A detailed knowledge of the mechanisms underlying the transcriptional control of gene expression is of fundamental importance to many areas of contemporary biomedical research, ranging from understanding basic issues (such as control of embryonic development) to practical applications in industry and medicine. Although elementary concepts of gene expression are described in all general molecular biology textbooks, the depth of coverage is often rather limited and recent discoveries are sometimes not adequately taken into consideration.This book presents much of the current thinking concerning molecular mechanisms of transcriptional control in a form easily accessible to undergraduates with an understanding of basic molecular biology concepts. It contains detailed information about the various pro- and eukaryotic transcriptional machineries that has recently become available through the combined efforts of geneticists, biochemists and structural biologists. The book will thus not only serve as an undergraduate text but also offer something new and interesting to more advanced readers and professional scientists who want to keep up to date with rapid advances in this field.
The scope and nature of this account of the modern history of reading/literacy education (especially tied to the aspirational readers) are unique. Enlisting the metaphor of waves, it traces monumental shifts in theory, research and practice related to reading education and literacy that represent developments that verge on revolutionary changes. Each of these waves is accompanied with a discussion of the aspirational reader that sets the stage for contemplating these shifts and their significance. The discussions trace the research and theoretical developments in a fashion that exemplifies the origins of the shifts and their influences"--
The fundamental idea of this book is to show – based on the example of Oswald Menghin, Minister of Education of the National Socialist Austrian “Anschluss”-government, and the networks surrounding him – how science and politics were interwoven in Austria in the first half of the 20th century and how the ideas and networks created in that milieu outlasted the alleged caesurae of this period and found continuation in post-war South America. As Menghin traversed an astonishing number of political upheavals and changes – time after time in exalted positions –, his biography may be considered as paradigmatic for the Age of Extremes. The following aspects form the core interest of this book: (1) Menghin’s position in the political and scientific field, as well as the interconnection between these spheres. (2) The transnational entanglement between the two central areas of Menghin’s geographic spheres of action. (3) Continuities and changes both in Menghin’s biography and in a broader political and scientific context in Austria and Argentina. (4) Menghin’s scope of action and the extent of his responsibility for crucial and often dire developments in all these facets.
This monograph reviews and summarizes the substantial body of work that has been published on the transcription by polymerase III over the past 5 years. Progress in this field has been very rapid since 1993, and this new edition incorporates all the recent developments and offers the reader a highly detailed analysis of the current state of research on this largest and most complex of the eukaryotic RNA polymerases.
The collapse of the Habsburg monarchy in 1918 galvanized discussion about national identity in the new Republic of Austria. As Robert Pyrah shows in this thoroughly documented study, the complex identity politics of interwar Austria were played out in the theatres of Vienna, which enjoyed a cultural prominence rarely matched in other countries. By 1934, productions across the city were being co-opted to serve the newly patriotic cause of the Dollfuss and Schuschnigg regimes, and the Burgtheater, once known as the ‘first German stage’, had been transformed into a ‘national theatre for Austria’. Using case studies of key productions and a wealth of previously unseen archival material, Pyrah sheds new light on artistic and ideological developments throughout the period, including the neglected earlier years. He documents previously unexplored overlaps in the cultural programmes of Left and Right, and unearths evidence that key institutions were subverted by the Right well before the suspension of parliamentary rule in 1933.
Evolutionary Tax Reform in Emerging Economies: an income-based approach provides one approach to tax reform in emerging economies. Conrad describes the context for tax reform in these economies and outlines the “Standard Approach” to tax reform, an approach that is critically evaluated. Emphasis is placed on revenue generation given to economic efficiency considerations and constraints, institutional and economic, that change through time, and the approach of the work is based on two main elements: policy, for all tax instruments, developed with the individual as the taxpayer, and policy implemented via the use of withholding taxes (advanced taxes), to the extent possible, and via the use of withholding agents, Advanced Payment Agents (APA's). Evolutionary Tax Reform in Emerging Economies examines APAs, direct tax (income tax), and VAT, excises, and tariffs, and discusses topics such as how the base of each tax is defined, how the base might change over time, how APAs are used to collect advanced payments, and how to preserve excise tax collection at the point of production (or import).
