Described herein is an account of my laboratory’s entry into the magnificent field of complex alkaloid total synthesis, spanning the development of novel methods for quickly assembling polycyclic frameworks through the total synthesis of various members of the Strychnos alkaloids. A discussion of the prior art related to our approach to these alkaloids in addition to strategic decisions and reasoning made en route to targets akuammicine ( 1 ), strychnine ( 2 ), and leuconicines A ( 3 ) and B ( 4 ) is carefully detailed. Finally, we present the retrosynthetic analyses of the aforementioned targets and respective total syntheses thereof (including asymmetric variants).
This title critically reviews old and new literature, help to create greater awareness of the disease in the US and helps in the evaluation of certain epidemiological and public health issues. During the first half of the 20th century, Chagas disease was assumed to be absent from the U.S. and considered an exotic disease, until the first two indigenous cases were discovered, almost simultaneously, in Texas, 1955. Since that time four indigenous cases have been documented in several places in the country. Although the disease is still considered uncommon in the US, this disease is not longer an exclusive Latin American illness. Physicians in the US are often unaware of the characteristics of the diseases, and are likely overlooking locally acquired cases. The influx of an estimated 300,000 Latin American immigrants with the Chagas parasite means that there is an urgent need for physicians and public health officials to become aware. - Helps to create greater awareness of Chagas disease in the USA - Helps to evaluate epidemiological and public health issues - Facilitates accurate and necessary future public health interventions
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