This book is based on the authors' significant practical experience partnering with scientists to develop strategies to accelerate the formulation (mixtures) development process. The authors not only explain the most important methods used to design and analyze formulation experiments, but they also present overall strategies to enhance both the efficiency and effectiveness of the development process.
With over 25 million dead, AIDS has pounced on the world like a medieval plague, ranking among the greatest killers in history. Despite billions of international aid dollars, the development of effective medical treatments for HIV (the virus that causes AIDS), and the efficacy of condoms in preventing the spread of HIV during sex, 6,000 people are dying daily, and over 15 million orphans have been left behind. Perhaps most surprisingly, many educated westerners are only vaguely aware of AIDS as a disease threatening gays or Africans, and do not believe it has any relevance for them. Few have noticed the “feminization” of AIDS, taking AIDS from a disease primarily infecting gay men to one infecting more women than men. Women are at the forefront of the fight against AIDS in many parts of the world, nowhere more so than in Sub-Saharan Africa. The authors of this book make a clear case that HIV and AIDS form the most critical crisis facing the human race in this century by providing the reader a deeper understanding of the root causes of, and plausible solutions for, the AIDS pandemic. They include several engaging human-interest stories of real people impacted by AIDS. Table Of Contents Part I: What Is AIDS and Why Should I Care? Chapter 1: Nikiwe’s Story: Why AIDS Is the Global Challenge of the 21st Century Chapter 2: Sinikithemba: What Exactly Are HIV and AIDS? Chapter 3: Say No to Sugar Daddies: From Rare Infections to Global Pandemic Part II: AIDS Trumps Foreign Aid Chapter 4: Life and Death in Zimbabwe: Why AIDS Is Easy to Solve—On Paper Chapter 5: But for the Grace of PEPFAR: The World Heard and Responded Chapter 6: Mama Africa’s Burden: The Limitations of Money Part III: How AIDS Can Be Defeated With Your Help Chapter 7: Bophelong Hospice: Some Things That Actually Work Chapter 8: The Softer Side of Capitalism: A Suggested Path Forward Chapter 9: Use What You Have: How You Can Play a Part in Defeating AIDS Excerpts from the foreword to the book, written by Dr. Helga Holst, CEO of McCord Hospital in Durban, South Africa, are given below: It was in Boston, on February 10, 2003, that the Sinikithemba Choir from Durban, South Africa, performed at the opening of the Tenth Conference on Retroviruses and Opportunistic Infections (CROI), and shared the stage with the keynote speaker, President Bill Clinton. This Zulu choir of HIV positive men and women were part of a much larger group of mostly infected women, who worked together at McCord Hospital on beadwork projects to support their medical care, and who sang as they worked. They used what they had, their powerful and beautiful voices, to bring hope, unity and resources to their communities. One of the choir members, a beautiful and eloquent young woman, shared the poignant story of her own journey with AIDS, and brought tears to the eyes of many of the world’s top scientists, researchers and clinicians as they were reminded of why they had committed their lives to finding the answers to this devastating disease. She shared what she had, her own story, and it impacted the hearts of thousands! By the time I took up the position of Medical Superintendent at McCord Hospital in Durban, in 1993, AIDS was more common, but there was still no affordable treatment available. In the mid 1990’s we started several social support programs, of which the income generating beadwork projects were one. Social clubs, consisting mostly of women, were formed. They supported each other through times of hardship, illness and death, and cared for the children. The Zulu people, amongst whom we work, have been gifted by the most beautiful voices. The women would often sit in the parking areas at the hospital between the cars with their hands speedily busy on beadwork orders, chatting and laughing, while keeping a
How statistical thinking and methodology can help you make crucial business decisions Straightforward and insightful, Statistical Thinking: Improving Business Performance, Second Edition, prepares you for business leadership by developing your capacity to apply statistical thinking to improve business processes. Unique and compelling, this book shows you how to derive actionable conclusions from data analysis, solve real problems, and improve real processes. Here, you'll discover how to implement statistical thinking and methodology in your work to improve business performance. Explores why statistical thinking is necessary and helpful Provides case studies that illustrate how to integrate several statistical tools into the decision-making process Facilitates and encourages an experiential learning environment to enable you to apply material to actual problems With an in-depth discussion of JMP® software, the new edition of this important book focuses on skills to improve business processes, including collecting data appropriate for a specified purpose, recognizing limitations in existing data, and understanding the limitations of statistical analyses.
