Despite three decades of vigorous efforts at deregulation across the government, regulation remains ubiquitous. It also continues to be unpopular because it forces individuals and businesses to do things—frequently costly and unpleasant things—that they don't want to do. If regulatory programs are to survive and remain effective, the challenge posed by their endemic unpopularity and political vulnerability must be met. Unlike much of the existing literature on regulation, Taming Regulation begins with the assumption that the government's capacity to utilize regulation as a policy tool is vital. The book examines the questions of how to make the inherently coercive aspects of regulation more politically acceptable in the present antiregulatory environment and how the legal and administrative challenges of reform in ongoing regulatory programs might best be approached. The authors explore these issues through a case study of administrative reform in the Superfund program. Chartered with an ambitious mission to clean up the nation's hazardous waste sites, Superfund was from its inception a uniquely aggressive and unpopular program. Yet despite the election in 1994 of a Republican Congress committed to fundamental changes in environmental regulation, the Superfund program weathered the storm and remains intact today. The authors credit this political and programmatic success to a series of artfully designed and orchestrated internal reforms that softened Superfund's implementation, thus increasing its political support while retaining its potent coercive tools. Taming Regulation provides a cautionary discussion of both the necessity and the difficulty of regulatory reform. It is essential reading for students of regulation and environmental policy, for practitioners contemplating reform of ongoing regulatory programs, and for those interested in the checkered history of Superfund.
In 1838 Charles Darwin jotted in a notebook, “He who understands baboon would do more towards metaphysics than Locke.” Baboon Metaphysics is Dorothy L. Cheney and Robert M. Seyfarth’s fascinating response to Darwin’s challenge. Cheney and Seyfarth set up camp in Botswana’s Okavango Delta, where they could intimately observe baboons and their social world. Baboons live in groups of up to 150, including a handful of males and eight or nine matrilineal families of females. Such numbers force baboons to form a complicated mix of short-term bonds for mating and longer-term friendships based on careful calculations of status and individual need. But Baboon Metaphysics is concerned with much more than just baboons’ social organization—Cheney and Seyfarth aim to fully comprehend the intelligence that underlies it. Using innovative field experiments, the authors learn that for baboons, just as for humans, family and friends hold the key to mitigating the ill effects of grief, stress, and anxiety. Written with a scientist’s precision and a nature-lover’s eye, Baboon Metaphysics gives us an unprecedented and compelling glimpse into the mind of another species. “The vivid narrative is like a bush detective story.”—Steven Poole, Guardian “Baboon Metaphysics is a distillation of a big chunk of academic lives. . . . It is exactly what such a book should be—full of imaginative experiments, meticulous scholarship, limpid literary style, and above all, truly important questions.”—Alison Jolly, Science “Cheney and Seyfarth found that for a baboon to get on in life involves a complicated blend of short-term relationships, friendships, and careful status calculations. . . . Needless to say, the ensuing political machinations and convenient romantic dalliances in the quest to become numero uno rival the bard himself.”—Science News “Cheney and Seyfarth’s enthusiasm is obvious, and their knowledge is vast and expressed with great clarity. All this makes Baboon Metaphysics a captivating read. It will get you thinking—and maybe spur you to travel to Africa to see it all for yourself.”—Asif A. Ghazanfar, Nature “Through ingenious playback experiments . . . Cheney and Seyfarth have worked out many aspects of what baboons used their minds for, along with their limitations. Reading a baboon’s mind affords an excellent grasp of the dynamics of baboon society. But more than that, it bears on the evolution of the human mind and the nature of human existence.”—Nicholas Wade, New York Times
2014 BMA Medical Book Awards Highly Commended in Radiology category! Image-Guided Interventions, a title in the Expert Radiology Series, brings you in-depth and advanced guidance on all of today?s imaging and procedural techniques. Whether you are a seasoned interventionalist or trainee, this single-volume medical reference book offers the up-to-the-minute therapeutic methods necessary to help you formulate the best treatment strategies for your patients. The combined knowledge of radiology experts from around the globe provides a broad range of treatment options and perspectives, equipping you to avoid complications and put today's best approaches to work in your practice. "... the authors and editors have succeeded in providing a book that is both useful, instructive and practical" Reviewed by RAD Magazine, March 2015 Formulate the best treatment plans for your patients with step-by-step instructions on important therapeutic radiology techniques, as well as discussions on equipment, contrast agents, pharmacologic agents, antiplatelet agents, and protocols. Make effective clinical decisions with the help of detailed protocols, classic signs, algorithms, and SIR guidelines. Make optimal use of the latest interventional radiology techniques with new chapters covering ablation involving microwave and irreversible electroporation; aortic endografts with fenestrated grafts and branch fenestrations; thoracic endografting (TEVAR); catheter-based cancer therapies involving drug-eluting beads; sacroiliac joint injections; bipedal lymphangiography; pediatric gastrostomy and gastrojejunostomy; and peripartum hemorrhage. Know what to look for and how to proceed with the aid of over 2,650 state-of-the-art images demonstrating interventional procedures, in addition to full-color illustrations emphasizing key anatomical structures and landmarks. Quickly reference the information you need through a functional organization highlighting indications and contraindications for interventional procedures, as well as tables listing the materials and instruments required for each. Access the fully searchable contents, online-only material, and all of the images online at Expert Consult.
