The time seems ripe for a critical compendium of that segment of the biological universe we call viruses. Virology, as a science, having passed only recently through its descriptive phase of naming and num bering, has probably reached that stage at which relatively few new truly new-viruses will be discovered. Triggered by the intellectual probes and techniques of molecular biology, genetics, biochemical cytology, and high resolution microscopy and spectroscopy, the field has experienced a genuine information explosion. Few serious attempts have been made to chronicle these events. This comprehensive series, which will comprise some 6000 pages in a total of about 18 volumes, represents a commitment by a large group of active investigators to analyze, digest, and expostulate on the great mass of data relating to viruses, much of which is now amorphous and disjointed, and scattered throughout a wide literature. In this way, we hope to place the entire field in perspective, and to develop an invalua ble reference and sourcebook for researchers and students at all levels. This series is designed as a continuum that can be entered anywhere, but which also provides a logical progression of developing facts and integrated concepts.
This unique reference set provides a broad-based, in-depth presentation on angiotensin II receptors, from the genes that encode them to the responses they mediate in humans. The books emphasize known and potential therapeutic applications of the antagonists of angiotensin II receptors and the angiotensin-converting enzyme inhibitors. The molecular biology of angiotensin II receptors is reviewed, as are the biochemical effects mediated by angiotensin II receptors. This is the first publication to analyze in detail the structure-activity relationships for both peptide and nonpeptide angiotensin II receptor agonists and antagonists. It also presents the pharmacological effects mediated by angiotensin II receptors both in the periphery and in the brain.
While apprenticing backstage at Richard Wagners legendary Festival Theatre in Bayreuth, Germany, C. R. Holloway happens onto a handwritten note purporting to be from King Ludwig II. If real, its allegations are so slanderous, they would further stain Wagners and Ludwigs already sullied reputations, and outrage their descendents and admirers. Reluctant to inform anyone of his discovery, Holloway hides the note inside the lining of his luggage and, on returning home to Honolulu, stows it in a safety deposit box, hoping eventually to find time to verify its genesis and authenticity. Shortly, his Waikiki postman delivers a letter in which its writer demands the found note be destroyed immediately. Written in a hand identical to the original, it is signed by someone claiming to be Ludwig, himself! Soon, a series of revealing letters arrive from Ludwig in which he becomes increasingly more hostile toward Holloway and proportionately less self-recriminatory. Concurrent with the arrival of these letters, Holloways life takes a bizarre and disquieting turn that includes his phone being tapped, frequent nightmares and surprise visitors from Germany. All of which energizes his determination to return to Bavaria, surreptitiously investigate Ludwigs world and prowl his castles in search of the truth about the tortured life and mysterious death of The Mad King. While a paying guest of the Hohenlohes, a wealthy family of nobility in Munich, Holloway becomes involved with their nineteen-year-old son, Reiger, a strikingly handsome, moody, first year medical student. Their edgy relationship nearly gets the two of them killed. In the end, Holloways findings are sure to anger Wagnerian purists, infuriate Bavarian bureaucrats, startle keepers of Ludwigs flame and give tourists a new perspective while tramping through the Mad Kings Dream Castles.
From Iraq to Bosnia to North Korea, the first question in American foreign policy debates is increasingly: Can air power alone do the job? Robert A. Pape provides a systematic answer. Analyzing the results of over thirty air campaigns, including a detailed reconstruction of the Gulf War, he argues that the key to success is attacking the enemy's military strategy, not its economy, people, or leaders. Coercive air power can succeed, but not as cheaply as air enthusiasts would like to believe.Pape examines the air raids on Germany, Japan, Korea, Vietnam, and Iraq as well as those of Israel versus Egypt, providing details of bombing and governmental decision making. His detailed narratives of the strategic effectiveness of bombing range from the classical cases of World War II to an extraordinary reconstruction of airpower use in the Gulf War, based on recently declassified documents. In this now-classic work of the theory and practice of airpower and its political effects, Robert A. Pape helps military strategists and policy makers judge the purpose of various air strategies, and helps general readers understand the policy debates.
