In late 1922, Judge Emil Fuchs purchased the woebegone Boston Braves--primarily to bring his ailing friend, Christy Mathewson, back into the game he loved so much. A true fan, Judge Fuchs poured his fortune into the team, intent on giving Boston's long-suffering National League fans a winner. He introduced Ladies' Days, contracted to have Braves games broadcast on radio, and successfully campaigned to allow Sunday baseball in Boston. Moreover, he gave the fans a competitive team, climaxed by the Braves' dramatic pennant race with the New York Giants in 1933. The Depression, however, weakened his financial position to the point where in 1935 Fuchs was forced to give up the team. Using Judge Fuchs' unfinished autobiography, the memories of his son who worked in the organization, and extensive additional research, this story of an owner and an era is complete.
The book gathers some papers concerning the dialogue between neuroscience and psychoanalysis. Following the Introduction written by Georg Northoff, concerning the possibility of overcoming the highly impasse generating contraposition between localizationism and holism, G. Vaslamatzis deals with a “Framework for a new dialogue between psychoanalysis and neurosciences”. In this chapter the author describes three points of epistemological congruence: firstly, dualism is no longer a satisfactory solution; secondly, cautions for the centrality of interpretation (hermeneutics); and, thirdly, the self-criticism of neuroscientists. David W.Mann in his contribution “The mirror crack’d: dissociation and reflexivity in self and group phenomena” tries to show how reflexive processes generate each of three levels of the human system (self, relationships, group) and integrate them one to another, while dissociative processes tend throughout to pull them apart. Health and illness within the self, the relationship and the group can be understood as special states of the dynamic equilibria between these cohesive and dispersive trends. In “Sleep, memory and plasticity” Matthew P. Walker and Robert Stickgold outline a review of the researches following the discovery of rapid eye movement (REM) and non-REM (NREM) sleep, and specifically of those that began testing the hypothesis that sleep, or even specific stages of sleep, actively participated in the process of memory development. The last two chapters, “Clinical implications of neuroscience research in PTSD” by Bessel A. Van Der Kolk, and “Dysregulation of the right brain: a fundamental mechanism of traumatic attachment and the psychopathogenesis of PTSD” by Allan N. Schore, demonstrate how the psychopathology of traumatic conditions can be a fertile field of dialogue between neuroscience and psychoanalysis.
Ischemic heart disease is the leading cause of morbidity and mortality in the developed world. The high metabolism and oxygen demand of the cardiac myocardium depends on both a high blood flow and a rich capillary density. For this reason, the growth of the coronary vasculature is vital, not only in early development, but also in the adult faced with various stresses. Novel technologies have enabled the discovery of the molecular mechanisms underlying the growth and assembly coronary vessels, and this volume covers the hierarchy of the coronary vasculature from its embryonic origins through its postnatal growth, adulthood, and senescence. Chapters address normal coronary development, coronary anomalies and their possible underlying developmental errors, coronary vessel adaptations to exercise training, aging, hypoxia, myocardial ischemia, and cardiac hypertrophy. This comprehensive overview of current research in coronary vessels and myocardial perfusion was written by Dr. Robert J. Tomanek, Emeritus Professor of Anatomy and Cell Biology at the University of Iowa. The book reviews, discusses, and integrates findings from various areas of coronary vasculature research, and as a result, will be a valuable reference source for cardiovascular scientists and physicians for many years to come.
New York Times Bestselling author! Over a decade ago, following a rise in developmental disorders such as autism and ADHD, the mercury-containing preservative Thimerosal was widely believed to have been eliminated from vaccine supplies. However, dangerous quantities of Thimerosal continue to be used, posing a threat to public health In this groundbreaking book, Robert F. Kennedy, Jr., and Dr. Mark Hyman examine the research literature on Thimerosal and make a very clear statement about its potentially dangerous effects. In the past, the CDC, FDA, NIH, and AAP, as well as the US Congress, the American Academy of Family Physicians, the US Department of Agriculture, the European Medicines Agency, and the California Environmental Protection Agency have expressed concerns over the use of Thimerosal in vaccines. But despite the many voices calling for action, the media and policy makers have repeatedly failed to adequately address the issue. Now, with Thimerosal: Let the Science Speak, the goals are to educate parents, doctors, and health policy makers; to eliminate this toxic chemical from the world’s vaccine supplies; to move toward safer alternatives; and to maintain or increase vaccination rates critical to the United States and developing nations. With safer options available, parents shouldn’t have to worry about the devastating effects of vaccinating their children.