Thermal analysis cuts a broad swathe through contemporary science. Within this domain, advances in instrumentation permit the application of quantitative calorimetry to the full spectrum of modern materials. This can be illustrated perhaps no better than by the set of contributions which make up this Volume 4 of Analytical Calorimetry. The research supported in this fourth volume of Analytical Calorimetry covers a wide variety of topics. The range indicates the sophistication which thermal analysis is reaching and additional ly the ever-widening applications that are being developed. The contributions to the Volume represent, in part, papers presented before the Division of Analytical Chemistry at the Fourth Symposium on Analytical Chemistry held at the 172nd National Meeting of the American Chemical Society, August 29 - September 3, 1976. Several additional key contributions are included by prominent workers in the field. Julian F. Johnson Roger S. Porter v Quantitative Scanning Calorimetry with Computerized Data Acquisition and Reduction . . . . . . . 1 Aris Doelman, Annie R. Gregges, and Edward M. Barrall, II Thermodynamic Properties of a Series of P-N-Alkyl-P'-Cyanobiphenyls 19 E. M. Barrall II, R. J. Cox, A. Doelman, N. Clecak, J. A. Logan, and A. R. Gregges Thermodynamic Properties of a Series of 37 P-N-Alkoxy-P'-Cyanobiphenyls R. J. Cox, E. M. Barrall II, A. Doelman, N. J. Clecak, J. A. Logan, R. D. Diller, and A. R. Gregges A New Equation for Predicting Polyethylene Lifetimes from Thermal Data 51 Cary F.
`I often... wonder to myself whether the field needs another book, handbook, or encyclopedia on this topic. In this case I think that the answer is truly yes. The handbook is well focused on important issues in the field, and the chapters are written by recognized authorities in their fields. The book should appeal to anyone who wants an understanding of important topics that frequently go uncovered in graduate education in psychology' - David C Howell, Professor Emeritus, University of Vermont Quantitative psychology is arguably one of the oldest disciplines within the field of psychology and nearly all psychologists are exposed to quantitative psychology in some form. While textbooks in statistics, research methods and psychological measurement exist, none offer a unified treatment of quantitative psychology. The SAGE Handbook of Quantitative Methods in Psychology does just that. Each chapter covers a methodological topic with equal attention paid to established theory and the challenges facing methodologists as they address new research questions using that particular methodology. The reader will come away from each chapter with a greater understanding of the methodology being addressed as well as an understanding of the directions for future developments within that methodological area. Drawing on a global scholarship, the Handbook is divided into seven parts: Part One: Design and Inference: addresses issues in the inference of causal relations from experimental and non-experimental research, along with the design of true experiments and quasi-experiments, and the problem of missing data due to various influences such as attrition or non-compliance. Part Two: Measurement Theory: begins with a chapter on classical test theory, followed by the common factor analysis model as a model for psychological measurement. The models for continuous latent variables in item-response theory are covered next, followed by a chapter on discrete latent variable models as represented in latent class analysis. Part Three: Scaling Methods: covers metric and non-metric scaling methods as developed in multidimensional scaling, followed by consideration of the scaling of discrete measures as found in dual scaling and correspondence analysis. Models for preference data such as those found in random utility theory are covered next. Part Four: Data Analysis: includes chapters on regression models, categorical data analysis, multilevel or hierarchical models, resampling methods, robust data analysis, meta-analysis, Bayesian data analysis, and cluster analysis. Part Five: Structural Equation Models: addresses topics in general structural equation modeling, nonlinear structural equation models, mixture models, and multilevel structural equation models. Part Six: Longitudinal Models: covers the analysis of longitudinal data via mixed modeling, time series analysis and event history analysis. Part Seven: Specialized Models: covers specific topics including the analysis of neuro-imaging data and functional data-analysis.