Reflecting the progress in recent years, this book provides in-depth information on the preparation, chemistry, and engineering of bioceramic coatings for medical implants. It is authored by two renowned experts with over 30 years of experience in industry and academia, who know the potentials and pitfalls of the techniques concerned. Following an introduction to the principles of biocompatibility, they present the structures and properties of various bioceramics from alumina to zirconia. The main part of the work focuses on coating technologies, such as chemical vapor deposition, sol-gel deposition and thermal spraying. There then follows a discussion of the major interactions of bioceramics with bone or tissue cells, complemented by an overview of the in-vitro testing methods of the biomineralization properties of bioceramics. The text is rounded off by chapters on the functionalization of bioceramic coatings and a look at future trends. As a result, the authors bring together all aspects of the latest techniques for designing, depositing, testing, and implementing improved and novel bioceramic coating compositions, providing a full yet concise overview for beginners and professionals.
Drs. Robert Kotloff and Francis McCormack have assembled an expert team of authors on the topic of Rare and Orphan Lung Diseases. Articles include: Lymphangioleiomyomatosis, Pulmonary Lymphangiomatosis, Langerhans Cell Histiocytosis and other Histiocytic Diseases of the Lung, Pulmonary Alveolar Proteinosis, Pulmonary Alveolar Microlithiasis, Primary Ciliary Dyskinesia, Birt-Hogg-Dube Syndrome, Hermansky-Pudlak Syndrome, Hereditary Hemorrhagic Telangiectasia, Non-CF Bronchiectasis, Eosinophilic Lung Diseases, Benign Metastasizing Leiomyomata, and more!
This second book in a two-volume set tells how the healthcare community is working with patients and their caregivers to help improve health using P4 medicine, proper nutrition and a healthy lifestyle. The healthcare community is finding ways to predict one’s susceptibility to diseases, so they can be prevented from occurring, when possible. When diseases do emerge, it is developing personalized therapies and ways for patients to participate in their own healthcare. At the same time, systems thinking dispels many misconceptions, such as ‘natural’ foods and ‘superfoods’. In fact, the only true superfood is mother’s breast milk. Also, dietary antioxidants prevent inflammation by activating our natural antioxidant system (Nrf2). However, environmental toxins can counteract our best efforts. Still, systems thinking encourages us to fix the problem and not the blame. This book will appeal to professionals, non-professionals and patients, who can learn how to improve healthcare and prevent diseases, while reversing the effects of global climate change.
Dysphonia, or change in voice quality, can have a devastating effect on both the physical and emotional state of cancer patients. Meeting the vocal needs of cancer patients allows physicians to care for the entire patient and can have a dramatic impact on the overall quality of life of afflicted individuals. Non-Laryngeal Cancer and Voice explores the literature on voice problems in cancer patients, with a particular emphasis on how both the disease and treatment can affect the voice. This text offers valuable information for a range of professionals involved in treating patients with non-laryngeal cancer, including laryngologists, speech-language pathologists, singing specialists, oncologists, and surgeons, as well as patients. By providing comprehensive information on disease- and treatment-induced dysphonia, the book can also act as a resource for voice professionals who develop common cancers and want to understand the potential voice consequences of the cancer and its treatment. The initial three chapters of Non-Laryngeal Cancer and Voice provide basic information about the voice for non-laryngologists. Each of the remaining chapters focuses on a common type of cancer, such as lung cancer and breast cancer, and its unique effect on the voice.
Illustrating the differences between urgent interventions and interventions performed to manage chronic conditions the authors present the chapters in a consistent template for ease of use covering; background, indications, evidence review, device description, procedural techniques, follow-up care, and complications. Shows the differences between interventions performed to manage chronic conditions and interventions that are truly urgent Chapters follow a consistent structure from background through indications, evidence review, device description, procedural techniques to follow-up care and complications More than 40 high definition videos, hosted on companion website www.wiley.com/go/kipshidze/interventionaltherapies, complete with tips and tricks, provide a visual learning tool
This book is a comprehensive, easy-to-read discussion of the organ-specific autoimmune endocrine diseases emphasizing new contributions and trends for research and management. It begins with a brief chapter introducing the general principles of immunology, followed by discussions covering topics such as immunogenetics and animal models and how they can be applied toward interpreting human autoimmune endocrine diseases, autoimmune thyroid diseases, insulin-dependent diabetes mellitus hypophysitis, and Addison's disease. The book also discusses future trends toward gaining an understanding of these disorders and possible therapeutic principles. It is well-illustrated and will prove to be a useful reference source for internists, endocrinologists, and postgraduate students interested in human autoimmune endocrine diseases.