Equip yourself with all the guidance you need to diagnose, stabilize and provide the initial management of MSK emergencies as effectively as possible. Optimize patient's disposition ranging from emergency department discharge to the operating room. A leading orthopaedic trauma surgeon and a respected emergency physician bridge the gap between these specialties to help you give these patients the best chances of favorable outcomes. - Address emergency orthopaedics - both acute trauma and urgent general orthopaedic issues - at the point of care with the multidisciplinary guidance from experts in both trauma surgery and emergency medicine. - Easily navigate the information you need to make critical decisions related to diagnosis; options for initial therapeutic intervention; disposition planning; and follow up through a consistent, templated format designed for rapid reference. - Manage the full spectrum of traumatic musculoskeletal challenges, including infections, soft tissue injuries, and compartment syndrome, that you might encounter in a hospital emergency department, urgent care facility, or primary care setting. - Make the best decisions for every patient with unique coverage of both adult and pediatric injuries. - Access Musculoskeletal Emergencies online at www.expertconsult.com, search the complete contents, and download all the images.
A political, cultural, and socioeconomic history of the Habsburg empire, discussing the rise of Habsburg power, its subsequent status and action as a great power, and its dissolution.
The Third Edition (formerly titled International Public Health) brings together contributions from the world's leading authorities into a single comprehensive text. It thoroughly examines the wide range of global health challenges facing low and middle income countries today and the various approaches nations adopt to deal with them. These challenges include measurement of health status, infectious and chronic diseases, injuries, nutrition, reproductive health, global environmental health and complex emergencies. This thorough revision also explores emerging health systems, their financing, and management, and the roles of nation states, international agencies, the private sector and nongovernmental organizations in promoting health. Your students will come away with a clear understanding of how globalization is impacting on global health, and of the relationship between health and economic development.
What will life be like in America, Europe, Japan or China in the year 2020? As everyone's lives across the world are become increasingly interconnected by globalization and new technologies quicken the pace of everything, the answer to that question depends on the fate and paths of the world's major nations. In Futurecast, Robert Shapiro, former U.S. Under Secretary of Commerce and Chairman/Co-founder of Sonecon, looks into the future to tell us what our world will over the next dozen years. Though that time span seems brief, Shapiro foresees monumental changes caused by three historic new forces—globalization, the aging of societies, and the rise of America as a sole superpower with no near peer— will determine the paths of nations and the lives of countless millions. What jobs will there be for you and your children? What will happen to your health care? How safe will you be at home or abroad? Answers to these questions will depend, even more than today, on where you live in the world: • Even as China expands its military and its economy, America will be the world's sole superpower for at least the next generation, and continue to lead efforts to preserve global security and stability. • The U.S. and China will be the world's two indispensable economies, dominating the course of globalization. • Globalization will continue to shift most heavy manufacturing and millions of high-end service jobs from advanced countries like the US, to China, India, Indonesia, Mexico, Romania, Turkey and other developing nations. • Europe's major nations and Japan will face the prospect of genuine economic decline and critical problems in their retirement pension systems, moving further towards the periphery of global economic and geopolitical power. • Every major country—the U.S., Europe, Japan, China—will face critical problems with their health care systems, and the entire world will face a crisis over energy and climate change. If one adds the wildcard of possible, catastrophic terrorist attacks to this mix, the period between now and 2020 will be as challenging as any in modern times. Taking these deep global developments into account when planning for the future isa necessity. Robert Shapiro's clear-eyed Futurecast is the knowledge portfolio you need to prepare for the years to come.
In response to the terrorist attacks of 11 September 2001, the United States embarked on a dramatic and sustained effort to reform and revitalize its homeland security policies and structures. This book offers an examination of the evolution of policy and the concurrent restructuring of existing agencies, as well as the creation of new bodies designed to counter the threat of transnational terrorism. Detailing the historical roots of US homeland security policy and its evolution in the aftermath of the 9/11 attacks, this book provides a unique overview of the emerging and existing agencies and bureaux at the national, state and local levels which are tasked with homeland security. Furthermore, by integrating the existing paradigms of contemporary security policy with the changing nature of threat and response, it provides an invaluable overview of existing and likely future security threats to the US homeland.
Not only does Keyserlingk show that Great Britain and the US recognized the Anschluss both in fact and in law throughout the war, he also reveals the growing importance of propaganda as a tool of government.
An "account of the continuing ethnic and state violence after the end of WWI--conflicts that more than anything else set the stage for WWII"--Provided by publisher.
