Rodrick Wallace's Books

Mathematical Approach To Multilevel, Multiscale Health Interventions, A: Pharmaceutical Industry Decline And Policy Response

By: Rodrick Wallace,Deborah Wallace

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Mathematical Approach To Multilevel, Multiscale Health Interventions, A: Pharmaceutical Industry Decline And Policy Response

By: Rodrick Wallace,Deborah Wallace

This book, based on published studies, takes a unique perspective on the 30-year collapse of pharmaceutical industry productivity in the search for small molecule “magic bullet” interventions. The relentless escalation of inflation-adjusted cost per approved medicine in the United States — from $200 million in 1950 to $1.2 billion in 2010 — has driven industry giants to, at best, slavish imitation in drug design, and at worst, abandonment of research and embracing of widespread fraud in consumer marketing.The book adapts formalism across a number of disciplines to the strategy for design of mutilevel interventions, focusing first on molecular, cellular, and larger scale examples, and then extending the argument to the simplifications provided by the dominant role of social and cultural structures and processes in individual and population patterns of health and illness.In place of “magic bullets”, we must now apply “magic strategies” that act across both the scale and level of organization. This book provides an introductory roadmap to the new tools that will be needed for the design of such strategies./a

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238

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World Scientific

Published Date

ISBN 10

1848169981

ISBN 13

9781848169982

Gene Expression and Its Discontents

The Social Production of Chronic Disease

By: Rodrick Wallace,Deborah Wallace

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Gene Expression and Its Discontents

The Social Production of Chronic Disease

By: Rodrick Wallace,Deborah Wallace

This book describes how epigenetic context, in a large sense, affects gene expression and the development of an organism, using the asymptotic limit theorems of information theory to construct statistical models useful in data analysis. The approach allows deep understanding of how embedding context affects development. We find that epigenetic information sources act as tunable catalysts, directing ontogeny into characteristic pathways, a perspective having important implications for epigenetic epidemiology. In sum, environmental stressors can induce a broad spectrum of developmental dysfunctions, and the book explores a number of pandemic chronic diseases, using U.S. data at different scales and levels of organization. In particular, we find the legacy of slavery has been grossly compounded by accelerating industrial decline and urban decay. Individual chapters are dedicated to obesity and its sequelae, coronary heart disease, cancer, mental disorders, autoimmune dysfunction, Alzheimer’s disease, and other conditions. Developmental disorders are driven by environmental factors channeled by historical trajectory and are unlikely to respond to medical interventions at the population level in the face of persistent individual and community stress. Drugs powerful enough to affect deleterious epigenetic programming will likely have side effects leading to shortened lifespan. Addressing chronic conditions and developmental disorders requires significant large-scale changes in public policy and resource allocation.

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344

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Springer

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ISBN 10

3319480782

ISBN 13

9783319480787

An Ecosystem Approach to Economic Stabilization

Escaping the Neoliberal Wilderness

By: Rodrick Wallace

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An Ecosystem Approach to Economic Stabilization

Escaping the Neoliberal Wilderness

By: Rodrick Wallace

The creation of economic institutions that can function well under substantial uncertainties -- Black Swans -- is analogous to the dilemmas confronting our hunter-gatherer forefathers in the face of large-scale ecological unpredictability. The ultimate solution was not the development of a super hunter-gatherer technology that could ride out repeated catastrophe, but rather the invention, in neolithic times, of culturally-adapted 'farmed' ecosystems constructed to maximize food yield and minimize risks of famine. Recent advances in evolutionary and ecosystem theory applied to economic structure and process may permit construction of both new economic theory and new tools for data analysis that can help in the design of more robust economic institutions. This may result in less frequent and less disruptive transitions, and enable the design of culturally-specific systems less affected by those that do occur. This unique and innovative book applies cutting-edge methods from cognitive science and evolutionary theory to the problem of the necessary stabilization of economic processes. At the core of this book is the establishment of a statistics-like toolbox for the study of empirical data that is consistent with generalized evolutionary approaches. This toolbox enables the construction of both new economic theories and methods of data analysis that can help in the design of more robust economic institutions. This in turn will result in less frequent and less disruptive Black Swans, and enable as well the design of culturally-specific systems less affected by those that do occur.