Elizabeth Anscombe's 1958 essay ‘Modern Moral Philosophy' contributed to the transformation of the subject from the late 1960s, reversing the trend to assume that there is no intrinsic connection between facts, values, and reasons for action; and directing attention towards the category of virtues. Her later ethical writings were focused on particular ideas and issues such as those of conscience, double-effect, murder, and sexual ethics. In this collection of new essays deriving from a conference held in Oxford these and other aspects of her moral philosophy are examined. Anyone interested in Anscombe’s work all want to read this volume.
A Holistic Approach to Performance Improvement That Reflects 30 Years of Six Sigma Learning Leading Holistic Improvement with Lean Six Sigma 2.0 distills all that’s been learned about Six Sigma over the past three decades, helping you build and execute on modern holistic strategies to radically improve processes and performance. It’s the definitive modern guide to Lean Six Sigma for executives, champions, Black Belts, Green Belts, and every stakeholder concerned with performance improvement. In addition, it notes the limitations of Lean Six Sigma and explains how to broaden deployments to true holistic improvement, integrating multiple improvement methodologies. Renowned experts Ronald Snee and Roger Hoerl help you launch or accelerate comprehensive “Lean Six Sigma 2.0” initiatives, integrating modern techniques to improve customer satisfaction, employee engagement, growth, and profitability across your organization. They introduce important recent advances in Lean Six Sigma theory and practice, and offer new case studies illuminating opportunities for holistic improvement. With an ideal mix of fundamental concepts and real-world case studies, the authors help you broaden your portfolio of improvement methodologies, integrating systems for process management, control, and risk management. This revision incorporates decades of collective experience in improvement initiatives, the most relevant research on what does and doesn’t work, and contains three completely new chapters, as well as two previously unpublished holistic improvement case studies. This innovative approach is specifically designed to help you solve large, complex, and unstructured problems; and manage risk in a world of cyberattacks, terrorism, and fragmentation. Plan and deploy a modern Lean Six Sigma strategy that fully reflects your organization Learn and apply key lessons from the world’s best implementations Integrate key success factors into a step-by-step process for improvement, and avoid common pitfalls that lead to failure Master all facets of Lean Six Sigma leadership, including strategy, goal setting, metrics, training, roles/responsibilities, processes, reporting, rewards, and ongoing management review Evolve your deployment to true holistic improvement that leverages modern methods and encompasses the entire organization Make the most of big data analytics and other modern methods Choose the optimal improvement method for each complex challenge you face Use a focus on improvement as a leadership development tool
In covering the topic of gynecologic and obstetric pathology, this book attempts to carve out its own niche midway between an atlas and a traditional textbook. The gross and microscopic images in this atlas are presented exclusively in color, and are supplemented by pertinent clinical information and discussions of differential diagnostic considerations. When deemed appropriate, images of immunohistochemical and special stains are included. To further enhance their visual appeal and the overall learning experience, many images in this book are presented with annotations and/or in composite form, and selected images have been enlarged. This image-intensive textbook also includes numerous Pap smear images and cytologic-histologic correlations. In addition to coverage of pathology of the organs of the female genital tract, brief overviews of the normal histology of these sites are provided as necessary background information. Separate chapters are also devoted to placental and peritoneal pathology. There is an emphasis on diagnostic-related issues pertaining to common lesions and their variants, although classic forms of rare lesions are also presented. In selected instances, recommendations on the processing of gross pathology specimens, discussions regarding the optimal approach for intraoperative consultations, and recommendations on the phrasing of key portions of pathology reports are provided. The 10 chapters of this book are organized by site, and the beginning of each chapter lists the entities discussed and their corresponding page numbers.
For more than 20 years, this has been the best selling guide to software engineering for students and industry professionals alike. This edition has been completely updated and contains hundreds of new references to software tools.