The Year Book of Oncology brings you abstracts of the articles that reported the year's breakthrough developments in oncology, carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. There's no faster or easier way to stay informed! Topics include Supportive Care, Breast Cancer, Gynecologic Cancers, Genitourinary Cancers, Hematologic Malignancies, Thoracic Cancer, Gastrointestinal Cancer and Cancer Biology. The Year Book of Oncology is available annually in November.
This issue dives into the study of sleep function, particularly as it relates to memory and cognition. Any clinician who sees patients with sleep disorders, or in particular any sleep medicine specialist, will find this information enlightening and invaluable, as it discusses the current state of understanding of how sleep affects humans' waking cognitive functions. These review articles describe the research that has taken place, and the lessons that can be taken away from them, so that clinicians can confidently advise their patients on the functional importance of adequate sleep, and recognize cognitive symptoms of inadequate sleep. Articles discuss such topics as animal and human research on sleep and memory, various imaging techniques to describe brain activity during sleep, and the role of dreams.
Cognitive Systems and the Extended Mind surveys philosophical issues raised by the situated movement in cognitive science, that is, the treatment of cognitive phenomena as the joint products of brain, body, and environment.
RNA Methodologies: A Laboratory Guide for Isolation and Characterization, Sixth Edition provides the most up-to-date ribonucleic acid lab techniques for seasoned scientists and graduate students alike. This edition features new material on RNA sequencing, RNA in Situ Hybridization, non-coding RNAs, computational RNA biology, transcriptomes and bioinformatics, along with the latest advances in methods and protocols across the field of RNA investigation. As a leader in the field, Dr. Farrell provides a wealth of knowledge on the topic of RNA biology while also giving readers helpful hints and troubleshooting techniques from his own personal experience in this subject area. This book presents the essential knowledge and techniques to use when working with RNA for the experienced practitioner, while also aiding the beginner in fully understanding this important branch of molecular biology. - Presents the latest information covering all aspects of working with RNA, delivering a holistic understanding of this leading field in molecular biology - Builds from basic information on RNA techniques to in-depth protocols for specific applications - Features new chapters on RNA sequencing and RNA in situ hybridization - Includes new material on RNA clinical applications and innovations, including RNA therapeutics and RNA vaccines, with particular relevance to coronavirus - Comprises the latest developments in transcriptomes and bioinformatics, with new material on computational RNA biology, RNA CHiP analysis, aptamer biology and RNA epigenetics
Fundamentals of Analytical Toxicology is an integrated introduction to the analysis of drugs, poisons, and other foreign compounds in biological and related specimens. Assuming only basic knowledge of analytical chemistry, this invaluable guide helps trainee analytical toxicologists understand the principles and practical skills involved in detecting, identifying, and measuring a broad range of compounds in various biological samples. Clear, easy-to-read chapters provide detailed information on topics including sample collection and preparation, spectrophotometric and luminescence techniques, liquid and gas-liquid chromatography, and mass spectrometry including hyphenated techniques. This new edition contains thoroughly revised content that reflects contemporary practices and advances in analytical methods. Expanding the scope of the 1995 World Health Organization (WHO) basic analytical toxicology manual, the text includes coverage of separation science, essential pharmacokinetics, xenobiotic absorption, distribution and metabolism, clinical toxicological and substance misuse testing, therapeutic drug monitoring, trace elements and toxic metals analysis, and importantly the clinical interpretation of analytical results. Written by a prominent team of experienced practitioners, this volume: Focuses on analytical, statistical, and pharmacokinetic principles Describes basic methodology, including colour tests and immunoassay and enzyme-based assays Outlines laboratory operations, such as method validation, quality assessment, staff training, and laboratory accreditation Follows IUPAC nomenclature for chemical names and recommended International Non-proprietary Name (rINN) for drugs and pesticides Includes discussion of 'designer drugs' (novel pharmaceutical substances NPS) Fundamentals of Analytical Toxicology: Clinical and Forensic, 2nd Edition is an indispensable resource for advanced students and trainee analytical toxicologists across disciplines, such as clinical science, analytical chemistry, forensic science, pathology, applied biology, food safety, and pharmaceutical and pesticide development.