Approximately 29 million Americans are diagnosed with Type 2 diabetes annually. Of that number, only about 36 percent (10.44 million diabetes sufferers) achieve satisfactory medical outcomes and would need additional help—rarely available—to reliably control their glucose levels. Contrary to popular belief, although anti-diabetic medications can lower sugar levels, nevertheless they have a poor performance track record because inflammation in the blood vessels persists. This book details recent scientific findings that cardiovascular, kidney, vision, peripheral nervous system, and other body damage caused by chronic high levels of blood sugar (hyperglycemia) in Type 2 diabetes is actually due to excessive generation of unopposed free radicals and reactive oxygen species (ROS). These, in turn, cause chronic systemic inflammation and dysfunction of the endothelial lining of the arterial blood vessels, jeopardizing the formation of the protective molecule nitric oxide (NO), thus severely impairing the blood supply to every organ and tissue in the body. This book also catalogues the evidence that chronic hyperglycemia causes profound and often irreversible damage—even long before Type 2 diabetes has been diagnosed. In addition, because conventional prescription treatments are, unfortunately, often inadequate, the book details evidence-based complementary means of blood sugar control.
When Germany launched its blitzkrieg invasion of France in 1940, it forever changed the way the world waged war. Although the Wehrmacht ultimately succumbed to superior Allied firepower in a two-front war, its stunning operational achievement left a lasting impression on military commanders throughout the world, even if their own operations were rarely executed as effectively. Robert Citino analyzes military campaigns from the second half of the twentieth century to further demonstrate the difficulty of achieving decisive results at the operational level. Offering detailed operational analyses of actual campaigns, Citino describes how UN forces in Korea enjoyed technological and air superiority but found the enemy unbeatable; provides analyses of Israeli operational victories in successive wars until the Arab states finally grasped the realities of operational-level warfare in 1973; and tells how the Vietnam debacle continued to shape U.S. doctrine in surprising ways. Looking beyond major-power conflicts, he also reveals the lessons of India’s blitzkrieg-like drive into Pakistan in 1971 and of the senseless bloodletting of the Iran-Iraq War. Citino especially considers the evolution of U.S. doctrine and assesses the success of Desert Storm in dismantling an entrenched defending force with virtually no friendly casualties. He also provides one of the first scholarly analyses of Operation Iraqi Freedom, showing that its plan was curiously divorced from the realities of military history, grounded instead on nebulous theories about expected enemy behavior. Throughout Citino points to the importance of mobility--especially mobilized armor--in modern operational warfare and assesses the respective roles of firepower, training, doctrine, and command and control mechanisms. Brimming with new insights, Citino’s study shows why technical superiority is no guarantee of victory and why a thorough grounding in the history of past campaigns is essential to anyone who wishes to understand modern warfare. Blitzkrieg to Desert Storm provides that grounding as it addresses the future of operational-level warfare in the post–9/11 era.
First published in 1961, Early Midwestern Travel Narratives records and describes first-person records of journeys in the frontier and early settlement periods which survive in both manuscript and print. Geographically, it deals with the states once part of the Old Northwest Territory-Ohio, Indiana, Michigan, Illinois, Wisconsin, and Minnesota-and with Missouri, Iowa, Kansas, and Nebraska. Robert Hubach arranged the narratives in chronological order and makes the distinction among diaries (private records, with contemporaneously dated entries), journals (non-private records with contemporaneously dated entries), and "accounts," which are of more literary, descriptive nature. Early Midwestern Travel Narratives remains to this day a unique comprehensive work that fills a long existing need for a bibliography, summary, and interpretation of these early Midwestern travel narratives.
This book synthesizes and extends modern political-economic theory to explain the postwar evolution of macroeconomic policy in developed democracies. Chapters 2-4 study transfers, debt, and monetary/wage policy-making and outcomes, stressing that participation enhances transfer-policy responsiveness to inequality and vice versa, that policy-making veto actors retard fiscal-policy adjustments, inducing greater long-run debt-responses to all other political-economic stimuli, and that monetary policy's nominal and real effects depend, respectively, on the broader political-economic interest-structure and on wage-price bargainers' sectorial composition and coordination. Broadly, the book argues that these developments have exacerbated the distributional conflicts inherent in the policies to which postwar governments had committed while undermining their more-universally desired efficiency-fostering roles. Battles that once raged primarily over policies conducted within postwar-commitment frameworks now rage over the putative 'reforms' of the frameworks that will set the institutional rules within which democratic struggle over macroeconomic policy and free-market competition will continue.