In Leading Six Sigma, two of the world's most experienced Six Sigma leaders offer a detailed, step-by-step strategy for leading Six Sigma initiatives in your company. Top Six Sigma consultant Dr. Ronald D. Snee and GE quality leader Dr. Roger W. Hoerl show how to deploy a Six Sigma plan that reflects your organization's unique needs and culture, while also leveraging key lessons learned by the world's most successful implementers. Snee and Hoerl share leadership techniques proven in companies both large and small, and in business functions ranging from R & D and manufacturing to finance. They also present a start-to-finish sample deployment plan encompassing strategy, goals, metrics, training, roles and responsibilities, reporting, rewards, and management review. Whether you're a CEO, line-of-business leader, or a project leader, Leading Six Sigma gives you the one thing other books on Six Sigma lack: a clear view from the top. * The right projects, the right people Identifying your company's most promising Six Sigma opportunities and leaders * How to hit the ground running Providing leadership, talent, and infrastructure for a successful launch * From launch to long-term success Implementing systems, processes, and budgets for ongoing Six Sigma projects * Getting the bottom-line results that matter most Measuring and maximizing the financial value of your Six Sigma initiative * Four detailed case studies: What works and what doesn't Avoiding the subtle mistakes that can make Six Sigma fall short. Proven techniques for leading successful quality initiatives. The Six Sigma guide designed specifically for business leaders Co-authored by Dr. Roger W. Hoerl, a leader in implementing Six Sigma at GE Draws on Six Sigma experiences at over 30 leading companies Covers the entire Six Sigma lifecycle, from planning onward Presents new solutions for overcoming the cultural resistance to Six Sigma initiatives Leading Six Sigma offers an insider's view of what it really takes to lead a successful Six Sigma initiative, drawing on the authors' experience at the top levels of the world's largest and most challenging organizations.Dr. Ronald D. Snee shares experiences drawn from executive-level consulting at over 30 major companies. Dr. Roger W. Hoerl teaches powerful lessons from his experience in pioneering Six Sigma throughout GE during the Jack Welch era. Together they offer unprecedented executive guidance on the issues most crucial to senior managers, covering every stage from planning through ongoingmanagement.Snee and Hoerl offer practical solutions for the cultural challenges and human resistance that face any executive seeking to initiate Six Sigma or improve an existing program. They even explain how and when to "wind down" initiatives, transitioning Six Sigma to a "fact of life" that doesn't require the support of a massive centralized infrastructure. " This is a truly insightful and well-researched book on Six Sigma by two of the leading experts in the field. Theirroadmap for successful deployment is supported by the experiences of major corporations, including GE and Honeywell. Itis extremely well presented in a step-by-step manner and backed up by real business-case examples. Bravo to the authors inbringing us a book that should be at the ready reach of leadership of organizations and the practitionersof Six Sigma. It reminded me so much of 'In Search of Excellence' as far as its potential impact on the way businessescan be successful. "&
How statistical thinking and methodology can help you make crucial business decisions Straightforward and insightful, Statistical Thinking: Improving Business Performance, Second Edition, prepares you for business leadership by developing your capacity to apply statistical thinking to improve business processes. Unique and compelling, this book shows you how to derive actionable conclusions from data analysis, solve real problems, and improve real processes. Here, you'll discover how to implement statistical thinking and methodology in your work to improve business performance. Explores why statistical thinking is necessary and helpful Provides case studies that illustrate how to integrate several statistical tools into the decision-making process Facilitates and encourages an experiential learning environment to enable you to apply material to actual problems With an in-depth discussion of JMP® software, the new edition of this important book focuses on skills to improve business processes, including collecting data appropriate for a specified purpose, recognizing limitations in existing data, and understanding the limitations of statistical analyses.
