives of the Colonists and ultimately helped win America's freedom from Mother England.
Despite international initiatives such as the Earth Summit in 1992 and ongoing efforts to implement the Kyoto Protocol, human activities continue to register a destructive toll on the planetary environment. At root, research on global environmental risk seeks new pathways for reversing unsustainable trends, curtailing ongoing destructive activities, and creating a life-sustaining planet. This book takes stock of the distinctive challenges posed by global environmental risks, the capacity of knowledge systems to identify and characterize such risks, and the competence of human society to manage the unprecedented complexity. Particular attention trains on engaging, in ways conducive to enhancing social learning and adaptation, the large uncertainties inherent in these risks. Various chapters enlist different scales of analysis to explore the manifestation and causes of global environmental risks in all the diversity of their regional expression. Throughout, the editors and contributors accord prominence to the vulnerability of people and places to environmental degradation. Understanding vulnerability is a neglected key to assessing the nature of the risks and determining strategies for altering trajectories of threat. Global risk futures, the editors argue, are not intractable, and are still amenable to a risk-analysis enterprise that is democratic in principle, humanistic in concept, and geared to the realities that pertain to the particular societies, locales, and regions that will ultimately bear the risk.
Most clinical laboratory tests utilize interstitial and extravascular such as blood, urine, cerebral spinal fluid (CSF), and saliva. For example, CSF is monitored in the context of cancer for both diagnostic and therapeutic reasons. And yet, our understanding of the makeup of interstitial fluids, their relationships to disease, as well as their commercial importance in therapeutics and diagnostics remains rudimentary. Although sometimes perceived as static, interstitial and extravascular fluids are surprisingly dynamic. More than half of serum albumin is in the extravascular space. These fluids move rapidly between the intravascular and extravascular spaces - one entire plasma volume is exchanged very nine hours. In the first half of the book, the authors cover fundamental concepts of interstitial fluids, including their composition and function. They then further review the mechanisms by which interstitial fluids are regulated, characterizing the importance of hyaluronan – a major constituent of interstitial spaces and an a component of synovial fluid; and, outlining the regulation of proteolysis in the interstitial space. In the second half of the book, the authors focus on the coagulation system. This system has been studied extensively in the context of vascular spaces. But many of its components exist in the interstitial spaces. Chapters are devoted to the fibrinolytic system, kallikrein, matrix metalloproteinases, coagulation factors, and protease inhibitors – all are interstitial. By covering a unique array of topics with broad application to biomedical scientists, this book expands our understanding of the importance of interstitial spaces and the fluids that move through and reside in this extravascular environment.
Considered the definitive resource in its field, The Chemistry of Environmental Tobacco Smoke: Composition and Measurement compiles observations on the properties of Environmental Tobacco Smoke (ETS) and on the concentrations of its constituents in indoor air. It focuses on common natural indoor environments and environments associated with chronic exposure. The authors -- all renowned experts -- stress both measurement methods and the competing sources of indoor air contaminants commonly attributed to ETS. For the second edition, each chapter has been updated to reflect new studies and up-to-date information.
This book tells the compelling saga of American higher education from the founding of Harvard College in 1636 to the outbreak of World War II. The author traces how colleges and universities were shaped by the shifting influences of culture, the emergence of new career opportunities, and the unrelenting advancement of knowledge. He describes how colonial colleges developed a unified yet diverse educational tradition capable of weathering the social upheaval of the Revolution as well as the evangelical fervor of the Second Great Awakening. He shows how the character of college education in different regions diverged significantly in the years leading up to the Civil War - for example, the state universities of the antebellum South were dominated by the sons of planters and their culture - and how higher education was later revolutionized by the land-grant movement, the growth of academic professionalism, and the transformation of campus life by students. By the beginning of the Second World War, the standard American university had taken shape, setting the stage for the postwar education boom. The author moves through each era, exploring the growth of higher education.
The use of the chemical modification of proteins has evolved over the past 80 years, benefiting from advances in analytical, physical, and organic chemistry. Over the past 30 years, the use of chemical reagents to modify proteins has been crucial in determining the function and structure of purified proteins. This groundbreaking work is part of the
The use of the chemical modification of proteins has evolved over the past 80 years, benefiting from advances in analytical, physical, and organic chemistry. Over the past 30 years, the use of chemical reagents to modify proteins has been crucial in determining the function and structure of purified proteins. This groundbreaking work is part of the foundation of emerging disciplines of proteomics, chemical biology, structure biology, and chemical proteomics. Chemical Reagents for Protein Modification, Fourth Edition provides a comprehensive review of reagents used for the chemical modification of proteins, representing a major revision of the work presented in previous editions. The completely updated Fourth Edition is substantially larger and includes five new chapters: Alkylating Agents Acylating Agents Nitration and Nitrosylation Oxidation Modification of Proteins with Reducing Agents There is greatly increased coverage of the chemical modification of cysteine, which is critical for bioconjugate synthesis. The chapter on reduction also provides information necessary for bioconjugate synthesis as well as for the processing of inclusion bodies. The book places emphasis on conditions that affect the specificity of the chemical modification of proteins, such as solvent and temperature. The format has been markedly revised, presenting information based on the chemical nature of the modifying material and on the amino acid residue modified. This new version has increased significance to biopharmaceuticals. Much of the information is in tabular form, which enables the rapid location of cited material.
This issue contains the first of a planned set of three publications greatly expanding knowledge of the platygastroid genus Oxyscelio Kieffer. We recognize 90 species in the Indo-Malayan and Palearctic realms, 71 of which are described here as new species. We divided these species into 13 species groups in order to highlight unique or unusual morphological features shared by certain species. A total of 438 specimen photographs are provided to aid in specimen identification. Newly discovered species are described from Brunei, China, Christmas Island, India, Indonesia, Japan, Laos, Malaysia, Nepal, The Philippines, Singapore, South Korea, Sri Lanka, Taiwan, Thailand, and Vietnam.
New Zealand has to rebuild the majority of its second-largest city after a devastating series of earthquakes – a unique challenge for a developed country in the twenty-first century. The 2010-2011 earthquakes fundamentally disrupted the conventions by which the people of Christchurch lived. The exhausting and exhilarating mix of distress, uncertainty, creativity, opportunities, divergent opinions and competing priorities generates an inevitable question: how do we know if the right decisions are being made? Once in Lifetime: City-building after Disaster in Christchurch offers the first substantial critique of the Government’s recovery plan, presents alternative approaches to city-building andarchives a vital and extraordinary time. It features photo and written essays from journalists, economists, designers, academics, politicians, artists, publicans and more. Once in a Lifetime presents a range of national and international perspectives on city-building and post-disaster urban recovery.
This is the new edition of the classic introductory text to electrophysiology. It covers many topics that are central to the field including the electrical properties of the cell membrane and cardiac electrophysiology. Organized as a textbook for the student needing to acquire the core competencies, this book meets the demands of advanced undergraduate or graduate coursework in biomedical engineering and biophysics. New features include extra, detailed illustrations. The book is authored by two eminent biomedical engineering professors at Duke University who discuss many topics that are central to biophysics and bioengineering and the quantitative methods employed.
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