Ideal for fellows and practicing pulmonologists who need an authoritative, comprehensive reference on all aspects of pulmonary medicine, Murray and Nadel’s Textbook of Respiratory Medicine offers the most definitive content on basic science, diagnosis, evaluation and treatment of the full spectrum of respiratory diseases. Full-color design enhances teaching points and highlights challenging concepts. Understand clinical applications and the scientific principles of respiratory medicine. Detailed explanations of each disease entity allow you to work through differential diagnoses. Expert Consult eBook version included with purchase. This enhanced eBook experience offers content updates, videos, review questions, and Thoracic Imaging Cases (TICs), all of which are easily navigable on any device for access on rounds or in the clinic. Includes more than 1,000 figures and over 200 videos and audio files. Key Points and Key Reading sections highlight the most useful references and resources for each chapter. An expanded sleep section now covers four chapters and includes control of breathing, consequences of sleep disruption, as well as obstructive and central apnea. New chapters in the Critical Care section cover Noninvasive Ventilation (NIV) and Extracorporeal Support of Gas Exchange (ECMO). New chapters focusing on diagnostic techniques now include Invasive Diagnostic Imaging and Image-Guided Interventions and Positron Emission Tomography, and a new chapter on Therapeutic Bronchoscopy highlights the interventional role of pulmonologists. Embedded videos feature thoracoscopy, therapeutic bronchoscopy, volumetric chest CT scans, and more. Brand-new audio files highlight normal and abnormal breath sounds and the separate components of cough.
Iron is indispensable for the growth, development and well-being of almost all living organisms. Biological systems from bacteria, fungi and plants to humans have evolved systems for the uptake, utilisation, storage and homeostasis of iron. Its importance for microbial growth makes its uptake systems a natural target for pathogenic microorganisms and parasites. Uniquely, humans suffer from both iron deficiency and iron overload, while the capacity of iron to generate highly reactive free radicals, causing oxidative stress, is associated with a wide range of human pathologies, including many neurodegenerative diseases. Whereas some essential metal ions like copper and zinc are closely linked with iron metabolism, toxic metals like aluminium and cadmium can interfere with iron metabolism. Finally, iron metabolism and homeostasis are key targets for the development of new drugs for human health. The 4th edition of Iron Metabolism is written in a lively style by one of the leaders in the field, presented in colour and covers the latest discoveries in this exciting area. It will be essential reading for researchers and students in biochemistry, molecular biology, microbiology, cell biology, nutrition and medical sciences. Other interested groups include biological inorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism, or of diseases in which iron uptake systems are involved (eg. microbial and fungal infections, cancer, neurodegenerative disorders), and researchers in the pharmaceutical industry interested in developing novel drugs targeting iron metabolism/homeostasis.
The principal aim of this book is to introduce chemists through a tutorial approach to the use of microwaves by examining several experiments of microwave chemistry and materials processing. It will subsequently enable chemists to fashion their own experiments in microwave chemistry or materials processing. Microwave heating has become a popular methodology in introducing thermal energy in chemical reactions and material processing in laboratory-scale experiments. Several research cases where microwave heating has been used in a wide range of fields have been reported, including organic synthesis, polymers, nanomaterials, biomaterials, and ceramic sintering, among others. In most cases, microwave equipment is used as a simple heat source. Therefore the principal benefits of microwave radiation have seldom been taken advantage of. One reason is the necessity to understand the nature of electromagnetism, microwave engineering, and thermodynamics. However, it is difficult for a chemist to appreciate these in a short time, so they act as barriers for the chemist who might take an interest in the use of microwave radiation. This book helps to overcome these barriers by using figures and diagrams instead of equations as much as possible.
In view of the rapid growth in both experimental and theoretical studies of multi-photon processes and multi-photon spectroscopy of atoms, ions and molecules in chemistry, physics, biology, materials science, etc., it is desirable to publish an advanced series of volumes containing review papers that can be read not only by active researchers in these areas, but also by those who are not experts but who intend to enter the field. The present series aims to serve this purpose. Each review article is written in a self-contained manner by the expert(s) in the area, so that the reader can grasp the knowledge without too much preparation.
Keep abreast of the latest advances in this complex field with the 5th Edition of Clinical Immunology: Principles and Practice. This substantially revised edition by Drs. Robert R. Rich, Thomas A. Fleisher, William T. Shearer, Harry W. Schroeder, Jr., Anthony J. Frew, and Cornelia M. Weyand, offers authoritative guidance from some of the most respected global leaders in immunology, helping you navigate today’s latest knowledge and evidence-based practices that result in improved patient care. This trusted resource features sweeping content updates, rewritten chapters, a highly clinical perspective, and an easy-to-use organization designed to enhance your diagnosis and management skills in daily practice. User-friendly format features color-coded boxes highlighting critical information on Key Concepts, Clinical Pearls, Clinical Relevance, and Therapeutic Principles. Includes new chapters on the Microbiota in Immunity and Inflammation, Immune Responses to Fungi, and Genetics and Genomics of Immune Response. Features extensive revisions to many chapters, including the Major Histocompatibility Complex, Multiple Sclerosis, Diabetes and Related Autoimmune Diseases, Biologic Modifiers of Inflammation and Tumor Immunotherapy. Covers hot topics such as the role of genetics and genomics in immune response and immunologic disease, atherosclerosis, recurrent fever syndromes, aging and deficiencies of innate immunity, the role of microbiota in normal immune system development and the pathogenesis of immunologic and inflammatory diseases, and novel therapeutics. Addresses notable advances in key areas such as the importance of the microbiota to normal immune system development and to the pathogenesis of immunologic and inflammatory diseases; relationships between the innate and adaptive immune systems; progress in rapid and cost-effective genomics; cell signaling pathways and the structure of cell-surface molecules; and many more. Summarizes promising research and development anticipated over the next 5-10 years with "On the Horizon" boxes and discussion of translational research. Includes new multiple choice questions in every chapter online, ideal for allergists and rheumatologists seeking certification or recertification in these subspecialties. Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Storage and conversion are critical components of important energy-related technologies. "Advanced Batteries: Materials Science Aspects" employs materials science concepts and tools to describe the critical features that control the behavior of advanced electrochemical storage systems. This volume focuses on the basic phenomena that determine the properties of the components, i.e. electrodes and electrolytes, of advanced systems, as well as experimental methods used to study their critical parameters. This unique materials science approach utilizes concepts and methodologies different from those typical in electrochemical texts, offering a fresh, fundamental and tutorial perspective of advanced battery systems. Graduate students, scientists and engineers interested in electrochemical energy storage and conversion will find "Advanced Batteries: Materials Science Aspects" a valuable reference.