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175

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Routledge

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ISBN 10

1317566696

ISBN 13

9781317566694

Clear-Cutting Disease Control

Capital-Led Deforestation, Public Health Austerity, and Vector-Borne Infection

By: Rodrick Wallace,Luis Fernando Chaves,Luke R. Bergmann,Constância Ayres,Lenny Hogerwerf,Richard Kock,Robert G. Wallace

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Clear-Cutting Disease Control

Capital-Led Deforestation, Public Health Austerity, and Vector-Borne Infection

By: Rodrick Wallace,Luis Fernando Chaves,Luke R. Bergmann,Constância Ayres,Lenny Hogerwerf,Richard Kock,Robert G. Wallace

The vector-borne Zika virus joins avian influenza, Ebola, and yellow fever as recent public health crises threatening pandemicity. By a combination of stochastic modeling and economic geography, this book proposes two key causes together explain the explosive spread of the worst of the vector-borne outbreaks. Ecosystems in which such pathogens are largely controlled by environmental stochasticity are being drastically streamlined by both agribusiness-led deforestation and deficits in public health and environmental sanitation. Consequently, a subset of infections that once burned out relatively quickly in local forests are now propagating across susceptible human populations whose vulnerability to infection is often exacerbated in structurally adjusted cities. The resulting outbreaks are characterized by greater global extent, duration, and momentum. As infectious diseases in an age of nation states and global health programs cannot, as much of the present modeling literature presumes, be described by interacting populations of host, vector, and pathogen alone, a series of control theory models is also introduced here. These models, useful to researchers and health officials alike, explicitly address interactions between government ministries and the pathogens they aim to control.

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Springer

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ISBN 10

3319728504

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9783319728506

Essays on the Extended Evolutionary Synthesis

Formalizations and Expansions

By: Rodrick Wallace

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Essays on the Extended Evolutionary Synthesis

Formalizations and Expansions

By: Rodrick Wallace

From the ‘punctuated equilibrium' of Eldrege and Gould, through Lewontin's ‘triple helix' and the various visions and revisions of the Extended Evolutionary Synthesis (EES) of Laland and others, both data and theory have demanded an opening-up of the 1950's Evolutionary Synthesis that so firmly wedded evolutionary theory to the mathematics of gene frequency analysis. It can, however, be argued that a single deep and comprehensive mathematical theory may simply not be possible for the almost infinite varieties of evolutionary process active at and across the full range of scales of biological, social, institutional, and cultural phenomena. Indeed, the case history of 'meme theory' should have raised a red flag that narrow gene-centered models of evolutionary process may indeed have serious limitations. What is attempted here is less grand, but still broader than a gene-centered analysis. Following the instruction of Maturana and Varela that all living systems are cognitive, in a certain sense, and that living as a process is a process of cognition, the asymptotic limit theorems of information and control theories that bound all cognition provide a basis for constructing an only modestly deep but wider-ranging series of probability models that might be converted into useful statistical tools for the analysis of observational and experimental data related to evolutionary process. The line of argument in this series of interrelated essays proves to be surprisingly direct.

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177

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Springer Nature

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ISBN 10

3031298799

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9783031298790

COVID-19 in New York City

An Ecology of Race and Class Oppression

By: Deborah Wallace,Rodrick Wallace

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COVID-19 in New York City

An Ecology of Race and Class Oppression

By: Deborah Wallace,Rodrick Wallace

This book is the first social epidemiological study of COVID-19 spread in New York City (NYC), the primary epicenter of the United States. New York City spread COVID-19 throughout the United States. The context of epicenter formation determined the rapid, extreme rise of NYC case and mortality rates. Decades of public policies destructive of poor neighborhoods of color heavily determined the spread within the City. Premature mortality rates revealed the "weathering" of policy-targeted communities: accelerated aging due to chronic stress. COVID attacks the elderly more severely than those under the age of 60. Communities with high proportions of prematurely aged residents proved fertile ground for COVID illness and mortality. The very public policies that created swaths of white wealth across much of Manhattan and parts of Brooklyn destroyed the human diversity needed to ride out crises. Topics covered within the chapters include: Premature Death Rate Geography in New York City: Implications for COVID-19 NYC COVID Markers at the ZIP Code Level Prospero's New Castles: COVID Infection and Premature Mortality in the NY Metro Region Pandemic Firefighting vs. Pandemic Fire Prevention Conclusion: Scales of Time in Disasters An exemplary study in health disparities, COVID-19 in New York City: An Ecology of Race and Class Oppression is essential reading for social epidemiologists, public health researchers of health disparities, those in public service tasked with addressing these problems, and infectious disease scientists who focus on spread in human populations of new zoonotic diseases. The brief also should appeal to students in these fields, civil rights scholars, science writers, medical anthropologists and sociologists, medical and public health historians, public health economists, and public policy scientists.