The Wiley Handbook of Contextual Behavioral Science describes the philosophical and empirical foundation of the contextual behavioral science movement; it explores the history and goals of CBS, explains its core analytic assumptions, and describes Relational Frame Theory as a research and practice program. This is the first thorough examination of the philosophy, basic science, applied science, and applications of Contextual Behavioral Science Brings together the philosophical and empirical contributions that CBS is making to practical efforts to improve human wellbeing Organized and written in such a way that it can be read in its entirety or on a section-by-section basis, allowing readers to choose how deeply they delve into CBS Extensive coverage of this wide ranging and complex area that encompasses both a rich basic experimental tradition and in-depth clinical application of that experimental knowledge Looks at the development of RFT, and its implications for alleviating human suffering
Addiction Counseling Review: Preparing for Comprehensive, Certification, and Licensing Examinations offers a clear, readable overview of the knowledge and skills those training as alcohol or other drug counselors need to pass their final degree program, certification, and licensing examinations. It is organized into six sections: Addiction Basics, Personality Development and Drugs, Common Client Problems, Counseling Theories and Skills, Treatment Resources, and Career Issues. Each chapter includes challenging study questions that enable readers to assess their own level of understanding, including true/false, multiple choice, and provocative discussion questions. Each chapter also provides a glossary of key terms and, in addition to references, annotated suggestions for further reading and Web site exploration. This book will be a resource to which students and trainees will go on referring to long after it has helped them through their examinations. In addition, faculty and established professionals will find it a useful one-stop summary of current thinking about best practice.
Authoritative, comprehensive and definitive, Pulmonary Circulation builds on the success of its previous two editions by providing practising respiratory physicians with a highly-ordered, unique reference work on the structure, function and pathophysiology of the pulmonary circulation. New for the third edition: Thoroughly revised with comprehensive coverage from diagnosis and clinical evaluation of pulmonary hypertension, to imaging techniques, disorders and treatment A new truly global team of expert editors, authors and key opinion leaders provide a wealth of detail on the latest developments and issues New chapters, such as: paediatrics, critical care, special environments including high altitude and underwater More quality chapters, authors, illustrations with thorough and thoughtful referencing make this book a contemporary essential reference text Pulmonary Circulation remains an essential resource for pulmonary hypertension specialists and should prove invaluable in all respiratory, cardiac and intensive care units.
This title is part of UC Press's Voices Revived program, which commemorates University of California Press’s mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1975.
Praise for the Second Edition . . . "A basic, how-to guide . . . for all those involved in the construction industry."--The Construction Lawyer "This book is indispensable for any contractor who, against his better judgment, bids a fixed price contract . . . highly recommended."--David S. Thaler, The Daily Record "Particularly useful to the construction contractor [and] also instructive to owners and design professionals."--Journal of Performance of Constructed Facilities "Practical advice on how to prevent a dispute--from the moment that the contract preparation begins through performance by the contractor and administration by the owner."--Concrete International Over two successful editions, Construction Claims has become the sourcebook of choice on the subject for construction professionals from all areas of the industry. Now extensively updated, the Third Edition includes new material on design/build implications for construction; dispute review boards and their proper use; partnering to avoid disputes; and federal and relevant state environmental regulations. Written by a prestigious and experienced author team, it uses an accessible, step-by-step approach that follows the contracting process from start to finish, with detailed coverage of provisions of the law, "red flag" contract clauses, and documentation issues and procedures. It also addresses the key aspects of prosecuting and defending claims, from claims presentation to formal dispute resolution. Complete with dozens of new forms and checklists, plus case histories, mini-cases, and more, this edition is an essential resource for anyone involved in construction and the law.
An extremely useful collection of the early evidence for writers of 'myth as history' -D. Felton, Bryn Mawr Classical ReviewThis is the first volume in a set of two. Volume 1 introduces and collects together the scattered quotations of the Greek writers of the sixth to the fourth centuries BC who first recorded in prose the tales of Greek mythology (the 'mythographers'), whilst Volume 2 will be a scholarly commentary.