Widely recognized as the definitive text in pediatric cardiology, Moss and Adams' Heart Disease in Infants, Children, and Adolescents provides the authoritative, state-of-the-art information you need when caring for young patients with heart disease. The editorial team, led by Dr. Robert Shaddy, from Children's Hospital Los Angeles and the University of Southern California, ensures that you are kept fully up to date with recent advances in this complex and fast-changing field. This award-winning title, now in its Tenth Edition, continues to be the reference of choice for today’s cardiology fellows, pediatric cardiologists, and cardiology practitioners worldwide.
Robert Arking's Biology of Aging, 3rd edition, is an introductory text to the biology of aging which gives advanced undergraduate and graduate students a thorough review of the entire field. His prior two editions have also served admirably as a reference text for clinicians and scientists. This new edition captures the extraordinary recent advances in our knowledge of the ultimate and proximal mechanisms underlying the phenomenon of aging. As a result, six important conceptual changes are included here: · Clarified distinctions between the biological mechanisms involved in longevity determination and those involved in senescent processes. · A new conceptual framework around which we can organize all the new facts about aging. This will assist readers to make sense of the information and use the data to form their own ideas. · Increased knowledge of aging cells has lead to new ideas on how a cell transits from a healthy state to a senescent state, while still allowing for high levels of intra- and inter-specific variability. · Discussion of senescent mechanisms assists the reader to understand that aging is a non-programmatic loss of function, likely arising from the loss of regulatory signals, and so is modifiable in the laboratory. · Because the standard evolutionary story does not fully explain the evolution of social organisms, this edition also includes recent work dealing with intergenerational resource transfers. · Lastly, if aging mechanisms are plastic, then the demand to move these anti-aging interventions into the human arena will inevitably grow. A discussion of the biological and ethical arguments on both sides of the question frames the question in an appropriate manner. The mass of data related to aging is summarized into fifteen focused chapters, each dealing with some particular aspect of the problem. The last two chapters integrate all this material into a coherent view of how the relevant biological processes change over the life span. This view is expressed in two non-technical figures (you might say that the whole book exists to fully support Figs 9-4 & 14-9), whose meanings are elucidated as the reader progresses through the book.
The federal Superfund program for cleaning up America's inactive toxic waste sites is noteworthy not only for its enormous cost - $15.2 billion has been authorized thus far - but also for its unique design. The legislation that created Superfund provided the Environmental Protection Agency with a diverse set of policy tools. Preeminent among them is a civil liability scheme that imposes responsibility for multimillion dollar cleanups on businesses and government units linked - even tangentially - to hazardous waste sites. Armed with this potent policy implement, the agency can order the parties who are legally responsible for the toxic substances at a site to clean it up, with large fines and damages for failure to comply. EPA can also offer conciliatory measures to bring about voluntary, privately financed cleanup; or it can launch a cleanup initially paid for by Superfund and later force the responsible parties to reimburse the government. In this book, Thomas W. Church and Robert T. Nakamura provide the first in-depth study of Superfund operations at hazardous waste sites. They examine six Superfund cleanups, including three regions and both 'hard' and 'easy' sites, to ask 'what works?' Based on detailed case studies, the book describes various strategies that have been applied by government regulators and lawyers and the responses to those different strategies by businesses and local government officials. The authors characterize the implementation strategies used by the EPA as prosecution, accommodation, and public works. They point out that the choice of strategy involves setting priorities among Superfund's competing objectives. They conclude that the best implementation strategy is one that considers the context of each site and the particular priorities in each case. Looking toward the reauthorization of Superfund, they also offer recommendations for improvements in the organization of the program and discuss proposals for change in its
Neoplastic mimics or "pseudotumors" can simulate neoplasms on all levels of analysis- clinical, radiologic, and pathologic--and thus represent particular diagnostic pitfalls for the pathologist that can ultimately lead to therapeutic misdirection. This book provides the pathologist with detailed morphologic descriptions and diagnostic guidance in recognizing these neoplastic mimics as they occur in the genitourinary system. In addition, descriptions and diagnostic guidance are provided for the range of genitourinary lesions tumors that may mimic benign masses but are in fact neoplastic. Throughout the book comparisons of neoplastic mimics with true neoplasms are provided, at clinical, gross, and histologic levels. In the presentation of every entity, the points that contribute to differential diagnosis are emphasized. More than 500 color images and this analysis of diagnostic mimics guide the pathologist through recognizing and distinguishing the unusual variants, morphologic anomalies and misleading features that may easily lead to an inaccurate interpretation and missed diagnosis. Since many of entities described are uncommon Neoplastic Mimics in Genitourinary emphasizes imaging and clinical correlations throughout to support the pathologist as consultant to the entire diagnostic and clinical management team. Every pathologist who sees genitourinary cases will find this book an invaluable working tool to ensure accurate diagnosis. Neoplastic Mimics in Genitourinary Pathology features: Over 500 high-quality images showing the full range of neoplastic mimics in the genitourinary tract Concise, specific text descriptions make the book easy to use as a visual reference Expert authors guide the reader to recognizing and distinguishing misleading specimens
Topics of special interest in current research are presented in each volume of the series Neuroendocrine Perspectives. Volume 8 has five major sections that address new findings in our knowledge of the CNS neurotransmitter and neuropeptide systems. They broaden the traditional view of the hypothalamo-pituitary control and of the modulation of brain function by target hormones.