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Springer Nature

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ISBN 10

3030596249

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9783030596248

A Plague on Your Houses

How New York Was Burned Down and National Public Health Crumbled

By: Deborah Wallace,Rodrick Wallace

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A Plague on Your Houses

How New York Was Burned Down and National Public Health Crumbled

By: Deborah Wallace,Rodrick Wallace

A Plague on Your Houses is a scorching indictment of the decision to close fire companies in New York in the 1970s and a frightening study of the way misguided and malevolent social policy can spark a chain reaction of enormous and unforeseen urban collapse.

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246

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Verso

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ISBN 10

1859842534

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9781859842539

Consciousness, Cognition and Crosstalk: The Evolutionary Exaptation of Nonergodic Groupoid Symmetry-Breaking

By: Rodrick Wallace

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Consciousness, Cognition and Crosstalk: The Evolutionary Exaptation of Nonergodic Groupoid Symmetry-Breaking

By: Rodrick Wallace

This book makes application to the dynamics of arousal and distraction, and to other examples. A modified version of the Kadanoff picture of phase transitions in consciousness emerges from the Morse Function itself in a surprisingly standard manner, closely associated with the breaking of groupoid symmetries driven by fundamental equivalence class algebras. Although this is far indeed from the familiar world of physical theory, it should be possible, on the basis of the probability models developed in the book, to develop new statistical tools for the analysis of observational and empirical data regarding cognition and consciousness.

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Springer Nature

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303087219X

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9783030872199

Consciousness

A Mathematical Treatment of the Global Neuronal Workspace Model

By: Rodrick Wallace

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Consciousness

A Mathematical Treatment of the Global Neuronal Workspace Model

By: Rodrick Wallace

This book is not an intellectual history or popular summary of recent work on consciousness in humans. Bernard Baars (1988), Edelman and Tononi (2000), and many others, have written such, and done it well indeed. This book, rather, brings the powerful analytic machinery of communication theory to bear on the Global Neuronal Workspace (GNW) model of consciousness which Baars introduced, and does so in a formal mathematical manner. It is not the first such attempt. The philospher Fred Dretske (1981), indep- dent of Baars, long ago outlined how information theory might illuminate the understanding of mind. Adapting his approach on the necessary conditions for mental process, we apply a previously-developed information theory analysis of interacting cognitive biological and social modules to Baars' GNW, which has become the principal candidate for a 'standard model' of consciousness. Invoking an obvious canonical homology with statistical physics, the method, when iterated in the spirit of the Hierarchical Linear Model of regression theory, generates a fluctuating dynamic threshold for consciousness which is similar to a tunable phase transition in a physical system. The phenomenon is, however, constrained to a manifold/atlas structure analogous to a retina; an adaptable Rate Distortion manifold, whose 'topology', in a large sense, reflects the hierarchy of embedding constraints acting on consciousness. This view greatly extends what Baars has characterized as 'contexts.

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125

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Springer Science & Business Media

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ISBN 10

0387252444

ISBN 13

9780387252445

The History of Great Britain

By: Anne B. Rodrick

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The History of Great Britain

By: Anne B. Rodrick

This addition to The Greenwood Histories of the Modern Nations provides an updated, clear, and concise history of Great Britain that will be of value to undergraduates and to a general readership This updated and expanded volume serves as an introduction to the history of Great Britain, from prehistory to the present. Guiding the reader through complex developments in politics, economics, culture, and empire, this book helps readers to understand how the four kingdoms of England, Wales, Scotland, and Ireland have come together and split apart over centuries of change. Chronologically arranged chapters will help readers to better understand British history as it includes pre-Roman Britain, Britain's Tudors, the Reformation, and World Wars I and II, in addition to current events such as Brexit and others for which Theresa May has been prime minister. A timeline, a glossary, and an appendix of significant individuals in the history of Great Britain help to round out the text. The strong narrative line allows readers to understand the ways in which Great Britain has both responded to and guided global changes in economics and class, gender and race, and the politics of expansionism and nativism.

