Bennett explains how he prepares for trial, handles witnesses in the courtroom, crafts his opening and closing arguments, and provides other terrific tips and object lessons for success in law and life.
Authoritative, comprehensive and definitive, Pulmonary Circulation builds on the success of its previous two editions by providing practising respiratory physicians with a highly-ordered, unique reference work on the structure, function and pathophysiology of the pulmonary circulation. New for the third edition: Thoroughly revised with comprehensive coverage from diagnosis and clinical evaluation of pulmonary hypertension, to imaging techniques, disorders and treatment A new truly global team of expert editors, authors and key opinion leaders provide a wealth of detail on the latest developments and issues New chapters, such as: paediatrics, critical care, special environments including high altitude and underwater More quality chapters, authors, illustrations with thorough and thoughtful referencing make this book a contemporary essential reference text Pulmonary Circulation remains an essential resource for pulmonary hypertension specialists and should prove invaluable in all respiratory, cardiac and intensive care units.
This handbook covers the widest possible range of organizational misbehaviors (age, race, and gender discrimination, abuse, bullying, aggression, violence, fraud and corruption), all with an eye toward the effects on individual and organizational health and well-being. It is the first-ever single-source resource on this important topic.
Reprint of the original, first published in 1873. The publishing house Anatiposi publishes historical books as reprints. Due to their age, these books may have missing pages or inferior quality. Our aim is to preserve these books and make them available to the public so that they do not get lost.
The New Penguin Dictionary of Modern Quotations contains over 8,000 quotations from 1914 to the present. As much a companion to the modern age as it is an entertaining and useful reference tool, it takes the reader on a tour of the wit and wisdom of the great and the good, from Margot Asquith to Monica Lewinsky, from George V to Boutros Boutros-Galli and Jonathan Aitken to Frank Zappa.
The Third Edition (formerly titled International Public Health) brings together contributions from the world's leading authorities into a single comprehensive text. It thoroughly examines the wide range of global health challenges facing low and middle income countries today and the various approaches nations adopt to deal with them. These challenges include measurement of health status, infectious and chronic diseases, injuries, nutrition, reproductive health, global environmental health and complex emergencies. This thorough revision also explores emerging health systems, their financing, and management, and the roles of nation states, international agencies, the private sector and nongovernmental organizations in promoting health. Your students will come away with a clear understanding of how globalization is impacting on global health, and of the relationship between health and economic development.
Twentieth Century Mouse Genetics: A Historical and Scientific Review provides a comprehensive examination of key advances in mouse genetics throughout the 20th century. Here Dr. Robert P. Erickson, a leader in the field, identifies the contributions of historic mouse genetics studies, and how those approaches and early discoveries are still shaping human genetics research and medical genetics today. In addition to historical overviews, the author provides researcher biographies and updates connecting historic research to ongoing advances. Past studies discussed use the T/t complex as an example and include the origins of mouse genetics, the synthesis of genetics and evolution, cytogenetics and gene mapping, population genetics and mutation research, immunogenetics, reproductive genetics, molecular cloning, X-inactivation and epigenetics, sex determination, and pharmacogenetics. Here researchers, students, and clinicians will find fresh inspiration to engage in human genetics research employing mouse models and to translate those findings to clinical practice. - Offers a comprehensive examination of key advances in mouse genetics throughout the 20th century - Includes updates connecting historic research to ongoing advances - Authored by a thought-leader in the field
This volume provides a comprehensive review of causes of voice changes in athletes and coaches, the clinical presentation of laryngeal dysfunction, and its different treatment modalities. The authors discuss the predisposing factors of these changes including the use of anabolic steroids, and highlight the pathophysiology of voice disorders in sports-occupational voice users who very often need to vocalize outdoors and/or while performing strenuous exercise over noise. Chapters cover the literature on vocal health risk factors in the sports industry; the common phonatory disturbances in athletes, fitness instructors and coaches; sports-related laryngeal trauma; the impact of sports-related musculoskeletal injuries on phonation; vocal fold dysfunction in athletes, as well as the adverse effect of anabolic steroids intake on occupational voice users. An updated, brief review of the anatomy and physiology of phonation, with guidelines on the work-up and treatment of common laryngeal pathologies in patients with voice disorders is included. A well-focused description of the interplay between musculoskeletal injuries, hyperkinetic body behavior, laryngeal hyperfunction and voice disorders in athletes and coaches is also provided, and the prevalence and pathophysiology of exercise-induced laryngeal dysfunction is discussed in depth. The text concludes with a thorough examination of laryngeal trauma in athletes, clinical presentations, diagnostic work-up and management. Voice Disorders in Athletes, Coaches and other Sports Professionals will be a go to resource for otolaryngologists, laryngologists, speech-language pathologists, voice therapists, sports-occupational voice users, sports medicine physicians, and physical therapists.