A comprehensive review of pediatric surgery for the general surgeon! Topics include pediatric pain management, hernias, hydroceles, and undescended testes, appendectomy, merckel's and intussusceptions, pyloric stenosis, childhood obesity, neonatal bowel obstruction, short gut syndrome and vascular access, abdominal wall reconstruction, gastroesophageal reflux disease, pediatric chest, CDH and protective ventilation strategies, chest wall deformities, congenital and pediatric neck lesions, vascular and lymphatic malformations, pediatric malignancies, teratoma and ovarian lesions, and more!
This new edition of Evaluation and Treatment of Myopathies is written for the clinician who sees patients with muscle disease, or the patient with complaints of pain or weakness of muscle. Like the original, this new edition is divided in to 3 primary sections: Approach to the Patient with Muscle Disease, Specific Myopathies, and General Strategies of Clinical Management, each section providing practical guidance to eliciting key histories and demonstrate findings upon examination. This new edition also provides guidance on the next steps in diagnoses as well as the latest information on pathogenesis, diagnosis, and treatment, in an integrated manner, so as to give trainees, practicing clinicians and others who see neuromuscular disease perspective on how to evaluate and care for patients. New and revised tables, figures, and references are selected and organized to present information of clinical importance to provide the most up-to-date resource on the myopathies.
The Definitive, Comprehensive Guide to Cutting-Edge Millimeter Wave Wireless Design “This is a great book on mmWave systems that covers many aspects of the technology targeted for beginners all the way to the advanced users. The authors are some of the most credible scholars I know of who are well respected by the industry. I highly recommend studying this book in detail.” —Ali Sadri, Ph.D., Sr. Director, Intel Corporation, MCG mmWave Standards and Advanced Technologies Millimeter wave (mmWave) is today's breakthrough frontier for emerging wireless mobile cellular networks, wireless local area networks, personal area networks, and vehicular communications. In the near future, mmWave products, systems, theories, and devices will come together to deliver mobile data rates thousands of times faster than today's existing cellular and WiFi networks. In Millimeter Wave Wireless Communications, four of the field's pioneers draw on their immense experience as researchers, entrepreneurs, inventors, and consultants, empowering engineers at all levels to succeed with mmWave. They deliver exceptionally clear and useful guidance for newcomers, as well as the first complete desk reference for design experts. The authors explain mmWave signal propagation, mmWave circuit design, antenna designs, communication theory, and current standards (including IEEE 802.15.3c, Wireless HD, and ECMA/WiMedia). They cover comprehensive mmWave wireless design issues, for 60 GHz and other mmWave bands, from channel to antenna to receiver, introducing emerging design techniques that will be invaluable for research engineers in both industry and academia. Topics include Fundamentals: communication theory, channel propagation, circuits, antennas, architectures, capabilities, and applications Digital communication: baseband signal/channel models, modulation, equalization, error control coding, multiple input multiple output (MIMO) principles, and hardware architectures Radio wave propagation characteristics: indoor and outdoor applications Antennas/antenna arrays, including on-chip and in-package antennas, fabrication, and packaging Analog circuit design: mmWave transistors, fabrication, and transceiver design approaches Baseband circuit design: multi–gigabit-per-second, high-fidelity DAC and ADC converters Physical layer: algorithmic choices, design considerations, and impairment solutions; and how to overcome clipping, quantization, and nonlinearity Higher-layer design: beam adaptation protocols, relaying, multimedia transmission, and multiband considerations 60 GHz standardization: IEEE 802.15.3c for WPAN, Wireless HD, ECMA-387, IEEE 802.11ad, Wireless Gigabit Alliance (WiGig)
Neurodegenerative diseases of the human brain appear in various forms, resulting in disorders of movement and coordination, cognitive deterioration and psychiatric disturbances. Many of the key factors leading to neurodegenerative diseases are similar, including the dysfunction of metal ion homeostasis, redox-active metal ions generating oxidative stress, and intracellular inclusion bodies. Metal-based Neurodegeneration presents a detailed survey of the molecular origins of neurodegenerative diseases. Each chapter is dedicated to a specific disease, presenting the latest scientific findings, including details of their biochemical actors (proteins or peptides), their normal and pathological conformations, and a description of the diseases characteristics, with an emphasis on the role of metal-induced oxidative stress, which can result in the production of intracellular aggregates of target proteins and peptides. Topics covered include: Brain function, physiology and the blood-brain barrier Immune system and neuroinflammation Aging and mild cognitive impairment, MCI Parkinson’s Disease Alzheimer’s Disease Creutzfelt-Jakob and related prion diseases Alcoholic Brain Damage Therapeutic strategies to combat the onset and progression of neurological diseases This extensively updated, full colour, second edition of Metal-based Neurodegeneration is an essential text for research scientists and clinicians working in gerontology, neuropathology, neurochemistry, and metalloprotein mechanisms.