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238

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Bloomsbury Publishing USA

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ISBN 13

9798216097471

Lecturing the Victorians

Knowledge-Based Culture and Participatory Citizenship

By: Anne B. Rodrick

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Lecturing the Victorians

Knowledge-Based Culture and Participatory Citizenship

By: Anne B. Rodrick

“We are a much-lectured people,” wrote Robert Spence Watson in 1897. Beginning at mid-century, cities and towns across England used the popular lecture for purposes ranging from serious education to effervescent entertainment and from regional pride to imperial belonging. Over time, the popular lecture became the quintessential embodiment of Victorian knowledge-based culture, which itself ranged from the production of new knowledge in the most elite of learned societies to the consumption of established knowledge in middle-class clubs and the hundreds of humble mechanics' institutions initially founded to provide scientific instruction to workers. What did the “average” Victorian talk and think about? How did the knowledge-based culture of lecture and debate enable men and women to demonstrate both civic engagement and cultural competence? How does this knowledge-based culture and its changing expression give us ways to look at Victorian citizenship long before the extension of the franchise? With engaging and accessible prose Anne Rodrick draws from a variety of primary sources to provide fascinating answers to these pertinent questions. Based on the analysis of several thousand lectures and debates delivered over more than 50 years, this book digs deeply into what those individuals below the most elite levels thought, heard, debated, and claimed as a badge of cultural competence. By the turn of the 20th century, the popular lecture was competing for attention with new institutions of leisure and of higher education, and the discourse surrounding its place in contemporary England helps illuminate important debates over access to and deployment of knowledge and culture.

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283

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Bloomsbury Publishing

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ISBN 10

1350288616

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9781350288614

Computational Psychiatry

A Systems Biology Approach to the Epigenetics of Mental Disorders

By: Rodrick Wallace

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Computational Psychiatry

A Systems Biology Approach to the Epigenetics of Mental Disorders

By: Rodrick Wallace

This book explores mental disorders from a uniquely evolutionary perspective. Although there have been many attempts to mathematically model neural processes and, to some extent, their dysfunction, there is very little literature that models mental function within a sociocultural, socioeconomic, and environmental context. Addressing this gap in the extant literature, this book explores essential aspects of mental disorders, recognizing the ubiquitous role played by the exaptation of crosstalk between cognitive modules at many different scales and levels of organization, the missing heritability of complex diseases, and cultural epigenetics. Further, it introduces readers to valuable control theory tools that permit the exploration of the environmental induction of neurodevelopmental disorders, as well as the study of the synergism between culture, psychopathology and sleep disorders, offering a distinctively unique resource.

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243

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Springer

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ISBN 10

3319539108

ISBN 13

9783319539102

Gene Expression and Its Discontents

The Social Production of Chronic Disease

By: Rodrick Wallace,Deborah Wallace

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Gene Expression and Its Discontents

The Social Production of Chronic Disease

By: Rodrick Wallace,Deborah Wallace

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344

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Springer

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3319480782

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9783319480787

Cognitive Dynamics on Clausewitz Landscapes

The Control and Directed Evolution of Organized Conflict

By: Rodrick Wallace

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Cognitive Dynamics on Clausewitz Landscapes

The Control and Directed Evolution of Organized Conflict

By: Rodrick Wallace

This book applies cutting-edge methods from cognitive and evolutionary theories to develop models of conflict between hierarchically-structured cognitive entities under circumstances of imprecision, uncertainty and stress. Characterized as friction and the fog-of-war by the Prussian military theorist Carl von Clausewitz, such conditions impair institutional cognition in real-time conflict and pose a real and continuing threat to organizations, such as the US military. In a linked collection of formal essays and a mathematical appendix, the book explores different aspects of cognitive and evolutionary process as conducted under the direction of doctrine that acts as a kind of genome for retention of what is learned through Lamarckian evolutionary selection pressures: armies and corporate entities learn from conflict, and incorporate that learning into their ongoing procedures. The book proposes models and policy solutions for strategic competence. A central feature of the book is a formal description of the famous OODA loop of the US military theorist John Boyd in terms of the Data Rate Theorem that links control and information theories. That description is expanded to cover more fully the impact of stochastic fog-of-war effects on tactical and operational scales of conflict. Subsequent chapters examine in more detail the role of doctrine, and the particular effect of embedding culture on cognitive and Lamarckian evolutionary processes associated with conflict on tactical, operational, and strategic scales and levels of organization. A scientifically sophisticated exercise in applied mathematics, history, evolutionary theory, and ecosystem theory, this book will be appropriate for researchers and students interested in defense, security, and international relations, as well as non-academic career professionals in government and industry.