Treatment of Voice Disorders, Second Edition presents the entire range of behavioral, medical, and surgical voice treatment options from the perspective of a variety of specialist practitioners with exceptional breadth and clarity. As suggested in the opening chapter, contemporary treatment of voice disorders draws on interdisciplinary expertise, and the book is true to that perspective. The team approach to voice treatment is realized through the contributions of laryngologists, speech-language pathologists, singing voice specialists, nurses, physiotherapists, acting voice trainers, and others. The reader will find discussion of various treatment procedures, including surgical, pharmacological, and behavioral. This text presents essential information that allows for the effective interaction of various specialties. For example, behavioral specialists can draw on the information that is given on surgery, trauma and injury, and medications. This book is at once a template for team-based treatment and a deep informational resource for treatment alternatives. Its scope and depth make it a book that the voice specialist will want to keep close at hand. New to this edition: New content on topics such as technology in the studio and pedagogy for children.Many topics have been expanded to highlight current practices, to include information published since the previous edition, and to present current management approaches.Chapters have been rewritten extensively to include the most current techniques and to reflect the latest beliefs and practices, as well as the most recent information from the evolving literature in this field.Chapter 16 on nutrition has been completely rewritten and includes important changes in criteria and strategy, reflecting developments in nutritional science over the past decade.New material on topics such as choral pedagogy for geriatric singers, laryngeal manipulation, and cosmetic procedures and their implications for voice professionals. Treatment of Voice Disorders, Second Edition is ideal for speech-language pathology students and clinicians and is suitable for classroom use as well as for reference. It is an essential volume for anyone concerned with voice disorders.
This work spanning twelve extensive volumes is the result of contributions by many Southern men to the literature of the United States that treats of the eventful years in which occurred the momentous struggle called by Mr. A. H. Stephens “the war between the States.” These contributions were made on a well-considered plan, to be wrought out by able writers of unquestionable Confederate record who were thoroughly united in general sentiment and whose generous labors upon separate topics would, when combined, constitute a library of Confederate military history and biography. According to the great principle in the government of the United States that one may result from and be composed of many — the doctrine of E pluribus unum--it was considered that intelligent men from all parts of the South would so write upon the subjects committed to them as to produce a harmonious work which would truly portray the times and issues of the Confederacy and by illustration in various forms describe the soldiery which fought its battles. Upon this plan two volumes — the first and the last-comprise such subjects as the justification of the Southern States in seceding from the Union and the honorable conduct of the war by the Confederate States government; the history of the actions and concessions of the South in the formation of the Union and its policy in securing the existing magnificent territorial dominion of the United States; the civil history of the Confederate States, supplemented with sketches of the President, Vice-President, cabinet officers and other officials of the government; Confederate naval history; the morale of the armies; the South since the war, and a connected outline of events from the beginning of the struggle to its close. The two volumes containing these general subjects are sustained by the other volumes of Confederate military history of the States of the South involved in the war. Each State being treated in separate history permits of details concerning its peculiar story, its own devotion, its heroes and its battlefields. The authors of the State histories, like those of the volumes of general topics, are men of unchallenged devotion to the Confederate cause and of recognized fitness to perform the task assigned them. It is just to say that this work has been done in hours taken from busy professional life, and it should be further commemorated that devotion to the South and its heroic memories has been their chief incentive. This volume one out of twelve, covering the Civil War in Maryland and West Virginia.
This work provides in-depth analysis of the origins of landscape ecology and its close alignment with the understanding of scale, the causes of landscape pattern, and the interactions of spatial pattern with a variety of ecological processes. The text covers the quantitative approaches that are applied widely in landscape studies, with emphasis on their appropriate use and interpretation. The field of landscape ecology has grown rapidly during this period, its concepts and methods have matured, and the published literature has increased exponentially. Landscape research has enhanced understanding of the causes and consequences of spatial heterogeneity and how these vary with scale, and they have influenced the management of natural and human-dominated landscapes. Landscape ecology is now considered mainstream, and the approaches are widely used in many branches of ecology and are applied not only in terrestrial settings but also in aquatic and marine systems. In response to these rapid developments, an updated edition of Landscape Ecology in Theory and Practice provides a synthetic overview of landscape ecology, including its development, the methods and techniques that are employed, the major questions addressed, and the insights that have been gained.”
Reprint of the original, first published in 1871. The publishing house Anatiposi publishes historical books as reprints. Due to their age, these books may have missing pages or inferior quality. Our aim is to preserve these books and make them available to the public so that they do not get lost.