Since 1898, when Tigerstadt and Bergman first extracted renin from rabbit kidney, the reninrugs, Enzymes and Receptors of the Renin is designed to highlight molecular and clinical approaches to understanding the renin Chapter topics have been specifically chosen to cover selected contemporary, controversial and unresolved issues. A novel and uni
This work occupies a unique place amongst the array of books addressing the inclusion of students with disabilities in general education classrooms. In contrast to the more prescriptive books on the market, Images of Mainstreaming emphasizes the extensive use of case studies and the use of reflection on case studies to change teaching practices. Its goal is to help preservice and practicing teachers and administrators examine the challenging issue of inclusion from the perspective of other teachers.
The definitive volume on opossums, a group of ecologically and scientifically important mammals, covering natural history, evolution, behavior, and biogeography. Opossums are the most diverse and ecologically important group of New World marsupials, although only the Virginia opossum is familiar to North American residents. In fact, many species of opossums are found in Neotropical rainforests, savannas, and other habitats, where they are key participants in food webs and other ecological relationships. One species, the short-tail opossum (Monodelphis domestica), has recently become a model organism for biomedical researchers. Eclipsed in the public imagination by their Australian relatives, opossums remained for many years a somewhat obscure group, of interest primarily to taxonomists and students of mammalian reproduction. While thousands of scientific articles have appeared in recent years on opossum systematics, morphology, behavior, physiology, genetics, and ecology, this important but widely scattered literature has never been effectively summarized—until now. In Opossums, the first book-length treatment of these fascinating organisms, recognized authorities Robert S. Voss and Sharon A. Jansa synthesize a wide range of available information about the diversity, comparative biology, and natural history of the opossum. Peering into every biological facet of the lives of these long-neglected mammals, the volume includes • introductory chapters explaining the paleontological and biogeographic context for opossum evolution • an overview of the extant fauna, which includes over 100 species in 18 genera • a section devoted to opossum phenotypes: morphology, physiology, and behavior • detailed information on opossum natural history, including habitats, diets, predators, and parasites • in-depth and novel interpretations of opossums' adaptive radiation in a phylogenetic context Intended for undergraduate biology majors, graduate students, and research professionals, this coherent and original portrait of opossums will be of particular interest to mammalogists, evolutionary biologists, and Neotropical field biologists as well as biomedical researchers working with Monodelphis domestica as a model organism.
This is a revised and updated edition of a text used in undergraduate courses on cancer biology. It covers everything from the molecular basis of cancer to clinical aspects of the subject, and has a lengthy bibliography designed to assist newcomers with the cancer literature. An introduction acquaints students with the biological principles of cancer and the human dimensions of the disease by considering genuine cases of cancer in fictionalized letters. Other chapters discuss cancer pathology, metastasis, carcinogenesis, genetics, oncogenes and tumor suppressors, epidemiology, and the biological basis of cancer treatment. Also included are an appendix with descriptions of common forms of cancer, a glossary of cancer-related terms and colour plates to illustrate the pathology of many of the types of cancer discussed in the text. Upper-division undergraduates with a background in freshman biology and chemistry, as well as beginning graduate students will find this a valuable text.
