Inflammation: Mediators and Pathways reviews key developments in the field of inflammation. It focuses on novel pathways of inflammation that have only recently surfaced. All the topics covered are currently the subject of intense investigation, and all contributors are established investigators in the field.
Katherine Lynn was eleven years old in the year 1860 and was destined to grow into young womanhood during the tumultuous times of the Civil War. Doria, the Lynn family estate, was located just in Virigina, just east of the Blue Ridge Mountains... Here is a family saga written with a deep understanding of the forces shaping the turning point in American history."--
This new edition of Evaluation and Treatment of Myopathies is written for the clinician who sees patients with muscle disease, or the patient with complaints of pain or weakness of muscle. Like the original, this new edition is divided in to 3 primary sections: Approach to the Patient with Muscle Disease, Specific Myopathies, and General Strategies of Clinical Management, each section providing practical guidance to eliciting key histories and demonstrate findings upon examination. This new edition also provides guidance on the next steps in diagnoses as well as the latest information on pathogenesis, diagnosis, and treatment, in an integrated manner, so as to give trainees, practicing clinicians and others who see neuromuscular disease perspective on how to evaluate and care for patients. New and revised tables, figures, and references are selected and organized to present information of clinical importance to provide the most up-to-date resource on the myopathies.
The transition from President Donald J. Trump to President Joseph R. Biden Jr. stands as one of the most dangerous periods in American history. But as #1 internationally bestselling author Bob Woodward and acclaimed reporter Robert Costa reveal for the first time, it was far more than just a domestic political crisis. Woodward and Costa interviewed more than 200 people at the center of the turmoil, resulting in more than 6,000 pages of transcripts—and a spellbinding and definitive portrait of a nation on the brink. This classic study of Washington takes readers deep inside the Trump White House, the Biden White House, the 2020 campaign, and the Pentagon and Congress, with eyewitness accounts of what really happened. Intimate scenes are supplemented with never-before-seen material from secret orders, transcripts of confidential calls, diaries, emails, meeting notes and other personal and government records, making Peril an unparalleled history. It is also the first inside look at Biden’s presidency as he began his presidency facing the challenges of a lifetime: the continuing deadly pandemic and millions of Americans facing soul-crushing economic pain, all the while navigating a bitter and disabling partisan divide, a world rife with threats, and the hovering, dark shadow of the former president.
Discover the inside story of life inside President Trump’s White House as only #1 internationally bestselling author Bob Woodward can tell it with this collection of Woodward’s most revealing and unprecedented works including Fear, Rage, and Peril. With authoritative reporting, internationally bestselling author Bob Woodward offers an exposing and riveting account of President Trump’s term in office—from the beginning to the final transfer of power to President Biden’s administration. In vivid detail, Woodward paints the most intimate portrait of a sitting president ever published in this complete trilogy following the Trump presidency. This collection includes: Fear: An “explosive” (The Washington Post) and “devastating” (The New Yorker) look at the harrowing life inside President Donald Trump’s White House and precisely how he makes decisions on major foreign and domestic policies. Fear is the inside story on President Trump as only Bob Woodward can tell it, drawing from hundreds of hours of interviews with firsthand sources, meeting notes, personal diaries, files, and documents. Rage: An unprecedented and intimate tour de force of reporting on the Trump presidency facing a global pandemic, economic disaster, and racial unrest. In dramatic detail, Woodward has uncovered the precise moment the president was warned that the Covid-19 epidemic would be the biggest national security threat to his presidency. Peril: The book covers the end of the Trump presidency and the early months of the Biden presidency.
This text focuses on the contemporary economic, social, geographical, environmental and political realities of the Caribbean region. Historical aspects of the Caribbean, such as slavery, the plantation system and plantocracy are explored in order to explain the contemporary nature of, and challenges faced by, the Caribbean. The book is divided into three parts, dealing respectively with: the foundations of the Caribbean, rural and urban bases of the contemporary Caribbean, and global restructuring and the Caribbean: industry, tourism and politics.