Offers essential guidance for discovering and optimizing novel drug therapies Using detailed examples, Evaluation of Enzyme Inhibitors in Drug Discovery equips researchers with the tools needed to apply the science of enzymology and biochemistry to the discovery, optimization, and preclinical development of drugs that work by inhibiting specific enzyme targets. Readers will applaud this book for its clear and practical presentations, including its expert advice on best practices to follow and pitfalls to avoid. This Second Edition brings the book thoroughly up to date with the latest research findings and practices. Updates explore additional forms of enzyme inhibition and special treatments for enzymes that act on macromolecular substrates. Readers will also find new discussions detailing the development and application of the concept of drug-target residence time. Evaluation of Enzyme Inhibitors in Drug Discovery begins by explaining why enzymes are such important drug targets and then examines enzyme reaction mechanisms. The book covers: Reversible modes of inhibitor interactions with enzymes Assay considerations for compound library screening Lead optimization and structure-activity relationships for reversible inhibitors Slow binding and tight binding inhibitors Drug-target residence time Irreversible enzyme inactivators The book ends with a new chapter exploring the application of quantitative biochemical principles to the pharmacologic evaluation of drug candidates during lead optimization and preclinical development. The Second Edition of Evaluation of Enzyme Inhibitors in Drug Discovery continues to offer a treatment of enzymology applied to drug discovery that is quantitative and mathematically rigorous. At the same time, the clear and simple presentations demystify the complex science of enzymology, making the book accessible to many fields— from pharmacology to medicinal chemistry to biophysics to clinical medicine.
A broad-ranging introduction to the provision, funding and governance of health care across a variety of systems. This revised fifth edition incorporates additional material on low/middle income countries, as well as broadened coverage relating to healthcare outside of hospitals and the ever-increasing diversity of the healthcare workforce today.
Free radicals and related reactive species, including reactive oxygen and nitrogen species (ROS/RNS) play a critical role in the pathophysiological processes of various human diseases, including cardiovascular diseases, diabetes and metabolic syndrome, neurological disorders, and cancer among many others. This peer-reviewed E-book covers both the fundamental principles and the recent advances in free radical biomedicine along with in-depth discussions of the clinical correlations. It also provides a thorough coverage of the commonly used methods in free radical and antioxidant research with detailed schematic illustrations as well as succinct descriptions of the procedures. This volume should also be a valuable source of information for readers who wish to gain a sound understanding of the research methodologies in this rapidly evolving field.