ANALYSIS AND DESIGN OF ANALOG INTEGRATED CIRCUITS Authoritative and comprehensive textbook on the fundamentals of analog integrated circuits, with learning aids included throughout Written in an accessible style to ensure complex content can be appreciated by both students and professionals, this Sixth Edition of Analysis and Design of Analog Integrated Circuits is a highly comprehensive textbook on analog design, offering in-depth coverage of the fundamentals of circuits in a single volume. To aid in reader comprehension and retention, supplementary material includes end of chapter problems, plus a Solution Manual for instructors. In addition to the well-established concepts, this Sixth Edition introduces a new super-source follower circuit and its large-signal behavior, frequency response, stability, and noise properties. New material also introduces replica biasing, describes and analyzes two op amps with replica biasing, and provides coverage of weighted zero-value time constants as a method to estimate the location of dominant zeros, pole-zero doublets (including their effect on settling time and three examples of circuits that create doublets), the effect of feedback on pole-zero doublets, and MOS transistor noise performance (including a thorough treatment on thermally induced gate noise). Providing complete coverage of the subject, Analysis and Design of Analog Integrated Circuits serves as a valuable reference for readers from many different types of backgrounds, including senior undergraduates and first-year graduate students in electrical and computer engineering, along with analog integrated-circuit designers.
Dr. Braunwald's masterwork returns ... bringing you the definitive guidance you need to overcome any challenge in clinical cardiology today, using the best approaches available! Hundreds of world authorities, many of them new to this edition, synthesize all of the recent developments that are revolutionizing practice - from the newest findings in molecular biology and genetics to the latest imaging modalities, interventional procedures, and medications. This multimedia e-dition includes not only the printed reference, but also access to the complete contents online, fully searchable, with regular updates and much more. The expertise of the contributors, the scope of the coverage, and the versatile, multimedia format all make this the ultimate reference for the practicing cardiologist. Locate the answers you need fast, thanks to a user-friendly, full-color design, complete with more than 1,500 color illustrations. Glean clinically actionable information quickly with Clinical Practice Points in every chapter. Access the complete contents of the 2-volume set online, fully searchable, plus regular updates to reflect the latest clinical developments · Focused Reviews · Commentaries · Late-Breaking Trials · and more. Apply the latest knowledge in your field with 7 new chapters on Acute Heart Failure · Device Therapy of Heart Failure · Emerging Therapies for Heart Failure · Complementary and Alternative Approaches to Management · Prevention and Management of Stroke · Hypertrophic Cardiomyopathy · and Coronary Arteriography Guidelines. Get fresh perspectives on your practice with contributions from more than 20 brand-new authors.
Featuring over 600 full-color illustrations, the Third Edition of this definitive reference provides comprehensive, current, and authoritative coverage of the entire spectrum of urologic surgical pathology. The book emphasizes diagnostic morphology and includes clinical-pathologic correlations. This thoroughly updated edition clarifies histologic variants of prognostic value in urinary bladder cancers and prostate carcinomas and identifies tumor markers useful in both diagnosis and post-therapy management of cancer patients. Also included are current diagnostic criteria for urothelial carcinomas, the latest TNM staging of urogenital organ malignancies, and up-to-date renal tumor classifications, including cytogenetic, immunohistochemical, and morphologic correlations. A companion Website will offer the fully searchable text and an image bank.