The most trusted, rigorous, and up-to-date toxicology resource and educational companion available – now in full color Goldfrank’s Toxicologic Emergencies continues to be the source you can turn to first for any poisoning or overdose. The text provides clear information on every aspect of toxicologic emergencies, from pharmacology to clinical presentation to management. Fully referenced and featuring a consistent organization, Goldfrank’s begins with an in-depth examination of general principles of medical toxicology. It then progresses to the biochemical principles and molecular basis of toxicology, and provides detailed insight into how xenobiotics affect vital signs, organs, and systems throughout the body. Next, a wide spectrum of clinically important exposures -- including drugs, plants, metals, household products, occupational and environmental xenobiotics are covered within logical categories for easy access to information. Finally, the book concludes with sections on principles of practicing clinical toxicology in today’s challenging healthcare environment. NEW TO THIS EDITION Full-color design and uniformly drawn figures clarify key concepts Special Considerations focus on decision-making in unique toxicologic circumstances, that influence clinical practice and have the potential to improve patient care Antidotes in Depth, following pertinent chapters, place each antidote in its proper context to ensure immediate availability of essential information relevant for clinical use More clinically-relevant figures and quick-reference tables Online learning center, available at www.goldfrankstoxicology.com, includes case studies, and a database of multiple choice questions that allow you to create a custom test for review and study. Every chapter is thoroughly rewritten and new chapters are added to reflect the very latest thinking in the field Here's why Goldfrank's is known worldwide as the field's leading text: General Approach to Medical Toxicology; The Biochemical and Molecular Basis of Medical Toxicology; The Pathophysiologic Basis of Medical; Toxicology: The Organ System Approach; The Clinical Basis of Medical Toxicology: Analgesics and Nonprescription Medications; Prescription Medications Psychopharmacologic Medications; Alcohols and Drugs of Abuse; Food Poisoning; Botanicals; Heavy Metals; Household Toxins; Pesticides; Occupational and Environmental Toxins; Toxic Envenomations; V. Special Populations; Preventive, Psychosocial, Nursing, Epidemiologic, Research & Legal Perspectives.
The question the authors pose is whether we have the wherewithal to finish the job." DEREK BURNEY, former Canadian Ambassador to the US "This timely and provocative book will remind Canadians that the smart fiscal and trade policies pursued. [...] My inestimable co-authors Jason Clemens and Niels Veldhuis and I therefore wrote a book to piece it together for our fellow Canadians, reviewing the reforms in detail and putting them in the context of Canada's long tradition of fiscal discipline and how the abandonment of that tradition had gotten us into the mess in the first place. [...] The federal debt held by the public escalated rapidly due to the large budget deficits since the onset. [...] Federal Entitlements One of the main difficulties in turning around the long-term fiscal condition of the United States government is the unsustainable current structure of entitlement. [...] The budget plan included a host of concrete actions such as • a substantial reduction in the size of the federal government - spending and employees - to reduce the deficit; • reform of government programs with an increased focus on efficiency; • reform and a reduction of the employment insurance (EI) program; • substantial reductions in business subsidies; and • restructured and reduced provincia.
This provocative book offers a revisionist history of the transdenominational initiatives of English evangelicals from 1965 to 2000. Warner provides an authoritative theological analysis and a constructive sociological critique. This is an invaluable study for all those--in the academy, the church, and wider society--who want a fuller understanding of the social and religious significance and the evolutionary dynamics of this influential and diversifying religious tradition.
The standard-setting reference in medical toxicology—trusted as the leading evidencebased resource for poison emergencies A Doody's Core Title for 2017! For decades, one name has been synonymous with the most respected, rigorous perspectives on medical toxicology and the treatment of poisoned and overdosed patients: Goldfrank's Toxicologic Emergencies. Presented in full color, Goldfrank’s delivers essential, patientcenteredcoverage of every aspect of poison management. The editors and authors are recognized as preeminent scholars in their specialties and provide unmatched coverage of all aspects of toxicologic emergencies, from pharmacology and clinical presentation to cutting-edge treatment strategies. Goldfrank's Toxicologic Emergencies, Tenth Edition begins with an examination of medical toxicology principles and techniques. It then reviews the biochemical, molecular, and pathophysiologic basis of toxicology, followed by an intense focus on toxicologic principles related to special patient populations. Features Case studies enhance your understanding of the clinical application of the text material Practical focus on the pathophysiologic basis of medical toxicology The Antidotes in Depth sections delivers the expertise of toxicologists across the world as they present treatments for critically ill poisoned and overdosed patients and allow you to easily identify key issues relating to the use of complex and often unfamiliar therapies The principles of risk management, medicolegal decision making, patient safety, post mortem toxicology and the assessment of ethanol induced impairment described in chapters and Special Considerations emphasize the interface between medical toxicology, the law, and quality care
Explores how urban nightlife is experiencing a 'McDonaldisation', where big branded names are taking over large parts of downtown areas, leaving consumers with an increasingly standardised experience.