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173

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Springer Nature

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ISBN 10

3030264246

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9783030264246

Politics, Hierarchy, and Public Health

Voting Patterns in the 2016 US Presidential Election

By: Deborah Wallace,Rodrick Wallace

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Politics, Hierarchy, and Public Health

Voting Patterns in the 2016 US Presidential Election

By: Deborah Wallace,Rodrick Wallace

Steep socioeconomic hierarchy in post-industrial Western society threatens public health because of the physiological consequences of material and psychosocial insecurities and deprivations. Following on from their previous books, the authors continue their exploration of the geography of early mortality from age-related chronic conditions, of risk behaviors and their health outcomes, and of infant and child mortality, all due to rigid hierarchy. They divide the 50 states into those that gave their electoral college votes to Trump and those that gave theirs to Clinton in the 2016 presidential election and compare the two sets for socioeconomic and public health profiles. They deliberately apply only simple standard statistical methods in the public health analyses: t-test, Mann-Whitney test, bivariate regression, and backward stepwise multivariate regression. The book assumes familiarity with basic statistics. The authors argue that the unequal power relations that result in eroding public health in the nation and, in particular, in the Trump-voting states, largely cascade from the collapse of American industry, and they analyze the Cold War roots of that collapse. In two largely independent chapters on economics, they explore both the suppression of countervailing forces, such as organized labor, and the diversion of technical resources to the military as essential foundations to the population-level suffering that expressed itself in the 2016 presidential election. This interdisciplinary book has several primary audiences: creators of public policies, such as legislators and governmental staff, public health professionals and social epidemiologists, economists, labor union professionals, civil rights advocates, political scientists, historians, and students of these disciplines from public health through the social sciences. The Open Access version of this book, available at http://www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.

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154

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Routledge

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1000005267

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9781000005264

A Plague on Your Houses

How New York Was Burned Down and National Public Health Crumbled

By: Deborah Wallace,Rodrick Wallace

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A Plague on Your Houses

How New York Was Burned Down and National Public Health Crumbled

By: Deborah Wallace,Rodrick Wallace

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246

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Verso

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1859842534

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9781859842539

Collective Consciousness and Its Discontents:

Institutional distributed cognition, racial policy, and public health in the United States

By: Rodrick Wallace,Mindy T. Fullilove

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Collective Consciousness and Its Discontents:

Institutional distributed cognition, racial policy, and public health in the United States

By: Rodrick Wallace,Mindy T. Fullilove

An earlier book by Rodrick Wallace entitled Consciousness: A Mathematical Treatment of the Global Neuronal Workspace Model, introduced a formal information-theoretic approach to individual consciousness. This latest book takes a more formal 'groupoid' perspective to its predecessor and generalizes the results presented in that earlier book. It applies a multiple-workspace version of Dr. Wallace’s earlier consciousness model to large-scale institutional cognition.

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206

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Springer

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ISBN 10

0387767649

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9780387767642

Cognitive Dynamics on Clausewitz Landscapes

The Control and Directed Evolution of Organized Conflict

By: Rodrick Wallace

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Cognitive Dynamics on Clausewitz Landscapes

The Control and Directed Evolution of Organized Conflict

By: Rodrick Wallace

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173

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Springer Nature

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3030264246

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9783030264246

Essays on the Extended Evolutionary Synthesis

Formalizations and Expansions

By: Rodrick Wallace

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Essays on the Extended Evolutionary Synthesis

Formalizations and Expansions

By: Rodrick Wallace

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177

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Springer Nature

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3031298799

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9783031298790

An Ecosystem Approach to Economic Stabilization

Escaping the Neoliberal Wilderness

By: Rodrick Wallace

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An Ecosystem Approach to Economic Stabilization

Escaping the Neoliberal Wilderness

By: Rodrick Wallace

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267

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Routledge

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1317566688

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9781317566687

Right-to-Work Laws and the Crumbling of American Public Health

By: Deborah Wallace,Rodrick Wallace

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Right-to-Work Laws and the Crumbling of American Public Health