The Markagunt and Sevier gravity slides are gigantic landslides that resulted from gravitationally induced catastrophic failure of the southern flank of the Oligocene to Miocene Marysvale volcanic field. Each is nearly 100 km long with runouts over the former land surface>35 km; together they span 7000 km2 and rank among Earth's largest terrestrial landslides. Basal cataclastic layers, injectites, pseudotachylyte, deformed clasts, and a variety of kinematic indicators demonstrate catastrophic emplacement, which was preceded by slow gravitational spreading of the volcanic field. This volume offers a history of their discovery, our current understanding of the gravity slides, and a guide to particularly instructive exposures for which the authors document their conclusions about the size, age, and significant structural features of these newly discovered features"--
Since their inception with New York's Crystal Palace Exhibition in the mid-nineteenth century, world's fairs have introduced Americans to “exotic” pleasures such as belly dancing and the Ferris Wheel; pathbreaking technologies such as telephones and X rays; and futuristic architectural, landscaping, and transportation schemes. Billed by their promoters as “encyclopedias of civilization,” the expositions impressed tens of millions of fairgoers with model environments and utopian visions. Setting more than 30 world’s fairs from 1853 to 1984 in their historical context, the authors show that the expositions reflected and influenced not only the ideals but also the cultural tensions of their times. As mainstays rather than mere ornaments of American life, world’s fairs created national support for such issues as the social reunification of North and South after the Civil War, U.S. imperial expansion at the turn of the 20th-century, consumer optimism during the Great Depression, and the essential unity of humankind in a nuclear age.
The rollicking memoir from the cardiologist turned legendary scientist and winner of the Nobel Prize that revels in the joy of science and discovery. Like Richard Feynman in the field of physics, Dr. Robert Lefkowitz is also known for being a larger-than-life character: a not-immodest, often self-deprecating, always entertaining raconteur. Indeed, when he received the Nobel Prize, the press corps in Sweden covered him intensively, describing him as “the happiest Laureate.” In addition to his time as a physician, from being a "yellow beret" in the public health corps with Dr. Anthony Fauci to his time as a cardiologist, and his extraordinary transition to biochemistry, which would lead to his Nobel Prize win, Dr. Lefkowitz has ignited passion and curiosity as a fabled mentor and teacher. But it's all in a days work, as Lefkowitz reveals in A Funny Thing Happened on the Way to Stockholm, which is filled to the brim with anecdotes and energy, and gives us a glimpse into the life of one of today's leading scientists.
- NEW! Revised chapter on motor development and control now closely examines the when, how, why, and what of developing motor skill and how it contributes to effective physical therapy. - NEW! Chapter on children with autism spectrum disorder (ASD) covers the characteristics of ASD, the diagnostic process, program planning, and evidence-based decision making for children with ASD. - NEW! Chapter on pediatric oncology addresses the signs and symptoms of pediatric cancers, the most common medical interventions used to treat these diseases, the PT examination, and common therapeutic interventions. - NEW! Chapter on tests and measures offers guidance on how to effectively use tests and measures in pediatric physical therapy practice. - NEW! Extensively revised chapter asthma offers more detail on the pathology of asthma; the primary and secondary impairments of asthma; the impact on a child's long term health and development; pharmacological management; and more. - NEW! Revised chapter on the neonatal intensive care unite better addresses the role of the physical therapist in the neonatal intensive care unit. - UPDATED! Full color photos and line drawings clearly demonstrate important concepts and clinical conditions that will be encountered in practice. - NEW! Expert Consult platform provides a number of enhancements, including a fully searchable version of the book, case studies, videos, and more. - NEW! Revised organization now includes background information — such as pathology, pathophysiology, etiology, prognosis and natural evolution, and medical and pharmacologic management — as well as foreground information — such as evidence-based recommendations on physical therapy examination strategies, optimal tests and measurement, interventions, patient/caregiver instruction, and more. - NEW! Additional case studies and videos illustrate how concepts apply to practice.