Features a comprehensive summary of the chemical, physiological, and nutritional relationships of all recognized vitamins! Maintaining the standards of excellence set forth in the previous editions, the Handbook of Vitamins, Third Edition presents a thorough examination of the fundamental characteristics, functions, and roles of vitamins in human health. Extensively updated and expanded to reflect the latest advances in analytical and separation methodologies! Offering a compendium of authoritative, current knowledge on the nature and function of each known nutrient, the Third Edition discusses.... improvements in the methodology, isolation, identification, and the synthesis of vitamins the chemistry, metabolism, and biochemical functions of vitamins vitamin interactions with environmental factors, drugs, alcohol, and smoking vitamins in disease prevention and health promotion the efficacy and hazards of high vitamin dosages and more! New sections cover... the roles vitamins play as catalysts, cellular regulators, and co-substrates biochemical markers for vitamin deficiency and groups at risk the relationship of B12 and folate metabolism to homocysteine regulation, and the possible connections of homocysteine to vascular diseases and developmental defects new roles for vitamins A, K, and D, and the role of vitamin E and flavonoids in oxidant defense Containing over 2800 literature references and 150 illustrations and tables, the Handbook of Vitamins, Third Edition serves as an indisputably valuable reference for human and animal nutritionists, dietitians, food scientists and technologists, biochemists, organic and analytical chemists, pharmacologists, toxicologists, physiologists, physicians in general practice, and makes an indispensable text for upper-level undergraduate and graduate students in these disciplines.
The safety, effectiveness, and utility of medical nanorobotic devices will critically depend upon their biocompatibility with human organs, tissues, cells, and biochemical systems. In this Volume, we broaden the definition of nanomedical biocompatibility to include all of the mechanical, physiological, immunological, cytological, and biochemical re
A leading orthodontics reference, Orthodontics: Current Principles and Techniques, 5th Edition provides the latest information from the best experts in the field. It reflects today's emerging techniques, including new information on esthetics, genetics, cone-beam and other three-dimensional technologies, and evidence-based treatment. Coverage of diagnosis and treatment ranges from basic to highly complex situations, all in a concise, extensively illustrated format. Also included with this edition is a companion website that includes an electronic version of all chapters, supplemental content in select chapters, and a complete image collection to help with research and presentations. Written by Lee W. Graber, Robert L. Vanarsdall Jr., and Katherine W. L. Vig, along with a team of expert contributors, this is your go-to book for the practical orthodontic information you can use every day. Comprehensive coverage includes foundational theory and the latest on materials and techniques used in today's practice. Full-color photographs make it easy to see and distinguish the subtle differences that are necessary to mastering treatment planning. More than 2,500 images include a mixture of radiographs, clinical photos, and anatomic or schematic line drawings, showing examples of treatments, techniques, and outcomes. Detailed case studies guide you through the decision-making process, showing the consequences of various treatment techniques over time. Extensive references cite the latest in orthodontic research, so it's easy to follow up on evidence-based information. Authoritative research is provided by a team of three experienced, renowned authors/editors along with a team of worldwide experts. Cutting-edge content includes the latest concepts and techniques in orthodontics, including new coverage of temporary anchorage devices, self-ligating bracket biomechanics, clear aligner treatments, technological advances in imaging, and lasers. Improved organization separates topics into six parts and 29 chapters, enhancing both learning and research. Chapter outlines serve as a handy reference tool for practitioners and researchers. New lead author Dr. Lee Graber adds a fresh perspective to the experience of authors Drs. Robert Vanarsdall Jr., and Katherine W. L. Vig. Access to a companion website includes an electronic version of all chapters, plus case studies, a complete image collection, and supplemental content.
Murray and Nadel’s Textbook of Respiratory Medicine has long been the definitive and comprehensive pulmonary disease reference. Robert J. Mason, MD now presents the fifth edition in full color with new images and highlighted clinical elements. The fully searchable text is also online at www.expertconsult.com, along with regular updates, video clips, additional images, and self-assessment questions. This new edition has been completely updated and remains the essential tool you need to care for patients with pulmonary disease. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Master the scientific principles of respiratory medicine and its clinical applications. Work through differential diagnosis using detailed explanations of each disease entity. Learn new subjects in Pulmonary Medicine including Genetics, Ultrasound, and other key topics. Grasp the Key Points in each chapter. Search the full text online at expertconsult.com, along with downloadable images, regular updates, more than 50 videos, case studies, and self-assessment questions. Consult new chapters covering Ultrasound, Innate Immunity, Adaptive Immunity, Deposition and Clearance, Ventilator-Associated Pneumonia. Find critical information easily using the new full-color design that enhances teaching points and highlights challenging concepts. Apply the expertise and fresh ideas of three new editors—Drs. Thomas R. Martin, Talmadge E. King, Jr., and Dean E. Schraufnagel. Review the latest developments in genetics with advice on how the data will affect patient care.
The updated edition of Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas is designed to act as a one-stop medical reference book for the entire gastrointestinal system, providing exhaustive coverage and equipping you with all of the necessary tools to make a comprehensive diagnostic workup. You'll access thousands of high-quality illustrations and eight brand-new chapters, so you can recognize and diagnose any pathological slide you encounter. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Make a comprehensive diagnostic workup with data from ancillary techniques and molecular findings whenever appropriate. Effectively grasp complex topics and streamline decision-making by using extensive tables, graphs, and flowcharts. Avoid diagnostic errors thanks to practical advice on pitfalls in differential diagnosis. Navigate the book quickly with a "road map" featured at the beginning of each chapter. Provide the clinician with the most accurate and up-to-date diagnostic and prognostic indicators, including key molecular aspects of tumor pathology, with access to the latest classification and staging systems available. Evaluate diagnostically challenging cases using diagnostic algorithms. Stay abreast of the latest advances with eight new chapters: Autoimmune Disorders of the GI Tract; Drug Induced Disorders of the GI Tract; Molecular Diagnostics of Tubal Gut Neoplasms; Molecular Diagnostics of the Gallbladder, Extrahepatic Biliary Tree, and Pancreatic Tumors; Tumors of the Ampulla; Molecular Diagnostics of Hepatocellular Neoplasms; Approach to the Liver Biopsy, and Approach to Gastrointestinal Tract Biopsies. Remain at the forefront of your field with coverage of new molecular and genetic markers in GI neoplasms; updated knowledge on liver and biliary tree pathology; and expanded information on tumors of the ampulla. Recognize and diagnose any tissue sample under the microscope with help from over 3000 high-quality color illustrations.