By: Deborah Wallace,Rodrick Wallace

This book discusses the socioeconomic effects of Right-to-Work (RTW) laws on state populations. RTW laws forbid requiring union membership even at union-represented worksites. The core of the 22 long-term RTW states was the Confederacy, cultural descendants of rigidly hierarchical agrarian feudal England. RTW laws buttress hierarchy and power imbalance which unions minimize at the worksite and by encouraging higher educational attainment, social mobility, and individual empowerment through group validation. Contrary to claims of RTW proponents, RTW and non-RTW states do not differ significantly in unemployment rates. RTW states have higher poverty rates, lower median household incomes, and lower educational attainment on average and median than non-RTW states. RTW states on average and median have lower life expectancy, higher obesity prevalence, and higher rates of all-cause mortality, early mortality from chronic conditions, child mortality, and risk behaviors than non-RTW states. The higher mortality rates result in startlingly higher annual numbers of years of life lost before age 75. Stroke mortality at age 55-64 in RTW states results in nearly 10,000 years annually lost in excess of what it would be if the mortality rate were that of non-RTW states. A review of respected publications describes the physiological mechanisms and epidemiology of accelerated aging due to socioeconomic stress. Unions challenge hierarchy directly at work-sites and indirectly through encouraging college education, social mobility, and community and political engagement. How startling that feudal hierarchy lives in 21st century America, shaping vast differences between states in macro- and micro-economics, educational attainment, innovation, life expectancy, obesity prevalence, chronic disease mortality, infant and child mortality, risk behaviors, and other public health markers! Readers will gain insight about the coming clash between feudal individualism and adaptive collectivism, and, in the last chapter, on ways to win the clash by “missionary” work for collectivism.

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162

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Springer

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3319727842

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9783319727844

COVID-19 in New York City

An Ecology of Race and Class Oppression

By: Deborah Wallace,Rodrick Wallace

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COVID-19 in New York City

An Ecology of Race and Class Oppression

By: Deborah Wallace,Rodrick Wallace

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Springer Nature

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3030596249

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9783030596248

The Recurrence of COVID-19 in New York State and New York City

Surfing the Second Wave

By: Deborah Wallace,Rodrick Wallace

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The Recurrence of COVID-19 in New York State and New York City

Surfing the Second Wave

By: Deborah Wallace,Rodrick Wallace

As a follow-up to COVID-19 in New York City: an Ecology of Race and Class Oppression, which showed that decades of discriminatory public policies shaped the Bronx into the epicenter of the first wave of COVID-19, this book examines the build up to the crest and subsequent ebbing of the second wave of COVID-19 across the 62 counties of New York State (NYS) and 152 ZIP Code areas of the four central boroughs of New York City (NYC). Like its predecessor, the sequel examines the vulnerabilities that give rise to spikes in infection rates that form epicenters. Unlike the first wave, NYC was not the epicenter of the second wave; high-incident counties just outside NYS formed an extended initial epicenter and exported COVID-19 to neighboring counties of NYS. Rural NYS counties differed significantly from urban ones socioeconomically and in infection rates during the cresting period. Before the crest, no socioeconomic factor was associated with county infection rates; rather, the major associating factor was political and cultural: percent of the 2020 vote garnered by Trump. Rural counties voted heavily for Trump. This association disappeared post-crest by mid-January 2021. In NYC, the Bronx again behaved like a single high-incidence entity, unlike the other three boroughs that had patches of high and low infection incidence. Among the topics covered: The Second COVID Wave Washes Over New York State The Second Wave Storm-Surges Across New York City Discussion of County Data from the Second Wave of COVID-19 Parsing Meaning From the 152 ZIP Code Data The book closes with a prescription for pandemic response planning based on empowered communities and workers interacting with health departments as equals. The Recurrence of COVID-19 in New York State and New York City is a valuable resource for social epidemiologists, public health researchers of health disparities, those in public service tasked with addressing these problems, and infectious disease scientists who focus on spread in human populations of new zoonotic diseases. The brief also will find readership among students in these fields, civil rights scholars, science writers, medical anthropologists and sociologists, medical and public health historians, public health economists, and public policy scientists.

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Springer Nature

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3030886190

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9783030886196

Information Approach To Mitochondrial Dysfunction, An: Extending Swerdlow's Hypothesis

By: Rodrick Wallace

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Information Approach To Mitochondrial Dysfunction, An: Extending Swerdlow's Hypothesis

By: Rodrick Wallace

The monograph applies sophisticated topological symmetry tools to biological applications of information theory, along with a Black-Scholes model invocation of the Data Rate Theorem which links information and control theories. The focus is on statistical mechanics and other models that explore pathological phase transitions — driven by changes in available rates of mitochondrial free energy — in physiological functions, a cutting-edge topic in the study of chronic disease. One of the key focuses is Alzheimer's disease — a relatively simple canonical example.