Robert Veatch is one of the founding fathers of contemporary bioethics. In Patient, Heal Thyself, he sheds light on a fundamental change sweeping through the American health care system, a change that puts the patient in charge of treatment to an unprecedented extent. The change is in how we think about medical decision-making. Whereas medicine's core idea was that medical decisions should be based on the hard facts of science--the province of the doctor--the "new medicine" contends that medical decisions impose value judgments. Since physicians are not trained to make value judgments, the pendulum has swung greatly toward the patient in making decisions about their treatment. Veatch shows how this is presently true only for value-loaded interventions (abortion, euthanasia, genetics) but is coming to be true for almost every routine procedure in medicine--everything from setting broken arms to choosing drugs for cholesterol. Veatch uses a range of fascinating examples to reveal how values underlie almost all medical procedures and to argue that this change is inevitable and a positive trend for patients.
A revolution in elementary school reform!"One Million Children" offers an in-depth description of Success for All, a reading program that transforms elementary schools, especially those serving disadvantaged children. The authors offer research on the program and discuss the impact this research is having on educational policy and practice. This program is now specifically tailored to meet the requirements of the NCLB Reading First and Early Reading First funding. Highlights research-based curricular strategies in reading, writing, and language arts; one-to-one tutoring for children struggling in reading; and active family support programs. Included are: Readable, "user-friendly" descriptions and rationales for all program elements Updated research, including large-scale evaluations using state accountability measures and third-party evaluations Studies of program variations and key student subgroups Discussions of policy implications for comprehensive school reform, Title I, bilingual education, and special education
New textbooks at all levels of chemistry appear with great regularity. Some fields like basic biochemistry, organic reaction mechanisms, and chemical thermody namics are well represented by many excellent texts, and new or revised editions are published sufficiently often to keep up with progress in research. However, some areas of chemistry, especially many of those taught at the graduate level, suffer from a real lack of up-to-date textbooks. The most serious needs occur in fields that are rapidly changing. Textbooks in these subjects usually have to be written by scientists actually involved in the research which is advancing the field. It is not often easy to persuade such individuals to set time aside to help spread the knowledge they have accumulated. Our goal, in this series, is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive introductions to their fields. These should serve the needs of one semester or one quarter graduate courses in chemistry and biochemistry. In some cases, the availability of texts in active research areas should help stimulate the creation of new courses.
This book-length meditation on the Hebrew alphabet offers profound insights into many important ideas found in Jewish thought. From time immemorial, the Hebrew alphabet has been considered to be more than a collection of individual letters. Indeed, the essence of each letter of the Hebrew alphabet can be seen as a fundamental building block of the world. Jewish scholars throughout the ages have meditated on these letters, deriving spiritual inspiration in the process. In The Inner Meaning of the Hebrew Letters, Robert M. Haralick looks closely at each of the Hebrew characters, helping us to gain insight from this remarkable tradition. Drawing primarily upon traditional kabbalistic and chasidic thought, Haralick combines his own insights with those of great Jewish personalities such as Moshe Chayim Luzzatto and Rabbi Nachman of Bratslav, as well as drawing upon classical texts, including the Bahir, the Zohar, the Midrash, and the Talmud. One of Haralick's main sources of inspiration is the ancient Jewish art of gematria, where each letter has a numerical value as does each combination of letters. Through this traditional methodology, Haralick shows his readers the many, often dazzling, ways that the Hebrew alphabet has been examined.
Practical Manual of Clinical Obesity provides practical, accessible and expert advice on the clinical diagnosis and management of obesity and will be your perfect go-to tool in the management of your patients. Information is clear, didactic and attractively presented, with every chapter containing plenty of engaging text features such as key points, pitfall boxes, management flowcharts and case studies to enable a rapid understanding of obesity diagnosis and management. Key clinical trials and major international society guidelines are referred to throughout. Topics covered include: • Assessment of the patient, including patient history, examination and investigations • Patterns, risks and benefits of weight loss • Evaluation of management options: diet, exercise, drugs, psychological treatments, and surgery • Management of obesity related co-morbidities Practical Manual of Clinical Obesity is ideal reading for endocrinologists of all levels, as well as all other health professionals who manage obese patients such as specialist nurses, dieticians, and GP’s with an interest in obesity management.
