Chapter 11. Decoding the Ascaris suum Genome using Massively Parallel Sequencing and Advanced Bioinformatic Methods – Unprecedented Prospects for Fundamental and Applied Research
Chapter 11. Decoding the Ascaris suum Genome using Massively Parallel Sequencing and Advanced Bioinformatic Methods – Unprecedented Prospects for Fundamental and Applied Research
Parasitic nematodes cause substantial morbidity and mortality in animals and people globally and major losses to food production annually. Ascaris is among the commonest geohelminths of swine and people worldwide, and causes major disease and socioeconomic losses, particularly in developing countries. The control of ascariasis has become a global health and welfare priority, but current treatment programs carry a significant risk of inducing anthelmintic resistance. Therefore, there is a need to work toward the sustainable control of Ascaris/ascariasis, built on a solid understanding of its molecular biology and genetics. Recently, we reported the 273 megabase (Mb) draft genome of Ascaris suum (sequenced from the reproductive tract of a single adult female worm) and explored transcription in different organs, stages, and both sexes of this nematode using advanced sequencing and computer technologies. We characterized key genes and biological pathways linked to the parasite’s migration in the host, and its immunobiology, reproduction, and development. We also predicted and prioritized drug targets in A. suum, providing a basis for discovering new groups of nematocides. The present chapter provides an account of these recent advances, describes new methodologies established, and emphasizes prospects for profound investigations into the comparative genomics, genetics, evolution, immunobiology, epidemiology, and ecology of Ascaris from both pig and human hosts as well as for the development of new interventions against ascariasis and other helminthiases.
The Cullman Democrat was established about 25 years after the first newspaper to publish in the town named for the famous German settler, John G. Cullman. While it came relatively late on the scene, its circulation soon grew to match that of the most successful Alabama weekly newspapers. The Democrat was first published by Major W.F. Palmer in June of 1901. Palmer sold the paper to R.L. and J.E. Griffin in 1902, but by the end of January of 1903, the paper was purchased by Joseph Robert Rosson. The Democrat remained in control of the Rosson family for man years after."--Publisher's description
Information comes from over 6,200 Cullman County men who filled out cards and submitted them to the Selective Service System. Information often includes full names (first, middle, last), full birth date, occupation, next of kin, marital status, and number of children. Birth dates range from 1870 to 1901 of service aged men who submitted cards in 1917 - 1919. Most of the birth dates are from the 1880s and 1890s. This book is a good substitute for the missing 1890 Federal Census. Additionally, the data is annotated with hundreds of marriages from Cullman County marriage records.
This book contains all the marriages which took place in Cullman County between the year 1921 and 1937. Images of the original documents from the Cullman County Court House were examined page by page and transcribed. Not only was the basic information recorded, but other significant details were gathered such as names of bondsmen, names of officials performing the ceremony, names and relationships of those granting permission, and the location of the ceremony. Sometimes, other details such as birthdays, were recorded. Additionally, details of all licenses returned unexecuted were recorded. The main part of the book is an alphabetical listing of all the grooms. A full name index of the brides follows in the last section. This book is a handy tool for those with ancestors in Cullman County, or surrounding counties.
This study explores the integral role of astrological concepts and imagery in preparing the ground for the Reformation, and in shaping the distinctive characteristics of German Christian culture through the early seventeenth century.
The first comprehensive history of the Catholic Church’s notorious Index, with resonance for ongoing debates over banned books, censorship, and free speech. For more than four hundred years, the Catholic Church’s Index Librorum Prohibitorum struck terror into the hearts of authors, publishers, and booksellers around the world, while arousing ridicule and contempt from many others, especially those in Protestant and non-Christian circles. Biased, inconsistent, and frequently absurd in its attempt to ban objectionable texts of every conceivable description—with sometimes fatal consequences—the Index also reflected the deep learning and careful consideration of many hundreds of intellectual contributors over the long span of its storied evolution. This book constitutes the first full study of the Index of Prohibited Books to be published in English. It examines the reasons behind the Church’s attempts to censor religious, scientific, and artistic works, and considers not only why this most sustained of campaigns failed, but what lessons can be learned for today’s debates over freedom of expression and cancel culture.