Pediatric Gastrointestinal and Liver Disease, by Drs. Robert Wyllie and Jeffrey S. Hyams provides the comprehensive reference you need to treat GI diseases in children. Review the latest developments in the field and get up-to-date clinical information on hot topics like polyps, capsule endoscopy, and pancreatic treatments. With expert guidance from an expanded international author base and online access to 475 board-review-style questions, this latest edition is a must-have for every practicing gastroenterologist. Confirm each diagnosis by consulting a section, organized by symptoms, that presents the full range of differential diagnoses and treatment options for each specific condition. Recognize disease processes at a glance with detailed diagrams that accurately illustrate complex concepts. Stay current with advances in the field by reviewing new chapters on Polyps and Polyposis Syndromes, Capsule Endoscopy and Small Bowel Enteroscopy, Small Bowel Transplantation, IBD, Short Gut Syndrome, Steatosis and Non-Alcoholic Fatty Liver Disease, and Pancreatic and Islet Cell Transplants. Gain fresh global perspectives from an expanded list of expert international contributors. Sharpen your visual recognition by accessing a color-plate section that displays additional endoscopy images. Prepare for certification or recertification with 475 online board review-style questions, answers, and rationales.
This is a self-contained introduction to the theory of information and coding. It can be used either for self-study or as the basis for a course at either the graduate or ,undergraduate level. The text includes dozens of worked examples and several hundred problems for solution.
A fully updated and expanded edition of the bestselling guide on toxicology and its practical application • Covers the diverse chemical hazards encountered in the modern work and natural environment, and provides a practical understanding of these hazards • New chapters cover the emerging areas of toxicology such as omics, computational toxicology, and nanotoxicology • Provides clear explanations and practical understanding of the fundamentals necessary for an understanding of the effects of chemical hazards on human health and ecosystems • Includes case histories and examples from industry demonstrate the application of toxicological principles • Supplemented with numerous illustrations to clarify and summarize key points, annotated bibliographies, and a comprehensive glossary of toxicological terms
Yen Jaffe's Reproductive Endocrinology helps you successfully diagnose and manage the spectrum of female and male reproductive system diseases, from impaired fertility, infertility, and recurrent pregnancy loss through problems of sexual development, puberty, menstrual disturbances, fibroids, endometriosis, and reproductive aging. This trusted endocrinology reference book is ideal for fellows, endocrinologists, or as a quick reference when making daily diagnostic and therapeutic decisions. It is just the resource you need to offer your patients the best possible reproductive care. "This new edition helps the reader to stay on top of recent developments. It is a must for subspecialists in reproductive medicine and a valuable source of information in the library of any department and clinical unit involved in reproductive medicine." Reviewed by Acta Obstetricia et Gynecologica Scandinavica February 2015 "It is a must for subspecialists in reproductive medicine and a valuable source of information in the library of any department and clinical unit involved in reproductive medicine." Reviewed by Acta Obstetricia et Gynecologica Scandinavica , March 2015 Get unmatched guidance you can trust, such as fresh insights into today's field and future advances, through the knowledge gleaned from worldwide fertility experts in reproductive medicine. Further your study of Reproductive Endocrinology with a list of suggested readings at the end of each chapter. Conveniently access the fully searchable text and view all of the images online at Expert Consult. Apply the latest reproductive endocrinology advances in basic and clinical science, including molecular, cellular, and genetic concepts, and grasp their relevance to pathophysiology, diagnosis, and therapy. Maximize fertility in women and men undergoing chemotherapy and other cancer treatments, and counsel patients on environmental factors affecting reproduction. Stay on top of recent developments including the impact of obesity on fertility; ovarian tissue banking; cryopreservation; pre-implantation genetic diagnosis; ovulation induction; and risks and treatments for steroid hormone-responsive cancers. View basic anatomic structures, endocrine processes, and cell function and dysfunction with absolute clarity through full-color illustrations and new images throughout. Confidently perform procedures through expanded coverage of reproductive and infertility surgery and online videos demonstrating key techniques.
Bennett explains how he prepares for trial, handles witnesses in the courtroom, crafts his opening and closing arguments, and provides other terrific tips and object lessons for success in law and life.
Describes and lists the values of popular collectible comics and graphic novels issued from the 1950s to today, providing tips on buying, collecting, selling, grading, and caring for comics and including a section on related toys and rings.
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