A Holistic Approach to Performance Improvement That Reflects 30 Years of Six Sigma Learning Leading Holistic Improvement with Lean Six Sigma 2.0 distills all that’s been learned about Six Sigma over the past three decades, helping you build and execute on modern holistic strategies to radically improve processes and performance. It’s the definitive modern guide to Lean Six Sigma for executives, champions, Black Belts, Green Belts, and every stakeholder concerned with performance improvement. In addition, it notes the limitations of Lean Six Sigma and explains how to broaden deployments to true holistic improvement, integrating multiple improvement methodologies. Renowned experts Ronald Snee and Roger Hoerl help you launch or accelerate comprehensive “Lean Six Sigma 2.0” initiatives, integrating modern techniques to improve customer satisfaction, employee engagement, growth, and profitability across your organization. They introduce important recent advances in Lean Six Sigma theory and practice, and offer new case studies illuminating opportunities for holistic improvement. With an ideal mix of fundamental concepts and real-world case studies, the authors help you broaden your portfolio of improvement methodologies, integrating systems for process management, control, and risk management. This revision incorporates decades of collective experience in improvement initiatives, the most relevant research on what does and doesn’t work, and contains three completely new chapters, as well as two previously unpublished holistic improvement case studies. This innovative approach is specifically designed to help you solve large, complex, and unstructured problems; and manage risk in a world of cyberattacks, terrorism, and fragmentation. Plan and deploy a modern Lean Six Sigma strategy that fully reflects your organization Learn and apply key lessons from the world’s best implementations Integrate key success factors into a step-by-step process for improvement, and avoid common pitfalls that lead to failure Master all facets of Lean Six Sigma leadership, including strategy, goal setting, metrics, training, roles/responsibilities, processes, reporting, rewards, and ongoing management review Evolve your deployment to true holistic improvement that leverages modern methods and encompasses the entire organization Make the most of big data analytics and other modern methods Choose the optimal improvement method for each complex challenge you face Use a focus on improvement as a leadership development tool
Strategies for Formulations Development: A Step-by-Step Guide Using JMP is based on the authors' significant practical experience partnering with scientists to develop strategies to accelerate the formulation (mixtures) development process. The authors not only explain the most important methods used to design and analyze formulation experiments, but they also present overall strategies to enhance both the efficiency and effectiveness of the development process. With this book you will be able to: Approach the development process from a strategic viewpoint with the overall end result in mind. Design screening experiments to identify components that are most important to the performance of the formulation. Design optimization experiments to identify the maximum response in the design space. Analyze both screening and optimization experiments using graphical and numerical methods. Optimize multiple criteria, such as the quality, cost, and performance of product formulations. Design and analyze formulation studies that involve both formulation components and process variables using methods that reduce the required experimentation by up to 50%. Linking dynamic graphics with powerful statistics, JMP helps construct a visually compelling narrative to interactively share findings that are coherent and actionable by colleagues and decision makers. Using this book, you can take advantage of computer generated experiment designs when classical designs do not suffice, given the physical and economic constraints of the experiential environment. Strategies for Formulations Development: A Step-by-Step Guide Using JMP(R) is unique because it provides formulation scientists with the essential information they need in order to successfully conduct formulation studies in the chemical, biotech, and pharmaceutical industries.