Comprehensive, cutting-edge content prepares you for today's orthodontics! Orthodontics: Current Principles and Techniques: 1st South Asia Edition provides evidence-based coverage of orthodontic diagnosis, planning strategies, and treatment protocols, including esthetics, genetics, temporary anchorage devices, aligners, technology-assisted biomechanics, and much more. From respected editors Lee Graber, Robert Vanarsdall, Katherine Vig, and Greg Huang, along with a veritable Who's Who of expert contributors, this classic reference has a concise, no-nonsense approach to treatment that makes it the go-to book for orthodontic residents and practitioners - Comprehensive coverage provides a one-stop resource for the field of orthodontics, including foundational theory and the latest on the materials and techniques used in today's practice. - Experienced, renowned editors lead a team of expert, international contributors, bringing the most authoritative clinical practice and supporting science from the best and brightest in the industry. - More than 3,400 images include a mixture of radiographs, full-color clinical photos, and anatomic or schematic line drawings, showing examples of treatment, techniques, and outcomes. - Extensive references make it easy to look up the latest in orthodontic research and evidence-based information, and all references also appear online. - Detailed, illustrated case studies show the decision-making process, showing the consequences of various treatment techniques over time
This book provides an introduction to the important methods of chiroptical spectroscopy in general, and circular dichroism (CD) in particular, which are increasingly important in all areas of chemistry, biochemistry, and structural biology. The book can be used as a text for undergraduate and graduate students and as a reference for researchers in academia and industry, with or without the companion volume in this set. Experimental methods and instrumentation are described with topics ranging from the most widely used methods (electronic and vibrational CD) to frontier areas such as nonlinear spectroscopy and photoelectron CD, as well as the theory of chiroptical methods and techniques for simulating chiroptical properties. Each chapter is written by one or more leading authorities with extensive experience in the field.
Compact, hand-carried ultrasound devices are revolutionizing how healthcare providers practice medicine in nearly every specialty. The 2nd Edition of this BMA-award-winning text features all-new chapters, a greatly expanded video library, and new review questions to keep you fully up to date with the latest technology and its applications. - Helps you interpret findings with a peer-reviewed, online video library with more than 1,000 ultrasound videos of normal and pathologic findings. These videos are complemented by anatomical illustrations and text descriptions to maximize learning. - Offers new online resources, including over 60 clinical cases and review questions in every chapter. - Features fully updated content throughout, plus all-new chapters on hemodynamics, transesophageal echocardiography, transcranial Doppler ultrasound, pediatrics, neonatology, and 2nd/3rd trimester pregnancy. - Shares the knowledge and expertise of expert contributors who are internationally recognized faculty from more than 60 institutions. - Recipient of British Medical Association's President's Choice Award and Highly Commended in Internal Medicine at the BMA Medical Book Awards 2015 (first edition).
Herbert Henri Jasper is a scientist whose research activities have initiated and encompassed many of the major themes of neuroscience. He has pioneered in single unit recording, chronic neuronal studies, neurochemistry, electroencephalography, and many other disciplines. His students now hold important positions in universities and hospitals around the world. From July 21 to 23, 1986, a symposium entitled Neurotransmitters and Cortical Function: From Molecules to Mind was held in Montreal to honor Professor Jasper and to continue his pioneering efforts. The following chapters originated in that meeting. They summarize the current v vi PREFACE status of our knowledge in some of the fields influenced by Professor Jasper. They share a focus on neurotransmitters in cortical function, where we presume higher mental events originate. Professor Jasper has made contributions to the understanding of three different classes of neuro transmitters: GABA, acetylcholine, and catecholamines. It is an interest in trying to link neu rochemical events to some aspects of complex brain function and behavior that has characterized his work, and it is this philosophy that led to the present symposium to honor him. We dedicate this volume to Professor Jasper and the integrative approach that he has fostered. The Editors Montreal Contents 1. H. H. Jasper, Neuroscientist of Our Century .......................... .
This issue of Rheumatic Disease Clinics provides important updates in myopathies. The following essential topics are covered. Clinical features, pathophysiology, and treatment of polymyositis and dermatomyositis; inclusion body myositis; metabolic myopathies; drug-induced myopathies; muscular dystrophies and neurologic diseases; laboratory testing and imaging; electrophysiological studies; metabolic and genetic testing; and pathology.
This will help us customize your experience to showcase the most relevant content to your age group
Please select from below
Login
Not registered?
Sign up
Already registered?
Success – Your message will goes here
We'd love to hear from you!
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.