This classic text, one of the true anchors of our clinical genetics publishing program, covers over 700 different genetic syndromes involving the head and neck, and it has established itself as the definitive, comprehensive work on the subject. The discussion covers the phenotype spectrum, epidemiology, mode of inheritance, pathogenesis, and clinical profile of each condition, all of which is accompanied by a wealth of illustrations. The authors are recognized leaders in the field, and their vast knowledge and strong clinical judgment will help readers make sense of this complex and burgeoning field. Dr. Gorlin retires as editor in this edition and co-editor Raoul Hennekam takes over. Dr. Hennekam is regarded as one of the top dysmorphologists--and indeed one of the top clinical geneticists--in the world. Judith Allanson is new to the book but is a veteran OUP author and a widely respected geneticist, and Ian Krantz at Penn is a rising star in the field. Dr. Gorlin's name has always been closely associated with the book, and it has now become part of the title. As in all fields of genetics, there has been an explosion in the genetics of dysmorphology syndromes, and the author has undertaken a complete updating of all chapters in light of the discoveries of the Human Genome Project and other ongoing advances, with some chapters requiring complete rewriting. Additional material has been added both in terms of new syndromes and in updating information on existing syndromes. The book will appeal to clinical geneticists, pediatricians, neurologists, head and neck surgeons, otolarynologists, and dentists. The 4th edition, which published in 2001, has sold 2,600 copies.
This 8th Edition of Moss and Adams' Heart Disease in Infants, Children, and Adolescents: Including the Fetus and Young Adult, provides updated and useful information from leading experts in pediatric cardiology. Added chapters and a companion web site that includes the full text with bonus question and answer sections make this Moss and Adams’ edition a valuable resource for those who care for infants, children, adolescents, young adults, and fetuses with heart disease. Features: · Access to online questions similar to those on the pediatric cardiology board examination to prepare you for certification or recertification · Leading international experts provide state-of-the-art diagnostic and interventional techniques to keep you abreast of the latest advances in treatment of young patients · Chapters on quality of life, quality and safety, pharmacology, and research design add to this well-respected text
Clinical Anesthesia, Seventh Edition covers the full spectrum of clinical options, providing insightful coverage of pharmacology, physiology, co-existing diseases, and surgical procedures. This classic book is unmatched for its clarity and depth of coverage. *This version does not support the video and update content that is included with the print edition. Key Features: • Formatted to comply with Kindle specifications for easy reading • Comprehensive and heavily illustrated • Full color throughout • Key Points begin each chapter and are labeled throughout the chapter where they are discussed at length • Key References are highlighted • Written and edited by acknowledged leaders in the field • New chapter on Anesthesia for Laparoscopic and Robotic Surgery Whether you’re brushing up on the basics, or preparing for a complicated case, the digital version will let you take the content wherever you go.
Long recognized as the leading text in this dynamic field, Rogers’ Textbook of Pediatric Intensive Care provides comprehensive, clear explanations of both the principles underlying pediatric critical care disease and trauma as well as how these principles are applied. Led by Drs. Donald H. Shaffner, John J. McCloskey, Elizabeth A. Hunt, and Robert C. Tasker, along with a team of 27 section editors as well as more than 250 expert global contributors, the fully revised Sixth Edition brings you completely up to date on today’s understanding, treatments, technologies, and outcomes regarding critical illness in children.
Widely recognized as the definitive text in pediatric cardiology, Moss and Adams' Heart Disease in Infants, Children, and Adolescents provides the authoritative, state-of-the-art information you need when caring for young patients with heart disease. The editorial team, led by Dr. Robert Shaddy, from Children's Hospital Los Angeles and the University of Southern California, ensures that you are kept fully up to date with recent advances in this complex and fast-changing field. This award-winning title, now in its Tenth Edition, continues to be the reference of choice for today’s cardiology fellows, pediatric cardiologists, and cardiology practitioners worldwide.
Clinical Anesthesia, Seventh Edition covers the full spectrum of clinical options, providing insightful coverage of pharmacology, physiology, co-existing diseases, and surgical procedures. This classic book is unmatched for its clarity and depth of coverage. *This version does not support the video and update content that is included with the print edition. Key Features: • Formatted to comply with Kindle specifications for easy reading • Comprehensive and heavily illustrated • Full color throughout • Key Points begin each chapter and are labeled throughout the chapter where they are discussed at length • Key References are highlighted • Written and edited by acknowledged leaders in the field • New chapter on Anesthesia for Laparoscopic and Robotic Surgery Whether you’re brushing up on the basics, or preparing for a complicated case, the digital version will let you take the content wherever you go.