The Cullman Democrat was established about 25 years after the first newspaper to publish in the town named for the famous German settler, John G. Cullman. While it came relatively late on the scene, its circulation soon grew to match that of the most successful Alabama weekly newspapers. The Democrat was first published by Major W.F. Palmer in June of 1901. Palmer sold the paper to R.L. and J.E. Griffin in 1902, but by the end of January of 1903, the paper was purchased by Joseph Robert Rosson. The Democrat remained in control of the Rosson family for man years after."--Publisher's description
Cullman County was established in 1877 in large part from the west side of Blount and the east side of Winston counties. Today, the few old cemeteries which existed in those counties in the early days are found within the borders of Cullman. The cemetery listings in this four volume set were conducted by the author beginning in 2003 and ending in early 2006. An attempt was made to personally visit every cemetery in Cullman County and record information from each readable monument. Volume 2 of this series covers alphabetically cemeteries E through G, beginning with the East Battleground Missionary Baptist Church Cemetery and concluding with the Garden City Cemetery. It also includes the large Cullman City Cemetery. The volumes are filled with photos of many of the old cemetery sites and notes describing the company and unit of most of the old Civil War era veterans. This set of books is vital to any serious student of Cullman County genealogy and history.
Cullman County was established in 1877 in large part from the west side of Blount and the east side of Winston counties. Today, the few old cemeteries which existed in those counties in the early days are found within the borders of Cullman. The cemetery listings in this four volume set were conducted by the author beginning in 2003 and ending in early 2006. An attempt was made to personally visit every cemetery in Cullman County and record information from each readable monument. Volume 4 of this series covers alphabetically cemeteries M through Z, beginning with the Mt. Zion United Methodist Church Cemetery and concluding with the Zion Grove Cemetery. The volumes are filled with photos of many of the old cemetery sites and notes describing the company and unit of most of the old Civil War era veterans. This set of books is vital to any serious student of Cullman County genealogy and history.
Kings County, sprawling across the San Joaquin Valley south of the Kings River and encompassing the bulk of the historic Tulare Lake bed, is an agricultural wonder with ranches, dairy farms, vineyards, and multiple other field and orchard crops. Created in 1893 from Tulare County and expanded in 1909 from elements of Fresno County, Kings County has grown in the last century from a forgotten corner of California into a major agricultural-economic force.
Robin Evans recasts the idea of the relationship between geometry and architecture, drawing on mathematics, engineering, art history, and aesthetics to uncover processes in the imagining and realizing of architectural form. Anyone reviewing the history of architectural theory, Robin Evans observes, would have to conclude that architects do not produce geometry, but rather consume it. In this long-awaited book, completed shortly before its author's death, Evans recasts the idea of the relationship between geometry and architecture, drawing on mathematics, engineering, art history, and aesthetics to uncover processes in the imagining and realizing of architectural form. He shows that geometry does not always play a stolid and dormant role but, in fact, may be an active agent in the links between thinking and imagination, imagination and drawing, drawing and building. He suggests a theory of architecture that is based on the many transactions between architecture and geometry as evidenced in individual buildings, largely in Europe, from the fifteenth to the twentieth century. From the Henry VII chapel at Westminster Abbey to Le Corbusier's Ronchamp, from Raphael's S. Eligio and the work of Piero della Francesca and Philibert Delorme to Guarino Guarini and the painters of cubism, Evans explores the geometries involved, asking whether they are in fact the stable underpinnings of the creative, intuitive, or rhetorical aspects of architecture. In particular he concentrates on the history of architectural projection, the geometry of vision that has become an internalized and pervasive pictorial method of construction and that, until now, has played only a small part in the development of architectural theory. Evans describes the ambivalent role that pictures play in architecture and urges resistance to the idea that pictures provide all that architects need, suggesting that there is much more within the scope of the architect's vision of a project than what can be drawn. He defines the different fields of projective transmission that concern architecture, and investigates the ambiguities of projection and the interaction of imagination with projection and its metaphors.
By the turn of the 20th Century, Cullman was firmly established as the preeminent settlement in the hill country between the Tennessee Valley and the mineral region surrounding Birmingham. The Cullman, Alabama Tribune continued to record news of the development of the city, county, and surrounding region. As with the first four books of this series, microfilm was obtained from the State Archives in Montgomery and Wallace College at Hanceville and reviewed, but the originals from the Cullman County Court House was the primary source. A page by page examination of the film and originals was conducted with every birth, death, marriage, obituary, and some news items important to the history and development of Cullman County was recorded. This book is important to any genealogist or historian with connections to Cullman County and contains many rare accounts and mentions of the earliest settlers of the region.