Developing large software projects is a complicated task and can be demanding for developers. Continuous integration is common practice for reducing complexity. By integrating and testing changes often, changesets are kept small and therefore easily comprehensible. Travis CI is a service that offers continuous integration and continuous deployment in the cloud. Software projects are build, tested, and deployed using the Travis CI infrastructure without interrupting the development process. This report describes how Travis CI works, presents how time-driven, periodic building is implemented as well as how CI data visualization can be done, and proposes a way of dealing with dependency problems.
Written in an accessible style and consistent format, the book covers both the fundamentals and advances in the pharmacology of cardiovascular drugs, as well as their integrated applications in the management of individual cardiovascular diseases. • Integrates fundamentals and recent advances regarding cardiovascular drugs, blending basic and clinical sciences needed to effectively understand and treat cardiovascular diseases • Facilitates understanding of drug action and mechanism by covering physiology / pathophysiology and pharmacology • Includes guidelines and algorithms for pharmacotherapeutic management of cardiovascular diseases • Uses case presentations and study questions to enhance understanding of the material • Serves as a resource for pharmaceutical and medical students and researchers interested in cardiovascular issues
Using comparative anthropology to get at the social dimensions of prophetic activity, Robert Wilson's study brings the study of Isrealite prophecy to a new level. Looking at both modern societies and Ancient Near Eastern ones, Wilson sketches the nature of prophetic activity, its social location, and its social functions. He then shows how these features appear in Israelite prophecy and sketches a history of prophecy in Israel.
After more than 75 years, Nelson Textbook of Pediatrics remains your indispensable source for definitive, state-of-the-art answers on every aspect of pediatric care. Embracing the new advances in science as well as the time-honored art of pediatric practice, this classic reference provides the essential information that practitioners and other care providers involved in pediatric health care throughout the world need to understand to effectively address the enormous range of biologic, psychologic, and social problems that our children and youth may face. Brand-new chapters and comprehensive revisions throughout ensure that you have the most recent information on diagnosis and treatment of pediatric diseases based on the latest recommendations and methodologies. "The coverage of such a wide range of subjects relating to child health makes this textbook still the gold standard and companion for all pediatricians across the world." Reviewed by Neel Kamal, Sept 2015 "All in all, this is an excellent and detailed paediatric review textbook which represents excellent value for money..truly a textbook for the global community" Reviewed by glycosmedia.com, Sept 2015 Form a definitive diagnosis and create the best treatment plans possible using evidence-based medicine and astute clinical experiences from leading international authors-many new to this edition. A NEW two-volume layout provides superior portability and exceptional ease of use. Gain a more complete perspective. Along with a broader emphasis on imaging and molecular diagnoses and updated references, the new edition includes an increased focus on international issues to ensure relevance in pediatrics practice throughout the world. Effectively apply the latest techniques and approaches with complete updates throughout 35 new chapters, including: Innovations in Addressing Child Health and Survival in Low Income Settings; Developmental Domains and Theories of Cognition; The Reggio Emilia Educational Approach Catatonia ; Refeeding Syndrome; Altitude-associated Illness; Genetic Approaches to Rare and Undiagnosed Diseases; Healthcare?Associated Infections; Intrapartum and Peripartum Infections; Bath salts and other drugs of abuse; Small Fiber Polyneuropathy; Microbiome; Kingella kingae; Mitochondrial Neurogastrointestinal Encephalomyopathy; Nonalcoholic Fatty Liver Disease; Plagiocephaly; CNS Vasculitis; Anterior Cruciate Ligament Rupture; and Sports-Related Traumatic Brain Injury. Recognize, diagnose, and manage genetic and acquired conditions more effectively. A new Rehabilitation section with 10 new chapters, including: Evaluation of the Child for Rehabilitative Services; Severe Traumatic Brain Injury; Spinal Cord Injury and Autonomic Crisis Management; Spasticity; Birth Brachial Plexus Palsy; Traumatic and Sports-Related Injuries; Meningomyelocele; Health and Wellness for Children with Disabilities. Manage the transition to adult healthcare for children with chronic diseases through discussions of the overall health needs of patients with congenital heart defects, diabetes, and cystic fibrosis. Understand the principles of therapy and which drugs and dosages to prescribe for every disease. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