With over 25 million dead, AIDS has pounced on the world like a medieval plague, ranking among the greatest killers in history. Despite billions of international aid dollars, the development of effective medical treatments for HIV (the virus that causes AIDS), and the efficacy of condoms in preventing the spread of HIV during sex, 6,000 people are dying daily, and over 15 million orphans have been left behind. Perhaps most surprisingly, many educated westerners are only vaguely aware of AIDS as a disease threatening gays or Africans, and do not believe it has any relevance for them. Few have noticed the “feminization” of AIDS, taking AIDS from a disease primarily infecting gay men to one infecting more women than men. Women are at the forefront of the fight against AIDS in many parts of the world, nowhere more so than in Sub-Saharan Africa. The authors of this book make a clear case that HIV and AIDS form the most critical crisis facing the human race in this century by providing the reader a deeper understanding of the root causes of, and plausible solutions for, the AIDS pandemic. They include several engaging human-interest stories of real people impacted by AIDS. Table Of Contents Part I: What Is AIDS and Why Should I Care? Chapter 1: Nikiwe’s Story: Why AIDS Is the Global Challenge of the 21st Century Chapter 2: Sinikithemba: What Exactly Are HIV and AIDS? Chapter 3: Say No to Sugar Daddies: From Rare Infections to Global Pandemic Part II: AIDS Trumps Foreign Aid Chapter 4: Life and Death in Zimbabwe: Why AIDS Is Easy to Solve—On Paper Chapter 5: But for the Grace of PEPFAR: The World Heard and Responded Chapter 6: Mama Africa’s Burden: The Limitations of Money Part III: How AIDS Can Be Defeated With Your Help Chapter 7: Bophelong Hospice: Some Things That Actually Work Chapter 8: The Softer Side of Capitalism: A Suggested Path Forward Chapter 9: Use What You Have: How You Can Play a Part in Defeating AIDS Excerpts from the foreword to the book, written by Dr. Helga Holst, CEO of McCord Hospital in Durban, South Africa, are given below: It was in Boston, on February 10, 2003, that the Sinikithemba Choir from Durban, South Africa, performed at the opening of the Tenth Conference on Retroviruses and Opportunistic Infections (CROI), and shared the stage with the keynote speaker, President Bill Clinton. This Zulu choir of HIV positive men and women were part of a much larger group of mostly infected women, who worked together at McCord Hospital on beadwork projects to support their medical care, and who sang as they worked. They used what they had, their powerful and beautiful voices, to bring hope, unity and resources to their communities. One of the choir members, a beautiful and eloquent young woman, shared the poignant story of her own journey with AIDS, and brought tears to the eyes of many of the world’s top scientists, researchers and clinicians as they were reminded of why they had committed their lives to finding the answers to this devastating disease. She shared what she had, her own story, and it impacted the hearts of thousands! By the time I took up the position of Medical Superintendent at McCord Hospital in Durban, in 1993, AIDS was more common, but there was still no affordable treatment available. In the mid 1990’s we started several social support programs, of which the income generating beadwork projects were one. Social clubs, consisting mostly of women, were formed. They supported each other through times of hardship, illness and death, and cared for the children. The Zulu people, amongst whom we work, have been gifted by the most beautiful voices. The women would often sit in the parking areas at the hospital between the cars with their hands speedily busy on beadwork orders, chatting and laughing, while keeping a
Strategies for Formulations Development: A Step-by-Step Guide Using JMP(R) is based on the authors' significant practical experience partnering with scientists to develop strategies to accelerate the formulation (mixtures) development process. The authors not only explain the most important methods used to design and analyze formulation experiments, but they also present overall strategies to enhance both the efficiency and effectiveness of the development process. With this book you will be able to: Approach the development process from a strategic viewpoint with the overall end result in mind. Design screening experiments to identify components that are most important to the performance of the formulation. Design optimization experiments to identify the maximum response in the design space. Analyze both screening and optimization experiments using graphical and numerical methods. Optimize multiple criteria, such as the quality, cost, and performance of product formulations. Design and analyze formulation studies that involve both formulation components and process variables using methods that reduce the required experimentation by up to 50%. Linking dynamic graphics with powerful statistics, JMP helps construct a visually compelling narrative to interactively share findings that are coherent and actionable by colleagues and decision makers. Using this book, you can take advantage of computer generated experiment designs when classical designs do not suffice, given the physical and economic constraints of the experiential environment. Strategies for Formulations Development: A Step-by-Step Guide Using JMP(R) is unique because it provides formulation scientists with the essential information they need in order to successfully conduct formulation studies in the chemical, biotech, and pharmaceutical industries.
Joseph Wolpe brought about a revolution in psychotherapy. He provided the first clear alternative to therapy as an esoteric exploration of mental forces and presented, instead, clearly specified procedures and documented outcomes - a practical technology based on a fundamental science of learning. Roger Poppen, who witnessed some of this revolution first hand as a doctoral student, describes the major impact Wolpe's theories had on psychotherapy, compelling it to address issues of effectiveness and accountability. He assesses the criticisms that Wolpe's work has attracted both from outside and within the behavioural school, and describes the development of Wolpe's ideas and his continuing role in the theory, practice and ev
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