Management consultants are typically seen as key mediators in the flow of management ideas. And yet little is known about exactly what happens when they work together with clients, behind closed doors in consulting projects. Do they really innovate or simply legitimate existing knowledge? This book presents research from a three year long 'fly-on-the-wall study' of consulting projects and challenges our taken for granted view of consultancy. It draws on and integrates theories of knowledge and social boundaries to reveal a picture of complex and shifting insider-outsider relationships. Here, the outsider or expert status of consultants in relation to their clients cannot be assumed in their day-to-day project interactions. Different actors, roles, and types of knowledge are involved in an interactive and dynamic process where various boundaries are constructed, reinforced, negotiated and transformed. The chapters selectively explore these dynamics, revealing the importance of boundary complexity, the role of humour and challenge in often tense relationships, and the importance of shared knowledge domains such as sector knowledge. This in-depth analysis of inter-organizational project teams also covers a wide range of consultancy contexts, drawing on cases studies which include: * a US-based strategy firm and a multinational client, * the public and private sectors, * a sole practitioner consultant, * IT implementation in financial services. The book is important for all those with an interest in management consultancy, project working and management knowledge as well as in innovation/change, inter-organisational relations, boundaries and professional services. The authors include some of the leading research experts on management consultancy as well as a former management consultant and current expert in management learning.
A comprehensive survey of artificial intelligence algorithms and programming organization for robot systems, combining theoretical rigor and practical applications. This textbook offers a comprehensive survey of artificial intelligence (AI) algorithms and programming organization for robot systems. Readers who master the topics covered will be able to design and evaluate an artificially intelligent robot for applications involving sensing, acting, planning, and learning. A background in AI is not required; the book introduces key AI topics from all AI subdisciplines throughout the book and explains how they contribute to autonomous capabilities. This second edition is a major expansion and reorganization of the first edition, reflecting the dramatic advances made in AI over the past fifteen years. An introductory overview provides a framework for thinking about AI for robotics, distinguishing between the fundamentally different design paradigms of automation and autonomy. The book then discusses the reactive functionality of sensing and acting in AI robotics; introduces the deliberative functions most often associated with intelligence and the capability of autonomous initiative; surveys multi-robot systems and (in a new chapter) human-robot interaction; and offers a “metaview” of how to design and evaluate autonomous systems and the ethical considerations in doing so. New material covers locomotion, simultaneous localization and mapping, human-robot interaction, machine learning, and ethics. Each chapter includes exercises, and many chapters provide case studies. Endnotes point to additional reading, highlight advanced topics, and offer robot trivia.
By the turn of the 20th Century, Cullman was firmly established as the preeminent settlement in the hill country between the Tennessee Valley and the mineral region surrounding Birmingham. The Cullman, Alabama Tribune continued to record news of the development of the city, county, and surrounding region. As with the first five books of this series, microfilm was obtained from the State Archives in Montgomery and Wallace College at Hanceville and reviewed, but the originals from the Cullman County Court House was the primary source. A page by page examination of the film and originals was conducted with every birth, death, marriage, obituary, and some news items important to the history and development of Cullman County was recorded. This book is important to any genealogist or historian with connections to Cullman County and contains many rare accounts and mentions of the earliest settlers of the region.
This is the first book that addresses the genesis and career of the modern day enterprise system in a comprehensive and robust manner. It does so through setting out a new approach for the study of packaged solutions and presents novel empirical studies based on in-depth ethnographic and longitudinal research conducted within supplier organisations
This monograph takes up recent advances in social network methods in sociology, together with data on economic segregation, in order to build a quantitative analysis of the class and network effects implicated in vowel change in a Southern American city. Studies of sociolinguistic variation in urban spaces have uncovered durable patterns of linguistic difference, such as the maintenance of blue collar/white collar distinctions in the case of stable linguistic variables. But the underlying interactional origins of these patterns, and the interactional reasons for their durability, are not well understood, due in part to the near-absence of large-scale network investigation. This book undertakes a sociolinguistic network analysis of data from the Raleigh corpus, a set of conversational interviews collected form natives of Raleigh, North Carolina, from 2008-2017. Acoustic analysis of the corpus shows the rapid, ongoing retreat from the Southern Vowel Shift and increasing participation in national vowel changes. The social distribution of these trends is explored via standard social factors such as occupation as well as innovative network variables, including a measure of nestedness in the community network. The book aims to pursue new network-based questions about sociolinguistic variation that can be applied to other corpora, making this key reading for students and researchers in sociolinguistics and historical linguistics as well as those interested in further understanding how existing quantitative network methods from sociological research might be applied to sociolinguistic data.