After more than 75 years, Nelson Textbook of Pediatrics remains your indispensable source for definitive, state-of-the-art answers on every aspect of pediatric care. Embracing the new advances in science as well as the time-honored art of pediatric practice, this classic reference provides the essential information that practitioners and other care providers involved in pediatric health care throughout the world need to understand to effectively address the enormous range of biologic, psychologic, and social problems that our children and youth may face. Brand-new chapters and comprehensive revisions throughout ensure that you have the most recent information on diagnosis and treatment of pediatric diseases based on the latest recommendations and methodologies. Form a definitive diagnosis and create the best treatment plans possible using evidence-based medicine and astute clinical experiences from leading international authors—many new to this edition. A NEW layout provides superior portability and exceptional ease of use. Gain a more complete perspective. Along with a broader emphasis on imaging and molecular diagnoses and updated references, the new edition includes an increased focus on international issues to ensure relevance in pediatrics practice throughout the world. Effectively apply the latest techniques and approaches with complete updates throughout 35 new chapters, including: Innovations in Addressing Child Health and Survival in Low Income Settings; Developmental Domains and Theories of Cognition; The Reggio Emilia Educational Approach Catatonia ; Refeeding Syndrome; Altitude-associated Illness; Genetic Approaches to Rare and Undiagnosed Diseases; Healthcare−Associated Infections; Intrapartum and Peripartum Infections; Bath salts and other drugs of abuse; Small Fiber Polyneuropathy; Microbiome; Kingella kingae; Mitochondrial Neurogastrointestinal Encephalomyopathy; Nonalcoholic Fatty Liver Disease; Plagiocephaly; CNS Vasculitis; Anterior Cruciate Ligament Rupture; and Sports-Related Traumatic Brain Injury. Recognize, diagnose, and manage genetic and acquired conditions more effectively. A new Rehabilitation section with 10 new chapters, including: Evaluation of the Child for Rehabilitative Services; Severe Traumatic Brain Injury; Spinal Cord Injury and Autonomic Crisis Management; Spasticity; Birth Brachial Plexus Palsy; Traumatic and Sports-Related Injuries; Meningomyelocele; Health and Wellness for Children with Disabilities. Manage the transition to adult healthcare for children with chronic diseases through discussions of the overall health needs of patients with congenital heart defects, diabetes, and cystic fibrosis. Understand the principles of therapy and which drugs and dosages to prescribe for every disease.
Offering up-to-date, comprehensive coverage of disease progression, diagnosis, management, and prognosis, Textbook of Pediatric Rheumatology is the definitive reference in the field. For physicians caring for children with rheumatic diseases, this revised 8th Edition is an unparalleled resource for the full spectrum of rheumatologic diseases and non-rheumatologic musculoskeletal disorders in children and adolescents. Global leaders in the field provide reliable, evidence-based guidance, highlighted by superb full-color illustrations that facilitate a thorough understanding of the science that underlies rheumatic disease. - Offers expanded coverage of autoinflammatory diseases, plus new chapters on Takayasu Arteritis and Other Vasculitides, Mechanistic Investigation of Pediatric Rheumatic Diseases, Genetics and Pediatric Rheumatic Diseases, and Global Issues in Pediatric Rheumatology. - Reflects the changes in diagnosis, monitoring, and management that recent advances have made possible. - Covers the latest information on small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies, helping you choose treatment protocols based on the best scientific evidence available today. - Features exhaustive reviews of the complex symptoms, signs, and lab abnormalities that characterize these clinical disorders. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
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