Offering up-to-date, comprehensive coverage of disease progression, diagnosis, management, and prognosis, Textbook of Pediatric Rheumatology is the definitive reference in the field. For physicians caring for children with rheumatic diseases, this revised 8th Edition is an unparalleled resource for the full spectrum of rheumatologic diseases and non-rheumatologic musculoskeletal disorders in children and adolescents. Global leaders in the field provide reliable, evidence-based guidance, highlighted by superb full-color illustrations that facilitate a thorough understanding of the science that underlies rheumatic disease. - Offers expanded coverage of autoinflammatory diseases, plus new chapters on Takayasu Arteritis and Other Vasculitides, Mechanistic Investigation of Pediatric Rheumatic Diseases, Genetics and Pediatric Rheumatic Diseases, and Global Issues in Pediatric Rheumatology. - Reflects the changes in diagnosis, monitoring, and management that recent advances have made possible. - Covers the latest information on small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies, helping you choose treatment protocols based on the best scientific evidence available today. - Features exhaustive reviews of the complex symptoms, signs, and lab abnormalities that characterize these clinical disorders. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Robert Grant draws upon his fifty years of experience dealing with the correlation of early Christianity and classical culture to demonstrate that Christian "heretics" were the first to apply literacy criticism to Christian books. He shows that the heretics' methods were the same as those of pagan contemporaries, and that literary criticism derived from the Hellenistic schools. Literary criticism was later used by famous orthodox leaders, and, as time passed, orthodox critics increasingly found that these methods could serve them well. Grant supports his argument by focusing on principal figures Origen, Dionysius of Alexandria, Eusebius, and Jerome.
This edition provides up-to-date reports on criminal victimization including current trends, the emotional impact of crime, the needs and problems of certain victims, and victim participation in the criminal justice system.
Head and neck cancer is a very common cancer worldwide with an estimated 500,000 individuals diagnosed each year. In the United States an average of 39,000 new cases are reported each year representing between 3 to 5% of all new cancer cases diagnosed annually. Head and neck cancers are more common in men and in individuals over the age of 50. The treatment of head and neck cancer is extremely challenging and involves insight and expertise from multiple disciplines. Multidisciplinary Management of Head and Neck Cancer is a comprehensive textbook looking at different aspects of head and neck cancer, including the diagnosis, treatment and outcomes for patients with this disease. The chapters written by world-renowned experts cover the entire discipline of head and neck oncology and include discussion of the role of HPV infections, advances in radiotherapy, new surgical techniques, novel agents in thyroid therapy and more. The book is designed to be both practical and comprehensive for the physicians treating this complex disease. Features of Multidisciplinary Management of Head and Neck Cancer include: A chapter on the role of HPV infections in head and neck cancer A chapter on new advances in radiotherapy for head and neck cancer, including review IMRT, new standards and potential pitfalls Detailed discussion of the role of chemotherapy in head and neck cancer, including commonly used drugs and how to combine them with radiotherapy to improve patient outcomes Detailed discussion on incorporating novel agents with radiotherapy Detailed discussion of novel therapeutics in head and neck cancer, including new drugs and biologics
Encapsulated cells offer enormous potential for the treatment of human disease. This work includes detailed descriptions of chemical properties of encapsulation materials, purification, biocompatibility issues and experimental protocols.
Pension reforms in former transition economies aimed to fiscal sustainability and market economy objectives. Estimating the gross and net replacement rates in 9 countries for steady conditions until 2040 show that they are adequate for most categories of workers, with the exception of those with intermittent or no formal sector employment.
Fully updated to reflect the latest developments, the third editionof Research Methods In Clinical Psychology offers acomprehensive introduction to the various methods, approaches, andstrategies for conducting research in the clinical psychologyfield. Represents the most accessible, user-friendly introduction toconducting and evaluating research for clinical psychologists andrelated professionals Ideal for students and practitioners who wish to conduct theirown research or gain a better understanding of publishedresearch Addresses important issues such as philosophical underpinningsof various methodologies, along with socio-political issues thatarise in clinical and community settings Step-by-step guidance through all phases of a clinicalpsychology research project—from initial concept andgroundwork, through to measurement, design, analysis, andinterpretation Updates to this edition include new or expanded coverage ofsuch topics as systematic review and literature searchingmethods, modern psychometric methods, guidance on choosing betweendifferent qualitative approaches, and conducting psychologicalresearch via the Internet
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