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164

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World Scientific

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ISBN 10

9814663522

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9789814663526

A Mathematical Approach to Multilevel, Multiscale Health Interventions

Pharmaceutical Industry Decline and Policy Response

By: Rodrick Wallace,Deborah Wallace

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A Mathematical Approach to Multilevel, Multiscale Health Interventions

Pharmaceutical Industry Decline and Policy Response

By: Rodrick Wallace,Deborah Wallace

This book, based on published studies, takes a unique perspective on the 30-year collapse of pharmaceutical industry productivity in the search for small molecule OC magic bulletOCO interventions. The relentless escalation of inflation-adjusted cost per approved medicine in the United States OCo from $200 million in 1950 to $1.2 billion in 2010 OCo has driven industry giants to, at best, slavish imitation in drug design, and at worst, abandonment of research and embracing of widespread fraud in consumer marketing.The book adapts formalism across a number of disciplines to the strategy for design of mutilevel interventions, focusing first on molecular, cellular, and larger scale examples, and then extending the argument to the simplifications provided by the dominant role of social and cultural structures and processes in individual and population patterns of health and illness.In place of OC magic bulletsOCO, we must now apply OC magic strategiesOCO that act across both the scale and level of organization. This book provides an introductory roadmap to the new tools that will be needed for the design of such strategies.

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238

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World Scientific

Published Date

ISBN 10

1848169973

ISBN 13

9781848169975

Clear-Cutting Disease Control

Capital-Led Deforestation, Public Health Austerity, and Vector-Borne Infection

By: Rodrick Wallace,Luis Fernando Chaves,Luke R. Bergmann,Constância Ayres,Lenny Hogerwerf,Richard Kock,Robert G. Wallace

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Clear-Cutting Disease Control

Capital-Led Deforestation, Public Health Austerity, and Vector-Borne Infection

By: Rodrick Wallace,Luis Fernando Chaves,Luke R. Bergmann,Constância Ayres,Lenny Hogerwerf,Richard Kock,Robert G. Wallace

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Springer

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3319728504

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9783319728506

Consciousness, Cognition and Crosstalk: The Evolutionary Exaptation of Nonergodic Groupoid Symmetry-Breaking

By: Rodrick Wallace

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Consciousness, Cognition and Crosstalk: The Evolutionary Exaptation of Nonergodic Groupoid Symmetry-Breaking

By: Rodrick Wallace

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Springer Nature

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ISBN 10

303087219X

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9783030872199

Mathematical Approach To Multilevel, Multiscale Health Interventions, A: Pharmaceutical Industry Decline And Policy Response

By: Rodrick Wallace,Deborah Wallace

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Mathematical Approach To Multilevel, Multiscale Health Interventions, A: Pharmaceutical Industry Decline And Policy Response

By: Rodrick Wallace,Deborah Wallace

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238

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World Scientific

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1848169981

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9781848169982

Consciousness

A Mathematical Treatment of the Global Neuronal Workspace Model

By: Rodrick Wallace

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Consciousness

A Mathematical Treatment of the Global Neuronal Workspace Model

By: Rodrick Wallace

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125

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Springer Science & Business Media

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ISBN 10

0387252444

ISBN 13

9780387252445

Information Theory Models Of Instabilities In Critical Systems

By: Rodrick Wallace

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Information Theory Models Of Instabilities In Critical Systems

By: Rodrick Wallace

The book is a unique exploration of a spectrum of unexpected analogs to psychopathologies likely to afflict real-time critical systems, written by a specialist in the epidemiology of mental disorders. The purpose of this book is to develop a set of information-theoretic statistical tools for analyzing the instabilities of real-time cognitive systems at those varying scales and levels of organization, with special focus on high level machine function.The book should be of particular interest to both industry and academic scientists, and government regulators, concerned with driverless cars on intelligent roads. Many of the same concerns also afflict high-end automated weapons systems. The book should appeal to students, researchers, and industrial and governmental administrators facing the design, operation, and maintenance of real time critical systems ranging across manufacturing facilities, transportation, finance, and military operations.