AARP Digital Editions offer you practical tips, proven solutions, and expert guidance. James Balch and Mark Stengler, coauthors of the hugely successful Prescription for Natural Cures, and Robin Young Balch have teamed up to create the most comprehensive and up-to-date book available on natural alternatives to prescription medications. The book provides natural, safe, and effective ways to treat a wide range of common ailments, including ADHD, allergies, diabetes, depression, erectile dysfunction, eczema, heart disease, headaches, and PMS. You'll read in-depth information, not found in any other popular book, about the pros and cons of prescription and over-the-counter drugs compared with natural treatment alternatives ranging from diet and lifestyle changes to supplements and herbal medicines. "This book is essential reading for anyone who wants to take charge of his or her health. Read it to live long and well." —Hyla Cass, M.D., author of Supplement Your Prescription: What Your Doctor Doesn't Know about Nutrition "An outstanding resource for comparing common pharmaceutical and holistic treatments." —Ronald M. Lawrence, M.D., coauthor of Preventing Arthritis and The Miracle of MSM "A must-read for every person who wants to achieve better health and avoid the dangers of synthetic medications. The authors do an exceptional job by telling you everything you need to know about getting well and how to use supplements correctly and safely." —Suzy Cohen, R.Ph., author of The 24-Hour Pharmacist
With different pedagogic practices come different ways of examining them and fresh understandings of their implications and assumptions. It is the examination of these changes and developments that is the subject of this book. The authors examine a number of questions posed by the rapid march of globalisation, incuding: What is the role of the teacher, and how do we teach in the context of globalisation? What curriculum is appropriate when people and ideas become more mobile? How do the technologies of the internet and mobile phone impact upon what is learnt and by whom? The second edition of this important book has been fully updated and extended to take account of developments in technology, pedagogy and practice, in particular the growth of distance and e-learning.
Ever since the publication of the first edition in 1997, the Companion to Specialist Surgical Practice series has met the needs of surgeons in higher training and practising consultants by providing contemporary, evidence-based information on the sub-specialist areas relevant to their general surgical practice. All eight volumes are thoroughly edited and supported by evidence-based references to support key recommendations. This new Fourth Edition brings together the relevant state-of-the-art specialist information that the editors and authors consider important for the practising sub-specialist general surgeon. Purchase of a print book also includes a downloadable version of the eBook. A standardised approach is used across the series to provide up-to-date information in a way that will be consistent and familiar to the reader. Each volume gives a current and concise summary of the key topics within each major surgical sub-specialty. Each volume highlights evidence-based practice both in the text and by also identifying the key papers in the extensive list of references at the end of every chapter. Written by an expanded group of authors with an increased international dimension to the content of all volumes. Reflects the development of the multidisciplinary team approach in cancer care. Takes account of the improvements in the quality of rectal cancer imaging Updates the evidence on the efficacy of preoperative radiation therapy for all rectal cancer. Includes a new chapter on colonoscopy and flexible sigmoidoscopy. Takes a modern look at less familiar operations such as stapled transanal rectal resection.
The Cullman Democrat was established about 25 years after the first newspaper to publish in the town named for the famous German settler, John G. Cullman. While it came relatively late on the scene, its circulation soon grew to match that of the most successful Alabama weekly newspapers. The Democrat was first published by Major W.F. Palmer in June of 1901. Palmer sold the paper to R.L. and J.E. Griffin in 1902, but by the end of January of 1903, the paper was purchased by Joseph Robert Rosson. The Democrat remained in control of the Rosson family for man years after."--Publisher's description.