Ideal for cardiologists who need to keep abreast of rapidly changing scientific foundations, clinical research results, and evidence-based medicine, Braunwald’s Heart Disease is your indispensable source for definitive, state-of-the-art answers on every aspect of contemporary cardiology, helping you apply the most recent knowledge in personalized medicine, imaging techniques, pharmacology, interventional cardiology, electrophysiology, and much more! Practice with confidence and overcome your toughest challenges with advice from the top minds in cardiology today, who synthesize the entire state of current knowledge and summarize all of the most recent ACC/AHA practice guidelines. Locate the answers you need fast thanks to a user-friendly, full-color design with more than 1,200 color illustrations. Learn from leading international experts, including 53 new authors. Explore brand-new chapters, such as Principles of Cardiovascular Genetics and Biomarkers, Proteomics, Metabolomics, and Personalized Medicine. Access new and updated guidelines covering Diseases of the Aorta, Peripheral Artery Diseases, Diabetes and the Cardiovascular System, Heart Failure, and Valvular Heart Disease. Stay abreast of the latest diagnostic and imaging techniques and modalities, such as three-dimensional echocardiography, speckle tracking, tissue Doppler, computed tomography, and cardiac magnetic resonance imaging. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability.
Murray and Nadel’s Textbook of Respiratory Medicine has long been the definitive and comprehensive pulmonary disease reference. Robert J. Mason, MD now presents the fifth edition in full color with new images and highlighted clinical elements. The fully searchable text is also online at www.expertconsult.com, along with regular updates, video clips, additional images, and self-assessment questions. This new edition has been completely updated and remains the essential tool you need to care for patients with pulmonary disease. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Master the scientific principles of respiratory medicine and its clinical applications. Work through differential diagnosis using detailed explanations of each disease entity. Learn new subjects in Pulmonary Medicine including Genetics, Ultrasound, and other key topics. Grasp the Key Points in each chapter. Search the full text online at expertconsult.com, along with downloadable images, regular updates, more than 50 videos, case studies, and self-assessment questions. Consult new chapters covering Ultrasound, Innate Immunity, Adaptive Immunity, Deposition and Clearance, Ventilator-Associated Pneumonia. Find critical information easily using the new full-color design that enhances teaching points and highlights challenging concepts. Apply the expertise and fresh ideas of three new editors—Drs. Thomas R. Martin, Talmadge E. King, Jr., and Dean E. Schraufnagel. Review the latest developments in genetics with advice on how the data will affect patient care.
Ideal for fellows and practicing pulmonologists who need an authoritative, comprehensive reference on all aspects of pulmonary medicine, Murray and Nadel’s Textbook of Respiratory Medicine offers the most definitive content on basic science, diagnosis, evaluation and treatment of the full spectrum of respiratory diseases. Full-color design enhances teaching points and highlights challenging concepts. Understand clinical applications and the scientific principles of respiratory medicine. Detailed explanations of each disease entity allow you to work through differential diagnoses. Expert Consult eBook version included with purchase. This enhanced eBook experience offers content updates, videos, review questions, and Thoracic Imaging Cases (TICs), all of which are easily navigable on any device for access on rounds or in the clinic. Includes more than 1,000 figures and over 200 videos and audio files. Key Points and Key Reading sections highlight the most useful references and resources for each chapter. An expanded sleep section now covers four chapters and includes control of breathing, consequences of sleep disruption, as well as obstructive and central apnea. New chapters in the Critical Care section cover Noninvasive Ventilation (NIV) and Extracorporeal Support of Gas Exchange (ECMO). New chapters focusing on diagnostic techniques now include Invasive Diagnostic Imaging and Image-Guided Interventions and Positron Emission Tomography, and a new chapter on Therapeutic Bronchoscopy highlights the interventional role of pulmonologists. Embedded videos feature thoracoscopy, therapeutic bronchoscopy, volumetric chest CT scans, and more. Brand-new audio files highlight normal and abnormal breath sounds and the separate components of cough.
Readers all over the world are discovering the works of Robert Stanek. Filled with mystery, intrigue, adventure, and magic the books transport readers to a world unlike any other. In this insightful book, you get the real scoop on Robert Stanek. From his childhood days to his recent success with the Ruin Mist books, this outstanding book sheds new light on his life and his struggle to excel as a writer. His story is a story of hope and dreams, and in many ways, reading this book is like visiting with an old friend. You'll laugh and you'll cry and you'll be enchanted. And that's just the beginning. You also get a complete collector's guide to the Ruin Mist books, complete rules for playing King's Mate, and more.
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