Robert Knight's book examines how the 60,000 strong Slovene community in the Austrian borderland province of Carinthia continued to suffer in the wake of Nazism's fall. It explores how and why Nazi values continued to be influential in a post-Nazi era in postwar Central Europe and provides valuable insights into the Cold War as a point of interaction of local, national and international politics. Though Austria was re-established in 1945 as Hitler's 'first victim', many Austrians continued to share principles which had underpinned the Third Reich. Long treated as both inferior and threatening prior to the rise of Hitler and then persecuted during his time in power, the Slovenes of Carinthia were prevented from equality of schooling by local Nazis in the years that followed World War Two, behavior that was tolerated in Vienna and largely ignored by the rest of the world. Slavs in Post-Nazi Austria uses this vital case study to discuss wider issues relating to the stubborn legacy of Nazism in postwar Europe and to instill a deeper understanding of the interplay between collective and individual (liberal) rights in Central Europe. This is a fascinating study for anyone interested in knowing more about the disturbing imprint that Nazism left in some parts of Europe in the postwar years.
Experimentation in Improvised Jazz: Chasing Ideas challenges the notion that in the twenty-first century, jazz can be restrained by a singular, static definition. The worldwide trend for jazz to be marginalized by the mainstream music industry, as well as conservatoriums and schools of music, runs the risk of stifling the innovative and challenging aspects of its creativity. The authors argue that to remain relevant, jazz needs to be dynamic, proactively experimental, and consciously facilitate new ideas to be made accessible to an audience broader than the innovators themselves. Experimentation in Improvised Jazz explores key elements of experimental jazz music in order to discern ways in which the genre is developing. The book begins with an overview of where, when and how new ideas in free and improvised jazz have been created and added to the canon, developing the genre beyond its initial roots. It moves on to consider how and why musicians create free and improvised jazz; the decisions they make while playing. What are they responding to? What are they depending on? What are they thinking? The authors analyse and synthesise the creation of free jazz by correlating the latest research to the reflections provided by some of the world’s greatest jazz innovators for this project. Finally, the book examines how we respond to free and improvised jazz: artistically, critically and personally. Free jazz is, the book argues, an environment that develops through experimentation with new ideas.
Concise, current, need-to-know coverage of emergency medicine in children – presented in full colorEndorsed by the American College of Emergency Physicians "...a comprehensive and current resource for anyone who cares for children in an acute setting, from the office to the emergency department. Its presentation is straightforward, and the information is easy to read and assimilate. It will be a valuable resource for those in the field of pediatric emergency medicine as well as other practitioners who occasionally care for sick children."—JAMA (reviewing an earlier edition)This clinically-focused guide covers the entire field of pediatric emergency medicine. Featuring a strong focus on practical need-to-know information Pediatric Emergency Medicine, Fifth Edition is bolstered by numerous full-color images, bulleted High-Yield Facts at the beginning of each chapter, nearly 100 diagnostic and treatment algorithms, and treatment tables with drug dosages. Endorsed by the American College of Emergency Physicians, this book is perfect for use in the emergency department or the pediatric clinic.FEATURES•Chapters open with bulleted High-Yield Facts, followed by just enough pathophysiology for understanding, and continue with a focus on what needs to be done to protect and save the child•Broad scope spans the full spectrum of pediatric emergencies -- from trauma care to psychosocial emergencies•NEW CHAPTER on Brief Resolved Unexplained Events (BRUE)•Opens with an important symptom-based section of Cardinal Presentations that familiarizes you with crucial life-saving protocols•Covers all major categories of disease that present in children on an urgent or emergent basisIf you are in need of a very readable and easily accessible, evidence-based text written to help you provide high quality emergency medical care to children, your search ends here.
ACHIEVE SUCCESSFUL OUTCOMES WITH THE MOST CLINICALLY FOCUSED GUIDE TO PEDIATRIC EMERGENCY MEDICINE "...A comprehensive and current resource for anyone who cares for children in an acute setting." -- JAMA (review of previous edition) Endorsed by the American College of Emergency Physicians, this thoroughly updated, full-color resource presents a complete overview of pediatric emergency medicine. Pediatric Emergency Medicine begins with an essential symptom-based section on cardinal presentations that familiarizes you with crucial life-saving protocols. Subsequent sections cover all major categories of disease--from respiratory failure to pediatric hypertension--that present in children on an urgent or emergent basis. FEATURES Broad scope of the text spans the entire spectrum of pediatric emergencies, from resuscitation and trauma, to gastrointestinal and psychosocial emergencies Over 100 diagnostic and treatment algorithms present an at-a-glance review of best practices for optimizing patient care 1200 color images show you what to expect and what to do Chapter-opening key points, followed by concise coverage of pathophysiology, offers incisive guidance on what needs to be done to effectively stabilize and treat the pediatric patient NEW! Chapter on foreign bodies offers an in-depth overview of this common pediatric problem NEW! Updated references throughout include the most recent pediatric emergency guidelines and recommendations from professional societies
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