Fundamentals of Analytical Toxicology is an integrated introduction to the analysis of drugs, poisons, and other foreign compounds in biological and related specimens. Assuming only basic knowledge of analytical chemistry, this invaluable guide helps trainee analytical toxicologists understand the principles and practical skills involved in detecting, identifying, and measuring a broad range of compounds in various biological samples. Clear, easy-to-read chapters provide detailed information on topics including sample collection and preparation, spectrophotometric and luminescence techniques, liquid and gas-liquid chromatography, and mass spectrometry including hyphenated techniques. This new edition contains thoroughly revised content that reflects contemporary practices and advances in analytical methods. Expanding the scope of the 1995 World Health Organization (WHO) basic analytical toxicology manual, the text includes coverage of separation science, essential pharmacokinetics, xenobiotic absorption, distribution and metabolism, clinical toxicological and substance misuse testing, therapeutic drug monitoring, trace elements and toxic metals analysis, and importantly the clinical interpretation of analytical results. Written by a prominent team of experienced practitioners, this volume: Focuses on analytical, statistical, and pharmacokinetic principles Describes basic methodology, including colour tests and immunoassay and enzyme-based assays Outlines laboratory operations, such as method validation, quality assessment, staff training, and laboratory accreditation Follows IUPAC nomenclature for chemical names and recommended International Non-proprietary Name (rINN) for drugs and pesticides Includes discussion of 'designer drugs' (novel pharmaceutical substances NPS) Fundamentals of Analytical Toxicology: Clinical and Forensic, 2nd Edition is an indispensable resource for advanced students and trainee analytical toxicologists across disciplines, such as clinical science, analytical chemistry, forensic science, pathology, applied biology, food safety, and pharmaceutical and pesticide development.
This book draws on a detailed corpus analysis of fifth-century historiographical texts to explore the influence of the Iranian languages on the syntax of Armenian. Robin Meyer argues that the Armenian periphrastic perfect was created on the model of similar constructions in Parthian via a long period of language contact.
The size of the problem, can be assessed This book is an off-shoot of the computerized from the following. Of 50 children bom, 1 London Dysmorphology Database which is now widely used by many geneticists and will have an easily detectable major malfor mation. Many of these will have a single dysmorphologists. Both the database and this malformation, but in the region of 8 in 1000 book have arisen out of a need to cope with the ever increasing nurober of multiple will have multiple abnormalities. This group will include 50% with chromosomal disorders congenital anomaly syndromes, especially recognizable by performing a karyotype, the details about their features and where infor mation can be found in the Iiterature. Indeed rest needing tobe diagnosed by other means. there are more than 2000 non-chromosomal It is to the diagnosis of this latter group that this book is dedicated. multiple malformation syndromes to which access is essential. If computerized databases have solved THE DIAGNOSIS OF DYSMORPHIC some of the problems, why is there a need SYNDROMES for this book? There are many physicians who do not have a desk computer or do not History feel at ease in using one. In addition geneticists are doing more satellite clinics and Before identifying the specific dysmorphic in some circumstances it would be more features, at least a three generation family history needs to be taken. It is necessary to convenient to carry a book than a computer.
Produced in cooperation with the National Association of School Nurses, this text includes comprehensive coverage of the multiple facets of school nursing—from the foundations of practice and the roles and functions of a school nurse through episodic and chronic illness and behavioral issues, to legal issues and leading and managing within school settings. Written and edited by school nurses and pediatric experts, it features real-world-tested, best practices based on evidence and experience. There’s content here that you won’t find in other books, such as health assessments, individualized health plan development, mental health conditions including adolescent depression, contemporary legal issues, and current policy statements essential to school nursing.
Now in a fully updated 9th Edition, Kendig's Disorders of the Respiratory Tract in Children, by Drs. Robert Wilmott, Andrew Bush, Robin Deterding, and Felix Ratjen, continues to provide authoritative, evidence-based information to residents, fellows, and practitioners in this wide-ranging specialty. Bringing key knowledge from global experts together in one easy-to-understand volume, it covers everything from the latest basic science and its relevance to today's clinical issues, to improving patient outcomes for the common and rare respiratory problems found in newborns and children worldwide. - Uses succinct, straightforward text, numerous tables and figures, summaries at the end of each chapter, and more than 500 full-color images to convey key information in an easy-to-digest manner. - Contains new chapters reflecting expanding knowledge on the respiratory complications of Down syndrome and other genetic disorders, modern molecular therapies for cystic fibrosis and asthma, and pulmonary embolism and thromboembolic disease. - Includes access to a new video library with demonstrations of key procedures. - Features a new templated format with more descriptive headings and bulleted text for quick reference and navigation. - Covers today's key issues, including the genetic basis of respiratory disease, new and emerging respiratory infections, interstitial lung diseases in infants and young children, technology and diagnostic techniques for pulmonary function tests, emerging lung infections, and new therapies for cystic fibrosis and asthma. - Provides up-to-date instruction on important procedures, such as bronchoscopy and pulmonary function testing. - Highlights the knowledge and expertise of three new editors, as well as more than 100 world authorities in the fields of pediatrics, pulmonology, neurology, microbiology, cardiology, physiology, diagnostic imaging, critical care, otolaryngology, allergy, and surgery. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
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