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245

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World Scientific

Published Date

ISBN 10

981314730X

ISBN 13

9789813147300

Farming Human Pathogens

Ecological Resilience and Evolutionary Process

By: Rodrick Wallace,Deborah Wallace,Robert G. Wallace

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Farming Human Pathogens

Ecological Resilience and Evolutionary Process

By: Rodrick Wallace,Deborah Wallace,Robert G. Wallace

Farming Human Pathogens: Ecological Resilience and Evolutionary Process introduces a cutting-edge mathematical formalism based on the asymptotic limit theorems of information theory to describe how punctuated shifts in mesoscale ecosystems can entrain patterns of gene expression and organismal evolution. The authors apply the new formalism toward characterizing a number of infectious diseases that have evolved in response to the world as humans have made it. Many of the human pathogens that are emerging out from underneath epidemiological control are 'farmed' in the metaphorical sense, as the evolution of drug-resistant HIV makes clear, but also quite literally, as demonstrated by avian influenza's emergence from poultry farms in southern China. The most successful pathogens appear able to integrate selection pressures humans have imposed upon them from a variety of socioecological scales. The book also presents a related treatment of Eigen's Paradox and the RNA 'error catastrophe' that bedevils models of the origins of viruses and of biological life itself.

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220

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Springer Science & Business Media

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ISBN 10

038792213X

ISBN 13

9780387922133

Carl von Clausewitz, the Fog-of-War, and the AI Revolution

The Real World Is Not A Game Of Go

By: Rodrick Wallace

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Carl von Clausewitz, the Fog-of-War, and the AI Revolution

The Real World Is Not A Game Of Go

By: Rodrick Wallace

The language of business is the language of dreams, but the language of war is the language of nightmare made real. Yet business dreams of driverless cars on intelligent roads, and of other real-time critical systems under the control of algorithmic entities, have much of war about them. Such systems, including military institutions at the tactical, operational and strategic scales, act on rapidly-shifting roadway topologies whose ‘traffic rules’ can rapidly change. War is never without both casualty and collateral damage, and realtime critical systems of any nature will inevitably partake of fog-of-war and frictional challenges almost exactly similar to those that have made warfare intractable for modern states. Into the world of Carl von Clausewitz, John Boyd, Mao Tse-Tung, Vo Nguyen Giap and Genghis Khan, come the brash, bright-eyed techies of Alphabet, Microsoft, Amazon, and Uber who forthrightly step in where a phalanx of angels has not feared to tread, but treaded badly indeed. In this book we use cutting-edge tools from information and control theories to examine canonical and idiosyncratic failure modes of real-time cognitive systems facing fog-of-war and frictional constraints. In sum, nobody ever navigates, or can navigate, the landscapes of Carl von Clausewitz unscathed.

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112

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Springer

Published Date

ISBN 10

3319746332

ISBN 13

9783319746333

Canonical Instabilities of Autonomous Vehicle Systems

The Unsettling Reality Behind the Dreams of Greed

By: Rodrick Wallace

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Canonical Instabilities of Autonomous Vehicle Systems

The Unsettling Reality Behind the Dreams of Greed

By: Rodrick Wallace

The asymptotic limit theorems of control and information theories make it possible to explore the dynamics of collapse likely to afflict large-scale systems of autonomous ground vehicles that communicate with each other and with an embedding intelligent roadway. Any vehicle/road system is inherently unstable in the control theory sense as a consequence of the basic irregularities of the traffic stream, the road network, and their interactions, placing it in the realm of the Data Rate Theorem that mandates a minimum necessary rate of control information for stability. It appears that large-scale V2V/V2I systems will experience correspondingly large-scale failures analogous to the vast, propagating fronts of power network blackouts, and possibly less benign but more subtle patterns of individual vehicle, platoon, and mesoscale dysfunction. The central matter is the synergism between poorly-understood traffic flow dynamics and similarly cryptic multisource information network dynamics, leading to highly punctuated phase transition analogs.

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ISBN 10

3319699350

ISBN 13

9783319699356

Deception and Delay in Organized Conflict

Essays on the Mathematical Theory of Maskirovka

By: Rodrick Wallace

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Deception and Delay in Organized Conflict

Essays on the Mathematical Theory of Maskirovka

By: Rodrick Wallace

This book explores the role of deception, delay, and self-deception in the dynamics of organized conflict, taking a formal approach that hews closely to the asymptotic limit theorems of information and control theories. The resulting probability models can, with some effort—and some confidence—be converted to statistical tools for the analysis of real-time observational and ‘experimental’ data on institutionalized confrontation across both traditional and emerging ‘Clausewitz Landscapes’.

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Springer Nature

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ISBN 10

303096177X

ISBN 13

9783030961770

Book's by Rodrick Wallace

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